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Wednesday, April 20 Integrated Neuroscience Session 1:00 p.m.–5:30 p.m. Integrated Neuroscience Session I11 S Neurocritical Care and Neuroscience Crossroads: From Bench To Bedside This program is offered in partnership with the Neurocritical Care Society and the Critical Care and Emergency Neurology Section. Coordinators: Susanne Muehlschlegel, MD, MPH, and Holly E. Hinson, MD Program Description: This INS session in neurocritical care will focus on translational discoveries in the Neuro ICU patient population and their potential translation into clinical practice. The field of neurocritical care has evolved rapidly in the last decade, incorporating new technology such as multi-modality monitoring and advanced imaging techniques. Observations gleaned from basic science have illuminated etiologies for previously mysterious entities, including inflammatory encephalitis. This session will highlight these bench to bedside insights, giving participants a grasp of cutting-edge neuroscience as it applies to the care of critically ill patients. Upon Completion: Participants should be able to describe the evidence base for the use of new technology in the ICU, including multi-modality monitoring. Participants will become familiar with the differential diagnosis and work-up of inflammatory encephalitis, receive updates on emerging areas of research including cortical spreading depression, the use of depth electrodes in the diagnoses of non-convulsive status epilepticus, and become comfortable with the complexities of disorders of consciousness. Part I 1:00 p.m.–3:00 p.m. 1:00 p.m.–1:10 p.m. Introduction Susanne Muehlschlegel, MD, MPH, and Holly E. Hinson, MD 1:10 p.m.–1:45 p.m. Invited Speaker Cortical Spreading Depression Jed Hartings, PhD, Cincinnati, OH 1:45 p.m.–1:50 p.m. I11.001 Data Blitz Using the Selective Inhibitor of Nuclear Export (SINE) Compound KPT-350 to Reduce Cortical Circuit Hyperexcitability and Interneuron Cell Loss in the Controlled Cortical Impact (CCI) Model of Traumatic Brain Injury (TBI) —David Cantu, Danielle Croker, Sharon Tamir, Sharon Shacham, Chris Dulla 1:50 p.m.–1:55 p.m. I11.002 Data Blitz Dynamics of Quantitative EEG Changes During Cerebral Hypoperfusion —Babak Razavi, Kimford Meador 1:55 p.m.–2:05 p.m. Audience Q&A 2:05 p.m.–2:40 p.m. Invited Speaker ICU Depth EEG vs surface EEG—What Does this Mean? Jan Claassen, MD, PhD, New York, NY 2:40 p.m.–2:45 p.m. I11.003 Data Blitz Ganaxolone Administered Intravenously Prevents Behavioral Seizures and Promotes Survival in the Rat Lithium-Pilocarpine Model of Status Epilepticus — Michael Saporito, Julia Tsai, Albena Patroneva, Steve White, Cameron Metcalf, Melissa L. Barker-Haliski 2:45 p.m.–2:50 p.m. I11.004 Data Blitz Frequency and Time-Course of Epileptiform Abnormalities in Subarachnoid Hemorrhage —Jennifer Kim, Sydney Cash, Eric Rosenthal, M. Westover 2:50 p.m.–3:00 p.m. Audience Q&A Guided Poster Rounds I11.001 Using the Selective Inhibitor of Nuclear Export (SINE) Compound KPT-350 to Reduce Cortical Circuit Hyperexcitability and Interneuron Cell Loss in the Controlled Cortical Impact (CCI) Model of Traumatic Brain Injury (TBI) —David Cantu, Danielle Croker, Sharon Tamir, Sharon Shacham, Chris Dulla I11.002 Dynamics of Quantitative EEG Changes During Cerebral Hypoperfusion —Babak Razavi, Kimford Meador I11.003 Ganaxolone Administered Intravenously Prevents Behavioral Seizures and Promotes Survival in the Rat Lithium-Pilocarpine Model of Status Epilepticus —Michael Saporito, Julia Tsai, Albena Patroneva, Steve White, Cameron Metcalf, Melissa L. Barker-Haliski I11.004 Frequency and Time-Course of Epileptiform Abnormalities in Subarachnoid Hemorrhage —Jennifer Kim, Sydney Cash, Eric Rosenthal, M. Westover 3:00 p.m.–3:30 p.m. I11.005 Sulfonylurea Receptor-1 As a Novel Biomarker for Cerebral Edema in Patients with Severe Traumatic Brain Injury —Ruchira Jha, Ava Puccio, Sherry Chou, Chung-Chou Chang, Jessica Wallisch, Bradley Molyneaux, Benjamin Zusman, Lori Shutter, Samuel Poloyac, Janesko-Feldman Keri, David Okonkwo, Patrick Kochanek I11.006 GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP: A Phase II Study Toward Preventing Edema After Ischemia —Kevin Sheth, Jordan Elm, Holly Hinson, Bradley Molyneaux, Lauren Beslow, Gordon Sze, Ann-Christin Ostwaldt, Gregory Del Zoppo, J Simard, Sven Jacobson, W. Kimberly I11.007 Extended Clinical Spectrum of Anti-NMDA Receptor Encephalitis in Children —Ajay Goenka, Hiroki Nariai, Mitchell Steinschneider, Alfred Spiro, Vimal Jain I11.008 Persistent EEG Patterns in Anti-NMDA Receptor Encephalitis: Implications for Pathophysiology — Michelle Ubels Van Noord, Evelyn Tecoma, Leena Kansal, Navaz Karanjia, Vicente Iragui- Madoz I11.009 Biomarkers of Vascular Integrity After Traumatic Brain Injury (TBI), and Correlation with Cerebrovascular Reactivity and Phosphodiesterase 5 Inhibition —Yunhua Gong, Christopher Campbell, Bao-Xi Qu, Erika Silverman, Carol Moore, Kimbra Kenney, Ramon Diaz-Arrastia Part II I11.010 GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP Trial: Intermediate Endpoint Analysis As Proof- Of-Concept —W. Taylor Kimberly, Jordan Elm, Holly Hinson, Bradley Molyneaux, Lauren Beslow, Gordon Sze, Ann-Christin Ostwaldt, Gregory Del Zoppo, Marc Simard, Kevin Sheth I11.011 ApoE E3 Allele and DRS Outcome in Patients with Severe Traumatic Brain Injury (TBI) —Lucido Ponce Mejia, Jovany Cruz Navarro, Goodman Jerry, Claudia Robertson I11.012 FTY720 Preserves Blood-Brain Barrier Integrity Following Subarachnoid Hemorrhage in Rats —Abdullah Muhammad, Jennifer Harris, Benjarat Changyaleket, Dale Pelligrino, Hao-liang Xu, Fernando Testai I11.013 WITHDRAWN 3:30 p.m.–5:30 p.m. 3:30 p.m.–4:05 p.m. Invited Speaker SUR-1 Channel and Malignant Brain Edema J. Marc Simard, MD, PhD, Baltimore, MD 4:05 p.m.–4:10 p.m. I11.005 Data Blitz Sulfonylurea Receptor-1 As a Novel Biomarker for Cerebral Edema in Patients with Severe Traumatic Brain Injury —Ruchira Jha, Ava Puccio, Sherry Chou, Chung- Chou Chang, Jessica Wallisch, Bradley Molyneaux, Benjamin Zusman, Lori Shutter, Samuel Poloyac, Janesko-Feldman Keri, David Okonkwo, Patrick Kochanek 4:10 p.m.–4:15 p.m. I11.006 Data Blitz GAMES (Glyburide Advantage in Malignant Edema and Stroke) RP: A Phase II Study Toward Preventing Edema After Ischemia —Kevin Sheth, Jordan Elm, Holly Hinson, Bradley Molyneaux, Lauren Beslow, Gordon Sze, Ann-Christin Ostwaldt, Gregory Del Zoppo, J. Simard, Sven Jacobson, W. Kimberly 4:15 p.m.–4:25 p.m. Audience Q&A 4:25 p.m.–5:00 p.m. Invited Speaker Autoimmune Encephalitis and Epilepsy Josep O. Dalmau, MD, PhD, Barcelona, Spain 5:00 p.m.–5:05 p.m. I11.007 Data Blitz Extended Clinical Spectrum of Anti-NMDA Receptor Encephalitis in Children — Ajay Goenka, Hiroki Nariai, Mitchell Steinschneider, Alfred Spiro, Vimal Jain 5:05 p.m.–5:10 p.m. I11.008 Data Blitz Persistent EEG Patterns in Anti-NMDA Receptor Encephalitis: Implications for Pathophysiology —Michelle Ubels Van Noord, Evelyn Tecoma, Leena Kansal, Navaz Karanjia, Vicente Iragui-Madoz 5:10 p.m.–5:20 p.m. Audience Q&A 5:20 p.m.–5:30 p.m. Conclusion 126 2016 AAN Annual Meeting Abstract Listing
Meeting Schedule 1:00 p.m.–5:30 p.m. I11 S Neurocritical Care and Neuroscience Crossroads: From Bench To Bedside I12 S Amyloid and Beyond: From Bench to Bedside . . . . . . . . . . . 128 C189 $ Neuromuscular Bedside Rounds Skills Workshop (registration required) Director: Michelle L. Mauermann, MD, Rochester, MN 3:00 p.m.–4:00 p.m. Health & Wellness Guts & Glory: The Importance of Diet & Exercise in Managing Persons with Multiple Sclerosis Director: Barbara S. Giesser, MD, FAAN, Los Angeles, CA 3:30 p.m.–4:30 p.m. I Mastering EMG Wave Form Recognition Skills in One Hour! Director: Devon I. Rubin, MD, FAAN, Jacksonville, FL $ A registration fee is required L The program is one of the AAN Leadership University sessions S The course is part of a Subspecialty in Focus track I The program is one of the I Talk sessions Learning Lab The program is part of the Excitement of Discovery Experiential Learning Area Health & Wellness sessions Real World of Neurology Invited Science: Multiple Sclerosis Wednesday, April 20, 3:30 p.m. to 5:30 p.m. Top abstracts previously presented at European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) will be presented by their authors in 20-minute platform sessions. Select abstracts from their “best of” lineups emphasize basic, clinical, and translational sciences as they evolve toward a more complete understanding of Multiple Sclerosis with the overall goal of developing more effective prevention and treatment. 3:30 p.m. to 3:50 p.m. Novel In Vivo Immunoglobulin G-driven Model of Multiple Sclerosis Kevin Blauth, PhD, Aurora, CO 3:50 p.m. to 4:10 p.m. PML Risk Stratification During Natalizumab Therapy Using Anti-JCV Antibody Index and L-selectin Nicholas Schwab, PhD, Münster, Germany 4:10 p.m. to 4:30 p.m. Efficacy and Safety of Ocrelizumab in Relapsing Multiple Sclerosis – Results of the Interferonbeta-1a-Controlled, Double-blind, Phase III OPERA I and II studies Stephen L. Hauser, MD, San Francisco, CA 4:30 p.m. to 4:50 p.m. Minocycline Reduces the Relative Risk of Multiple Sclerosis in People Experiencing Their First Demyelinating Event by 44.6%; Results of Phase III Double-blind Placebo-controlled Canadian Multicentre Trial Luanne Metz, MD, Calgary, AB, Canada 4:50 p.m. to 5:10 p.m. Dynamic Model for Predicting Prognosis in CIS Patients Mar Tintore, MD, Barcelona, Spain 5:10 p.m. to 5:30 p.m. Functional Consequences of Risk Genes Calliope A. Dendrou, PhD Wed· April 20
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