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Management of DAAs Failure

If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B

If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B

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Pts With NS5A RAVs (%)<br />

Durability <strong>of</strong> Treatment-Emergent NS5A RAVs After<br />

Virologic <strong>Failure</strong><br />

• NS5A RAVs persisted in majority <strong>of</strong> pts for 96 wks<br />

100<br />

80<br />

98 100 98 100<br />

95<br />

86<br />

60<br />

40<br />

n/N =<br />

20<br />

0<br />

62/<br />

63<br />

58/<br />

58<br />

42/<br />

43<br />

VF Baseline FU-12 FU-24 FU-48 FU-96<br />

45/<br />

45<br />

Registry Study<br />

52/<br />

55<br />

50/<br />

58<br />

Dvory-Sobol H, et al. EASL 2015. Abstract O059.

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