First International Conference on MOLDAVIAN RISKS – FROM ...
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First International Conference on MOLDAVIAN RISKS – FROM ...

First International Conference on MOLDAVIAN RISKS – FROM ... First International Conference on MOLDAVIAN RISKS – FROM ...

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ong>Firstong> ong>Internationalong> ong>Conferenceong> on MOLDAVIAN RISKS - FROM GLOBAL TO LOCAL SCALE 16-19 May 2012, Bacau, Romania QUANTITATIVE DETERMINATIONS OF CARBON OXIDES FROM ATMOSPHERE AFTER ELECTRONIC ABSORPTION SPECTRA Iuliana Caraman 1 , Oxana Racovet 2 , Dumitru Untila 2 , Silvia Evtodiev 2 , Marius Stamate 1 1 “Vasile Alecsandri” University of Bacau. Romania 2 Laboratory of Scientific Research "Photonics and Metrology Physics", Moldova State University Corresponding author: Iuliana Caraman, iucaraman@yahoo.ca Abstract: In the process of carbonates burning and different chemical reactions with organic compounds participating are forming diverse CO2 and CO carbon oxides. These gases concentration relation determines in a meaningful measure the level of alimentary products fermentation process. So, different technologic processes conducting are necessary quantitative determinations of carbon oxides concentration (CO2, CO). In present are elaborated chemical methods of measuring, but these need much time and special equipment. This shortcoming it is not characteristic for optical methods after absorption spectrums. As it was demonstrated through experimental measurements, CO2 and CO molecules don’t posed absorption electronic bands in visible domain and UV near spectrum. The first electronic stare, absolute gap, of CO2 molecule (stare 2 Σ + g) is found at 45320cm -1 higher than fundamental stare 2 П3/2. Thus, fundamental absorption band of this molecule is in the vacuum UV region (70000 ÷64000) cm -1 . In the paperwork it is analyzed the intensity of the first overtone of the vibration bands v”=0 → v’=1 in dependence of the CO2 and CO molecules concentration in atmosphere. These bands for CO2 and CO molecules are situated respectively at ~ 4260 cm -1 and ~ 4700 cm -1 . Both absorption bands on the 2168 cm - 1and 2347 cm -1 basis respective for CO2 and CO molecules and first overtone represent bands with two branches P and R. for quantitative determinations of these gases concentration in atmosphere was took the intensities ratio in the P branch maximum of the R branch and the absorption intensity at 50 cm -1 from these maximums in dependence of the gases concentration in atmosphere. Also, for verification there were analyzed the P and R branches intensity ratio from the CO2 and CO molecules absorption spectrums and the intensity at the maximum of vibration-rotation band of water vapors from atmosphere. It was established the concentrations interval in which take place linear dependence of the intensities ratio of CO2 and CO molecules concentration in normal atmosphere. Investigations were made in the Laboratory of Scientific Research "Photonics and Metrology Physics", Moldova State University. Key words: carbon, concentration, absorption band, vibration-rotation. 92

ong>Firstong> ong>Internationalong> ong>Conferenceong> on MOLDAVIAN RISKS - FROM GLOBAL TO LOCAL SCALE 16-19 May 2012, Bacau, Romania RISK OF MYOCARDIAL INFARCTION REVEALED BY VARIATION OF CARDIAC TROPONIN I LEVELS WITH AGE AND GENDER: A STUDY OF PATIENTS HOSPITALIZED IN THE CARDIOLOGY DEPARTMENT OF BACAU CITY HOSPITAL DURING THE 2008-2011 PERIOD Laura Vasile 1 , Vlad Artenie 1 , Iuliana Lazar 2 1 ”Al. I. Cuza” University, Department of Molecular Biology and Biochemistry 2 ”Vasile Alecsandri” University of Bacau, Department of Chemical and Food Engineering Corresponding author: Iuliana Lazar, ilazar@ub.ro Abstract Cardiac troponin (cTn) is a reference biomarker for the diagnosis of myocardial necrosis. Cardiac troponin I (cTnI) is a key regulatory protein in cardiac muscle contraction linking Ca2+-cTn combining it with cross-bridge activation reaction between thin and thick filaments. The cTn inhibits actomyosin ATP leading to muscle relaxation by disrupting the actin-myosin bond. Due to coronary absolute specificity and high sensitivity, cardiac Troponin I helps to confirm, even when the acute event happened two weeks ago. Our study includes 65 patients with myocardial infarction, hospitalized in the cardiology department of Bacau City Hospital, of which 20 patients are women and 45 patients are men. The purpose of this study was to compare the value of cTnI between the two sexes with the same diagnosis and early diagnosis of myocardial infarction. High values of troponin in patients revealed a higher risk for development of cardiac events during short and long term, therefore being necessary the use of this test. Most healthy people have not detectable cTnI. Values between 0.3 µg/L and 2.0 µg/L are considered limit values. Values higher than 2.0 µg/L are considered as signs of myocardial infarction. In our study cardiac Troponin was analyzed by immuno-analyzer Pathfast compact device. Parametric One- Sample Tests and Error Bar T test are used to compare the mean of cTnI values by age and sex that differ significantly from the 2.0 mg/L limit value. Following troponin level in subjects grouped by gender shows that in women the cTnl level increases progressively with age, approaching normal at the 36-50 years age group and that of 51-65 years. In the >65 years group there are registered values above the maximum allowable (ie mean of 3.56 µg / L). The minimum values are registered at the female patients between 51-65 years, where the average is 0.08 µg / L, so is within normal limits. The highest risk was observed with predilection in males. The performed analysis shows warning for the 36-50 years age groups and 51-65 years for males as being at risk of myocardial ischemia. In conclusion, this study shows the age and gender of patients with an increased risk of myocardial infarction hospitalized in the cardiology department of Bacau City Hospital, and in men the age from which a much lower potential risk can occur (i.e. over 35 years) compared to women (i.e. over 65). Keywords: Cardiac Troponin I, myocardial infarction, dispersion parameter, age, gender. 93

<str<strong>on</strong>g>First</str<strong>on</strong>g> <str<strong>on</strong>g>Internati<strong>on</strong>al</str<strong>on</strong>g> <str<strong>on</strong>g>C<strong>on</strong>ference</str<strong>on</strong>g> <strong>on</strong> <strong>MOLDAVIAN</strong> <strong>RISKS</strong> - <strong>FROM</strong> GLOBAL TO LOCAL SCALE<br />

16-19 May 2012, Bacau, Romania<br />

RISK OF MYOCARDIAL INFARCTION REVEALED BY<br />

VARIATION OF CARDIAC TROPONIN I LEVELS WITH AGE<br />

AND GENDER: A STUDY OF PATIENTS HOSPITALIZED IN<br />

THE CARDIOLOGY DEPARTMENT OF BACAU CITY<br />

HOSPITAL DURING THE 2008-2011 PERIOD<br />

Laura Vasile 1 , Vlad Artenie 1 , Iuliana Lazar 2<br />

1 ”Al. I. Cuza” University, Department of Molecular Biology and Biochemistry<br />

2 ”Vasile Alecsandri” University of Bacau, Department of Chemical and Food Engineering<br />

Corresp<strong>on</strong>ding author: Iuliana Lazar, ilazar@ub.ro<br />

Abstract Cardiac trop<strong>on</strong>in (cTn) is a reference biomarker for the diagnosis of myocardial<br />

necrosis. Cardiac trop<strong>on</strong>in I (cTnI) is a key regulatory protein in cardiac muscle<br />

c<strong>on</strong>tracti<strong>on</strong> linking Ca2+-cTn combining it with cross-bridge activati<strong>on</strong> reacti<strong>on</strong> between<br />

thin and thick filaments. The cTn inhibits actomyosin ATP leading to muscle relaxati<strong>on</strong> by<br />

disrupting the actin-myosin b<strong>on</strong>d. Due to cor<strong>on</strong>ary absolute specificity and high sensitivity,<br />

cardiac Trop<strong>on</strong>in I helps to c<strong>on</strong>firm, even when the acute event happened two weeks ago.<br />

Our study includes 65 patients with myocardial infarcti<strong>on</strong>, hospitalized in the cardiology<br />

department of Bacau City Hospital, of which 20 patients are women and 45 patients are<br />

men. The purpose of this study was to compare the value of cTnI between the two sexes<br />

with the same diagnosis and early diagnosis of myocardial infarcti<strong>on</strong>. High values of<br />

trop<strong>on</strong>in in patients revealed a higher risk for development of cardiac events during short<br />

and l<strong>on</strong>g term, therefore being necessary the use of this test. Most healthy people have not<br />

detectable cTnI. Values between 0.3 µg/L and 2.0 µg/L are c<strong>on</strong>sidered limit values. Values<br />

higher than 2.0 µg/L are c<strong>on</strong>sidered as signs of myocardial infarcti<strong>on</strong>. In our study cardiac<br />

Trop<strong>on</strong>in was analyzed by immuno-analyzer Pathfast compact device. Parametric One-<br />

Sample Tests and Error Bar T test are used to compare the mean of cTnI values by age and<br />

sex that differ significantly from the 2.0 mg/L limit value. Following trop<strong>on</strong>in level in<br />

subjects grouped by gender shows that in women the cTnl level increases progressively<br />

with age, approaching normal at the 36-50 years age group and that of 51-65 years. In the<br />

>65 years group there are registered values above the maximum allowable (ie mean of 3.56<br />

µg / L). The minimum values are registered at the female patients between 51-65 years,<br />

where the average is 0.08 µg / L, so is within normal limits. The highest risk was observed<br />

with predilecti<strong>on</strong> in males. The performed analysis shows warning for the 36-50 years age<br />

groups and 51-65 years for males as being at risk of myocardial ischemia. In c<strong>on</strong>clusi<strong>on</strong>,<br />

this study shows the age and gender of patients with an increased risk of myocardial<br />

infarcti<strong>on</strong> hospitalized in the cardiology department of Bacau City Hospital, and in men<br />

the age from which a much lower potential risk can occur (i.e. over 35 years) compared to<br />

women (i.e. over 65).<br />

Keywords: Cardiac Trop<strong>on</strong>in I, myocardial infarcti<strong>on</strong>, dispersi<strong>on</strong> parameter, age, gender.<br />

93

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