Where are we on the path to eliminate hepatitis C virus ?

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Nearly Everyone With HCV Can Now Be Treated Successfully • Very high SVR rates; therapies highly tolerable • All-oral therapy for almost every pt • Treatment generally just 12 wks 100 80 60 40 Standard Interferon 1991 Ribavirin 1998 34 Peginterferon 2001 42 39 55 Direct-Acting Antivirals 2011 70+ 2013 90+ All-Oral Therapy Current 95+ 20 0 6 IFN 6 Mos 16 IFN 12 Mos IFN/RBV 6 Mos IFN/RBV 12 Mos PegIFN 12 Mos PegIFN/ RBV 12 Mos PegIFN/ RBV + DAA DAA + RBV ± PegIFN All–Oral DAA± RBV 7
We Now Have the Tools . . . What Do We Do With Them? ‣Should We Focus Primarily On Pts With Cirrhosis? ‣Should We Try To Cure Everyone? 8
Page 2 and 3: Are we on the path
Page 4 and 5: Control vs. Elimination vs. Eradica
Page 6 and 7: Why HCV Is A Tractable Target For E
Page 10 and 11: 9
Page 12 and 13: Viremic Infections (by Stage) Impac
Page 14 and 15: Focusing on Cirrhosis Rapid reducti
Page 16 and 17: Pts (%) HCV in the US: Gaps in Curr
Page 18 and 19: HCV is not JUST a liver virus ‣Pe
Page 20 and 21: Pts (%) HCV Affects Pts’ Lives No
Page 22 and 23: Treating Everyone ‣Encourages tes
Page 24 and 25: Increasing SVR >90% with increase i
Page 26 and 27: Eliminating HCV Is Everyone’s Job
Page 28 and 29: WHAT needs to be done? 1 • Innova
Page 30 and 31: 29
Page 32 and 33: Could HCV Be Eliminated Through Ant
Page 34 and 35: Impact Of Prevention On Outcome Of
Page 36 and 37: 35
Page 38: 37

Where are we on the path to eliminate hepatitis C virus ?

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