DESCRIPTIONS OF MEDICAL FUNGI
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Descriptions of Medical Fungi 47<br />
Candida parapsilosis complex<br />
RG-1 organism.<br />
Candida parapsilosis (Ashford) Langeron & Talice<br />
Culture: Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.<br />
Microscopy: Predominantly small, globose to ovoid budding blastoconidia, 3-4 x 5-8<br />
µm, with some larger elongated forms present.<br />
India Ink Preparation: Negative - no capsules present.<br />
Dalmau Plate Culture: Abundant, much-branched pseudohyphae in a delicate treelike<br />
pattern with 2-3 blastoconidia in small clusters at intervals along the pseudohyphae.<br />
Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow<br />
Germ Tube - L-Sorbose +,s L-Arabinose + D-Glucitol +<br />
Fermentation Sucrose + D-Arabinose - M-D-glucoside +<br />
Glucose + Maltose + D-Ribose v D-Gluconate v<br />
Galactose + Cellobiose - L-Rhamnose - DL-Lactate -<br />
Sucrose + Trehalose + D-Glucosamine v myo-Inositol -<br />
Maltose -,s Lactose - N-A-D-glucosamine + 2-K-D-gluconate +<br />
Lactose - Melibiose - Glycerol + D-Glucuronate -<br />
Trehalose -,s Raffinose - Erythritol - Nitrate -<br />
Assimilation Melezitose + Ribitol v Urease -<br />
Glucose + Soluble Starch - Galactitol - 0.1% Cycloheximide -<br />
Galactose + D-Xylose + D-Mannitol + Growth at 37 O C +<br />
Key Features: Germ tube negative yeast and sugar assimilation pattern. C. parapsilosis<br />
is commonly found on the skin and is a causative agent of candidaemia.<br />
Antifungal Susceptibility: C. parapsilosis (Australian National data); MIC µg/mL.<br />
CLSI clinical breakpoints are marked where available (Pfaller and Diekema 2012).<br />
No 64<br />
AmB 607 2 8 28 131 142 210 80 2<br />
FLU 608 12 66 122 169 136 67 27 4 4 1<br />
VORI 529 145 98 120 100 48 14 3 1<br />
POSA 437 4 41 126 182 69 13 2<br />
ITRA 608 1 15 80 134 279 84 12 3<br />
ANID 342 3 6 7 45 149 107 18 7<br />
MICA 342 1 3 2 51 164 90 26 5<br />
CAS 459 1 1 5 38 183 177 46 4 1 3<br />
5FC 608 2 1 31 193 176 158 38 5 2 2