UCSF HELEN DILLER FAMILY COMPREHENSIVE CANCER CENTER
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Presentations<br />
Tumor suppressive role of a novel microRNA at frequently<br />
deleted chromosomal locus 8p21 in prostate cancer<br />
Authors*: Nathan Bucay, Kiran Sekhon, Shahana Majid, Varahram Shahryari, Soichiro Yamamura,<br />
Z. Laura Tabatabai, Kirsten Greene, Yuichiro Tanaka, Rajvir Dahiya, Guoren Deng, Sharanjot Saini<br />
Pres #: 1103 Section: 7 Presentation Date/Time: Monday, April 18: 8:00AM-12:00PM<br />
Location:<br />
Presentation Type: Poster Session<br />
Saini Lab Expertise: The Saini lab focuses primarily on understanding the molecular basis of progression<br />
and metastasis of prostate cancer, in particular the role of microRNA (miRNA) genes located at frequently<br />
deleted genomic regions in prostate cancer epithelial-to mesenchymal transition (EMT), recurrence and<br />
metastasis. A role for miRNAs that affects EMT and progression and metastasis of human cancers has<br />
begun to emerge and Dr. Saini’s research provided initial evidence that miR-203 regulates EMT by directly<br />
targeting ZEB2 and other EMT regulators that in turn regulate PCa invasion and metastasis. Her recent<br />
research has identified additional novel miRNAs in prostate cancer that play an important role in prostate<br />
cancer EMT, recurrence and metastasis.<br />
https://www.ncire.org/research/researchers_by_name/Sharanjot-Saini-PhD/<br />
__________________________________________________________________________<br />
Inhibitory effect of CYP1B1 on antitumor activities induced<br />
by dysregulated CDC20 and DAPK1 in renal cell carcinoma<br />
Authors*: Yozo Mitsui, Inik Chang, Shinichiro Fukuhar, Hiroshi Hirata, Ryan Kenji Wong, Soichiro Yamamura,<br />
Varahram Shahryari, Guoren Deng, Saini Sharanjot, Shahana Majid, Hiroaki Shiina, Rajvir Dahiya,<br />
Yuichiro Tanaka<br />
Pres #: 1155 Section: 9 Presentation Date/Time: Monday, April 18: 8:00AM-12:00PM<br />
Location:<br />
Presentation Type: Poster Session<br />
Tanaka Lab Expertise: The Tanaka lab’s research focuses on genetic risk factors for urological cancers, their<br />
effects within the cell, as well as the functional role of various genes at the cellular and molecular levels. They<br />
have shown that variable expression between isoforms of estrogen, progesterone and androgen receptors<br />
in prostatic carcinogenesis and that inactivation is due to CpG methylation. They have identified genetic<br />
polymorphisms shown to be risk factors for prostate & kidney cancers and have examined genetic alterations<br />
in the estrogen-related pathway. They have also found a race-specific polymorphism in the coding region of<br />
the MLH1 DNA repair gene that confers protection from prostate cancer among a Japanese population.<br />
https://www.ncire.org/research/researchers_by_name/Yuichiro-Tanaka-PhD/<br />
*<strong>UCSF</strong> authors in bold<br />
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