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Wednesday, April 20<br />

Poster Session 8:30 a.m.–7:00 p.m.<br />

P5.161 Epilepsy Treatment Patterns<br />

Among Patients with Tuberous Sclerosis<br />

Complex —Steven Sparagana, Elyse<br />

Swallow, Jinlin Song, Sarah King, Miranda<br />

Peeples, James Signorovitch, Zhimei Liu,<br />

Judith Prestifilippo, Michael Kohrman, Bruce<br />

Korf, Darcy Krueger, Michael Wong<br />

P5.162 A Rare Case of Progressively<br />

Expanding Total Hemimegalencephaly —<br />

Jayson Rodriguez, Arun Asha Kalra, Eduardo<br />

Gonzalez-Toledo<br />

Aging and Dementia: Neurogenetics<br />

P5.163 The Frequency of Damaging<br />

Genetic Variants in a Cohort of Over<br />

1500 Patients with Early Onset Familial<br />

Alzheimer’s Disease —Alison Bright,<br />

Izabela Karbassi, Marc Meservey, Jennifer<br />

Yokoyama, Natasha Rabinowitz, Angela<br />

Bean, Khalida Liaquat, Matthew Gallen, Carol<br />

Hoffman, Meagan Krasner, Whitney Dodge,<br />

Joseph Higgins<br />

P5.164 A Rare Coding Variant in<br />

TREM2 increases Risk for Alzheimer’s<br />

Disease in Han Chinese —Teng Jiang, Jin-<br />

Tai Yu, Ying-Dong Zhang, Lan Tan<br />

P5.165 The Questionable Role of GWA<br />

in Identification of Genetic Risk Factors<br />

for Alzheimer’s Disease —Rosanna<br />

Tortelli, Francesco Panza, Maria Rosaria<br />

Barulli, Antonio Daniele, Antonio Greco,<br />

Patrizia Mecocci, Carlo Masullo, Giancarlo<br />

Logroscino, Davide Seripa<br />

P5.166 Role of INPP5D, PTK2B,<br />

ZCWPW1 and TREM 2 in Predicting Risk<br />

of Progression in Cognitively Impaired<br />

Subjects to Alzheimer's Disease —Connor<br />

Hawkins, Alice Fok, Howard Feldman, Dessa<br />

Sadovnick, Ging-Yuek Hsiung<br />

P5.167 Poor Cognitive Outcomes<br />

Are Associated with UNC5C Intronic<br />

Polymorphisms Independent of<br />

Pathologies —Hyun-Sik Yang, Charles<br />

White, Lori Chibnik, Julie Schneider, David<br />

Bennett, Philip De Jager<br />

P5.168 Epigenetic Evidence That<br />

C9orf72 Promoter Hypermethylation Is<br />

Protective: A Blinded Replication —Corey<br />

McMillan, Emma Devenney, Elaine Liu, Olivier<br />

Piguet, Lauren Bartley, John Hodges, Glenda<br />

Halliday, Edward Lee<br />

P5.169 Association of Genetic<br />

Variation and Neuropsychiatric Symptoms<br />

in 4-Repeat Tauopathies —Kylie Ternes,<br />

Katya Rascovsky, Elisabeth Wood, Murray<br />

Grossman, Vivianna Van Deerlin, Corey<br />

McMillan<br />

P5.170 Literature Review of Genetic<br />

Disorders with Tau Pathology —Pawel<br />

Tacik, Zbigniew Wszolek, Monica Sanchez-<br />

Contreras, Rosa Rademakers, Dennis Dickson<br />

P5.171 A Novel POLR1C Mutation<br />

Causing Autosomal Recessive Adult-<br />

Onset Leukodystrophy —Michael<br />

Geschwind, Mee-Ohk Kim, Colleen Wahl,<br />

William Gahl, Camilo Toro<br />

Aging and Dementia: Biomarkers<br />

P5.172 CSF and Plasma Aβ40 and<br />

Aβ42 Levels in Down Syndrome (DS)<br />

Persons with Alzheimer Disease (AD) [DS/<br />

AD+] and Those Without [DS/AD-] —<br />

Pankaj Mehta, Juan Fortea, Maria Carmona<br />

Iragui, Mony De Leon, Warren Zigman<br />

P5.173 Plasma Aβ Levels Are<br />

Correlated with Cognitive and Motor<br />

Functions in Iwaki Health Promotion<br />

Project —Takumi Nakamura, Mikio Shoji<br />

P5.174 The Role of Age on Beta-<br />

Amyloid1-42 Plasma Levels in Healthy<br />

Subjects —Chiara Zecca, Simona Arcuti,<br />

Francesco Panza, Rosanna Tortelli, Vincenzo<br />

Brescia, Giancarlo Logroscino<br />

P5.175 Role of Hemostatic and<br />

Inflammatory Biomarkers in Alzheimer’s<br />

and Vascular Dementia —Venugopalan<br />

Vishnu, Manish Modi, Vivek Garg, Manju<br />

Mohanty, Manoj Goyal, Vivek Lal, Bhagwant<br />

Mittal, Sudesh Prabhakar<br />

P5.176 Sleep EEG Changes in<br />

Preclinical Alzheimer Disease: A Pilot<br />

Study —Sonja Schütz, Andrew Varga, Korey<br />

Kam, Emma Ducca, Margaret Wohlleber,<br />

Clifton Lewis, Girardin Jean-Louis, Indu<br />

Ayappa, David Rapoport, Ricardo Osorio,<br />

Helen Scharfman<br />

P5.177 Optical Coherence Tomography<br />

As Potential Biomarker in Parkinson’s<br />

Disease and Alzheimer’s Disease —<br />

Annabel Boeke, Darin Rosen, James<br />

Mastrianni, Tao Xie, Jacqueline Bernard<br />

P5.178 Myelin Basic Protein Is<br />

Associated with White Matter Integrity<br />

in 4-Repeat Tauopathies —Kim Firn, David<br />

Irwin, Murray Grossman, Corey McMillan<br />

P5.179 Antibody-Free Detection<br />

and Quantitation of TDP-43 by Mass<br />

Spectrometry —Yu Zi (Emma) Zheng, Mari<br />

DeMarco<br />

P5.180 Higher Levels of Hs-CRP<br />

Related to Corpus Callosum Volume in<br />

the Elderly —Matthew Wynn, Shubir Dutt,<br />

Rowan Saloner, Joel Kramer<br />

Aging and Dementia: Atypical<br />

Dementia<br />

P5.181 Biomarker Confirmed<br />

Alzheimer’s Disease Presenting As<br />

Amnestic, Aphasic, and Visual Variants:<br />

Hippocampal Volume Comparison —Alissa<br />

Butts, Mary Machulda, Joseph Duffy, Edythe<br />

Strand, Daniel Drubach, Scott Przybelski,<br />

Ronald Petersen, Clifford Jack, Val Lowe,<br />

Keith Josephs, Jennifer Whitwell<br />

P5.182 Development of a Diagnostic<br />

Decision Tree for Rapidly Progressive<br />

Dementia —Jeffrey Gelfand, Carolyn<br />

Fredericks, Natasha Rabinowitz, Katherine<br />

Rankin, Christopher Hess, Matteo Paoletti,<br />

Joseph Higgins, Gary Williams, Bruce Miller,<br />

Howard Rosen, Michael Geschwind<br />

P5.183 Rapidly Progressive<br />

Alzheimer’s Disease in Two Distinct<br />

Autopsy Cohorts —Jagan Pillai, Brian<br />

Appleby, Jiri Safar, James Leverenz<br />

P5.184 Differentiating Individuals with<br />

Cognitive Complaints Due to Corticobasal<br />

Degeneration and Alzheimer Disease<br />

by Clinical Features —Gregory Day, Tae<br />

Sung Lim, Jason Hassenstab, Alison Goate,<br />

Elizabeth Grant, Catherine Roe, Nigel Cairns,<br />

John Morris<br />

P5.185 A Case of Familial Prion<br />

Disease Caused by a Six-Octapeptide<br />

Repeat Insertion Mutation —Christopher<br />

Doughty, Jennifer Lyons<br />

P5.186 Clinical Utility of Amyloid<br />

Imaging in Differential Diagnosis of<br />

Atypical/Unclear Dementias and Its<br />

Impact on Caregivers —Robert Laforce,<br />

Mohamed Reda Bensaïdane, Remi Bouchard,<br />

Marie-Pierre Fortin, Michele Houde, Pedro<br />

Rosa Neto, Stephane Poulin, Louis Verret,<br />

Jean-Paul Soucy, Jean-Mathieu Beauregard<br />

P5.187 Definite Fatal Familial Insomnia<br />

(FFI) Disease with Voltage-Gated<br />

Potassium Channel (VGKC)-Complex<br />

Autoimmunity: A Rare Case of Molecular<br />

Mimicry or Incidental Finding? —Sirisha<br />

Sanamandra, Teddy Youn, Carolina Maciel,<br />

Matthew Schrag, Duarte Machado, Emily<br />

Gilmore<br />

P5.188 Amyloid Beta-Related<br />

Angiitis (ABRA) with Rapidly Progressive<br />

Dementia and Myoclonia, Thus Mimicking<br />

CJD —Wolfgang Heide, Viviane Heide,<br />

Michael Trauscheid, Oliver Pape, Walter<br />

Schulz-Schaeffer<br />

P5.189 Functional and Structural Brain<br />

Alterations in Patients with Posterior<br />

Cortical Atrophy —Francesca Imperiale,<br />

Federica Agosta, Elisa Canu, Gorana Mandic-<br />

Stojmenovic, Tanya Stojkovic, Elka Stefanova,<br />

Vladimir Kostic, Massimo Filippi<br />

P5.190 Hickam’s Dictum: Creutzfeldt<br />

Jakob Disease in a Patient with<br />

Concurrent Stage IV Esophageal<br />

Carcinoma —Michael Lane, Sanjay<br />

Anandaram, Andrew Cichowski, Barbara Nye<br />

Aging and Dementia:<br />

Neuropsychology/Neuropsychiatry<br />

P5.191 Dissociations in<br />

Socioemotional Test Performance<br />

Predict Neurodegeneration in Intrinsic<br />

Connectivity Networks —Natanya Russek,<br />

Babu Adhimoolam, Suzanne Shdo, Peter<br />

Fonseca, Heaven Mesfun, Laura Bouvet,<br />

Clinton Mielke, Tal Shany-Ur, Bruce Miller,<br />

Katherine Rankin<br />

P5.192 Cognitive Symptoms<br />

Questionnaire. A Novel Reliable and Quick<br />

Survey in Spanish for the Assessment of<br />

Cognitive Impairment —Marcos Fernandez<br />

Suarez, Griselda Russo, Yanina Sasson, Lucila<br />

Heredia, Ramon Leiguarda, Ricardo Allegri<br />

P5.193 Dissociable Substrates<br />

Underlie the Production of Abstract and<br />

Concrete Nouns —Katheryn Cousins,<br />

Sharon Ash, Murray Grossman<br />

P5.194 Evidence of Social Norm<br />

Deficits in Progressive Supranuclear<br />

Palsy —Amy Halpin, Katya Rascovsky,<br />

Lauren Massimo, David Irwin, Corey<br />

McMillan, Murray Grossman<br />

P5.195 Neuropsychiatric Symptoms in<br />

Early Autosomal Dominant and Late Onset<br />

Alzheimer’s Disease —Nicholas Olney,<br />

Edmond Teng, Yan Zhou, Liana Apostolova,<br />

Sarah Kremen, Ellen Woo, John Ringman<br />

P5.196 Indifference to Sweaty Feet:<br />

Reward Deficits in Behavioral Variant<br />

Frontotemporal Dementia Include<br />

Insensitivity to Negative Stimuli —Samir<br />

Datta, Virginia Sturm, Kristie Wood, Jessica<br />

Zakrzewski, Bruce Miller, Joel Kramer,<br />

Howard Rosen, David Perry<br />

P5.197 The TabCAT Brain Health<br />

Assessment: A Highly Efficient and<br />

Sensitive Approach to Detecting Very<br />

Mild Cognitive Impairment —Tacie<br />

Moskowitz, Natasha Rabinowitz, Erica<br />

Johnson, Edward Huey, Daniel Kaufer, Gary<br />

Small, Robert Stern, Bruce Miller, Katherine<br />

Rankin, Katherine Possin<br />

P5.198 It’s Not Just How Much: The<br />

Effects of Night-to-Night Variability in<br />

Sleep Patterns on Working Memory —<br />

Christine Walsh, Nihar Patel, Kathleen<br />

Walker, Leslie Ruoff, Jonathan Varbel,<br />

Matthew Wynn, Bruce Miller, Thomas<br />

Neylan, Joel Kramer<br />

P5.199 Now You See It; Now You<br />

Don’t: One of the Best Established<br />

Age-related Changes in Neural Activity<br />

Vanishes After Controlling for Visual<br />

Acuity —Fabio Porto, Erich Tusch, Anne Fox,<br />

Brittany Alperin, Phillip Holcomb, Kirk Daffner<br />

P5.200 Neuropsychological Profile<br />

in Carriers of E46K Mutation of the<br />

Alpha-Synuclein Gene —Olaia Lucas-<br />

Jiménez, Rocío Del Pino, Marian Acera, Iñigo<br />

Gabilondo, Juan Carlos Gómez-Esteban,<br />

Beatriz Tijero, María Díez-Cirarda, Javier<br />

Peña, Naroa Ibarretxe-Bilbao, Natalia Ojeda<br />

Aging and Dementia: Disease Models<br />

and Mechanisms<br />

P5.201 Zinc, Copper and Manganese<br />

Porphyrins Restore Mitochondrial<br />

Function and Improve Cognition Without<br />

Reducing Aβ Levels in Alzheimer's Mice<br />

and Cells —Natasa Dragicevic, Kimberly<br />

Fields, Chuanhai Cao, Patrick Bradshaw<br />

P5.202 When Pigs Fly: Dynamic<br />

Susceptibility Contrast MRI for Cerebral<br />

White Matter Injury in a Hypobaric Swine<br />

Model —Philippine Dana Peralta, John<br />

Sladky, Stephen McGuire<br />

P5.203 Role of an Endogenous<br />

Retrovirus in ALS Pathophysiology and<br />

Effect of Anti-Retrovirals In Vitro —<br />

Avindra Nath, Myoung-Hwa Lee, Lisa<br />

Henderson, Muznabanu Bachani, Joseph<br />

Steiner, Gloria von Geldern, Katherine Pak,<br />

Andrew Mammen, Lyle Ostrow, Jeffrey<br />

Rothstein, Wenxue Li<br />

P5.204 Combination Therapy<br />

with Doxycycline, Chlorpromazine<br />

or Quinacrine Inhibits Prion Protein<br />

Replication in a N2A Model —Adam Witt,<br />

Jody Campeau, Valerie Sim<br />

P5.205 Neuroprotective Effects<br />

of Ezetimibe Versus Simvastatin<br />

in Alzheimer’s Induced Dementia:<br />

Perspectives from Female Rats. —<br />

Mahmoud KhalafAllah, Mohamed Zalabia,<br />

116 2016 AAN Annual Meeting Abstract Listing

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