Management of DAAs Failure
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
If you have failure of plan A in treating a patient with chronic hepatitis C. What's your plan B
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NS5B RAV(S)<br />
• S<strong>of</strong>osbuvir has a high resistance barrier.<br />
• Although the S282T mutation has been selected in all genotypes during<br />
in vitro studies, the clinical significance <strong>of</strong> this RAV is unclear; it has<br />
been found in 1 <strong>of</strong> 1545 trial participants, who was not cured.<br />
• Yet successful re-treatment with s<strong>of</strong>osbuvir may be possible, even for<br />
people who were not cured by a s<strong>of</strong>osbuvir-containing regimen
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