DESCRIPTIONS OF MEDICAL FUNGI

Descriptions of Medical Fungi 41
Candida glabrata complex
RG-2 organism.
Candida glabrata (Anderson) S.A. Meyer & Yarrow
Culture: Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.
Microscopy: Ovoid to ellipsoidal budding blastoconidia, 3.4 x 2.0 µm in size. No
pseudohyphae or chlamydospores produced.
India Ink Preparation: Negative - no capsules present.
Dalmau Plate Culture: Ovoid budding yeast cells only. No pseudohyphae produced.
Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow
Germ Tube - L-Sorbose - L-Arabinose - D-Glucitol -
Fermentation Sucrose - D-Arabinose - α-M-D-glucoside -
Glucose + Maltose - D-Ribose - D-Gluconate +
Galactose - Cellobiose - L-Rhamnose - DL-Lactate v
Sucrose - Trehalose v D-Glucosamine - myo-Inositol -
Maltose - Lactose - N-A-D-glucosamine - 2-K-D-gluconate v
Lactose - Melibiose - Glycerol v D-Glucuronate -
Trehalose v Raffinose - Erythritol - Nitrate -
Assimilation Melezitose - Ribitol - Urease -
Glucose + Soluble Starch - Galactitol - 0.1% Cycloheximide -
Galactose - D-Xylose - D-Mannitol - Growth at 40 O C +
Key Features: Germ tube negative yeast and sugar assimilation pattern. C. glabrata
is a common yeast species found on the body surface. Approximately 10% of clinical
isolates show azole cross-resistance.
Antifungal Susceptibility: C. glabrata complex (Australian National data); MIC
µg/mL. CLSI clinical breakpoints are marked where available (Pfaller and Diekema
2012).
No 64
AmB 999 1 1 8 25 274 339 283 63 5
FLU 1000 1 1 1 8 21 60 77 316 302 213
VORI 892 1 8 16 45 90 195 278 119 45 68 26 1
POSA 770 3 8 15 40 115 228 231 5 125
ITRA 1000 2 7 30 88 210 316 110 32 6 199
ANID 629 50 215 208 134 5 2 3 10 1 1
MICA 629 167 338 95 7 4 3 2 3 3 2 5
CAS 779 1 34 187 292 185 58 9 3 1 9
5FC 998 3 306 631 27 7 6 5 4 1 1 7