Management of DAAs Failure

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• HCV is an enveloped, positive-sense, single-stranded RNA virus that replicates using RNA polymerase that lacks general proof-reading ability. • This error-prone RNA polymerase is responsible for the genetic variability exhibited by HCV isolates.The spontaneous nucleotide substitution rate of HCV is high, with a frequency of 10 2 to 10 3 substitutions per nucleotide site per year • Accumulation of nucleotide substitution in the HCV genome results in alteration and evolution into distinct genotypes, subtypes
Sequence homology of whole genome and specific genes among HCV classifications
Page 2 and 3: Management of DAAs Failure Prof. Ga
Page 6 and 7: Antiviral Resistance • Each patie
Page 8 and 9: All DAAs Can Select Resistant Varia
Page 10 and 11: Barrier to Resistance Low-barrier d
Page 13: NS5B RAV(S) • Sofosbuvir has a hi
Page 16 and 17: Protease inhibitor-Resistant Viruse
Page 18 and 19: SVR12 (%) 24 Wks of LDV/SOF Retreat
Page 20 and 21: DAA Treatment Failure •Relapse or
Page 22 and 23: Treatment recommendations for retre
Page 24 and 25: A- Retreatment of patients with pre
Page 26 and 27: A- Retreatment of patients with pre
Page 28 and 29: Abstract ID: 849 Author: Ng T. et a
Page 30 and 31: Summary • Treatment-emergent RAV(

Management of DAAs Failure

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