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Wednesday, April 20<br />
Poster Session 8:30 a.m.–7:00 p.m.<br />
P5.161 Epilepsy Treatment Patterns<br />
Among Patients with Tuberous Sclerosis<br />
Complex —Steven Sparagana, Elyse<br />
Swallow, Jinlin Song, Sarah King, Miranda<br />
Peeples, James Signorovitch, Zhimei Liu,<br />
Judith Prestifilippo, Michael Kohrman, Bruce<br />
Korf, Darcy Krueger, Michael Wong<br />
P5.162 A Rare Case of Progressively<br />
Expanding Total Hemimegalencephaly —<br />
Jayson Rodriguez, Arun Asha Kalra, Eduardo<br />
Gonzalez-Toledo<br />
Aging and Dementia: Neurogenetics<br />
P5.163 The Frequency of Damaging<br />
Genetic Variants in a Cohort of Over<br />
1500 Patients with Early Onset Familial<br />
Alzheimer’s Disease —Alison Bright,<br />
Izabela Karbassi, Marc Meservey, Jennifer<br />
Yokoyama, Natasha Rabinowitz, Angela<br />
Bean, Khalida Liaquat, Matthew Gallen, Carol<br />
Hoffman, Meagan Krasner, Whitney Dodge,<br />
Joseph Higgins<br />
P5.164 A Rare Coding Variant in<br />
TREM2 increases Risk for Alzheimer’s<br />
Disease in Han Chinese —Teng Jiang, Jin-<br />
Tai Yu, Ying-Dong Zhang, Lan Tan<br />
P5.165 The Questionable Role of GWA<br />
in Identification of Genetic Risk Factors<br />
for Alzheimer’s Disease —Rosanna<br />
Tortelli, Francesco Panza, Maria Rosaria<br />
Barulli, Antonio Daniele, Antonio Greco,<br />
Patrizia Mecocci, Carlo Masullo, Giancarlo<br />
Logroscino, Davide Seripa<br />
P5.166 Role of INPP5D, PTK2B,<br />
ZCWPW1 and TREM 2 in Predicting Risk<br />
of Progression in Cognitively Impaired<br />
Subjects to Alzheimer's Disease —Connor<br />
Hawkins, Alice Fok, Howard Feldman, Dessa<br />
Sadovnick, Ging-Yuek Hsiung<br />
P5.167 Poor Cognitive Outcomes<br />
Are Associated with UNC5C Intronic<br />
Polymorphisms Independent of<br />
Pathologies —Hyun-Sik Yang, Charles<br />
White, Lori Chibnik, Julie Schneider, David<br />
Bennett, Philip De Jager<br />
P5.168 Epigenetic Evidence That<br />
C9orf72 Promoter Hypermethylation Is<br />
Protective: A Blinded Replication —Corey<br />
McMillan, Emma Devenney, Elaine Liu, Olivier<br />
Piguet, Lauren Bartley, John Hodges, Glenda<br />
Halliday, Edward Lee<br />
P5.169 Association of Genetic<br />
Variation and Neuropsychiatric Symptoms<br />
in 4-Repeat Tauopathies —Kylie Ternes,<br />
Katya Rascovsky, Elisabeth Wood, Murray<br />
Grossman, Vivianna Van Deerlin, Corey<br />
McMillan<br />
P5.170 Literature Review of Genetic<br />
Disorders with Tau Pathology —Pawel<br />
Tacik, Zbigniew Wszolek, Monica Sanchez-<br />
Contreras, Rosa Rademakers, Dennis Dickson<br />
P5.171 A Novel POLR1C Mutation<br />
Causing Autosomal Recessive Adult-<br />
Onset Leukodystrophy —Michael<br />
Geschwind, Mee-Ohk Kim, Colleen Wahl,<br />
William Gahl, Camilo Toro<br />
Aging and Dementia: Biomarkers<br />
P5.172 CSF and Plasma Aβ40 and<br />
Aβ42 Levels in Down Syndrome (DS)<br />
Persons with Alzheimer Disease (AD) [DS/<br />
AD+] and Those Without [DS/AD-] —<br />
Pankaj Mehta, Juan Fortea, Maria Carmona<br />
Iragui, Mony De Leon, Warren Zigman<br />
P5.173 Plasma Aβ Levels Are<br />
Correlated with Cognitive and Motor<br />
Functions in Iwaki Health Promotion<br />
Project —Takumi Nakamura, Mikio Shoji<br />
P5.174 The Role of Age on Beta-<br />
Amyloid1-42 Plasma Levels in Healthy<br />
Subjects —Chiara Zecca, Simona Arcuti,<br />
Francesco Panza, Rosanna Tortelli, Vincenzo<br />
Brescia, Giancarlo Logroscino<br />
P5.175 Role of Hemostatic and<br />
Inflammatory Biomarkers in Alzheimer’s<br />
and Vascular Dementia —Venugopalan<br />
Vishnu, Manish Modi, Vivek Garg, Manju<br />
Mohanty, Manoj Goyal, Vivek Lal, Bhagwant<br />
Mittal, Sudesh Prabhakar<br />
P5.176 Sleep EEG Changes in<br />
Preclinical Alzheimer Disease: A Pilot<br />
Study —Sonja Schütz, Andrew Varga, Korey<br />
Kam, Emma Ducca, Margaret Wohlleber,<br />
Clifton Lewis, Girardin Jean-Louis, Indu<br />
Ayappa, David Rapoport, Ricardo Osorio,<br />
Helen Scharfman<br />
P5.177 Optical Coherence Tomography<br />
As Potential Biomarker in Parkinson’s<br />
Disease and Alzheimer’s Disease —<br />
Annabel Boeke, Darin Rosen, James<br />
Mastrianni, Tao Xie, Jacqueline Bernard<br />
P5.178 Myelin Basic Protein Is<br />
Associated with White Matter Integrity<br />
in 4-Repeat Tauopathies —Kim Firn, David<br />
Irwin, Murray Grossman, Corey McMillan<br />
P5.179 Antibody-Free Detection<br />
and Quantitation of TDP-43 by Mass<br />
Spectrometry —Yu Zi (Emma) Zheng, Mari<br />
DeMarco<br />
P5.180 Higher Levels of Hs-CRP<br />
Related to Corpus Callosum Volume in<br />
the Elderly —Matthew Wynn, Shubir Dutt,<br />
Rowan Saloner, Joel Kramer<br />
Aging and Dementia: Atypical<br />
Dementia<br />
P5.181 Biomarker Confirmed<br />
Alzheimer’s Disease Presenting As<br />
Amnestic, Aphasic, and Visual Variants:<br />
Hippocampal Volume Comparison —Alissa<br />
Butts, Mary Machulda, Joseph Duffy, Edythe<br />
Strand, Daniel Drubach, Scott Przybelski,<br />
Ronald Petersen, Clifford Jack, Val Lowe,<br />
Keith Josephs, Jennifer Whitwell<br />
P5.182 Development of a Diagnostic<br />
Decision Tree for Rapidly Progressive<br />
Dementia —Jeffrey Gelfand, Carolyn<br />
Fredericks, Natasha Rabinowitz, Katherine<br />
Rankin, Christopher Hess, Matteo Paoletti,<br />
Joseph Higgins, Gary Williams, Bruce Miller,<br />
Howard Rosen, Michael Geschwind<br />
P5.183 Rapidly Progressive<br />
Alzheimer’s Disease in Two Distinct<br />
Autopsy Cohorts —Jagan Pillai, Brian<br />
Appleby, Jiri Safar, James Leverenz<br />
P5.184 Differentiating Individuals with<br />
Cognitive Complaints Due to Corticobasal<br />
Degeneration and Alzheimer Disease<br />
by Clinical Features —Gregory Day, Tae<br />
Sung Lim, Jason Hassenstab, Alison Goate,<br />
Elizabeth Grant, Catherine Roe, Nigel Cairns,<br />
John Morris<br />
P5.185 A Case of Familial Prion<br />
Disease Caused by a Six-Octapeptide<br />
Repeat Insertion Mutation —Christopher<br />
Doughty, Jennifer Lyons<br />
P5.186 Clinical Utility of Amyloid<br />
Imaging in Differential Diagnosis of<br />
Atypical/Unclear Dementias and Its<br />
Impact on Caregivers —Robert Laforce,<br />
Mohamed Reda Bensaïdane, Remi Bouchard,<br />
Marie-Pierre Fortin, Michele Houde, Pedro<br />
Rosa Neto, Stephane Poulin, Louis Verret,<br />
Jean-Paul Soucy, Jean-Mathieu Beauregard<br />
P5.187 Definite Fatal Familial Insomnia<br />
(FFI) Disease with Voltage-Gated<br />
Potassium Channel (VGKC)-Complex<br />
Autoimmunity: A Rare Case of Molecular<br />
Mimicry or Incidental Finding? —Sirisha<br />
Sanamandra, Teddy Youn, Carolina Maciel,<br />
Matthew Schrag, Duarte Machado, Emily<br />
Gilmore<br />
P5.188 Amyloid Beta-Related<br />
Angiitis (ABRA) with Rapidly Progressive<br />
Dementia and Myoclonia, Thus Mimicking<br />
CJD —Wolfgang Heide, Viviane Heide,<br />
Michael Trauscheid, Oliver Pape, Walter<br />
Schulz-Schaeffer<br />
P5.189 Functional and Structural Brain<br />
Alterations in Patients with Posterior<br />
Cortical Atrophy —Francesca Imperiale,<br />
Federica Agosta, Elisa Canu, Gorana Mandic-<br />
Stojmenovic, Tanya Stojkovic, Elka Stefanova,<br />
Vladimir Kostic, Massimo Filippi<br />
P5.190 Hickam’s Dictum: Creutzfeldt<br />
Jakob Disease in a Patient with<br />
Concurrent Stage IV Esophageal<br />
Carcinoma —Michael Lane, Sanjay<br />
Anandaram, Andrew Cichowski, Barbara Nye<br />
Aging and Dementia:<br />
Neuropsychology/Neuropsychiatry<br />
P5.191 Dissociations in<br />
Socioemotional Test Performance<br />
Predict Neurodegeneration in Intrinsic<br />
Connectivity Networks —Natanya Russek,<br />
Babu Adhimoolam, Suzanne Shdo, Peter<br />
Fonseca, Heaven Mesfun, Laura Bouvet,<br />
Clinton Mielke, Tal Shany-Ur, Bruce Miller,<br />
Katherine Rankin<br />
P5.192 Cognitive Symptoms<br />
Questionnaire. A Novel Reliable and Quick<br />
Survey in Spanish for the Assessment of<br />
Cognitive Impairment —Marcos Fernandez<br />
Suarez, Griselda Russo, Yanina Sasson, Lucila<br />
Heredia, Ramon Leiguarda, Ricardo Allegri<br />
P5.193 Dissociable Substrates<br />
Underlie the Production of Abstract and<br />
Concrete Nouns —Katheryn Cousins,<br />
Sharon Ash, Murray Grossman<br />
P5.194 Evidence of Social Norm<br />
Deficits in Progressive Supranuclear<br />
Palsy —Amy Halpin, Katya Rascovsky,<br />
Lauren Massimo, David Irwin, Corey<br />
McMillan, Murray Grossman<br />
P5.195 Neuropsychiatric Symptoms in<br />
Early Autosomal Dominant and Late Onset<br />
Alzheimer’s Disease —Nicholas Olney,<br />
Edmond Teng, Yan Zhou, Liana Apostolova,<br />
Sarah Kremen, Ellen Woo, John Ringman<br />
P5.196 Indifference to Sweaty Feet:<br />
Reward Deficits in Behavioral Variant<br />
Frontotemporal Dementia Include<br />
Insensitivity to Negative Stimuli —Samir<br />
Datta, Virginia Sturm, Kristie Wood, Jessica<br />
Zakrzewski, Bruce Miller, Joel Kramer,<br />
Howard Rosen, David Perry<br />
P5.197 The TabCAT Brain Health<br />
Assessment: A Highly Efficient and<br />
Sensitive Approach to Detecting Very<br />
Mild Cognitive Impairment —Tacie<br />
Moskowitz, Natasha Rabinowitz, Erica<br />
Johnson, Edward Huey, Daniel Kaufer, Gary<br />
Small, Robert Stern, Bruce Miller, Katherine<br />
Rankin, Katherine Possin<br />
P5.198 It’s Not Just How Much: The<br />
Effects of Night-to-Night Variability in<br />
Sleep Patterns on Working Memory —<br />
Christine Walsh, Nihar Patel, Kathleen<br />
Walker, Leslie Ruoff, Jonathan Varbel,<br />
Matthew Wynn, Bruce Miller, Thomas<br />
Neylan, Joel Kramer<br />
P5.199 Now You See It; Now You<br />
Don’t: One of the Best Established<br />
Age-related Changes in Neural Activity<br />
Vanishes After Controlling for Visual<br />
Acuity —Fabio Porto, Erich Tusch, Anne Fox,<br />
Brittany Alperin, Phillip Holcomb, Kirk Daffner<br />
P5.200 Neuropsychological Profile<br />
in Carriers of E46K Mutation of the<br />
Alpha-Synuclein Gene —Olaia Lucas-<br />
Jiménez, Rocío Del Pino, Marian Acera, Iñigo<br />
Gabilondo, Juan Carlos Gómez-Esteban,<br />
Beatriz Tijero, María Díez-Cirarda, Javier<br />
Peña, Naroa Ibarretxe-Bilbao, Natalia Ojeda<br />
Aging and Dementia: Disease Models<br />
and Mechanisms<br />
P5.201 Zinc, Copper and Manganese<br />
Porphyrins Restore Mitochondrial<br />
Function and Improve Cognition Without<br />
Reducing Aβ Levels in Alzheimer's Mice<br />
and Cells —Natasa Dragicevic, Kimberly<br />
Fields, Chuanhai Cao, Patrick Bradshaw<br />
P5.202 When Pigs Fly: Dynamic<br />
Susceptibility Contrast MRI for Cerebral<br />
White Matter Injury in a Hypobaric Swine<br />
Model —Philippine Dana Peralta, John<br />
Sladky, Stephen McGuire<br />
P5.203 Role of an Endogenous<br />
Retrovirus in ALS Pathophysiology and<br />
Effect of Anti-Retrovirals In Vitro —<br />
Avindra Nath, Myoung-Hwa Lee, Lisa<br />
Henderson, Muznabanu Bachani, Joseph<br />
Steiner, Gloria von Geldern, Katherine Pak,<br />
Andrew Mammen, Lyle Ostrow, Jeffrey<br />
Rothstein, Wenxue Li<br />
P5.204 Combination Therapy<br />
with Doxycycline, Chlorpromazine<br />
or Quinacrine Inhibits Prion Protein<br />
Replication in a N2A Model —Adam Witt,<br />
Jody Campeau, Valerie Sim<br />
P5.205 Neuroprotective Effects<br />
of Ezetimibe Versus Simvastatin<br />
in Alzheimer’s Induced Dementia:<br />
Perspectives from Female Rats. —<br />
Mahmoud KhalafAllah, Mohamed Zalabia,<br />
116 2016 AAN Annual Meeting Abstract Listing