10.04.2016 Views

NEW!

16AMAbstracListing

16AMAbstracListing

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Tuesday, April 19<br />

Integrated Neuroscience Session<br />

I9<br />

1:00 p.m.–5:30 p.m. Integrated Neuroscience Session<br />

S Sleep, Clocks, and Alzheimer's Disease<br />

This program is offered in partnership with the Sleep Section.<br />

Coordinators: Aleksandar Videnovic, MD, MSc, FAAN, and Yo-El Ju, MD<br />

Program Description: Sleep is important for optimal cognitive performance. Understanding the mechanisms through which sleep homeostasis provides these cognitive<br />

benefits allows for novel approaches to enhance cognitive performance. This program will present new scientific discoveries related to the interface of sleep, circadian<br />

biology, and cognitive decline. An overview of the spectrum of disturbed sleep and alertness in Alzheimer’s disease (AD) will set the stage for more specific discussions on<br />

sleep in cognitive disorders. These presentations will address 1) the bidirectional relationship between impaired sleep/circadian function and dementia/AD, 2) the impact of<br />

sleep-disordered breathing on cognitive function, and 3) the physiology of a newly described cerebral glymphatic system, a functional waste clearance pathway for the CNS,<br />

and its impact for cognitive functions. These presentations will be complemented by data blitz-presentations and poster discussions with topics covering sleep, alertness, and<br />

dementia.<br />

Upon Completion: Participants should be able to: discuss sleep and circadian dysregulation in dementia, understand the bi-directional relationship between sleep-wake<br />

regulation and Alzheimer’s disease, discuss the impact of sleep disordered breathing on cognitive outcomes, and understand the physiology of the glymphatic system and its<br />

relevance for optimal cognitive function.<br />

Part I<br />

1:00 p.m.–3:00 p.m.<br />

1:00 p.m.–1:10 p.m. Introduction<br />

Aleksandar Videnovic, MD, MSc, FAAN, and Yo-El Ju, MD<br />

1:10 p.m.–1:45 p.m. Invited Speaker<br />

Sleep: Role in Risk for Dementia and Changes Across the Spectrum of<br />

Cognitive Decline and Alzheimer’s Disease<br />

David M. Holtzman, MD, FAAN, St. Louis, MO<br />

1:45 p.m.–1:50 p.m. I9.001 Data Blitz<br />

Association Between Sleep Problems and Brain Volume in the Elderly —Angeliki<br />

Tsapanou, Yian Gu, Jennifer Manly, Nicole Schupf, Nikolaos Scarmeas, Sandra<br />

Barral, Adam Brickman, Yaakov Stern<br />

1:50 p.m.–1:55 p.m. I9.002 Data Blitz<br />

Use of Benzodiazepines and Risk of Dementia: A Retrospective Case-Control<br />

Study —Tsz-tai Chan, William Chun-yin Leung, Wesley Kin-yiu Wong, Wing-ming<br />

Chu, Ka-chun Leung, Yuey-zhun Ng, Gary Yuen-ming Kai, Victor Li, Yat-fung Shea,<br />

Chang Richard Shek-kwan, Shu-leong Ho<br />

1:55 p.m.–2:05 p.m. Audience Q&A<br />

2:05 p.m.–2:40 p.m. Invited Speaker<br />

Circadian Timing, Clocks, and Alzheimer’s Disease<br />

Sonia Ancoli-Israel, PhD, La Jolla, CA<br />

2:40 p.m.–2:45 p.m. I9.003 Data Blitz<br />

Impact of Armodafinil Therapy on Neuropsychiatric Features in Dementia with<br />

Lewy Bodies —Karen Kuntz, Sara Mason, Maria Lapid, Jeremiah Aakre, Emily<br />

Lundt, Bradley Boeve<br />

2:45 p.m.–2:50 p.m. I9.004 Data Blitz<br />

Sleep Deficiency Is Associated with Lack of Exercise and Higher BMI Among<br />

Community-Dwelling Older Adults —Kelly Sullivan<br />

2:50 p.m.–3:00 p.m. Audience Q&A<br />

Guided Poster Rounds<br />

I9.001 Association Between Sleep<br />

Problems and Brain Volume in the<br />

Elderly —Angeliki Tsapanou, Yian Gu,<br />

Jennifer Manly, Nicole Schupf, Nikolaos<br />

Scarmeas, Sandra Barral, Adam Brickman,<br />

Yaakov Stern<br />

I9.002 Use of Benzodiazepines<br />

and Risk of Dementia: A Retrospective<br />

Case-Control Study —Tsz-tai Chan, William<br />

Chun-yin Leung, Wesley Kin-yiu Wong, Wingming<br />

Chu, Ka-chun Leung, Yuey-zhun Ng,<br />

Gary Yuen-ming Kai, Victor Li, Yat-fung Shea,<br />

Chang Richard Shek-kwan, Shu-leong Ho<br />

I9.003 Impact of Armodafinil Therapy<br />

on Neuropsychiatric Features in Dementia<br />

with Lewy Bodies —Karen Kuntz, Sara<br />

Mason, Maria Lapid, Jeremiah Aakre, Emily<br />

Lundt, Bradley Boeve<br />

I9.004 Sleep Deficiency Is Associated<br />

with Lack of Exercise and Higher BMI<br />

Among Community-Dwelling Older<br />

Adults —Kelly Sullivan<br />

3:00 p.m.–3:30 p.m.<br />

I9.005 A Unique Pattern on Memory<br />

Testing in Dementia Screening Predicts<br />

Obstructive Sleep Apnea —Amber Gerber,<br />

Donn Dexter<br />

I9.006 Severity of Sleep Disordered<br />

Breathing in Amnestic MCI and in the MCI<br />

Preceding Dementia with Lewy Bodies —<br />

Linda Hershey, Barbara Carlson, Kellie Jones,<br />

Michael Wenger, John Carlson<br />

I9.007 Hemispheric Differences in<br />

EEG Spectral Power in Patients with<br />

Obstructive Sleep Apnea —Derek Su,<br />

Pradeep Sahota, Mahesh Thakkar<br />

I9.008 Cerebral Perfusion and the Risk<br />

of Dementia in the General Population —<br />

Frank Wolters, Hazel Zonneveld, Peter<br />

Koudstaal, Albert Hofman, Meike Vernooij,<br />

Mohammad Ikram<br />

I9.009 The Effect of Age in the<br />

Association Between Frailty and Poor<br />

Sleep Quality in Community-Dwellers<br />

(The Atahualpa Project) —Pablo Castillo,<br />

Kristen Cagino, Robertino Mera, Johnathan<br />

Nieves, Marleni Milla-Martinez, Mauricio<br />

Zambrano, Kathryn Fanning, Mark Sedler,<br />

Oscar Del Brutto<br />

I9.010 Sleep Duration is Associated<br />

with Depression in the Northern<br />

Manhattan Study —Suzanne Lippman,<br />

Hannah Gardener, Tatjana Rundek, Azizi<br />

Seixas, Maria Santiago, Mitchell Elkind,<br />

Ralph Sacco, Clinton Wright, Alberto Ramos<br />

Part II<br />

I9.011 Is the EEG Important in<br />

the Study of Patients with Cognitive<br />

Symptoms? —Agustina Tamargo, Analia<br />

Calle, Alejandro Thomson, Maria Gonzalez<br />

Toledo, Diego Nadile, José Molina, Santiago<br />

O'Neill, Elena Fontela, Alfredo Thomson<br />

I9.012 Sleep EEG Changes in<br />

Preclinical Alzheimer Disease: A Pilot<br />

Study —Sonja Schütz, Andrew Varga, Korey<br />

Kam, Emma Ducca, Margaret Wohlleber,<br />

Clifton Lewis, Girardin Jean-Louis, Indu<br />

Ayappa, David Rapoport, Ricardo Osorio,<br />

Helen Scharfman<br />

3:30 p.m.–5:30 p.m.<br />

3:30 p.m.–4:05 p.m. Invited Speaker<br />

Imaging Glymphatics in the Sleeping Brain: Implications for Alzheimer’s Disease<br />

Miranda M. Lim, MD, PhD, Portland, OR<br />

4:05 p.m.–4:10 p.m. I9.005 Data Blitz<br />

Hemispheric Differences in EEG Spectral Power in Patients with Obstructive Sleep<br />

Apnea —Derek Su, Columbia, MO<br />

4:10 p.m.–4:15 p.m. I9.006 Data Blitz<br />

Cerebral Perfusion and the Risk of Dementia in the General Population —Frank J.<br />

Wolters, Rotterdam, Netherlands<br />

4:15 p.m.–4:25 p.m. Audience Q&A<br />

4:25 p.m.–5:00 p.m. Invited Speaker<br />

Sleep Disturbances, Sleep Disordered Breathing, and Cognitive Health<br />

Michael K. Scullin, PhD, Waco, TX<br />

5:00 p.m.–5:05 p.m. I9.007 Data Blitz<br />

A Unique Pattern on Memory Testing in Dementia Screening Predicts Obstructive<br />

Sleep Apnea —Amber Gerber, Eau Claire, WI<br />

5:05 p.m.–5:10 p.m. I9.008 Data Blitz<br />

Severity of Sleep Disordered Breathing in Amnestic MCI and in the MCI Preceding<br />

Dementia with Lewy Bodies —Linda Hershey, Oklahoma City, OK<br />

5:10 p.m.–5:20 p.m. Audience Q&A<br />

5:20 p.m.–5:30 p.m. Conclusion<br />

104 2016 AAN Annual Meeting Abstract Listing

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!