UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

Presentations
Functional annotation of cancer driver genes in breast cancer patientderived
xenografts to identify a novel target for PARP inhibitors.
Authors*: Xiaosong Zhang, Meng Li, Olga Momcilovic, Andrew Beardsley, Roman Camarda, Andrei Goga
Abstract #: e23192
Presentation Date/Time: Publication Only
Location: Publication Only
Session: Publication Only
Citation: J Clin Oncol 34, 2016 (suppl; abstr e23192)
Goga Research Interests: Tumor cells are driven to proliferate, alter their metabolism, and deregulate
cell death pathways by oncogene over-expression or the loss of tumor-suppressor genes. We seek to
understand how oncogenes alter these pathways using cell-based and transgenic animal models. We are
especially interested in how the prototypical oncogene Myc acts in diverse tumor types, including amongst
the most aggressive breast and liver cancers and lymphomas. Myc has also been postulated to drive a
‘stem cell like’ gene expression pattern which may regulate tumor stem cell function. We seek to elucidate
the genes and pathways that are indispensable for Myc function, and thus uncover potential ‘achilles heels’
of tumor cells. Our ultimate goal is to translate our basic discoveries to novel cancer therapeutics.
http://oncogenes.net/Goga_Lab/Home.html
*UCSF authors in bold
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