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Main Lines of treatment of diseases in farm animals

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<strong>Ma<strong>in</strong></strong> <strong>L<strong>in</strong>es</strong> <strong>of</strong> <strong>treatment</strong><br />

<strong>of</strong> <strong>diseases</strong><br />

<strong>in</strong> <strong>farm</strong> <strong>animals</strong><br />

استاذ<br />

دكتور حامد عطية<br />

أمراض الباطنة ‏-كلية الطب البيطرى<br />

جامعة الزقازيق


عوامل النجاح<br />

قى عل ج حالة<br />

To Success <strong>in</strong> Treatment<br />

Correct<br />

Diagnosis<br />

Drug Used<br />

Dose<br />

&<br />

Route<br />

Duration


<strong>Ma<strong>in</strong></strong> L<strong>in</strong>e <strong>of</strong> Treatment<br />

Hyagenic Medical Supportive T


<strong>Ma<strong>in</strong></strong> <strong>L<strong>in</strong>es</strong> <strong>of</strong> <strong>treatment</strong>-1<br />

<strong>of</strong> enteritis<br />

1-Anti-acid (systemic).<br />

2-Fluid therapy.<br />

3-Anti-<strong>in</strong>flammatory<br />

Cl<strong>in</strong>ical signs <strong>of</strong> diarrhea<br />

Calves are weak ,depressed ,anorexic<br />

Affected <strong>animals</strong> either recovered or die<br />

After five days.<br />

4-Antibiotic<br />

5-Antiparastic drugs<br />

6-Intest<strong>in</strong>al astr<strong>in</strong>gent<br />

and coat<strong>in</strong>g


Important Notes<br />

-1<br />

Appetite<br />

In Calf Scour<br />

Look on the animal<br />

not on the feces<br />

-2<br />

Temperature<br />

-3<br />

General condition<br />

•Stand<strong>in</strong>g position<br />

•Recumbent<br />

-4<br />

Dehydration


Metabolic effects <strong>of</strong> calf scour<br />

Dehydration<br />

Acidosis<br />

Electrolyte imbalance


.Anti-acid (systemic)- 1<br />

• R/Na bicarbonate 1.3% 0.5-1 L I/V<br />

accord<strong>in</strong>g to the degree <strong>of</strong> acedemia


Oral Fluid Therapy<br />

I/V Fluid Therapy


Non steriodal anti-<strong>in</strong>flammatory-3<br />

• R/ Dicloprima 5%<br />

• Dose:<br />

• 2 Ml/ 100Kg B.W<br />

Advantages<br />

Anti-<strong>in</strong>flammatory<br />

Strong analgesic<br />

Atipyretic<br />

Anti-endotoxic<br />

:N B<br />

Non Steroidal anti-<strong>in</strong>flammatory should be given after<br />

hydration <strong>of</strong> the calf


Broad spectrum antibiotic-4<br />

Antibiotice more effective on E<br />

coli & Salmonelle<br />

Nuflor<br />

Marbocele<br />

Cefotaxim<br />

Borgal(Sulfa &Trimethoprime)


Antiparasitic agents<br />

-6<br />

---<br />

• R/ Ivermect<strong>in</strong>e<br />

1cc /50 Kg. B.w.<br />

S/C


Prescription <strong>in</strong> dietetic diarrhea<br />

<strong>in</strong> Large <strong>animals</strong><br />

• R/S Guand<strong>in</strong>e 60 g<br />

• R/Tannic acide 40 g<br />

• R/Cloramphenicol 15 g<br />

• R/Starch<br />

½ Kg<br />

:NB<br />

Zanil 100 Ml for paramphistomum+


General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />

Acidosis<br />

• 1-Evacuation <strong>of</strong> rumen content:<br />

•<br />

• By us<strong>in</strong>g 3 liter Paraff<strong>in</strong> oil by stomach tube<br />

• 2-Antiacid<br />

• (a) Local: 500 g sodium bicarbonate<br />

• &<br />

• (b)Systemic: 2 liter isotonic sodium bicarbonate 1.3% I/V<br />

• 3-Fluid therapy:<br />

• Nacl 0.9% 4-6 liter I/V<br />

•<br />

• Accord<strong>in</strong>g to degree <strong>of</strong> dehydration<br />

• 4-Antihistam<strong>in</strong>ic:<br />

• R/Antistam<strong>in</strong>e 30-40 Ml I/V


General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />

Acidosis<br />

• 5-Ant<strong>in</strong>flamatory<br />

• 6-Antibiotic<br />

•<br />

orally)<br />

Orally (proca<strong>in</strong>e penicill<strong>in</strong> 10million IU<br />

• &<br />

• Systemic<br />

• 7-Rum<strong>in</strong>al tonic stomachic<br />

• -Bykahepar -genabell<br />

• -Hepanol -propylene glycol


General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />

simple <strong>in</strong>digestion<br />

• 1-Antiacid<br />

• 0.5 kg sodium bicarbonate/orally<br />

• 2-Rum<strong>in</strong>al tonic stomachic<br />

• -Bykahebar<br />

-Genabel<br />

• 3-Purgative<br />

• 0.5 kg orally <strong>of</strong> Mg oxide<br />

• OR<br />

• 2 liter <strong>of</strong> Paraff<strong>in</strong> oil<br />

• 4-Massage <strong>of</strong> rumen from left flank<br />

• 5-Rectal enema, back rack<strong>in</strong>g &exercise


General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />

Masititis<br />

• 1-AntiBiotic<br />

• Systemic:<br />

Gentamyc<strong>in</strong>,<br />

Cefotaxim Snylox-Pentomyc<strong>in</strong><br />

• Pentomyc<strong>in</strong><br />

• 2-Ant<strong>in</strong>flammatory<br />

• 3 days Non steroidal AI<br />

• 3-Antihistam<strong>in</strong>ic<br />

• 1st day<br />

• 4-Oxytoc<strong>in</strong><br />

• 5-Vitam<strong>in</strong> AD3E&C


General l<strong>in</strong>e <strong>of</strong> <strong>treatment</strong> <strong>of</strong><br />

pneumonia<br />

• Broad spectrum antibiotic<br />

• Ant <strong>in</strong>flammatory<br />

• Bronchodilator<br />

• Mucolytics & Expectorants<br />

• Antihistam<strong>in</strong>ic


Antibiotic used <strong>in</strong> pneumonia<br />

1. 1-In less sever cases:<br />

1-Oxytetracycl<strong>in</strong>e drugs<br />

2-Ener<strong>of</strong>loxac<strong>in</strong>e<br />

IN sever cases (Shipp<strong>in</strong>g fever):<br />

Flurphenicol<br />

Cephalosporion .<br />

Sulfa &Trimethoprime<br />

Marb<strong>of</strong>lxac<strong>in</strong>e


Metabolic Diseases<br />

Therapy


General l<strong>in</strong>e for <strong>treatment</strong><br />

• 1)Source <strong>of</strong> Calcium<br />

A-Small cow(300-<br />

400 Kg):<br />

R/500 ml (375 ml IV<br />

very slowly and<br />

125 ml SC after 30<br />

m<strong>in</strong>. at different<br />

sites.<br />

<strong>of</strong> milk fever


• Large cow( More<br />

than 500 Kg B .w.)<br />

• 1 Liter:<br />

• ½ Liter at morn<strong>in</strong>g<br />

• ½ Liter at even<strong>in</strong>g


Examples <strong>of</strong> Ca preparation<br />

• R/Ca boro-gluconate (20% or 25%)<br />

• Or<br />

R/ Cal. D. Mg (Ca & Dextrose & Mg)<br />

R/Calcium am<strong>in</strong>o-plex (Ca & am<strong>in</strong>o acids).<br />

NB:<br />

• I/v Ca solution should be slowly to<br />

prevent cardiac arrest.<br />

• Cont<strong>in</strong>ue for 3-5 days days or till complete<br />

recovery


(2) Compounds which <strong>in</strong>creas<strong>in</strong>g calcium<br />

level <strong>in</strong> blood:<br />

R/ AD3E&C (15 ml / daily IM).<br />

& R/ACTH 400-500 IU I/M<br />

3) Anti-<strong>in</strong>flammatory (Non Steroidal)<br />

R/Declo-phenac Na 2.5% 4 ml/100 Kg B W.<br />

(4) Supportive <strong>treatment</strong>:<br />

R/Dextrose 25% or 40% 2 liter IV.


Medical General l<strong>in</strong>es for<br />

<strong>treatment</strong> <strong>of</strong> hypo-phosphatemia<br />

Source <strong>of</strong> ph Hemat<strong>in</strong>cs Sal<strong>in</strong>e


Source <strong>of</strong> ph-1<br />

I/V&I/M S/C Orally


Hemat<strong>in</strong>ics-2<br />

A-Blood transfusion<br />

) In sever cases(<br />

. Iron & VitB12


Sources <strong>of</strong> phosphorus( 1)<br />

• A) IV slowly adm<strong>in</strong>istration<br />

<strong>of</strong> 60 <strong>of</strong> sodium acid<br />

phosphate <strong>in</strong> 300 ml <strong>of</strong><br />

distilled water on the first<br />

day .<br />

• Followed by further SC<br />

<strong>in</strong>jections <strong>of</strong> similar doses at<br />

12-hours <strong>in</strong>tervals till<br />

recovery.<br />

• Similar daily doses (60 g) by<br />

mouth<br />

:NB<br />

Treatment should be cont<strong>in</strong>ued till 3-5 days<br />

.after disappearance <strong>of</strong> red ur<strong>in</strong>e (complete recoverty


• B) patent phosphorus preparation<br />

as:<br />

• R/ Tonophosphan (Ph 10%)<br />

• R/ 50ml( 25 ml IV daily&25 ml I/M till<br />

recovery).


• C) Oral dos<strong>in</strong>g with bone meal (120 g)<br />

twice daily or dicalcium phosphate<br />

daily for 5 days till recovery.<br />

• Or:<br />

• Superphos Sachets 3<br />

• One sachet daily (oral route)


• (2) Hemat<strong>in</strong>ic preparation:<br />

• (A) <strong>in</strong> sever cases:<br />

• Blood transfusion 3-4 L <strong>of</strong> whole blood to a<br />

450 kg cow is <strong>in</strong>dicated <strong>in</strong> severe cases.<br />

• Additional transfusion is necessary if cow is<br />

still weak and mucous membranes are pale.<br />

• (B) In less sever cases:<br />

• iron, copper, cobalt, vitam<strong>in</strong> B12. (4)<br />

R/Antoplex 15 ml I/M


• (3) Supportive therapy:<br />

• (Glucose 25%) to treat ketosis &<br />

hypoglycemia.<br />

• (4)Kidney wash:<br />

• (Glucose 5% or sal<strong>in</strong>e(0.9%NaCl ( to<br />

m<strong>in</strong>imize the danger <strong>of</strong> hemoglob<strong>in</strong>uric<br />

nephritis.


3- General <strong>L<strong>in</strong>es</strong> Of<br />

Treatment <strong>of</strong> Ketosis<br />

1-Dextrose 25%<br />

Make Glucose<br />

2-Propylene glycol<br />

3-Dexamethasone<br />

Insul<strong>in</strong>e-4<br />

Decreased Production<br />

(less glucose<br />

demand)<br />

Increased Appetite<br />

Facilitate transport glucose<br />

<strong>in</strong>to the cell


Medical <strong>treatment</strong><br />

• 1-Sources <strong>of</strong> glucose:<br />

• IV <strong>in</strong>jection <strong>of</strong> dextrose 25-40%<br />

500ml for cattle (<strong>in</strong> ewes 150-<br />

250 ml) IV, twice daily for 3-5<br />

successive days caus<strong>in</strong>g<br />

temporary hyperglycemia.


• Oral hyperglycemic<br />

agents: propylene glycol .05<br />

Liter orally<br />

• Or:<br />

• Glycerol or glycer<strong>in</strong> 0.25 Liter or<br />

sodium propionate )100-200 gm (<br />

once daily for 3 day(.<br />

R/Primaton :<br />

.025 L orally<br />

• They are glucogenic and thus<br />

produce glucose.<br />

Primaton


2-Hormonal therapy:<br />

A-Glucocorticoids:<br />

Such as dexamethazone 10 ml )30<br />

mg( I/M one or two doses for cattle<br />

to <strong>in</strong>crease the blood sugar level &<br />

reduces ketone bodies formation by<br />

utilization <strong>of</strong> acetyl coenzyme A.


L<strong>in</strong>e <strong>of</strong> <strong>treatment</strong> <strong>of</strong> blood parasites<br />

Babesiosis-1<br />

• Fever (40-41C)<br />

• Red Ur<strong>in</strong>e<br />

• Partial loss <strong>of</strong> appetite<br />

• Jaundice


:I- Treatment<br />

• Important Notes:<br />

• Treatment should be tried early before the<br />

animal becomes anemic<br />

· Care must also be taken to avoid complete<br />

sterilization <strong>of</strong> the blood before sufficient<br />

antibody is produced to provide a durable<br />

immunity.


Drugs used<br />

1- Dim<strong>in</strong>azen aceturate (Batr<strong>in</strong>il-Ber<strong>in</strong>il)<br />

· Aqueous solution7% )1.05gm vial dissolved <strong>in</strong><br />

12.5 ml water(.<br />

· Dose 1ml/20kg ·<br />

2-Imidocarb dipropionate (Imisol)<br />

2ml/100Kg B W.


Symptomatic <strong>treatment</strong><br />

• Non steroidal ant <strong>in</strong>flammatory<br />

• R/ Decl<strong>of</strong>lam )1CC/25kg I/M(<br />

• -Blood transfusion:-<br />

• - In Sever cases 1Liter/100 Kg B W.<br />

• General hemat<strong>in</strong>ics.<br />

• R/Antoplex 15mlI/M<br />

• Or Iron 100 1 ml /100Kg B W.


L<strong>in</strong>e <strong>of</strong> <strong>treatment</strong> <strong>of</strong> blood parasites<br />

Theleriasis-2<br />

• Fever (40-41C)<br />

• Corneal opacity<br />

• Partial loss <strong>of</strong> appetite<br />

• Enlarged pre-scapular<br />

L.N<br />

Corneal opacity


Treatment<br />

R/butalex <strong>in</strong>jection<br />

Or:<br />

1CC /20 Kg I/M<br />

Oxytetracycl<strong>in</strong>e L.A(5 Doses)<br />

+ Ars<strong>in</strong>al for 5 days


L<strong>in</strong>e <strong>of</strong> <strong>treatment</strong><br />

Of<br />

ur<strong>in</strong>ary tract affections<br />

Antibiotic<br />

Ur<strong>in</strong>ary<br />

Antiseptic<br />

-Anti<br />

<strong>in</strong>flammatory


Types <strong>of</strong> Antibiotic<br />

ephalospor<strong>in</strong>e<br />

entamyc<strong>in</strong>e<br />

Sulpha<br />

&<br />

Trimethprime<br />

Penicll<strong>in</strong>e<br />

&<br />

streptomyc<strong>in</strong>e


Types <strong>of</strong> Antibiotic<br />

Accord<strong>in</strong>g to species<br />

Equ<strong>in</strong>es<br />

lpha & Trimethoprime<br />

Rumm<strong>in</strong>ant<br />

Cephalospor<strong>in</strong>e<br />

penicill<strong>in</strong>es


Duration<br />

<strong>of</strong><br />

Antibiotic<br />

Acute<br />

days<br />

3-5<br />

Chronic<br />

D 7-10<br />

Chronic pyogenic<br />

weeks<br />

2-4


Ur<strong>in</strong>ary-2<br />

Antiseptic<br />

Local<br />

use <strong>of</strong><br />

catheters<br />

Systemic<br />

Coli-ur<strong>in</strong>al<br />

Hexam<strong>in</strong><br />

Ur<strong>in</strong>ary lavage<br />

IV glucose


Anti-<strong>in</strong>flammatory-3<br />

Decloprema<br />

F<strong>in</strong>ady<strong>in</strong>e<br />

Ketopr<strong>of</strong>en


Causes Antibiotic Failure<br />

• 1-Exposure to strong sunlight<br />

• 2-Too-much-water<br />

• 3-Frequency-<strong>of</strong>-dose ( daily <strong>treatment</strong><br />

but we decided to just double the dose<br />

and give it every other day).<br />

• 4-Duration is not enough.


• 5-The causative agent is virus not bacteria<br />

• 6-The drug is not specific aga<strong>in</strong>st the<br />

pathogen<br />

• 7-Contam<strong>in</strong>ated needle back <strong>in</strong>to the bottle.


Viral<br />

vacc<strong>in</strong>es<br />

1. PNEUMO 3<br />

2. PNEUMO 4<br />

3. Cattle Master4<br />

4. Vira Shield 5<br />

Nasal Gene-5<br />

Bacterial<br />

vacc<strong>in</strong>es<br />

1. Pneumo - Bac<br />

2. Covex<strong>in</strong>* 8& 10<br />

3 Ultrabac® 8<br />

Mixed<br />

vacc<strong>in</strong>es<br />

1. Entero – 3<br />

Vacc<strong>in</strong>e<br />

2. Scour Guard 3<br />

Rotvec vacc<strong>in</strong>e-3<br />

Coli immune-oral-4<br />

E Coli + Rota & Corana Virus


VACCINE FAILURES<br />

• NO RESPONSE :<br />

• Efficacy- expire Date<br />

• stress<br />

• Malnutrition<br />

• Improper Dose .<br />

• Improper Route.

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