Main Lines of treatment of diseases in farm animals
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3h0IUEk8W
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<strong>Ma<strong>in</strong></strong> <strong>L<strong>in</strong>es</strong> <strong>of</strong> <strong>treatment</strong><br />
<strong>of</strong> <strong>diseases</strong><br />
<strong>in</strong> <strong>farm</strong> <strong>animals</strong><br />
استاذ<br />
دكتور حامد عطية<br />
أمراض الباطنة -كلية الطب البيطرى<br />
جامعة الزقازيق
عوامل النجاح<br />
قى عل ج حالة<br />
To Success <strong>in</strong> Treatment<br />
Correct<br />
Diagnosis<br />
Drug Used<br />
Dose<br />
&<br />
Route<br />
Duration
<strong>Ma<strong>in</strong></strong> L<strong>in</strong>e <strong>of</strong> Treatment<br />
Hyagenic Medical Supportive T
<strong>Ma<strong>in</strong></strong> <strong>L<strong>in</strong>es</strong> <strong>of</strong> <strong>treatment</strong>-1<br />
<strong>of</strong> enteritis<br />
1-Anti-acid (systemic).<br />
2-Fluid therapy.<br />
3-Anti-<strong>in</strong>flammatory<br />
Cl<strong>in</strong>ical signs <strong>of</strong> diarrhea<br />
Calves are weak ,depressed ,anorexic<br />
Affected <strong>animals</strong> either recovered or die<br />
After five days.<br />
4-Antibiotic<br />
5-Antiparastic drugs<br />
6-Intest<strong>in</strong>al astr<strong>in</strong>gent<br />
and coat<strong>in</strong>g
Important Notes<br />
-1<br />
Appetite<br />
In Calf Scour<br />
Look on the animal<br />
not on the feces<br />
-2<br />
Temperature<br />
-3<br />
General condition<br />
•Stand<strong>in</strong>g position<br />
•Recumbent<br />
-4<br />
Dehydration
Metabolic effects <strong>of</strong> calf scour<br />
Dehydration<br />
Acidosis<br />
Electrolyte imbalance
.Anti-acid (systemic)- 1<br />
• R/Na bicarbonate 1.3% 0.5-1 L I/V<br />
accord<strong>in</strong>g to the degree <strong>of</strong> acedemia
Oral Fluid Therapy<br />
I/V Fluid Therapy
Non steriodal anti-<strong>in</strong>flammatory-3<br />
• R/ Dicloprima 5%<br />
• Dose:<br />
• 2 Ml/ 100Kg B.W<br />
Advantages<br />
Anti-<strong>in</strong>flammatory<br />
Strong analgesic<br />
Atipyretic<br />
Anti-endotoxic<br />
:N B<br />
Non Steroidal anti-<strong>in</strong>flammatory should be given after<br />
hydration <strong>of</strong> the calf
Broad spectrum antibiotic-4<br />
Antibiotice more effective on E<br />
coli & Salmonelle<br />
Nuflor<br />
Marbocele<br />
Cefotaxim<br />
Borgal(Sulfa &Trimethoprime)
Antiparasitic agents<br />
-6<br />
---<br />
• R/ Ivermect<strong>in</strong>e<br />
1cc /50 Kg. B.w.<br />
S/C
Prescription <strong>in</strong> dietetic diarrhea<br />
<strong>in</strong> Large <strong>animals</strong><br />
• R/S Guand<strong>in</strong>e 60 g<br />
• R/Tannic acide 40 g<br />
• R/Cloramphenicol 15 g<br />
• R/Starch<br />
½ Kg<br />
:NB<br />
Zanil 100 Ml for paramphistomum+
General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />
Acidosis<br />
• 1-Evacuation <strong>of</strong> rumen content:<br />
•<br />
• By us<strong>in</strong>g 3 liter Paraff<strong>in</strong> oil by stomach tube<br />
• 2-Antiacid<br />
• (a) Local: 500 g sodium bicarbonate<br />
• &<br />
• (b)Systemic: 2 liter isotonic sodium bicarbonate 1.3% I/V<br />
• 3-Fluid therapy:<br />
• Nacl 0.9% 4-6 liter I/V<br />
•<br />
• Accord<strong>in</strong>g to degree <strong>of</strong> dehydration<br />
• 4-Antihistam<strong>in</strong>ic:<br />
• R/Antistam<strong>in</strong>e 30-40 Ml I/V
General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />
Acidosis<br />
• 5-Ant<strong>in</strong>flamatory<br />
• 6-Antibiotic<br />
•<br />
orally)<br />
Orally (proca<strong>in</strong>e penicill<strong>in</strong> 10million IU<br />
• &<br />
• Systemic<br />
• 7-Rum<strong>in</strong>al tonic stomachic<br />
• -Bykahepar -genabell<br />
• -Hepanol -propylene glycol
General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />
simple <strong>in</strong>digestion<br />
• 1-Antiacid<br />
• 0.5 kg sodium bicarbonate/orally<br />
• 2-Rum<strong>in</strong>al tonic stomachic<br />
• -Bykahebar<br />
-Genabel<br />
• 3-Purgative<br />
• 0.5 kg orally <strong>of</strong> Mg oxide<br />
• OR<br />
• 2 liter <strong>of</strong> Paraff<strong>in</strong> oil<br />
• 4-Massage <strong>of</strong> rumen from left flank<br />
• 5-Rectal enema, back rack<strong>in</strong>g &exercise
General l<strong>in</strong>e for <strong>treatment</strong> <strong>of</strong><br />
Masititis<br />
• 1-AntiBiotic<br />
• Systemic:<br />
Gentamyc<strong>in</strong>,<br />
Cefotaxim Snylox-Pentomyc<strong>in</strong><br />
• Pentomyc<strong>in</strong><br />
• 2-Ant<strong>in</strong>flammatory<br />
• 3 days Non steroidal AI<br />
• 3-Antihistam<strong>in</strong>ic<br />
• 1st day<br />
• 4-Oxytoc<strong>in</strong><br />
• 5-Vitam<strong>in</strong> AD3E&C
General l<strong>in</strong>e <strong>of</strong> <strong>treatment</strong> <strong>of</strong><br />
pneumonia<br />
• Broad spectrum antibiotic<br />
• Ant <strong>in</strong>flammatory<br />
• Bronchodilator<br />
• Mucolytics & Expectorants<br />
• Antihistam<strong>in</strong>ic
Antibiotic used <strong>in</strong> pneumonia<br />
1. 1-In less sever cases:<br />
1-Oxytetracycl<strong>in</strong>e drugs<br />
2-Ener<strong>of</strong>loxac<strong>in</strong>e<br />
IN sever cases (Shipp<strong>in</strong>g fever):<br />
Flurphenicol<br />
Cephalosporion .<br />
Sulfa &Trimethoprime<br />
Marb<strong>of</strong>lxac<strong>in</strong>e
Metabolic Diseases<br />
Therapy
General l<strong>in</strong>e for <strong>treatment</strong><br />
• 1)Source <strong>of</strong> Calcium<br />
A-Small cow(300-<br />
400 Kg):<br />
R/500 ml (375 ml IV<br />
very slowly and<br />
125 ml SC after 30<br />
m<strong>in</strong>. at different<br />
sites.<br />
<strong>of</strong> milk fever
• Large cow( More<br />
than 500 Kg B .w.)<br />
• 1 Liter:<br />
• ½ Liter at morn<strong>in</strong>g<br />
• ½ Liter at even<strong>in</strong>g
Examples <strong>of</strong> Ca preparation<br />
• R/Ca boro-gluconate (20% or 25%)<br />
• Or<br />
R/ Cal. D. Mg (Ca & Dextrose & Mg)<br />
R/Calcium am<strong>in</strong>o-plex (Ca & am<strong>in</strong>o acids).<br />
NB:<br />
• I/v Ca solution should be slowly to<br />
prevent cardiac arrest.<br />
• Cont<strong>in</strong>ue for 3-5 days days or till complete<br />
recovery
(2) Compounds which <strong>in</strong>creas<strong>in</strong>g calcium<br />
level <strong>in</strong> blood:<br />
R/ AD3E&C (15 ml / daily IM).<br />
& R/ACTH 400-500 IU I/M<br />
3) Anti-<strong>in</strong>flammatory (Non Steroidal)<br />
R/Declo-phenac Na 2.5% 4 ml/100 Kg B W.<br />
(4) Supportive <strong>treatment</strong>:<br />
R/Dextrose 25% or 40% 2 liter IV.
Medical General l<strong>in</strong>es for<br />
<strong>treatment</strong> <strong>of</strong> hypo-phosphatemia<br />
Source <strong>of</strong> ph Hemat<strong>in</strong>cs Sal<strong>in</strong>e
Source <strong>of</strong> ph-1<br />
I/V&I/M S/C Orally
Hemat<strong>in</strong>ics-2<br />
A-Blood transfusion<br />
) In sever cases(<br />
. Iron & VitB12
Sources <strong>of</strong> phosphorus( 1)<br />
• A) IV slowly adm<strong>in</strong>istration<br />
<strong>of</strong> 60 <strong>of</strong> sodium acid<br />
phosphate <strong>in</strong> 300 ml <strong>of</strong><br />
distilled water on the first<br />
day .<br />
• Followed by further SC<br />
<strong>in</strong>jections <strong>of</strong> similar doses at<br />
12-hours <strong>in</strong>tervals till<br />
recovery.<br />
• Similar daily doses (60 g) by<br />
mouth<br />
:NB<br />
Treatment should be cont<strong>in</strong>ued till 3-5 days<br />
.after disappearance <strong>of</strong> red ur<strong>in</strong>e (complete recoverty
• B) patent phosphorus preparation<br />
as:<br />
• R/ Tonophosphan (Ph 10%)<br />
• R/ 50ml( 25 ml IV daily&25 ml I/M till<br />
recovery).
• C) Oral dos<strong>in</strong>g with bone meal (120 g)<br />
twice daily or dicalcium phosphate<br />
daily for 5 days till recovery.<br />
• Or:<br />
• Superphos Sachets 3<br />
• One sachet daily (oral route)
• (2) Hemat<strong>in</strong>ic preparation:<br />
• (A) <strong>in</strong> sever cases:<br />
• Blood transfusion 3-4 L <strong>of</strong> whole blood to a<br />
450 kg cow is <strong>in</strong>dicated <strong>in</strong> severe cases.<br />
• Additional transfusion is necessary if cow is<br />
still weak and mucous membranes are pale.<br />
• (B) In less sever cases:<br />
• iron, copper, cobalt, vitam<strong>in</strong> B12. (4)<br />
R/Antoplex 15 ml I/M
• (3) Supportive therapy:<br />
• (Glucose 25%) to treat ketosis &<br />
hypoglycemia.<br />
• (4)Kidney wash:<br />
• (Glucose 5% or sal<strong>in</strong>e(0.9%NaCl ( to<br />
m<strong>in</strong>imize the danger <strong>of</strong> hemoglob<strong>in</strong>uric<br />
nephritis.
3- General <strong>L<strong>in</strong>es</strong> Of<br />
Treatment <strong>of</strong> Ketosis<br />
1-Dextrose 25%<br />
Make Glucose<br />
2-Propylene glycol<br />
3-Dexamethasone<br />
Insul<strong>in</strong>e-4<br />
Decreased Production<br />
(less glucose<br />
demand)<br />
Increased Appetite<br />
Facilitate transport glucose<br />
<strong>in</strong>to the cell
Medical <strong>treatment</strong><br />
• 1-Sources <strong>of</strong> glucose:<br />
• IV <strong>in</strong>jection <strong>of</strong> dextrose 25-40%<br />
500ml for cattle (<strong>in</strong> ewes 150-<br />
250 ml) IV, twice daily for 3-5<br />
successive days caus<strong>in</strong>g<br />
temporary hyperglycemia.
• Oral hyperglycemic<br />
agents: propylene glycol .05<br />
Liter orally<br />
• Or:<br />
• Glycerol or glycer<strong>in</strong> 0.25 Liter or<br />
sodium propionate )100-200 gm (<br />
once daily for 3 day(.<br />
R/Primaton :<br />
.025 L orally<br />
• They are glucogenic and thus<br />
produce glucose.<br />
Primaton
2-Hormonal therapy:<br />
A-Glucocorticoids:<br />
Such as dexamethazone 10 ml )30<br />
mg( I/M one or two doses for cattle<br />
to <strong>in</strong>crease the blood sugar level &<br />
reduces ketone bodies formation by<br />
utilization <strong>of</strong> acetyl coenzyme A.
L<strong>in</strong>e <strong>of</strong> <strong>treatment</strong> <strong>of</strong> blood parasites<br />
Babesiosis-1<br />
• Fever (40-41C)<br />
• Red Ur<strong>in</strong>e<br />
• Partial loss <strong>of</strong> appetite<br />
• Jaundice
:I- Treatment<br />
• Important Notes:<br />
• Treatment should be tried early before the<br />
animal becomes anemic<br />
· Care must also be taken to avoid complete<br />
sterilization <strong>of</strong> the blood before sufficient<br />
antibody is produced to provide a durable<br />
immunity.
Drugs used<br />
1- Dim<strong>in</strong>azen aceturate (Batr<strong>in</strong>il-Ber<strong>in</strong>il)<br />
· Aqueous solution7% )1.05gm vial dissolved <strong>in</strong><br />
12.5 ml water(.<br />
· Dose 1ml/20kg ·<br />
2-Imidocarb dipropionate (Imisol)<br />
2ml/100Kg B W.
Symptomatic <strong>treatment</strong><br />
• Non steroidal ant <strong>in</strong>flammatory<br />
• R/ Decl<strong>of</strong>lam )1CC/25kg I/M(<br />
• -Blood transfusion:-<br />
• - In Sever cases 1Liter/100 Kg B W.<br />
• General hemat<strong>in</strong>ics.<br />
• R/Antoplex 15mlI/M<br />
• Or Iron 100 1 ml /100Kg B W.
L<strong>in</strong>e <strong>of</strong> <strong>treatment</strong> <strong>of</strong> blood parasites<br />
Theleriasis-2<br />
• Fever (40-41C)<br />
• Corneal opacity<br />
• Partial loss <strong>of</strong> appetite<br />
• Enlarged pre-scapular<br />
L.N<br />
Corneal opacity
Treatment<br />
R/butalex <strong>in</strong>jection<br />
Or:<br />
1CC /20 Kg I/M<br />
Oxytetracycl<strong>in</strong>e L.A(5 Doses)<br />
+ Ars<strong>in</strong>al for 5 days
L<strong>in</strong>e <strong>of</strong> <strong>treatment</strong><br />
Of<br />
ur<strong>in</strong>ary tract affections<br />
Antibiotic<br />
Ur<strong>in</strong>ary<br />
Antiseptic<br />
-Anti<br />
<strong>in</strong>flammatory
Types <strong>of</strong> Antibiotic<br />
ephalospor<strong>in</strong>e<br />
entamyc<strong>in</strong>e<br />
Sulpha<br />
&<br />
Trimethprime<br />
Penicll<strong>in</strong>e<br />
&<br />
streptomyc<strong>in</strong>e
Types <strong>of</strong> Antibiotic<br />
Accord<strong>in</strong>g to species<br />
Equ<strong>in</strong>es<br />
lpha & Trimethoprime<br />
Rumm<strong>in</strong>ant<br />
Cephalospor<strong>in</strong>e<br />
penicill<strong>in</strong>es
Duration<br />
<strong>of</strong><br />
Antibiotic<br />
Acute<br />
days<br />
3-5<br />
Chronic<br />
D 7-10<br />
Chronic pyogenic<br />
weeks<br />
2-4
Ur<strong>in</strong>ary-2<br />
Antiseptic<br />
Local<br />
use <strong>of</strong><br />
catheters<br />
Systemic<br />
Coli-ur<strong>in</strong>al<br />
Hexam<strong>in</strong><br />
Ur<strong>in</strong>ary lavage<br />
IV glucose
Anti-<strong>in</strong>flammatory-3<br />
Decloprema<br />
F<strong>in</strong>ady<strong>in</strong>e<br />
Ketopr<strong>of</strong>en
Causes Antibiotic Failure<br />
• 1-Exposure to strong sunlight<br />
• 2-Too-much-water<br />
• 3-Frequency-<strong>of</strong>-dose ( daily <strong>treatment</strong><br />
but we decided to just double the dose<br />
and give it every other day).<br />
• 4-Duration is not enough.
• 5-The causative agent is virus not bacteria<br />
• 6-The drug is not specific aga<strong>in</strong>st the<br />
pathogen<br />
• 7-Contam<strong>in</strong>ated needle back <strong>in</strong>to the bottle.
Viral<br />
vacc<strong>in</strong>es<br />
1. PNEUMO 3<br />
2. PNEUMO 4<br />
3. Cattle Master4<br />
4. Vira Shield 5<br />
Nasal Gene-5<br />
Bacterial<br />
vacc<strong>in</strong>es<br />
1. Pneumo - Bac<br />
2. Covex<strong>in</strong>* 8& 10<br />
3 Ultrabac® 8<br />
Mixed<br />
vacc<strong>in</strong>es<br />
1. Entero – 3<br />
Vacc<strong>in</strong>e<br />
2. Scour Guard 3<br />
Rotvec vacc<strong>in</strong>e-3<br />
Coli immune-oral-4<br />
E Coli + Rota & Corana Virus
VACCINE FAILURES<br />
• NO RESPONSE :<br />
• Efficacy- expire Date<br />
• stress<br />
• Malnutrition<br />
• Improper Dose .<br />
• Improper Route.