UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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Presentations Identification of new therapeutic targets and molecular predictors of response in oesophageal cancer Authors*: Irene Chong, lauren Aronson, David Cunningham, James Campbell, Colm Ryan, Michael Davidson, Ian Chau, Alan Ashworth, Christopher J. Lord Pres #: 69 Section: 3 Presentation Date/Time: Sunday, April 17: 1:00-5:00PM Location: Presentation Type: Poster Session __________________________________________________________________________ Functional effects of MutL homolog 1 promoter polymorphisms in prostate cancer Authors*: Shinichiro Fukuhara, Yozo Mitsui, Yutaka Hashimoto, Taku Kato, Ryan K. Wong, Varahram Shahryari, Soichiro Yamamura, Shahana Majid, Sharanjot Saini, Guoren Deng, Rajvir Dahiya, Yuichiro Tanaka Pres #: 86 Section: 3 Presentation Date/Time: Sunday, April 17: 1:00-5:00PM Location: Presentation Type: Poster Session Tanaka Lab Expertise: The Tanaka lab’s research focuses on genetic risk factors for urological cancers, their effects within the cell, as well as the functional role of various genes at the cellular and molecular levels. They have shown that variable expression between isoforms of estrogen, progesterone and androgen receptors in prostatic carcinogenesis and that inactivation is due to CpG methylation. They have identified genetic polymorphisms shown to be risk factors for prostate & kidney cancers and have examined genetic alterations in the estrogen-related pathway. They have also found a race-specific polymorphism in the coding region of the MLH1 DNA repair gene that confers protection from prostate cancer among a Japanese population. https://www.ncire.org/research/researchers_by_name/Yuichiro-Tanaka-PhD/ *<strong>UCSF</strong> authors in bold 8
Presentations Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas Authors*: Hio Chung Kang, Hong Kwan Kim, Sharon Lee, Pedro Mendez, James Kim, Gavitt Woodard, Kuang-Yu Jen, Li Tai Fang, Kirk Jones, David Jablons, Il Jin Kim Pres #: 108 Section: 4 Presentation Date/Time: Sunday, April 17: 1:00-5:00PM Location: Presentation Type: Poster Session Kim Lab Expertise: Dr. Il-Jin Kim has focused his career on three important cancer-related areas: 1) cancer genetics and genomics, 2) early detection and 3) cancer prevention. Dr. Kim has published approximately 70 papers in these areas. He has also been granted three patents for mutation detection methods. Projects in these areas include: genetic screening in hereditary (familial) cancers to distinguishing carriers from noncarriers, development of new genetic screening methods for cancer prevention, and genome-wide gene expression microarray analysis. Current projects in the Kim Lab include: Cancer Genetics and Genomics, Early Detection, Cancer Prevention. http://kimlab.surgery.ucsf.edu/about-us.aspx __________________________________________________________________________ Investigating microtubule growth dynamics in patient-derived metastatic prostate cancer cells Authors*: Alexandre Matov, Johan de Rooij, Jay Gatlin, Julia Rohrberg, Nikta Ahmad, Rahul Aggarwal, Jeff Simko, Andrei Goga, Charles Ryan, Torsten Wittmann Pres #: 243 Section: 14 Presentation Date/Time: Sunday, April 17: 1:00-5:00PM Location: Presentation Type: Poster Session Wittman Lab Expertise: The Wittmann lab aims to elucidate molecular mechanisms by which polarity of intracellular cell biological processes – such as cytoskeleton dynamics or vesicular transport – controls complex behavior and function of mammalian cells. We are specifically interested in the function & dynamics of the microtubule cytoskeleton & a diverse group of +TIP proteins that associate with growing microtubule ends. In addition to molecular biology & biochemistry, we use advanced quantitative fluorescence microscopy. We are also interested in how deregulation of intracellular microtubule dynamics contributes to cancer pathology and resistance to microtubule targeting agents, and if this can be used to predict drug response. Finally, we also develop novel ‘opto-cell biology’ to interfere with intracellular protein function at high spatial & temporal resolution by using plant-derived light-sensitive protein domains. http://wittmann.ucsf.edu/ *<strong>UCSF</strong> authors in bold 9
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UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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