DESCRIPTIONS OF MEDICAL FUNGI

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176 Descriptions of Medical Fungi Saksenaea vasiformis Saksena 15 µm Saksenaea vasiformis showing a typically flask-shaped sporangium. References: Saksena (1953), Ellis and Hesseltine (1966), Ajello et al. (1976), Ellis and Ajello (1982), Ellis and Kaminski (1985), Pritchard et al. (1986), Padhye et al. (1988), Padhye and Ajello (1988), Goldschmied-Reouven et al. (1989), de Hoog et al. (2000) and Ellis (2005b).
Descriptions of Medical Fungi 177 Saprochaete clavata (de Hoog et al.) de Hoog & M.Th. Smith Synonmy: Geotrichum clavatum de Hoog, M.Th. Smith & Guého. Saprochaete clavata (formerly known as Geotrichum clavatum), which is also closely related to Magnusiomyces capitatus (formerly known as Geotrichum capitatum or Saprochaeta capitata), has only very infrequently been described as involved in invasive human infection. However, an outbreak of invasive infections caused by Saprochaete clavata in haematology patients has been reported (Vaux et al. 2013). RG-1 organism. Morphological Description: Colonies are moderately fast growing, flat, whitish and butyrous. True hyphae are abundant, soon breaking up into rectangular arthroconidia of variable size, 2.8-4 3 x 6-20 μm. Sympodial conidiogenesis is occasionally present. Terminal parts of hyphae may swell and become thick-walled. Note: Saprochaete clavata and Magnusiomyces capitatus are human pathogens that are closely related and are frequently mistaken for each other. Molecular Identification: ITS sequencing is recommended for accurate species identification. MALDI-T<strong>OF</strong> MS: reliably identifies S. clavata, M. capitatus and Geotrichum candidum to the species level (Desnos-Ollivier et al. 2014). Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data Germ Tube - L-Sorbose + L-Arabinose - D-Glucitol - Fermentation Sucrose - D-Arabinose - M-D-glucoside - Glucose - Maltose - D-Ribose - D-Gluconate - Galactose - Cellobiose + L-Rhamnose - DL-Lactate +,w Sucrose - Trehalose - D-Glucosamine - myo-Inositol - Maltose - Lactose - N-A-D-glucosamine nd 2-K-D-gluconate - Lactose - Melibiose - Glycerol + D-Glucuronate nd Trehalose - Raffinose - Erythritol - Nitrate - Assimilation Melezitose - Ribitol - Urease - Glucose + Soluble Starch - Galactitol - 0.1% Cycloheximide - Galactose + D-Xylose - D-Mannitol - Growth at 37 O C + Antifungal Susceptibility: Saprochaete clavata (Vaux et al. 2013); MIC µg/mL. Note: S. clavata is intrinsically resistant to echinocandins. Antifungal Range Median Antifungal Range Median AmB 0.125-1 0.5 POSA 0.125-1 0.5 5FC
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DESCRIPTIONS OF MEDICAL FUNGI

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