UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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Presentations Overcoming mTOR resistance mutations with a new generation mTOR inhibitor Authors*: Vanessa S. Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Chris Novotny, Claire McWhirter, Arpitha Banaji, Helen Won, Wai Wong, Mike Berger, Elisa de Stanchina, Derek G. Barrae, Sabina Cosulich, Teresa Klinowska, Neal Rosen, Kevan M. Shokat Pres #: 2147 Section: 18 Presentation Date/Time: Monday, April 18: 1:00-5:00PM Location: Presentation Type: Poster Session Shokat Lab Expertise: My lab focuses on discovery of new chemical tools to decipher cellular signaling networks, particularly protein kinases and GTPases. Analysis of signal transduction pathways is challenging using traditional tools. Biochemical approaches have limited utility since signaling networks span from the cell surface to the nucleus, confounding reconstitution efforts. Genetic approaches allow specific perturbations, yet can be confounded by the emergent properties of signaling cascades. Chemical and pharmacological approaches enable rapid, reversible & graded inactivation of single components, but highly selective chemical probes are difficult to develop. My lab has solved this problem for protein kinases with a strategy based on a combination of protein engineering and organic synthesis. http://shokatlab.ucsf.edu/ __________________________________________________________________________ Functional characterization of combining epigenetic modifiers azacitidine and AG-221 in the TF-1:IDH2R140Q AML model Authors*: Vivek S. Chopra, Brian Avanzino, Konstantinos Mavrommatis, Adam Olshen, Jorge DiMartino, Kyle J. MacBeth Pres #: 2280 Section: 23 Presentation Date/Time: Monday, April 18: 1:00-5:00PM Location: Presentation Type: Poster Session Olshen Lab Expertise: My research is focused on developing statistical tools that enhance understanding of genomic data. Tools that I have helped to develop are Circular Binary Segmentation (CBS) for analyzing copy number data, iCluster for integrating multiple types of genomic data, and Babel for identifying genes with unusual levels of translation from ribosome profiling data. I have additional projects in machine learning and analysis of genomic data sets with few replicates. I lead a team of computational biologists as Director of the Computational Biology Core in the Helen Diller Family Comprehensive Cancer Center. http://cancer.ucsf.edu/people/profiles/olshen_adam.3576 *<strong>UCSF</strong> authors in bold 24
Presentations The genetic evolution of melanoma Authors*: Alan H. Shain, Richard Yu, Iwei Yeh, Jamal Benhamida, Ivanka Kovalyshyn, Aravindhan Sriharan, Eric Talevich, Reinhard Dummer, Jeffrey North, Laura Pincus, Beth Ruben, William Rickaby, Corrado D’Arrigo, Alistair Robson, Robert Judson, Nancy Joseph, Boris Bastian Pres #: 2372 Section: 28 Presentation Date/Time: Monday, April 18: 1:00-5:00PM Location: Presentation Type: Poster Session Bastian Lab Expertise: My laboratory is interested in the genetic alterations involved in skin cancer pathogenesis and predisposition as well as in understanding their role in biology, markers to improve diagnosis, and targets for treatment. __________________________________________________________________________ Combined BET-bromodomain and CDK2 inhibition in MYC-driven medulloblastoma Authors*: Sara Bolin, Anna Borgenvik, Camilla Persson, Gabriela Rosén, Anders Sundström, Jun Qi, James E. Bradner, William A. Weiss, Yoon-Jae Cho, Holger Weishaupt, Fredrik J. Swartling Pres #: 2473 Section: 32 Presentation Date/Time: Monday, April 18: 1:00-5:00PM Location: Presentation Type: Poster Session Weiss Lab Expertise: The Weiss lab is broadly interested in developing and characterizing mouse models that faithfully recapitulate the biology and genetics of human tumors of the nervous system, and using observations in the mouse to inform the biology, genetics, and therapy of human tumors. Specifically, we are: 1) Identifying the subsequent genetic events that promote tumorigenesis. 2) Studying cancer stem and progenitor cells to understand their contribution to malignant progression. 3) Evaluating new targets, therapies, and mechanistic rationales for combining targeted agents. http://waweisslab.ucsf.edu/ __________________________________________________________________________ Optimizing cervical cancer screening for HIV-infected women: A risk-based approach Authors*: Hilary A. Robbins, L. Stewart Massad, Christopher B. Pierce, Lisa Flowers, Teresa M. Darragh, Howard Minkoff, Lisa Rahangdale, Marla J. Keller, Joel Milam, Margaret Fisch, Sadeep Shrestha, Christine Colie, Howard Strickler, Gypsyamber D’Souza Pres #: 2580 Section: 36 Presentation Date/Time: Monday, April 18: 1:00-5:00PM Location: Presentation Type: Poster Session *<strong>UCSF</strong> authors in bold 25
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UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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