Final Program
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56 SUNDAY • MAY 15<br />
P749<br />
P750<br />
P751<br />
P752<br />
P753<br />
P754<br />
P755<br />
Facilitator:<br />
P756<br />
P757<br />
P758<br />
P759<br />
P760<br />
Induction of Human Airway Epithelial to Mesenchymal<br />
Transition (EMT) upon Human Rhinovirus Infection/D. Minor, S.<br />
Traves, D. Proud, Calgary, Canada, p.A1473<br />
An Exploratory Pathway Analysis of Wound-Induced Gene<br />
Responses in Healthy and Asthmatic Human Airway Epithelial<br />
Cells (HAEC)/H. Inoue, W. Horne, J.K. Kolls, X. Zhou, J.B.<br />
Trudeau, S.E. Wenzel, Pittsburgh, PA, p.A1474<br />
Clarithromycin Attenuates IL-13-Induced Goblet Cell<br />
Hyperplasia Through SPDEF/CLCA1 Suppression in Normal<br />
Human Bronchial Epithelial Cells/A. Nagashima, M. Shinkai, T.<br />
Shimokawaji, M. Shinoda, K. Mishina, H. Ishii, Y. Kimura, S. Sudo,<br />
Y. Tei, Y. Hara, T. Kodama, K. Tanaka, M. Toda, J. Tsukiji, M.<br />
Kudo, Y. Inayama, T. Sato, M. Yamamoto, B.K. Rubin, T. Kaneko,<br />
Yokohama, Japan, p.A1475<br />
Mucosal Cytokines in Asthmatic Bronchoalveolar Lavage<br />
(BAL) Fluid Reflect Systemic Inflammation and Disease<br />
Severity/E. Hunt, S. Lapthorne, A. Sullivan, C. Ward, J. Eustace,<br />
B. Plant, J. MacSharry, D. Murphy, Cork, Ireland, p.A1476<br />
Transcriptomic Profiles of Bronchial Epithelial Cells in<br />
Asthmatics Differ From Controls/N. Assad, Y. Tesfaigzi, S.A.<br />
Ness, A. Sood, Albuquerque, NM, p.A1477<br />
Relationship Between AirwayHyperresponsiveness to Dosed<br />
Exercise Load and Hyperosmolar Stimuli in Patients with<br />
Asthma/J.M. Perelman, L.G. Nakhamchen, E. Afanas’eva, A.<br />
Prikhodko, V. Kolosov, Blagoveshchensk, Russian Federation,<br />
p.A1478<br />
Glucocorticoid-Driven Expression of Transcriptional<br />
Regulators in the Human Airways/M.M. Mostafa, C.F. Rider, R.<br />
Leigh, R. Newton, Calgary, Canada, p.A1479<br />
R.W. Harper, MD, Sacramento, CA<br />
The Role of Secreted HSP90a on Asthmatic Airway Epithelial<br />
Barrier Dysfunction Induced by HDM/H. Dong, C. Huang, Y. Le,<br />
L. Luo, Z. Xie, S. Cai, Guangzhou, China, p.A1480<br />
Inflammatory Pattern of Bronchial Mucosa in Asthmatics with<br />
Hyperresponsiveness to Hyposmolar Stimulus/V. Kolosov, A.B.<br />
Pirogov, A. Prikhodko, J.M. Perelman, E. Borodin, S.V. Zinovyev,<br />
M. Shtarberg, D. Naumov, E. Ushakova, Blagoveshchensk,<br />
Russian Federation, p.A1481<br />
Pseudomonas Aeruginosa Flagellin Stimulates Broad Gene<br />
Expression in Human Airway Epithelial Cells that Is Mitigated by<br />
Concurrent Treatment with Azithromycin/S.R. White, B. Laxman,<br />
S. Hashemifar, B. Xie, R. Stern, N. Maltsev, Chicago, IL, p.A1482<br />
Inhaled Corticosteroids Upregulate IL10 and GILZ in Human<br />
Sputum-Derived Bronchial Epithelial Cells in Asthma/B. Bleck,<br />
J.P.I. Egan, M. Cotrina-Vidal, A. Kazeros, G. Grunig, J. Reibman,<br />
New York, NY, p.A1483<br />
Epithelial Cells and Fibroblasts from Asthmatic and COPD<br />
Patients Cocultures, an In Vitro Model of Asthma-COPD<br />
Overlap Syndrome (ACOS)?/O. Le Rouzic, N. Ijiri, S. Audusseau,<br />
C. Baglole, M.S. Ludwig, D.H. Eidelman, Q. Hamid, Montreal,<br />
Canada, p.A1484<br />
P761<br />
P762<br />
P763<br />
P764<br />
P765<br />
Facilitator:<br />
P766<br />
P767<br />
P768<br />
P769<br />
P770<br />
P771<br />
P772<br />
Human ß-Defensin 1, 2 and 3 Enhance TGF-ß1-Mediated<br />
Epithelial-Mesenchymal Transition (EMT) in Bronchial<br />
Epithelial Cells/X.-Y. Qu, X.-M. Dang, D. Shang, W.-J. Wang, D.<br />
Xu, Y.-P. Shao, W.-Y. Lu, Y. Chang, Xi’an, China, p.A1485<br />
Spleen Tyrosine Kinase and Calcium Play Critical Roles in the<br />
Release of IL-33 from Airway Epithelial Cells Exposed to<br />
Fungus Alternaria Alternata/N. Sasaki, H. Kita, Y. Nakamura, K.<br />
Yamauchi, Rochester, MN, p.A1486<br />
Studying the Relationship Between Lung Inflammation and<br />
Epithelial Cell Outside-in Barrier Permeability In Vivo/T.J.<br />
Chapman, S. Hillman, S. Knowlden, J. Veazey, S. Georas,<br />
Rochester, NY, p.A1487<br />
Antisense microRNA Therapy Reduces Goblet Cell Mucousal<br />
Metaplasia and MUC5AC Production in House Dust Mite<br />
(HDM)-Sensitized Mice/S.C. Ramelli, J.M. McLendon, A. Ferretti,<br />
I. Aragon, J. Fewell, R. Barringtion, W. Gerthoffer, Mobile, AL,<br />
p.A1488<br />
The Role of miR-141 in IL-13-Mediated Mucus Production/S.<br />
Siddiqui, L. Zlock, D. Jun, L.R. Bonser, W. Finkbeiner, D. Erle, P.G.<br />
Woodruff, San Francisco, CA, p.A1489<br />
D.A. Knight, PhD, Callaghan, Australia<br />
Potentiation of MARCKS Phosphorylation in Airway Epithelia<br />
in Response to IL-13: Important Implications in Asthma/C.-H.<br />
Chen, R. Li, C.-C. Lee, A.L. Linderholm, R. Harper, N.J. Kenyon, R.<br />
Wu, Davis, CA, p.A1490<br />
A New Role for the Bcl-2 Family of Proteins in Blocking<br />
NF-kappaB Activation and Regulating House Dust<br />
Mite-induced Inflammation/J.T. Jones, H.S. Chand, E.G. Awji, Y.<br />
Mebratu, Y. Tesfaigzi, Albuquerque, NM, p.A1491<br />
Malondialdehyde-Acetaldehyde (MAA) Adducted Surfactant<br />
Protein Alters SRA/CD204 Gene and Protein Expression in Mouse<br />
Lung/M. Sapkota, J.M. DeVasure, T.A. Wyatt, Omaha, NE, p.A1492<br />
Surfactant Protein-A Promotes Resolution of Allergic<br />
Airways/J.G. Ledford, K. Addison, D. Francisco, A.M. Pastva, J.J.<br />
Lee, M. Kraft, Tucson, AZ, p.A1493<br />
A Peptide Modeled After the Bik BH3 Helix Dissociates the<br />
Bak-Bcl-2 Complex to Stabilize Bak and Reduce Allergen- and<br />
Cigarette Smoke-Induced Mucous Cell Metaplasia in Culture<br />
and In Vivo/Y. Mebratu, I. Leyva-Baca, E.G. Awji, M.<br />
Delgado-Vargas, J.T. Jones, H.S. Chand, Y. Tesfaigzi,<br />
Albuquerque, NM, p.A1494<br />
In the Maturing Layer of Primary Human Bronchial Epithelial<br />
Cells, Transforming Growth Factor-Beta Priming of Normal<br />
Cells Recapitulates Delayed Jamming as Seen in Asthmatic<br />
Cells/J.A. Mitchel, J. Notbohm, J. Butler, J.J. Fredberg, J.-A. Park,<br />
Boston, MA, p.A1495<br />
IL-13 Induces Periostin Production by MAP Kinase and STAT6<br />
Phosphorylation. Inhibiting Periostin Production Modestly<br />
Decreases MUC5AC Mucin Secretion/I. Suzaki, K. Komiya, T.<br />
Akaba, S. Kawano, T. Tanabe, B.K. Rubin, Richmond, VA, p.A1496<br />
ATS 2016 • San Francisco