UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

Presentations
A randomized, phase 3, open-label study of nivolumab versus
temozolomide (TMZ) in combination with radiotherapy (RT) in
adult patients (pts) with newly diagnosed, O-6-methylguanine DNA
methyltransferase (MGMT)-unmethylated glioblastoma (GBM):
CheckMate-498.
Authors*: John H. Sampson, Antonio Marcilio Padula Omuro, Matthias Preusser, Michael Lim,
Nicholas A. Butowski, Timothy Francis Cloughesy, Lewis C. Strauss, Robert Raymond Latek, Prashni
Paliwal, Michael Weller, David A. Reardon
Abstract #: TPS2079
Presentation Date/Time: Saturday, June 4: 1:00 - 4:30 PM
Location: Hall A, Poster Board #265b
Session: Central Nervous System Tumors
Citation: J Clin Oncol 34, 2016 (suppl; abstr TPS2079)
Butowski Research Interests: My research includes translational research and a wide range of clinical trials,
including those with convection-enhanced delivery (CED) with real-time MRI imaging, targeted agents,
immunotherapy, and combination strategies. I am the Director of Translational Research in Neuro-Oncology
and lead the translational effort on behalf of the UCSF Brain Tumor Research Center and Preclinical Core.
My work has helped to create the groundwork for allied research in neuro-oncology and an extensive
UCSF clinical trial portfolio for patients with primary brain and spine tumors, including an assortment of
immunotherapy trials and surgically based trials. I have also designed investigator initiated trials, including a
clinical trial employing intratumoral delivery with real-time MRI imaging as well as those with a range of novel
targets, molecular markers and imaging biomarkers. I have also authored a number of peer-reviewed papers
and presented work at national and international meetings.
https://www.ucsfhealth.org/nicholas.butowski
__________________________________________________________________________
Phase 2 study to evaluate the clinical efficacy and safety of
MEDI4736 (durvalumab) in patients with glioblastoma (GBM).
Authors*: David A. Reardon, Thomas Joseph Kaley, Jorg Dietrich, Michael Lim, Gavin P Dunn,
Hui Kong Gan, Timothy Francis Cloughesy, Jennifer Leigh Clarke, Andrew J. Park, Mary J. Macri,
Aileen Ryan, Toni Ricciardi, Vijay Reddy, Ralph Rudolph Venhaus
Abstract #: TPS2080
Presentation Date/Time: Saturday, June 4: 1:00 - 4:30 PM
Location: Hall A, Poster Board #266a
Session: Central Nervous System Tumors
Citation: J Clin Oncol 34, 2016 (suppl; abstr TPS2080)
*UCSF authors in bold
34