Management of DAAs Failure
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
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Antiviral Resistance<br />
• Each patient carries a preexisting<br />
heterogeneous population <strong>of</strong><br />
viruses:<br />
Sensitive viral variants (wild-type)<br />
Resistant viral variants<br />
– Wild-type: dominant and drugsensitive<br />
– Resistant-associated variants<br />
/substitutes) minority population(<br />
• The selection <strong>of</strong> drug- resistant<br />
variants has been observed in<br />
patient who had treatment failure.
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