UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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Presentations P32-targeting TT1 peptide delivers nanoparticles to intracranial glioblastomas Authors*: Pille Säälik, Hedi Hunt, Allan Tobi, Anne-Mari Anton Willmore, Kadri Toome, Shweta Sharma, Ramana Kotamraju, Gabriele Bergers, Rolf Bjerkvig, Erkki Ruoslahti, Tambet Teesalu, Tambet Teesalu Pres #: 1343 Section: 20 Presentation Date/Time: Monday, April 18: 8:00AM-12:00PM Location: Presentation Type: Poster Session Bergers Lab Expertise: The Bergers laboratory focuses on revealing the dialogue between the tumor cell compartment and the vascular niche, of which the vasculature is an integral component. The vascular niche consists of distinct cell types and specialized matrices that provide signals controlling stem cell proliferation, fate specification, and protection in not only normal tissue, but tumors, as well. The long-term goal of Dr. Bergers’ research is to conduct a comprehensive investigation that defines the heterotypical signals of the tumor-host dialogue in the vascular niche in regulating neovascularization, stem cell maintenance, and tumor invasion during tumor progression and therapeutic resistance. http://neurosurgery.ucsf.edu/index.php/research_BTRC_bergers.html __________________________________________________________________________ Identification of the functional significance of mutations using the novel precision cancer analysis system Authors*: Gabi Tarcic, Nir Peled, Zohar Barbash, Naama Barabash-Katzir, Shlomo Yaakobi, Naama Barabash-Katzir, Hani Nevo, Michael Vidne, Mariusz Adamek, Mordechai R. Kramer, Nikolai Goncharenko, Yakov Fellig, Karen Meir, Keith Mostov, Yoram Altschuler Pres #: 1379 Section: 21 Presentation Date/Time: Monday, April 18: 8:00AM-12:00PM Location: Presentation Type: Poster Session Mostov Lab Expertise: The Mostov laboratory studies epithelial morphogenesis and polarity in several organs including the liver. One of our interests is the mechanism by which cholangiocytes differentiate from hepatoblasts and progress to form ductal plates and eventually branching tubular networks. We recently developed a culture system in which a liver progenitor cell line, HPPL, reorganizes from a monolayer to tubular structures by being overlaid with a gel containing type I collagen and Matrigel. HPPL assumed a double layer configuration in the specialized culture environment and then developed a luminal space. Formation of the double layer does not involve cholangiocyte proliferation, but is associated with phosphatidylinositol 3-kinase and Akt activity, as well as transcriptional activity of HNF1. http://mostovlab.ucsf.edu/Mostov_Lab_Website/Welcome.html *<strong>UCSF</strong> authors in bold 18
Presentations MicroRNA-466 regulates bone metastasis by targeting RUNX2 in prostate cancer Authors*: Shahana Majid, Hanna Nip, Altaf A. Dar, Sharanjot Saini, Varahram Shahryari, Soichiro Yamamura, Yozo Mitsui, Nathan Bucay, Guoren Deng, Rajvir Dahiya, Yuichiro Tanaka Pres #: 1619 Section: 31 Presentation Date/Time: Monday, April 18: 8:00AM-12:00PM Location: Presentation Type: Poster Session Tanaka Lab Expertise: The Tanaka lab’s research focuses on genetic risk factors for urological cancers, their effects within the cell, as well as the functional role of various genes at the cellular and molecular levels. They have shown that variable expression between isoforms of estrogen, progesterone and androgen receptors in prostatic carcinogenesis and that inactivation is due to CpG methylation. They have identified genetic polymorphisms shown to be risk factors for prostate & kidney cancers and have examined genetic alterations in the estrogen-related pathway. They have also found a race-specific polymorphism in the coding region of the MLH1 DNA repair gene that confers protection from prostate cancer among a Japanese population. https://www.ncire.org/research/researchers_by_name/Yuichiro-Tanaka-PhD/ __________________________________________________________________________ Body size and incidence of TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer Authors*: Thomas Ahearn, Rebecca E. Graff, Andreas Peeersson, Claire Pernar, Sarah C. Markt, Kathryn M. Wilson, Michelangelo Fiorentino, Massimo Loda, Edward L. Giovannucci, Lorelei A. Mucci Pres #: 1763 Section: 35 Presentation Date/Time: Monday, April 18: 8:00AM-12:00PM Location: Presentation Type: Poster Session Witte Lab Expertise: Our research program encompasses a synthesis of methodological and applied genetic epidemiology, with the overall aim of deciphering the mechanisms underlying complex diseases and traits (Witte, Visscher & Wray, Nature Reviews Genetics 2014). Our methods work is focused on the design and statistical analysis of next-generation sequencing and genetic association studies. We are applying these methods to studies of cancer (e.g., of the prostate), birth defects, and pharmacogenomics. http://wittelab.ucsf.edu/pages/research *<strong>UCSF</strong> authors in bold 19
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UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER

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