UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

Presentations
Whole exome and targeted deep sequencing identify
genome-wide allelic loss and frequent SETDB1 mutations
in malignant pleural mesotheliomas
Authors*: Hio Chung Kang, Hong Kwan Kim, Sharon Lee, Pedro Mendez, James Kim, Gavitt Woodard,
Kuang-Yu Jen, Li Tai Fang, Kirk Jones, David Jablons, Il Jin Kim
Pres #: 108 Section: 4 Presentation Date/Time: Sunday, April 17: 1:00-5:00PM
Location:
Presentation Type: Poster Session
Kim Lab Expertise: Dr. Il-Jin Kim has focused his career on three important cancer-related areas: 1) cancer
genetics and genomics, 2) early detection and 3) cancer prevention. Dr. Kim has published approximately 70
papers in these areas. He has also been granted three patents for mutation detection methods. Projects in
these areas include: genetic screening in hereditary (familial) cancers to distinguishing carriers from noncarriers,
development of new genetic screening methods for cancer prevention, and genome-wide gene
expression microarray analysis.
Current projects in the Kim Lab include: Cancer Genetics and Genomics, Early Detection, Cancer Prevention.
http://kimlab.surgery.ucsf.edu/about-us.aspx
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Investigating microtubule growth dynamics in patient-derived
metastatic prostate cancer cells
Authors*: Alexandre Matov, Johan de Rooij, Jay Gatlin, Julia Rohrberg, Nikta Ahmad, Rahul Aggarwal,
Jeff Simko, Andrei Goga, Charles Ryan, Torsten Wittmann
Pres #: 243 Section: 14 Presentation Date/Time: Sunday, April 17: 1:00-5:00PM
Location:
Presentation Type: Poster Session
Wittman Lab Expertise: The Wittmann lab aims to elucidate molecular mechanisms by which polarity of
intracellular cell biological processes – such as cytoskeleton dynamics or vesicular transport – controls
complex behavior and function of mammalian cells. We are specifically interested in the function & dynamics
of the microtubule cytoskeleton & a diverse group of +TIP proteins that associate with growing microtubule
ends. In addition to molecular biology & biochemistry, we use advanced quantitative fluorescence microscopy.
We are also interested in how deregulation of intracellular microtubule dynamics contributes to cancer
pathology and resistance to microtubule targeting agents, and if this can be used to predict drug response.
Finally, we also develop novel ‘opto-cell biology’ to interfere with intracellular protein function at high spatial
& temporal resolution by using plant-derived light-sensitive protein domains.
http://wittmann.ucsf.edu/
*UCSF authors in bold
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