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Tuesday, April 19 Integrated Neuroscience Session 1:00 p.m.–5:30 p.m. Integrated Neuroscience Session I10 Remyelination and Repair in Multiple Sclerosis Coordinators: Myla Goldman, MD, and Eric Klawiter, MD Program Description: This program will provide audience members with an understanding of where the MS field is currently working in the areas of remyelination and repair. The broad expertise of speakers will discuss this issue from the bench to the bedside where are we in studying this critical issue and what are the next steps towards therapeutics in remyelination and repair. Faculty will discuss the biology of demyelination and remyelination, how remyelination can be evaluated using advanced imaging (MRI and PET) techniques, and how compounds with remyelinating potential can be screened and selected for further study. The current status of remyelinating therapies in clinical trials will be reviewed. Interactive case discussions will be included. Upon Completion: Participants should become familiar with the process of remyelination and repair in the central nervous system. Participants should become familiar with emerging remyelinating therapeutics for multiple sclerosis. They should be equipped to improve their management of patients with multiple sclerosis. Part I 1:00 p.m.–3:00 p.m. 1:00 p.m.–1:10 p.m. Introduction Myla Goldman, MD, and Eric Klawiter, MD 1:10 p.m.–1:45 p.m. Invited Speaker The Biology of Demyelination and Remyelination in MS Jack P. Antel, MD, FAAN, Montreal, QC, Canada 1:45 p.m.–1:50 p.m. I10.001 Data Blitz IL-33 Expression in MS: Role in Remyelination and Repair —Subramaniam Sriram, Chandramohan Natarajan, Song-Yi Yao, Charles Spurlock, John Tossberg, Thomas Aune 1:50 p.m.–1:55 p.m. I10.002 Data Blitz LINGO-1 Negatively Regulates Oligodendrocyte Differentiation by Blocking the β-integrin Signaling Pathway —Sha Mi, Guanrong Huang, Xinhua Lee, Zhaohui Shao 1:55 p.m.–2:05 p.m. Audience Q&A 2:05 p.m.–2:40 p.m. Invited Speaker Remyelination and Repair in MS: Molecular Mechanisms, Epigenetics, and Therapeutic Development TBD 2:40 p.m.–2:45 p.m. I10.003 Data Blitz The Development of a Novel Zebrafish Model of Demyelination Allowing Therapeutic Development to Promote Remyelination in Multiple Sclerosis — Alexander McGown, Tennore Ramesh, Basil Sharrack 2:45 p.m.–2:50 p.m. I10.004 Data Blitz Oligodendrogliopathy in Multiple Sclerosis: Relation to Low Glycolytic Metabolic Rate of Oligodendrocytes —Qiao Ling Cui, Malena Rone, Damla Khan, Melissa Bedard, Guillermina Almazan, Samuel Ludwin, Timophy Kennedy, Jack Antel 2:50 p.m.–3:00 p.m. Audience Q&A Guided Poster Rounds I10.001 IL-33 Expression in MS: Role in Remyelination and Repair —Subramaniam Sriram, Chandramohan Natarajan, Song-Yi Yao, Charles Spurlock, John Tossberg, Thomas Aune I10.002 LINGO-1 Negatively Regulates Oligodendrocyte Differentiation by Blocking the β-integrin Signaling Pathway —Sha Mi, Guanrong Huang, Xinhua Lee, Zhaohui Shao I10.003 The Development of a Novel Zebrafish Model of Demyelination Allowing Therapeutic Development to Promote Remyelination in Multiple Sclerosis —Alexander McGown, Tennore Ramesh, Basil Sharrack I10.004 Oligodendrogliopathy in Multiple Sclerosis: Relation to Low Glycolytic Metabolic Rate of Oligodendrocytes —Qiao Ling Cui, Malena Rone, Damla Khan, Melissa Bedard, Guillermina Almazan, Samuel Ludwin, Timophy Kennedy, Jack Antel 3:00 p.m.–3:30 p.m. I10.005 Multiple Sclerosis White Matter Demyelination and Remyelination Using T1-, T2- and T2*-Weighted Images: A Post Mortem Validation Study at 7.0 Tesla —Michael Bradshaw, Assunta Dal-Bianco, Simon Hametner, Siddharama Pawate, Subramaniam Sriram, Seth Smith, John Gore, Brian Welch, Hans Lassmann, Francesca Bagnato I10.006 Differential Relationship Between Cortical Thinning and Myelin Water Fraction in RRMS and SPMS — Michael Dayan, Sandra Hurtado Rua, Elizabeth Monohan, Sneha Pandya, Jai Perumal, Nancy Nealon, Timothy Vartanian, Thanh Nguyen, Ashish Raj, Susan Gauthier I10.007 NDC-1308, a Small Molecule with Remyelinating Activity for Treatment of Secondary Progressive Multiple Sclerosis Patients —Steven Nye, James Yarger I10.008 Multiple Intrathecal Dosing of Neural Progenitors Administered to Progressive MS Patients with Disability Is Safe and Improves Disability Scores — Saud Sadiq, Leslie Blackshear, Gloria Joo, Tamara Vyshkina, Violaine Harris I10.009 Evidence That the Anti- LINGO-1 Monoclonal Antibody BIIB033 Protects Against Multifocal Visual Evoked Potential Amplitude Loss in the Fellow Eye of Subjects with Unilateral Acute Optic Neuritis —Diego Cadavid, Alexander Klistorner, Yi Chai, Letizia Leocani, Orhan Aktas, Helmut Butzkueven, Tjalf Ziemssen, Focke Ziemssen, Jette Frederiksen, Lei Xu I10.010 Neurite Orientation Dispersion and Density Imaging (NODDI) at the Onset of Clinically Isolated Syndrome (CIS): New Insights in the Early Microstructural Brain Tissue Changes —Sara Collorone, Niamh Cawley, Ferran Prados, Sebastien Ourselin, Carmen Tur Gomez, Francesco Grussu, CAM Gandini Wheeler-Kingshott, David Miller, Alan Thompson, Ahmed Toosy, Olga Ciccarelli Part II I10.011 The Sphingosine 1-phosphate (S1P) Receptor Modulator, Siponimod Decreases Oligodendrocyte Cell Death and Axon Demyelination in a Mouse Model of Multiple Sclerosis —Seema Tiwari-Woodruff, Hana Yamate-Morgan, Maria Sekyi, Kelli Lauderdale, Jonathan Hasselmann, Anna Schubart I10.012 Exploring Mechanisms of Multiple Sclerosis Lesion Evolution Using Advanced MRI —Vanessa Wiggermann, Inga Ibs, Stephanie Schoerner, Enedino Hernandez-Torres, Galina Vorobeychik, Luanne Metz, David Li, Anthony Traboulsee, Alexander Rauscher I10.013 Practical Experience with Animal Models for Translational Research in MS and NMO —Melina Jones, Kateryna Schwartz, Michael Levy 3:30 p.m.–5:30 p.m. 3:30 p.m.–4:05 p.m. Invited Speaker Use of Imaging to Evaluate Remyelination and Repair in MS Daniel S. Reich, MD, PhD, Bethesda, MD 4:05 p.m.–4:10 p.m. I10.005 Data Blitz Multiple Sclerosis White Matter Demyelination and Remyelination Using T1-, T2- and T2*-Weighted Images: A Post Mortem Validation Study at 7.0 Tesla — Michael Bradshaw, Assunta Dal-Bianco, Simon Hametner, Siddharama Pawate, Subramaniam Sriram, Seth Smith, John Gore, Brian Welch, Hans Lassmann, Francesca Bagnato 4:10 p.m.–4:15 p.m. I10.006 Data Blitz Differential Relationship Between Cortical Thinning and Myelin Water Fraction in RRMS and SPMS —Michael Dayan, Sandra Hurtado Rua, Elizabeth Monohan, Sneha Pandya, Jai Perumal, Nancy Nealon, Timothy Vartanian, Thanh Nguyen, Ashish Raj, Susan Gauthier 4:15 p.m.–4:25 p.m. Audience Q&A 4:25 p.m.–5:00 p.m. Invited Speaker Remyelination and Repair in MS: Therapeutic Compound Screening and Clinical Trials Ari Green, MD, San Francisco, CA 5:00 p.m.–5:05 p.m. I10.007 Data Blitz NDC-1308, a Small Molecule with Remyelinating Activity for Treatment of Secondary Progressive Multiple Sclerosis Patients —Steven Nye, James Yarger 5:05 p.m.–5:10 p.m. I10.008 Data Blitz Multiple Intrathecal Dosing of Neural Progenitors Administered to Progressive MS Patients with Disability Is Safe and Improves Disability Scores —Saud Sadiq, Leslie Blackshear, Gloria Joo, Tamara Vyshkina, Violaine Harris 5:10 p.m.–5:20 p.m. Audience Q&A 5:20 p.m.–5:30 p.m. Conclusion 106 2016 AAN Annual Meeting Abstract Listing
$ A registration fee is required L The program is one of the AAN Leadership University sessions S The course is part of a Subspecialty in Focus track I The program is one of the I Talk sessions Learning Lab Excitement of Discovery Health & Wellness Real World of Neurology The program is part of the Experiential Learning Area sessions Meeting Schedule 3:30 p.m.–5:30 p.m. Scientific Platform Sessions S34: Neuro-oncology 3:30 p.m. Presentation of the Neurooncology Investigator Award Sponsored by the American Academy of Neurology and the AAN Neuro-oncology Section and supported by friends of Dr. Jerome Posner. Recipient: Eudocia Lee, MD, MPH Boston, MA 3:45 p.m. Presentation of the Neurooncology Scientific Award Sponsored by the American Academy of Neurology and the AAN Neuro-oncology Section and supported by friends of Dr. WK Alfred Yung. Recipient: Jeremy Rich, MD Cleveland, OH 4:00 p.m. S34.003 The K27M Mutation in Histone H3 Is Present in Supratentorial Midline Diffuse Gliomas in Young Adult Patients —David Munoz, Scott Ryall, Sunit Das, Cynthia Hawkins 4:15 p.m. S34.004 Bevacizumab Impact on Hearing Loss Due to Neurofibromatosis Type 2 Associated Vestibular Schwannomas and Associated Biomarkers —Jaishri Blakeley, Xiobu Ye, Gabriel Duda, Christopher Halpin, Amanda Bergner, Alona Muzikansky, Vanessa Merker, Elizabeth Gerstner, Laura Fayad, Shivani Ahlawat, Michael Jacobs, Rakesh Jain, Eva Dombi, Brigitte Widemann, Scott Plotkin 4:30 p.m. S34.005 Effect of Everolimus on Subependymal Giant Cell Astrocytoma in Patients Being Treated for Renal Angiomyolipoma: Final Results from EXIST-2 —Michael Frost, John Bissler, Klemens Budde, Elena Belousova, Noah Berkowitz, Julie Niolat, J. Kingswood, E Bebin 4:45 p.m. S34.006 The Association of the MTHFR Gene Polymorphisms C677T and A1298C with Methotrexate-Related Toxicity in Patients with Primary CNS Lymphoma —Sylvia Eisele, Corey Gill, Michelle Pisapia, SooAe Jones, Tracy Batchelor, Scott Plotkin 5:00 p.m. S34.007 High Frequency of Inaccurate Prognostic Understanding Among Patients with Malignant Glioma —Eli Diamond, Holly Prigerson, Katherine Panageas, Denise Correa, Maria Kryza- Lacombe, Elizabeth Neil, Anne Reiner, Justin Buthorn, William Breitbart, Lisa DeAngelis, Allison Applebaum 5:15 p.m. S34.008 Acute Care Utilization in Glioblastoma (GBM): A Descriptive Analysis of Causes, Burden and Outcomes — Andrea Wasilewski, Jennifer Serventi, Lily Kamalyan, Thomas Wychowski, Nimish Mohile S35: Behavioral and Cognitive Neurology 3:30 p.m. Presentation of the Norman Geschwind Prize in Behavioral Neurology Sponsored by the American Academy of Neurology and the AAN Behavioral Neurology Section and endowed through Dr. Geschwind’s family, friends, and colleagues; Pfizer Inc; and the Society for Behavioral and Cognitive Neurology. Recipient: Madhav R. Thambisetty, MBBS, DPhil Baltimore, MD 3:45 p.m. Presentation of the S. Weir Mitchell Award Sponsored by the American Academy of Neurology and endowed by the former American Academy of Neurology Alliance. Recipient: Aaron D. Boes, MD, PhD Boston, MA 4:00 p.m. S35.003 Amyloid-β, Neuropsychiatric Symptoms and the Risk of Incident Mild Cognitive Impairment: A Prospective Cohort Study —Jennifer Neureiter, Janina Krell-Roesch, Anna Pink, Gorazd Stokin, Rosebud Roberts, Michelle Mielke, Teresa Christianson, Kathleen Spangehl, Val Lowe, Clifford Jack, David Knopman, Bradley Boeve, Ronald Petersen, Yonas Geda 4:15 p.m. S35.004 A Human Brain Network Linking Arousal to Awareness —David Fischer, Aaron Boes, Athena Demertzi, Henry Evrard, Stephen Laureys, Brian Edlow, Clifford Saper, Alvaro Pascual-Leone, Michael Fox, Joel Geerling 4:30 p.m. S35.005 Longitudinal Decline in Speech Fluency in Lewy Body Spectrum Disorder — Sharon Ash, Collin York, Teagan Bisbing, Nam Min, Olga Kofman, Murray Grossman 4:45 p.m. S35.006 Olfactory Dysfunction and Neuroimaging Biomarkers Among Cognitively Normal Individuals — Maria Vassilaki, Michelle Mielke, Teresa Christianson, Yonas Geda, Walter Kremers, Rabe Alhurani, Mary Machulda, David Knopman, Ronald Petersen, Val Lowe, Clifford Jack, Rosebud Roberts 5:00 p.m. S35.007 Mentally Stimulating Activities in Late-Life and the Risk of Incident Mild Cognitive Impairment: A Prospective Cohort Study —Janina Krell-Roesch, Rosebud Roberts, Anna Pink, Gorazd Stokin, Michelle Mielke, Prashanthi Vemuri, Teresa Christianson, Kathleen Spangehl, David Knopman, Ronald Petersen, Yonas Geda 5:15 p.m. S35.008 Assessing the Therapeutic Potential of Epothilone D and an ApoE Mimetic Peptide in a Murine Model of Chronic Traumatic Encephalopathy —Alexandra Rosenberg, Hana Dawson, Daniel Laskowitz S34 S35 Neuro-oncology Behavioral and Cognitive Neurology 4:00 p.m.–5:00 p.m. Health & Wellness What in the World is Positive Psychology and How Can It Help Me? Directors: Jennifer R. Molano, MD, FAAN, Cincinnati, OH Heidi M. Schwarz, MD, FAAN, Rochester, NY Tue· April 19 Frequently Asked Question How can I guarantee that I have a seat in a particular session? The sessions that do not require pre-registration are first-come, first-serve seating. Please arrive early to any session(s) that you must attend. Full session(s) may be overflowed to a second room. Fast and easy registration · AAN.com/view/AM16 107
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Meeting! INTRODUCTION See You in Va
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Additional Information INTRODUCTION
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OVERVIEWS Mon April 18 Tue April 19
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Schedule Planning Forms Use the con
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Hot Topics Plenary Session Friday,
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Meeting Schedule 11:30 a.m.-6:30 p.
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