Hepatitis E: What’s New?

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Complications of Acute HEV Acute Liver Failure Cholestatic <strong>Hepatitis</strong> Chronic <strong>Hepatitis</strong> E Mortality Low 0.5%-4% Increase in young infants
HEV and Pregnancy In endemic regions ■ Up to 70% of pregnant women progress to AHF in 2 nd & 3 rd trimester. 1 ■ Worse fetal and maternal outcomes. ■ High mortality rate 15-25% in 3 rd trimester. 2 ■ HEV G-1 and 2, virulence of these human-specific viruses, hormonal and immunological changes. ■ AHF and poor pregnancy outcomes not observed with G-3. 3,4 1.Patra S, et al. Ann Intern Med 2007; 147:28. 2.Khuroo MS, et al. Am J Med 1981; 70:252. 3.Anty R, et al. J Clin Virol 2012; 54:76. 4.Tabatabai J, et al. J Clin Virol 2014; 61:170.
Page 2 and 3: HEPATITIS E: WHAT’S NEW? Naglaa Z
Page 4 and 5: Known Facts: HEV ■ 20 million HEV
Page 6 and 7: Geographical Distribution of HEV Eg
Page 8 and 9: HEV Genotypes Four genotypes/24 sub
Page 10 and 11: Modes of HEV Transmission Fecal-ora
Page 12 and 13: Clinical Picture of HEV
Page 16 and 17: Clinical Picture: Complications Acu
Page 18 and 19: Chronic Hepatitis E Persistently el
Page 20 and 21: Chronic Hepatitis E Other Immunosup
Page 22 and 23: Diagnostic tests for HEV IgM anti-H
Page 24 and 25: HEV Diagnosis Acute HEV Chronic HEV
Page 26 and 27: Treatment of HEV Acute HEV Signific
Page 28 and 29: Treatment of Chronic HEV Reduction
Page 30 and 31: Response to Antiviral Therapy Stool
Page 34 and 35: Treatment of HEV: Future Therapy
Page 36 and 37: Randomized trial in China, 112,604

Hepatitis E: What’s New?

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