You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Tuesday, April 19<br />
Integrated Neuroscience Session<br />
I9<br />
1:00 p.m.–5:30 p.m. Integrated Neuroscience Session<br />
S Sleep, Clocks, and Alzheimer's Disease<br />
This program is offered in partnership with the Sleep Section.<br />
Coordinators: Aleksandar Videnovic, MD, MSc, FAAN, and Yo-El Ju, MD<br />
Program Description: Sleep is important for optimal cognitive performance. Understanding the mechanisms through which sleep homeostasis provides these cognitive<br />
benefits allows for novel approaches to enhance cognitive performance. This program will present new scientific discoveries related to the interface of sleep, circadian<br />
biology, and cognitive decline. An overview of the spectrum of disturbed sleep and alertness in Alzheimer’s disease (AD) will set the stage for more specific discussions on<br />
sleep in cognitive disorders. These presentations will address 1) the bidirectional relationship between impaired sleep/circadian function and dementia/AD, 2) the impact of<br />
sleep-disordered breathing on cognitive function, and 3) the physiology of a newly described cerebral glymphatic system, a functional waste clearance pathway for the CNS,<br />
and its impact for cognitive functions. These presentations will be complemented by data blitz-presentations and poster discussions with topics covering sleep, alertness, and<br />
dementia.<br />
Upon Completion: Participants should be able to: discuss sleep and circadian dysregulation in dementia, understand the bi-directional relationship between sleep-wake<br />
regulation and Alzheimer’s disease, discuss the impact of sleep disordered breathing on cognitive outcomes, and understand the physiology of the glymphatic system and its<br />
relevance for optimal cognitive function.<br />
Part I<br />
1:00 p.m.–3:00 p.m.<br />
1:00 p.m.–1:10 p.m. Introduction<br />
Aleksandar Videnovic, MD, MSc, FAAN, and Yo-El Ju, MD<br />
1:10 p.m.–1:45 p.m. Invited Speaker<br />
Sleep: Role in Risk for Dementia and Changes Across the Spectrum of<br />
Cognitive Decline and Alzheimer’s Disease<br />
David M. Holtzman, MD, FAAN, St. Louis, MO<br />
1:45 p.m.–1:50 p.m. I9.001 Data Blitz<br />
Association Between Sleep Problems and Brain Volume in the Elderly —Angeliki<br />
Tsapanou, Yian Gu, Jennifer Manly, Nicole Schupf, Nikolaos Scarmeas, Sandra<br />
Barral, Adam Brickman, Yaakov Stern<br />
1:50 p.m.–1:55 p.m. I9.002 Data Blitz<br />
Use of Benzodiazepines and Risk of Dementia: A Retrospective Case-Control<br />
Study —Tsz-tai Chan, William Chun-yin Leung, Wesley Kin-yiu Wong, Wing-ming<br />
Chu, Ka-chun Leung, Yuey-zhun Ng, Gary Yuen-ming Kai, Victor Li, Yat-fung Shea,<br />
Chang Richard Shek-kwan, Shu-leong Ho<br />
1:55 p.m.–2:05 p.m. Audience Q&A<br />
2:05 p.m.–2:40 p.m. Invited Speaker<br />
Circadian Timing, Clocks, and Alzheimer’s Disease<br />
Sonia Ancoli-Israel, PhD, La Jolla, CA<br />
2:40 p.m.–2:45 p.m. I9.003 Data Blitz<br />
Impact of Armodafinil Therapy on Neuropsychiatric Features in Dementia with<br />
Lewy Bodies —Karen Kuntz, Sara Mason, Maria Lapid, Jeremiah Aakre, Emily<br />
Lundt, Bradley Boeve<br />
2:45 p.m.–2:50 p.m. I9.004 Data Blitz<br />
Sleep Deficiency Is Associated with Lack of Exercise and Higher BMI Among<br />
Community-Dwelling Older Adults —Kelly Sullivan<br />
2:50 p.m.–3:00 p.m. Audience Q&A<br />
Guided Poster Rounds<br />
I9.001 Association Between Sleep<br />
Problems and Brain Volume in the<br />
Elderly —Angeliki Tsapanou, Yian Gu,<br />
Jennifer Manly, Nicole Schupf, Nikolaos<br />
Scarmeas, Sandra Barral, Adam Brickman,<br />
Yaakov Stern<br />
I9.002 Use of Benzodiazepines<br />
and Risk of Dementia: A Retrospective<br />
Case-Control Study —Tsz-tai Chan, William<br />
Chun-yin Leung, Wesley Kin-yiu Wong, Wingming<br />
Chu, Ka-chun Leung, Yuey-zhun Ng,<br />
Gary Yuen-ming Kai, Victor Li, Yat-fung Shea,<br />
Chang Richard Shek-kwan, Shu-leong Ho<br />
I9.003 Impact of Armodafinil Therapy<br />
on Neuropsychiatric Features in Dementia<br />
with Lewy Bodies —Karen Kuntz, Sara<br />
Mason, Maria Lapid, Jeremiah Aakre, Emily<br />
Lundt, Bradley Boeve<br />
I9.004 Sleep Deficiency Is Associated<br />
with Lack of Exercise and Higher BMI<br />
Among Community-Dwelling Older<br />
Adults —Kelly Sullivan<br />
3:00 p.m.–3:30 p.m.<br />
I9.005 A Unique Pattern on Memory<br />
Testing in Dementia Screening Predicts<br />
Obstructive Sleep Apnea —Amber Gerber,<br />
Donn Dexter<br />
I9.006 Severity of Sleep Disordered<br />
Breathing in Amnestic MCI and in the MCI<br />
Preceding Dementia with Lewy Bodies —<br />
Linda Hershey, Barbara Carlson, Kellie Jones,<br />
Michael Wenger, John Carlson<br />
I9.007 Hemispheric Differences in<br />
EEG Spectral Power in Patients with<br />
Obstructive Sleep Apnea —Derek Su,<br />
Pradeep Sahota, Mahesh Thakkar<br />
I9.008 Cerebral Perfusion and the Risk<br />
of Dementia in the General Population —<br />
Frank Wolters, Hazel Zonneveld, Peter<br />
Koudstaal, Albert Hofman, Meike Vernooij,<br />
Mohammad Ikram<br />
I9.009 The Effect of Age in the<br />
Association Between Frailty and Poor<br />
Sleep Quality in Community-Dwellers<br />
(The Atahualpa Project) —Pablo Castillo,<br />
Kristen Cagino, Robertino Mera, Johnathan<br />
Nieves, Marleni Milla-Martinez, Mauricio<br />
Zambrano, Kathryn Fanning, Mark Sedler,<br />
Oscar Del Brutto<br />
I9.010 Sleep Duration is Associated<br />
with Depression in the Northern<br />
Manhattan Study —Suzanne Lippman,<br />
Hannah Gardener, Tatjana Rundek, Azizi<br />
Seixas, Maria Santiago, Mitchell Elkind,<br />
Ralph Sacco, Clinton Wright, Alberto Ramos<br />
Part II<br />
I9.011 Is the EEG Important in<br />
the Study of Patients with Cognitive<br />
Symptoms? —Agustina Tamargo, Analia<br />
Calle, Alejandro Thomson, Maria Gonzalez<br />
Toledo, Diego Nadile, José Molina, Santiago<br />
O'Neill, Elena Fontela, Alfredo Thomson<br />
I9.012 Sleep EEG Changes in<br />
Preclinical Alzheimer Disease: A Pilot<br />
Study —Sonja Schütz, Andrew Varga, Korey<br />
Kam, Emma Ducca, Margaret Wohlleber,<br />
Clifton Lewis, Girardin Jean-Louis, Indu<br />
Ayappa, David Rapoport, Ricardo Osorio,<br />
Helen Scharfman<br />
3:30 p.m.–5:30 p.m.<br />
3:30 p.m.–4:05 p.m. Invited Speaker<br />
Imaging Glymphatics in the Sleeping Brain: Implications for Alzheimer’s Disease<br />
Miranda M. Lim, MD, PhD, Portland, OR<br />
4:05 p.m.–4:10 p.m. I9.005 Data Blitz<br />
Hemispheric Differences in EEG Spectral Power in Patients with Obstructive Sleep<br />
Apnea —Derek Su, Columbia, MO<br />
4:10 p.m.–4:15 p.m. I9.006 Data Blitz<br />
Cerebral Perfusion and the Risk of Dementia in the General Population —Frank J.<br />
Wolters, Rotterdam, Netherlands<br />
4:15 p.m.–4:25 p.m. Audience Q&A<br />
4:25 p.m.–5:00 p.m. Invited Speaker<br />
Sleep Disturbances, Sleep Disordered Breathing, and Cognitive Health<br />
Michael K. Scullin, PhD, Waco, TX<br />
5:00 p.m.–5:05 p.m. I9.007 Data Blitz<br />
A Unique Pattern on Memory Testing in Dementia Screening Predicts Obstructive<br />
Sleep Apnea —Amber Gerber, Eau Claire, WI<br />
5:05 p.m.–5:10 p.m. I9.008 Data Blitz<br />
Severity of Sleep Disordered Breathing in Amnestic MCI and in the MCI Preceding<br />
Dementia with Lewy Bodies —Linda Hershey, Oklahoma City, OK<br />
5:10 p.m.–5:20 p.m. Audience Q&A<br />
5:20 p.m.–5:30 p.m. Conclusion<br />
104 2016 AAN Annual Meeting Abstract Listing