UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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Presentations Novel genetic variants protective against breast cancer in Latinas Authors*: Laura Fejerman Pres #: Section: Presentation Date/Time: Tuesday, April 19: 11:00-11:20AM Location: Room 383 Presentation Type: Major Symposium Fejerman Lab Expertise: Dr. Fejerman focuses on the discovery of genetic and non-genetic factors that contribute to breast cancer risk and prognosis in Latinas. Her past work established a relationship between genetic ancestry and breast cancer risk, where higher European ancestry in U.S. and Mexican Latinas was associated with an increased risk. Her subsequent research has built upon this observation, exploring genetic variants, through admixture mapping and genome-wide association approaches, as well as the possible environmental and lifestyle related factors, and ancestry-gene interactions. Recent work explores disparities in breast cancer prognosis by genetic ancestry in Latinas and its potential causes. http://fejerman.ucsf.edu __________________________________________________________________________ A new innovative and robust targeted deep sequencing system: 36 hours turn round time from patient samples to the final mutation report Authors*: Pedro Mendez, Jun-Hee Yoon, Sharon Lee, James Kim, Jenny Dang, Thomas Kim, David Jablons, Il Jin Kim Pres #: 3609 Section: 6 Presentation Date/Time: Tuesday, April 19: 1:00-5:00PM Location: P resentation Type: Poster Session Kim Lab Expertise: Dr. Il-Jin Kim has focused his career on three important cancer-related areas: 1) cancer genetics and genomics, 2) early detection and 3) cancer prevention. Dr. Kim has published approximately 70 papers in these areas. He has also been granted three patents for mutation detection methods. Projects included in these areas include: genetic screening in hereditary (familial) cancers to distinguishing carriers from non-carriers, development of new genetic screening methods for cancer prevention, and genome-wide gene expression microarray analysis. Current projects in the Kim Lab include: Cancer Genetics and Genomics, Early Detection, Cancer Prevention. http://kimlab.surgery.ucsf.edu/about-us.aspx *<strong>UCSF</strong> authors in bold 32
Presentations Overcoming resistance to HER2 inhibitors through cell based screening Authors*: Chris J. Novotny, Sirkku Pollari, Jin H. Park, Mark A. Lemmon, Peter G. Schultz, Weijun Shen, Kevan M. Shokat Pres #: 3904 Section: 21 Presentation Date/Time: Tuesday, April 19: 1:00-5:00PM Location: Presentation Type: Poster Session Shokat Lab Expertise: My lab focuses on discovery of new chemical tools to decipher cellular signaling networks, particularly protein kinases and GTPases. Analysis of signal transduction pathways is challenging using traditional tools. Biochemical approaches have limited utility since signaling networks span from the cell surface to the nucleus, confounding reconstitution efforts. Genetic approaches allow specific perturbations, yet can be confounded by the emergent properties of signaling cascades. Chemical and pharmacological approaches enable rapid, reversible & graded inactivation of single components, but highly selective chemical probes are difficult to develop. My lab has solved this problem for protein kinases with a strategy based on a combination of protein engineering and organic synthesis. http://shokatlab.ucsf.edu/ __________________________________________________________________________ Highly sensitive detection of MYB-NFIB fusion transcripts in adenoid cystic carcinoma Authors*: Piotr T. Wysocki, Shizhang Ling, Chunbo Shao, Marieea Tan, David Sidransky, Patrick Ha, Mariana Brait Pres #: 3893 Section: 24 Presentation Date/Time: Tuesday, April 19: 1:00-5:00PM Location: Presentation Type: Poster Session Ha Lab Expertise: Dr. Ha’s lab interests align with his clinical practice of managing patients with complex head and neck cancers. He has had multiple NIH grants examining the molecular underpinnings of salivary gland adenoid cystic carcinoma in order to learn more about this rare but deadly disease. He serves on the editorial board of several journals including Head and Neck and Oral Oncology, and is now serving as the Chief of Head and Neck Surgical Oncology at the University of California San Francisco. http://ohns.ucsf.edu/patrick-ha __________________________________________________________________________ Structural basis of recognition of farnesylated and methylated KRAS4b by PDE-δ Authors*: Sathiya Dharmaiah, Lakshman Bindu, Peter Frank, William Gilleee, Dominic Esposito, Dwight Nissley, Frank McCormick, Andrew Stephen, Dhirendra Simanshu Pres #: 4373 Section: Presentation Date/Time: Tuesday, April 19: 3:05-3:20PM Location: Room 354 Presentation Type: Minisymposium *<strong>UCSF</strong> authors in bold 33
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UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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