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426 Chapter 8 THE UBIQUITY OF PRIME NUMBERS<br />

Another appearance of the noble primes—this time in connection with<br />

molecular biology—is in [Yan et al. 1991]. These authors infer that certain<br />

amino acid sequences in genetic matter exhibit patterns expected of (binary<br />

representations of) prime numbers. In one segment they say:<br />

Additively generated numbers can be primes or nonprimes. Multiplicatively<br />

generated numbers are nonprimes (“composites” in number theory<br />

terminology). Thus, prime numbers are more creative than nonprimes ....<br />

The creativeness and indivisibility of prime numbers leads one to infer that<br />

primes smaller than 64 are the number equivalents of amino acids; or that<br />

amino acids are such Euclid units of living molecules.<br />

The authors go on to suggest Diophantine rules for their theory. The present<br />

authors do not intend to critique the interdisciplinary notion that composite<br />

numbers somehow contain less information (are less profound) than the<br />

primes. Rather, we simply point out that some thought has gone into this<br />

connection with genetic codes.<br />

Let us next mention some involvements of prime numbers in the particular<br />

field of physics. We have already touched upon the connection of quantum<br />

computation and number-theoretical problems. Aside from that, there is the<br />

fascinating history of the Hilbert–Pólya conjecture, saying in essence that<br />

the behavior of the Riemann zeta function on the critical line Re(s) =1/2<br />

depends somehow on a mysterious (complex) Hermitian operator, of which<br />

the critical zeros would be eigenvalues. Any results along these lines—even<br />

partial results—would have direct implications about prime numbers, as we<br />

saw in Chapter 1. The study of the distribution of eigenvalues of certain<br />

matrices has been a strong focus of theoretical physicists for decades. In the<br />

early 1970s, a chance conversation between F. Dyson, one of the foremost<br />

researchers on the physics side of random matrix work, and H. Montgomery,<br />

a number theorist investigating the influence of critical zeros of the zeta<br />

function on primes, led them to realize that some aspects of the distribution<br />

of eigenvalues of random matrices are very close to those of the critical zeros.<br />

As a result, it is widely conjectured that the mysterious operator that would<br />

give rise to the properties of ζ is of the Gaussian unitary ensemble √ (GUE)<br />

class. A relevant n × n matrix G in such a theory has Gaa = xaa 2 and for<br />

a>b, Gab = xab + iyab, together with the Hermitian condition Gab = G∗ ba ;<br />

where every xab,yab is a Gaussian random variable with unit variance, mean<br />

zero. The works of [Odlyzko 1987, 1992, 1994, 2005] show that the statistics<br />

of consecutive critical zeros are in many ways equivalent—experimentally<br />

speaking—to the theoretical distribution of eigenvalues of a large such matrix<br />

G. In particular, let {zn : n =1, 2,...} be the collection of the (positive)<br />

imaginary parts of the critical zeros of ζ, in increasing order. It is known from<br />

the deeper theory of the ζ function that the quantity<br />

δn = zn+1 − zn<br />

2π<br />

ln zn<br />

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