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Wednesday, April 20<br />
Poster Session 8:30 a.m.–7:00 p.m.<br />
P5.255 Impact of IDH-1 Mutation<br />
Status on Outcome in Clinical Trials for<br />
Recurrent Glioblastoma —Jacob Mandel,<br />
David Cachia, Diane D. Liu, Kenneth Aldape,<br />
Gregory Fuller, John De Groot<br />
P5.256 Molecular and Clinical<br />
Characterization of Gliosarcomas —<br />
Synphen Wu, Cameron Brennan, Ahmet Zahir,<br />
Michael Berger, David Solit, David Hyman,<br />
Jason Huse, Marc Rosenblum, Antonio<br />
Omuro<br />
P5.257 Clinical and Molecular<br />
Characterization of Glioneuronal<br />
Tumors —Julie Miller, Corey Gill, Tracy<br />
Batchelor, Priscilla Brastianos<br />
P5.258 Using ACT1, a Connexin 43<br />
Blocker, Against Glioblastoma Stem<br />
Cells —Pratik Kanabur, Zhi Sheng<br />
P5.259 Ionizing Radiation Induces<br />
Autophagy in Human Microglial Cells —<br />
Nizar Souayah, Hongxin Chen<br />
P5.260 Paraneoplastic Cerebellar<br />
Degeneration (PCD) Syndrome in<br />
Diffuse Large B-cell Lymphoma<br />
(DLBCL): Expanding the Spectrum of<br />
Malignancies Associated with Cerebellar<br />
Degeneration —Vasu Saini, Ariana Weisz,<br />
James Hoffman<br />
P5.261 Ionizing Radiation Induces<br />
Cellular Senescence in Human Microglial<br />
Cells —Hongxin Chen, Nizar Souayah<br />
General Neurology: Genetics<br />
P5.262 Chronic Gastrointestinal<br />
Dysmotility in Adult M.3243A>G-Related<br />
Mitochondrial Disease: An Under-<br />
Recognised and Under-Treated Clinical<br />
Entity —Yi Shiau Ng, Paula Hynd, Catherine<br />
Feeney, Andrew Schaefer, Carol Holmes,<br />
Charlotte Alston, John Grady, Mark Roberts,<br />
Robert Taylor, Yan Yiannakou, Robert<br />
McFarland, Doug Turnbull<br />
P5.263 Leukodystrophy and<br />
Neurogenic EMG Changes Associated<br />
with Variants in POLR3A and PMP22 —<br />
Anand Venkatraman, J. Austin Hamm, Alexis<br />
Shaefer, John Rinker, Kenkichi Nozaki<br />
P5.264 Susceptibility to MELAS<br />
Exacerbations in a POLG1 Mutation<br />
Carrier —Divya Nadkarni, Lucas Restrepo<br />
P5.265 Fhl1 W122S Mutant<br />
Female Mice Develop Late-Onset<br />
Cardiomyopathy —Akatsuki Kubota,<br />
Valentina Emmanuele, Shingo Kariya, Martí<br />
Juanola, Fusako Sera, Shunichi Homma,<br />
Kurenai Tanji, Catarina Quinzii Hirano, Michio<br />
Hirano<br />
P5.266 A Novel Mutation of SPAST<br />
Gene in Family Members Presenting with<br />
Spastic Paraparesis —Mohammed Elkider,<br />
Paul Crowley<br />
P5.267 Periventricular Heterotopia<br />
and Ehlers-Danlos Syndrome: An<br />
Underdiagnosed Association? —Manuel<br />
Seijo-Martinez, Susana Mederer Hengstl<br />
P5.268 CSF Markers of Inflammation<br />
and Neurodegeneration in Two Hereditary<br />
Diffuse Leukoencephalopathy with<br />
Spheroids (HDLS) Families with Diverging<br />
Genotype and Phenotype —Virginija<br />
Karrenbauer, Henrik Zetterberg, Christina<br />
Sundal, Oluf Andersen<br />
P5.269 Retinal Vasculopathy and<br />
Cerebral Leukodystrophy (RVCL) in a<br />
Spanish Family —Leticia Alvarez, Maria<br />
Rodriguez Rodriguez, Robustiano Reigosa,<br />
Manuel Seijo-Martinez, Jose Antonio Cortes<br />
Laino<br />
P5.270 Identification of the Protective<br />
Role of DJ-1 in Hypoglycemic Astrocyte<br />
Injury Using Proteomics —Deng Jiangshan,<br />
Zhao Yuwu<br />
P5.271 A Case of Tapia’s Syndrome:<br />
Iatrogenic Hypoglossal and Recurrent<br />
Laryngeal Nerve Palsy —Jared Noroozi, Brij<br />
Singh Ahluwalia<br />
MS and CNS Inflammatory Disease:<br />
Genetics and Therapeutics MOA<br />
P5.272 The Retinoid X Receptor (RXR)<br />
Selective Agonist IRX4204 Promotes<br />
Differentiation of Human Treg Cells and<br />
Inhibits Differentiation of Human TH17<br />
Cells —Daniel Mielcarz, Alan Bergeron,<br />
John DeLong, Ryan Andreozzi, Elizabeth<br />
Nowak, Rosh Chandraratna, Martin Sanders,<br />
Randolph Noelle, Jacqueline Channon<br />
P5.273 MerTK As a Functional<br />
Regulator of Anti-Inflammatory Myelin<br />
Phagocytosis by Human Myeloid Cells —<br />
Luke Healy, Gabrielle Perron, So-Yoon Won,<br />
Craig Moore, Amit Bar-Or, Jack Antel<br />
P5.274 The HLA-haplotype<br />
(DRB1*1501/DQB1*0602) is Not Primarily<br />
Responsible for Its Apparent Association<br />
with MS —Douglas Goodin, Pouya<br />
Khankhanian, Pierre-Antoine Gourraud,<br />
Antoine Lizee<br />
P5.275 Variants Within the Leptin<br />
Receptor Gene (LEPR) on Chromosome<br />
1p31 Are Associated with MS<br />
Susceptibility in a Model Adjusted for<br />
Known Disease Risk Factors —Anna<br />
Barcellos, Milena Gianfrancesco, Xiaorong<br />
Shao, Brooke Rhead, Ling Shen, Cathy<br />
Schaefer, Lisa Barcellos<br />
P5.276 Anti-KIR4.1 Antibodies Do Not<br />
Differentiate Multiple Sclerosis Patients<br />
from Controls —Anne-Katrin Proebstel, Jens<br />
Kuhle, Anne-Catherine Lecourt, Isabelle Vock,<br />
Nicholas Sanderson, Ludwig Kappos, Tobias<br />
Derfuss<br />
P5.277 Dynamics of Th17 Cells During<br />
and After Cessation of Natalizumab<br />
Therapy —Brigitte Wildemann, Alexander<br />
Schwarz, Mirjam Korporal-Kuhnke, Juergen<br />
Haas<br />
P5.278 HLA-DRB1*1501 Is Associated<br />
with Retinal Deterioration in Multiple<br />
Sclerosis —Dorlan Kimbrough, Kathryn<br />
Fitzgerald, Omar Al-Louzi, Julia Button,<br />
Marieme Dembele, Nikolaos Patsopoulos,<br />
Elias Sotirchos, Charles White, Shiv Saidha,<br />
Ellen Mowry, Philip De Jager, Peter Calabresi<br />
P5.279 IPhemap: An Atlas of<br />
Phenotype to Genotype Relationships<br />
of Human Induced Pluripotent Stem Cell<br />
Models of Neurological Diseases —Jaime<br />
Imitola, Ethan Hollingsworth, Michael Racke,<br />
Jacob Vaughn, Fumihiro Watanabe<br />
P5.280 Finding Novel Candidate<br />
Genes for Human Cortical Neurons and<br />
Corpus Callosum in Obscure Regions of<br />
the Genome —Jaime Imitola, Fumihiro<br />
Watanabe<br />
P5.281 Reversible Effects of<br />
Daclizumab HYP on Lymphocyte Counts<br />
in RRMS Patients: Data from the SELECT<br />
Trilogy Studies —Sami Fam, Oksana<br />
Mokliatchouk, Devangi Mehta, Katherine<br />
Riester, James Sheridan, Peter McCroskery,<br />
Jacob Elkins, Lakshmi Amaravadi<br />
P5.282 TERI-DYNAMIC: Exploring the<br />
Impact of Teriflunomide on Immune Cell<br />
Population Size, Receptor Repertoire,<br />
and Function in Patients With RRMS —<br />
Heinz Wiendl, Catharina Gross, Maren<br />
Lindner, Melanie Eschborn, Linda Weisser,<br />
Anita Posevitz-Fejfar, Andreas Schulte-<br />
Mecklenbeck, Bart Van Wijmeersch,<br />
Raymond Hupperts, Sandrine Brette, Timothy<br />
Turner, Amit Bar-Or, Luisa Klotz<br />
P5.283 Tecfidera Modulates<br />
Transcriptional Expression of Genes<br />
Involved in Regulation of the Immune<br />
Response and Antigen Processing —<br />
Gafson Arie, James Porter, Yi-Fang Wang,<br />
Sanjay Khadayate, Richard Nicholas, Paul<br />
Matthews<br />
P5.284 A Proteomics Approach for<br />
the Identification of Cerebrospinal Fluid<br />
Proteins Associated with Conversion to<br />
Multiple Sclerosis —Murat Kurtuncu, Recai<br />
Turkoglu, Erdem Tuzun, Cem Kucukali<br />
P5.285 Exosomal MiRNA As<br />
Biomarkers for Disease Activity in RR<br />
MS —Igor Selmaj, Krzysztof Selmaj,<br />
Magdalena Namiecinska, Maria Cichalewska,<br />
Marcin Mycko<br />
P5.286 IFN-b-1a Therapy Induces the<br />
Expansion of TGF-β1-Producing B-Cells<br />
and FOXP3+ T-Regulatory Cells in Patients<br />
with Relapsing-Remitting Multiple<br />
Sclerosis (RRMS)—Silva Markovic Plese,<br />
Yazhong Tao, Xin Zhang, Ming-Jeong Kim,<br />
Danny Bruce, Haibo Yang, Kaitlyn Townsend,<br />
Sarah Pruteanu-Malinici, Kinnari Buch, Julia<br />
Dunn, Beliz Kurtoglu, Dehan Kong, Jessica<br />
Craddock, Manisha Chopra, Hongtu Zhu,<br />
Valerie Jewells<br />
P5.287 The Melanocortin Receptor<br />
ACTH1-39 May Protect Oligodendroglia by<br />
Inhibiting Protein Kinase C —Robert Lisak,<br />
Liljana Nedelkoska, Joyce Benjamins<br />
P5.288 Haematologic Modifications<br />
As Markers of Response to Treatment in<br />
Multiple Sclerosis Patients Treated with<br />
Natalizumab —Nuala McNicholas, Hugh<br />
Kearney, Anita Krakar, Sinead Jordan, Deepti<br />
Sharma, Stephen Cox, Gillian O'Boyle, Niall<br />
Tubridy, Michael Hutchinson, Christopher<br />
McGuigan<br />
P5.289 Cell Type-Specific Gene<br />
Expression Changes in the Blood of<br />
Multiple Sclerosis Patients in the Early<br />
Phase of Interferon-beta Treatment —<br />
Michael Hecker, Brit Fitzner, Dirk Koczan, Ina<br />
Schroeder, Hans-Juergen Thiesen, Uwe Zettl<br />
P5.290 Genomic Analysis of Co-<br />
Regulated Genes Associated with Neural<br />
Stem Cells Identifies Pathways for<br />
Self-Renewal Capacity and Oncogenic<br />
Potential in Neurospheres —Maria Prieto<br />
Eibl, Josh Orack, Fumihiro Watanabe, Mark<br />
Zucker, Jaime Imitola<br />
P5.291 Additional Mode of Action?<br />
Fingolimod Inhibits the IL-33 Induced<br />
IFN-γ Formation in CD8 + and Affects the<br />
Formation of Bioactive Sphingolipids in<br />
Patients with Multiple Sclerosis —Florian<br />
Ottenlinger, Christoph Mayer, Christine<br />
Schuhmann, Nerea Ferreiros Bouzas, Anja<br />
Schwiebs, Joseph Pfeilschifter, Heinfried<br />
Radecke<br />
P5.292 Longitudinal Analysis<br />
of Natalizumab Treated Multiple<br />
Sclerosis (MS) Patients Using PK11195-<br />
PET Demonstrates Reduced CNS<br />
Inflammation —Ulrike Kaunzner, Yeona<br />
Kang, Elizabeth Monahan, Paresh Kothari,<br />
Nancy Nealon, Jai Perumal, Claire Riley,<br />
Stephen Newman, Timothy Vartanian,<br />
Shankar Vallabhajosula, Susan Gauthier<br />
P5.293 Clinical and Biochemical<br />
Pictures of Anti-Neutral Glycolipids<br />
Antibody-Positive Central and Peripheral<br />
Nervous System-Involving Disorders —<br />
Tatsuro Mutoh, Sayuri Shima, Akihiro Ueda,<br />
Kunihiko Asakura<br />
P5.294 Lymphocyte Dynamics<br />
During and After Fingolimod Therapy:<br />
Long-Term Data from the INFORMS<br />
Trial —Fred Lublin, Mark Freedman, Bruce<br />
Cree, Jerry Wolinsky, Howard Weiner,<br />
Catherine Lubetzki, Hans-Peter Hartung,<br />
Xavier Montalban, Bernard Uitdehaag, Martin<br />
Merschhemke, Bingbing Li, Norman Putzki,<br />
Dieter Haering, Ludwig Kappos<br />
P5.295 Neuronal Uptake of<br />
Paraneoplastic IgG Autoantibodies<br />
Reactive with Intracellular Antigens<br />
Requires the Fc Portion of the IgG<br />
Molecule and Can Be Competitively<br />
Inhibited by Normal IgG —John Greenlee,<br />
Susan Clawson, Blair Wood, Kenneth Hill,<br />
Stacey Clardy, Noel Carlson<br />
P5.296 Preferential Entrapment of<br />
Naive T Cells Associates with a Less<br />
Diverse T Cell Receptor Repertoire in<br />
MS Patients Treated with Fingolimod —<br />
Clemens Warnke, Anne Mausberg, Thomas<br />
Dehmel, Kathleen Ingenhoven, Mark Stettner,<br />
Leslie Fitz-Gerald, Amit Bar-Or, Jack Antel,<br />
Manuel Comabella Lopez, Xavier Montalban,<br />
Hans Hartung, Bernd Kieseier<br />
P5.297 Metabolomic Networks<br />
Associated with Changes in Cytokine<br />
Expression Differ in Multiple Sclerosis<br />
Patients and Healthy Controls Following<br />
Vitamin D Supplementation —Kathryn<br />
Fitzgerald, Pavan Bhargava, Sonya Steele,<br />
Sandra Cassard, Emmanuelle Waubant, Peter<br />
Calabresi, Ellen Mowry<br />
P5.298 LINGO-1 Negatively Regulates<br />
Oligodendrocyte Differentiation by<br />
Blocking the β-integrin Signaling<br />
Pathway —Sha Mi, Guanrong Huang, Xinhua<br />
Lee, Zhaohui Shao<br />
118 2016 AAN Annual Meeting Abstract Listing
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