YSM Issue 90.1

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NEWS in brief Modeling Mars: Life-Supporting Earthquakes? By Isa del Toro M. IMAGE COURTESY OF WIKIPEDIA ►A topography map of Mars with different color intensities indicating the depth of craters and highlighting areas of possible seismic activity on its surface. There’s a new hypothesis on the block related to the possibility of life on Mars. Research conducted by Sean McMahon of the Yale Geology and Geophysics department, in collaboration with John Parnell and Nigel Blamey, looks into Earth’s subsurface hydrogen levels and how these indicate potential microbial activity on Mars. Hydrogen serves as an energy source for certain types of organisms. Subsurface hydrogen gas is created on Earth due to the grinding of rocks along ancient earthquake fault lines. McMahon’s experiment sought to determine whether these gas levels were enough to have spurred microbial life. Using crushfast-scan, a technique that involves crushing rocks to expel the gas contained with them and measuring the released gas composition, the researchers concluded that the hydrogen contained in these rocks was sufficient to fuel anaerobic life on Earth. Many types of rocks, including the basalt found on Mars, can likewise create hydrogen, leading researchers to determine that quake activity on Mars could fuel microbial life. In 2018, NASA’s InSight mission will collect data concerning seismological activity on Mars. This data will allow the researchers to re-evaluate the “Marsquake” models they used in their conclusions and determine whether their models fit Mars’s actual surface. McMahon’s results are an exciting find. They shed light on another possibility of life on Mars, which would have important consequences on how we approach the idea of human activity on the Red Planet, as well as our understanding of how life came to be in the universe. The Gruber Cosmology Conference at Yale By Urmila Chadayammuri PHOTOGRAPHY BY URMILA CHADAYAMMURI ►Professor Manuela Campanelli of the University of Rochester presents her pioneering simulations of black hole mergers. The third annual Gruber Cosmology Conference took place at Yale on October 7th, honoring discoveries advancing our understanding of the universe. This year’s Gruber Prize recipients were Rainer Weiss, Kip Thorne, and Ronald Drever, the leading scientists on the LIGO collaboration, which made the groundbreaking discovery of gravitational waves. The conference began with a history of gravitational waves, after which Weiss explained how the LIGO project worked. Speakers also highlighted upcoming detectors in Europe, India and Japan, which aim to pinpoint the origin of gravitational waves. The afternoon session outlined the impact of the discovery. Thorne described the new science we can probe with the help of gravitational waves, from learning about how the very early universe grew, to understanding spinning and colliding black holes. Harvard radio astronomer Shep Doeleman closed the conference with prospects for how we can directly image black holes and their power as gravitational lenses, which bend light from sources behind them, to directly image black holes. The presenters all spoke of their work as a conversation across centuries with the father of general relativity, Albert Einstein. What would Einstein have said if he heard of the LIGO observation? Thorne guessed he would try understanding the black hole merger that caused it, while Weiss thought he would ask how the equipment worked. Doeleman took a step back. We knew general relativity was correct before the gravitational wave detection, he said, as GPS would not work without it. If we were to present a map app to Einstein, he would most likely wonder, “What is a phone?” 6 Yale Scientific Magazine December 2016 www.yalescientific.org

in brief NEWS The Miller laboratory of Yale’s Department of Chemistry recently made a discovery in peptide catalysis that could change how we think about enzymes. This discovery capitalized on the laboratory’s previous discovery of two peptide catalysts. Enzymes, or protein catalysts, are characterized by high specificity. Alford, the study’s first author, and his colleagues demonstrated that two short peptides, which are comprised of protein building block called amino acids, can catalyze two distinct, complementary reactions called oxidation reactions. This remarkable capacity is presumably due to the synthetic peptide’s overall structure: by varying just a few key amino acids outside of the active site where the reaction takes place, the same active residue can switch between catalyzing two very different reactions. This control of catalytic activity by Shrinking Enzymes By Giorgio Caturegli modifying secondary structure is a hallmark of enzymes but has had limited application in organic synthesis. “This finding is a really interesting manifestation of what the [Miller] group tries to do…using tools that nature has to understand natural processes,” said Nadia Abascal, a coauthor. Synthetic reactions can be studied to gain insight into processes in nature, which may follow a similar mechanism to the reactions observed in this study. Especially notable is the fact that peptides are orders of magnitude smaller than enzymes, and their small size and precise control could allow for synthetic applications in pharmaceutical and materials research. The Miller group’s recent finding in peptide catalysis is important to both understanding natural biochemical processes and developing synthetic applications. PHOTOGRAPHY BY NATALIA ZALIZNYAK ►Miller’s laboratory discovered two peptides that can catalyze two different reactions based on secondary structure and reaction conditions. A New Excuse for Playing Video Games? By Jasper Feinberg Imagine if video games were a key to improving learning. Yale psychiatry professor Bruce Wexler believes they are. A study found that a video game-based learning regimen called Activate, developed by Wexler, improved the test performance of 583 schoolchildren compared to those without the regimen and those with one-on-one tutoring. The curriculum includes computer games aimed at cognitive improvement and a five minute warm-up computer activity designed to prepare students for learning. The Activate program harnesses neuroplasticity. The structure of the brain is shaped after birth from environmental stimuli that reorganize neuronal connections. Activate stimulates areas of the brain often underdeveloped in children who grow up in poverty or have neurodevelopmental problems like attention deficit hyperactivity disorder (ADHD). To accomplish this, Wexler used neuroimaging studies to identify the regions of the brain corresponding to certain cognitive tasks. Wexler describes Activate as “a school lunch program for the brain” customized to each individual student. The social implications of this educational strategy are vast. First, Activate has the potential to close the achievement gap by helping students with different educational backgrounds. As a technology-based tool, it is cheaper than many current solutions. Wexler’s research is also an effective treatment for depression and, in some cases, ADHD. Going forward, C8 Sciences, a Yale startup dedicated to spreading Activate, hopes to increase awareness and continue improving the program. Activate has been translated into multiple languages, and appears primed to expand. IMAGE COURTESY OF BRUCE WEXLER ►A student using Activate, a gamebased learning program shown to improve test performance, in her school’s computer lab. www.yalescientific.org December 2016 Yale Scientific Magazine 7

NEWS<br />

in brief<br />

Modeling Mars: Life-Supporting Earthquakes?<br />

By Isa del Toro M.<br />

IMAGE COURTESY OF WIKIPEDIA<br />

►A topography map of Mars with different<br />

color intensities indicating the depth<br />

of craters and highlighting areas of possible<br />

seismic activity on its surface.<br />

There’s a new hypothesis on the block related<br />

to the possibility of life on Mars. Research<br />

conducted by Sean McMahon of the Yale Geology<br />

and Geophysics department, in collaboration<br />

with John Parnell and Nigel Blamey,<br />

looks into Earth’s subsurface hydrogen levels<br />

and how these indicate potential microbial<br />

activity on Mars.<br />

Hydrogen serves as an energy source for<br />

certain types of organisms. Subsurface hydrogen<br />

gas is created on Earth due to the grinding<br />

of rocks along ancient earthquake fault<br />

lines. McMahon’s experiment sought to determine<br />

whether these gas levels were enough<br />

to have spurred microbial life. Using crushfast-scan,<br />

a technique that involves crushing<br />

rocks to expel the gas contained with them<br />

and measuring the released gas composition,<br />

the researchers concluded that the hydrogen<br />

contained in these rocks was sufficient to fuel<br />

anaerobic life on Earth. Many types of rocks,<br />

including the basalt found on Mars, can likewise<br />

create hydrogen, leading researchers<br />

to determine that quake activity on Mars<br />

could fuel microbial life. In 2018, NASA’s<br />

InSight mission will collect data concerning<br />

seismological activity on Mars. This data<br />

will allow the researchers to re-evaluate the<br />

“Marsquake” models they used in their conclusions<br />

and determine whether their models<br />

fit Mars’s actual surface.<br />

McMahon’s results are an exciting find.<br />

They shed light on another possibility of life<br />

on Mars, which would have important consequences<br />

on how we approach the idea of human<br />

activity on the Red Planet, as well as our<br />

understanding of how life came to be in the<br />

universe.<br />

The Gruber Cosmology Conference at Yale<br />

By Urmila Chadayammuri<br />

PHOTOGRAPHY BY URMILA CHADAYAMMURI<br />

►Professor Manuela Campanelli of<br />

the University of Rochester presents<br />

her pioneering simulations of black<br />

hole mergers.<br />

The third annual Gruber Cosmology<br />

Conference took place at Yale on October<br />

7th, honoring discoveries advancing our<br />

understanding of the universe. This year’s<br />

Gruber Prize recipients were Rainer Weiss,<br />

Kip Thorne, and Ronald Drever, the leading<br />

scientists on the LIGO collaboration, which<br />

made the groundbreaking discovery of<br />

gravitational waves. The conference began<br />

with a history of gravitational waves, after<br />

which Weiss explained how the LIGO project<br />

worked. Speakers also highlighted upcoming<br />

detectors in Europe, India and Japan, which<br />

aim to pinpoint the origin of gravitational<br />

waves.<br />

The afternoon session outlined the impact<br />

of the discovery. Thorne described the<br />

new science we can probe with the help of<br />

gravitational waves, from learning about how<br />

the very early universe grew, to understanding<br />

spinning and colliding black holes. Harvard<br />

radio astronomer Shep Doeleman closed the<br />

conference with prospects for how we can<br />

directly image black holes and their power as<br />

gravitational lenses, which bend light from<br />

sources behind them, to directly image black<br />

holes.<br />

The presenters all spoke of their work as a<br />

conversation across centuries with the father<br />

of general relativity, Albert Einstein. What<br />

would Einstein have said if he heard of the<br />

LIGO observation? Thorne guessed he would<br />

try understanding the black hole merger that<br />

caused it, while Weiss thought he would ask<br />

how the equipment worked. Doeleman took<br />

a step back. We knew general relativity was<br />

correct before the gravitational wave detection,<br />

he said, as GPS would not work without it. If<br />

we were to present a map app to Einstein, he<br />

would most likely wonder, “What is a phone?”<br />

6 Yale Scientific Magazine December 2016 www.yalescientific.org

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