DESCRIPTIONS OF MEDICAL FUNGI

Descriptions of Medical Fungi 79
Cyberlindnera fabianii (Wick.) Minter
Synonymy: Candida fabianii (Hartmann) S.A. Meyer & Yarrow.
Cyberlindnera fabianii is a rare cause of candidaemia.
RG-1 organism.
Culture: Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.
Microscopy: Spheroidal to ellipsoidal budding blastoconidia, 3.0-6.5 x 2-5.5 µm in
size. No pseudohyphae are produced. Asci when present, are spherical, containing
one to four spherical, finely roughened ascospores.
India Ink Preparation: Negative - no capsules present.
Dalmau Plate Culture: Spherical to ovoid budding yeast cells and occasional
pseudohyphae produced.
Molecular Identification: ITS sequencing recommended.
MALDI-TOF MS: Able to accurately identify this species.
Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol +
Fermentation Sucrose + D-Arabinose - α-M-D-glucoside +
Glucose + Maltose + D-Ribose - D-Gluconate +
Galactose - Cellobiose + L-Rhamnose - DL-Lactate +
Sucrose + Trehalose + D-Glucosamine - myo-Inositol -
Maltose +,s Lactose - N-A-D-glucosamine - 2-K-D-gluconate -
Lactose - Melibiose - Glycerol + D-Glucuronate nd
Trehalose - Raffinose + Erythritol - Nitrate +
Assimilation Melezitose + Ribitol - Urease -
Glucose + Soluble Starch + Galactitol - 0.1% Cycloheximide nd
Galactose - D-Xylose + D-Mannitol + Growth at 37 O C +
Key Features: Germ tube negative yeast and sugar assimilation pattern. Molecular
identification may be required.
Antifungal Susceptibility: C. fabianii very limited data (Pfaller et al. 2015, Australian
National data); MIC µg/mL.
No. 64
AmB 1 1
FLU 1 1
VORI 5 1 3 1
POSA 5 3 2
ITRA 1 1
MICA 4 2 1 1
CAS 1 1
5FC 1 1