Management of DAAs Failure
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
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• HCV is an enveloped, positive-sense, single-stranded RNA virus that replicates using<br />
RNA polymerase that lacks general pro<strong>of</strong>-reading ability.<br />
• This error-prone RNA polymerase is responsible for the genetic variability exhibited by<br />
HCV isolates.The spontaneous nucleotide substitution rate <strong>of</strong> HCV is high, with a<br />
frequency <strong>of</strong> 10 2 to 10 3 substitutions per nucleotide site per year<br />
• Accumulation <strong>of</strong> nucleotide substitution in the HCV genome results in alteration and<br />
evolution into distinct genotypes, subtypes
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