Product Datasheet Tocotrienol VitaTrin™ Gelpells®

Product Datasheet
Tocotrienol VitaTrin Gelpells ®
Tocotrienols
Tocotrienols are members of the vitamin E family, an essential nutrient
for the body. Four tocopherols (alpha, beta, gamma, and delta)
and four tocotrienols (alpha, beta, gamma, and delta) are belonging
to this group of fat-soluble vitamins.
Tocotrienols are natural components found at low levels in vegetable
oils, wheat germ, barley, saw palmetto, and some nuts and grains.
They are extracted and concentrated from palm oil.
Chemically seen, the tocotrienols are antioxidants. One model for the
function of the tocotrienols in the body is that they protect cell membranes,
active enzyme sites, and DNA from free radical damage.
Tocotrienols can protect brain cell damage [1] , prevent cancer [2] and
reduce cholesterol. [3] These biological characteristics, do not apply
for Tocopherols. [4]
On the other hand, symptoms caused by alpha-tocopherol deficiency
can be alleviated by Tocotrienols. Tocotrienols may be seen as being
members of the natural vitamin E family, not only structurally but
also functionally.
Dosage
The effective dosage of VitaTrin-Tocotrienols is 300 mg per day,
which is equal to two capsules size “0” containing 420mg Pellets
(36% tocotrienols load).
Gelpells enhance bioavailability
Tocotrienols are insoluble in water. The bioavailability of
the Tocotrienols depends on the particle size of the oil
droplets in water. The smaller the particle size, the
higher is the surface for the absorption in the gut. The
gelatin of the pellets is a natural polymer which is soluble
in warm water. During this solution process the gelatin
polymer is able to disperse the nutrients in water.
This in-situ micro emulsion enhances the bioavailability
of the nutrients. In clinical studies Gelpell found that the
AUC of the plasma levels of fat soluble ingredients such
as Q10, Vitamin E, and Vitamin K2 after oral supplementation
in pellet form was increased by some 30% in
comparison to softgel formulations. Piperine may be
added to the GSM Oil pellet increasing the bioavailability
of fat soluble ingredients by another 30% [5] .
Advantages of the Tocotrienol Gelpells
• Unique delivery form
• Appealing pellets with a shiny surface
• Regular shape and natural orange colour
• Gelatin matrix 100% natural and digestible
• Easy to fill into capsules, sticks or sachets
• No colorants, additives or preservatives
• Increased bioavailability
Tocotrienol Gelpells
(Load 36%)
1. Sen CK, Khanna S, Roy S (March 2006). "Tocotrienols: Vitamin E beyond tocopherols". Life Sciences 78 (18): 2088–98.
2. Nesaretnam K (October 2008). "Multitargeted therapy of cancer by tocotrienols". Cancer Letters 269 (2): 388–95.
3. Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ (May 1993). "Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3methylglutaryl-coenzyme
A reductase". The Journal of Biological Chemistry 268 (15): 11230–8.
4. Das S, Lekli I, Das M, et al. (February 2008). "Cardioprotection with palm oil tocotrienols: comparison of different isomers". American Journal of Physiology. Heart and Circulatory Physiology 294
(2): H970–8.
5. Badmaev, V., et al, "Piperine Derived from Black Pepper Increases the Plasma Levels of Coenzyme Q10 Following Oral Supplementation" J Nutr Biochem 11.2 (2000),109-13

Tocotrienol VitaTrin Gelpells ®
Product 420 mg Pellets in a capsule size „0“
Label claim 150 mg Tocotrienols
Raw material quality Active Ingredient Tocotrienols VitaTrin
(ex Lipid Nutrition)
Gelatin food-grade bovine gelatin
min. 86% protein content
Phys. - chem. parameters Appearance round pellets, free-flowing
Colour brownish-yellow
Size > 95% between 1 - 2 mm
Bulk density, loose app. 730 g / l
Dissolution in water max. 30 minutes
Nutritional values per 100 g Fat 23.2 g
Protein 50.0 g
Carbohydrates 0.0 g
Energy 1’708 kJ (417 kcal)
Microbiology fulfils Ph. Eur. 5.1.4
TAMC max. 10'000 / g
TYMC max. 100 / g
Gram-negative, bile-
tolerant bacteria max. 100 / g
E. coli negative / g
Staph. aureus negative / g
Salmonella negative / 10g
Contaminants Gelpells fulfil requirements for heavy metals and mycotoxins:
Contaminants regulations (EC) No. 1881/2006 and 629/2008
Other quality parameters GMO-free, not irradiated, no allergen, Gluten-free, Lactose-free
We can fill the Gelpells in two-piece capsules and/or jars, e.g.:
Hard gelatin capsule Size „0“, from Gelatin or HPMC
Length 21.7 +/- 0.7 mm, weight (empty) 96 +/- 6 mg
Fill weight 420 mg
Daily dosage 2 capsules
Price indication We would be pleased to provide a detailed offer
June 18, 2010
GELPELL AG Kirchbergerstrasse 10 CH-9534 Gähwil Switzerland
Phone +41(0)71 932 13 33 Fax +41(0)71 932 13 34 info@gelpell.com www.gelpell.com