DESCRIPTIONS OF MEDICAL FUNGI
fungus3-book
fungus3-book
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
118<br />
Descriptions of Medical Fungi<br />
Magnusiomyces capitatus (de Hoog et al.) de Hoog & M.Th. Smith<br />
Synonymy: Saprochaete capitata (Diddens & Lodder) de Hoog & M.Th. Smith;<br />
Geotrichum capitatum (Diddens & Lodder) v. Arx; Trichosporon capitatum Diddens &<br />
Lodder; Blastoschizomyces capitis (Diddens & Lodder) Salkin et al.<br />
Based on a phylogenetic analysis of rDNA gene sequences, de Hoog and Smith (2004)<br />
transferred Geotrichum capitatum to the genus Magnusiomyces. Magnusiomyces<br />
capitatus occurs quite commonly in humans, usually as a transient component of<br />
normal skin flora and sputum. Systemic infections including pulmonary, fungaemia and<br />
endocarditis have been reported in immunosuppressed patients. RG-1 organism.<br />
Morphological Description: Colonies are moderately fast growing, flat, whitish, and<br />
finely suede-like with no reverse pigment. Hyphae are profusely branched at acute<br />
angles, with terminal and intercalary conidiogenous cells which form long, cicatrised<br />
rachids on which conidia are borne. Conidia are hyaline, smooth, one-celled, cylindrical<br />
to clavate, with a rounded apex and flat base, 7-10 x 2.5-3.5 µm. Rectangular<br />
arthroconidia are also often present.<br />
Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data<br />
Germ Tube - L-Sorbose v L-Arabinose - D-Glucitol +<br />
Fermentation Sucrose - D-Arabinose - α-M-D-glucoside -<br />
Glucose - Maltose - D-Ribose - D-Gluconate -<br />
Galactose - Cellobiose - L-Rhamnose - DL-Lactate +<br />
Sucrose - Trehalose - D-Glucosamine - myo-Inositol -<br />
Maltose - Lactose - N-A-D-glucosamine nd 2-K-D-gluconate -<br />
Lactose - Melibiose - Glycerol + D-Glucuronate nd<br />
Trehalose - Raffinose - Erythritol - Nitrate -<br />
Assimilation Melezitose - Ribitol - Urease -<br />
Glucose + Soluble Starch - Galactitol - 0.1% Cycloheximide +<br />
Galactose + D-Xylose - D-Mannitol + Growth at 40 O C +<br />
Molecular Identification: ITS sequencing recommended (de Hoog and Smith 2004).<br />
Note: Magnusiomyces capitatus and Saprochaete clavata are human pathogens<br />
that are closely related and are frequently mistaken for each other. Desnos-Ollivier<br />
et al. (2014) proposed species-specific carbon assimilation patterns and MALDI-T<strong>OF</strong><br />
MS profiles to enable the identification of S. clavata, M. capitatus and Geotrichum<br />
candidum to the species level.<br />
References: de Hoog and Smith (2004, 2011c), de Hoog et al. (2015), Garcia-Ruiz et<br />
al. (2013), Desnos-Ollivier et al. (2014), Arendrup et al. (2014).<br />
Antifungal Susceptibility: M. capitatus limited data (Garcia-Ruiz et al. 2013,<br />
Australian National data); MIC µg/mL. Note: Isolates of M. capitatus are intrinsically<br />
resistant to echinocandins (Arendrup et al. 2014).<br />
No. 64<br />
AmB 9 1 1 4 3<br />
FLU 9 1 1 2 3 2<br />
VORI 8 2 2 2 1 1<br />
POSA 8 2 1 2 2 1<br />
ITRA 9 1 4 4<br />
5FC 4 2 1 1