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<strong>Apollo</strong><br />

Research and<br />

Innovations ( ARI)<br />

A division of <strong>Apollo</strong> Hospitals Enterprise Ltd.<br />

Research &<br />

Innovation<br />

Bulletin<br />

2016<br />

“Every great advance in science has issued from a new<br />

audacity of imagination” – John Dewey


<strong>Apollo</strong> Research Bulletin<br />

Vision<br />

“<br />

Enable a Research & Innovations led<br />

<strong>Apollo</strong> Hospitals, which consistently rides<br />

the cutting edge in Technology, Therapy,<br />

Delivery for improved patient outcomes,<br />

affordability and reach.<br />

”<br />

Quick<br />

Facts<br />

• Dedicated umbrella organization for spearheading<br />

Research and Innovations for <strong>Apollo</strong>.<br />

• Unmatched experience from 800 clinical studies.<br />

• Diverse portfolio : Drugs, Software, Devices &<br />

others.<br />

Inside<br />

2


From the desk of …<br />

<strong>Apollo</strong> Research Bulletin<br />

This edition of the research newsletter is dedicated to our beloved Padmashree<br />

Prof. Ranjit Roy Chaudhury ….<br />

Prof. Ranjit Roy Chaudhury; an iconic individual, had<br />

joined our family in 2003 as the Chairman - Task Force<br />

for Research, <strong>Apollo</strong> Hospitals. He was at the forefront<br />

of bringing pioneering change in healthcare for more<br />

than 40 years as the Chairman, Clinical Trials & Ethics<br />

Sub-Committee, Ministry of Health and Family Welfare,<br />

Government of India.<br />

We express our deepest and heartfelt condolences to his<br />

family, friends and colleagues and pray for his soul to rest<br />

in peace.<br />

“ARI is dedicated to spawning Research and Innovation<br />

within the <strong>Apollo</strong> ecosystem and such endeavours are<br />

likely to become cornerstones to prepare the hospital<br />

group for next generation. Having already created some<br />

momentum in introducing genetics and medical device<br />

innovations, we are moving on to a very exciting times<br />

ahead. In the coming year we are likely to see introduction<br />

of pharmacogenetics and liquid biopsies which shall push<br />

the envelope in personalized medicine and diagnostics. “<br />

Dr. Prathap C Reddy<br />

Founder-chairman,<br />

<strong>Apollo</strong> Hospitals<br />

Ms. Shobana Kamineni<br />

Executive Vice chairperson,<br />

<strong>Apollo</strong> Hospitals<br />

“We at <strong>Apollo</strong> believe that a research led hospital shall<br />

differentiate us sustainably. In this context, the research<br />

foundation and the research related joint ventures shall<br />

contribute significantly in introducing disruptive innovation<br />

in our ecosystem. We have already observed traction in<br />

terms of establishing a Biobank, introducing genetics<br />

through APHC, DNA+, commencing device innovations<br />

and etc. The effort no doubt requires patience, diligence<br />

and a vision. I look forward to each one of you to play a<br />

distinct role in furthering realization of this vision.”<br />

3


Research at <strong>Apollo</strong>: Portfolio Snapshot<br />

<strong>Apollo</strong> Research Bulletin<br />

ARI has been mandated to consolidate the research efforts through various<br />

research ventures and initiatives across <strong>Apollo</strong> Hospitals. ARI is focused on leading<br />

Clinical Research and Innovations, Basic and Public Research, Technology/<br />

therapy validation, Incubation, Deal Structuring and co-development of intellectual<br />

property.<br />

4


Research at <strong>Apollo</strong>: Portfolio Snapshot<br />

<strong>Apollo</strong> Research Bulletin<br />

<strong>Apollo</strong> Research and Innovations:<br />

An Ecosystem… Real & Thriving !!!<br />

5


Cover Story<br />

<strong>Apollo</strong> Research Bulletin<br />

Introduction of Genetics at <strong>Apollo</strong><br />

Pioneering New Age of Healthcare in India<br />

Genomic testing involves analyses of patient genomes and translating insights gained<br />

from the analysis to develop better healthcare interventions. This is done by way of<br />

prognostic tools for improved disease screening/prevention strategies, better diagnostic<br />

tests for optimization of clinical care, better theranostic tests for personalization of<br />

treatment and monitoring of outcomes.<br />

Our vision for genetics is predictive testing, pharmacogenetics & sensitivity<br />

and Disruptive cancer detection.<br />

<strong>Apollo</strong> Hospitals is committed to translating research into clinical outcomes for patient<br />

benefit. With this aspiration, <strong>Apollo</strong> Hospitals through ARI, incubated and launched<br />

Sapien Biosciences as a first step in this direction. Sapien shall focus on creation of<br />

a national bio-repository and derivative products and services. These products and<br />

services shall augment personalized medicine and bridge the gap with Life sciences.<br />

<strong>Apollo</strong> Hospitals offers DNA+ as a part of Personalized health<br />

Check<br />

As a part of predictive genetic screening, <strong>Apollo</strong><br />

Hospitals has partnered with Datar Genetics to offer<br />

a comprehensive Disease Predisposition Gene Test<br />

(DNA+), for the first time in India. This one time test<br />

will analyze and assess unique DNA make-up to<br />

understand its impact on genetic predisposition for<br />

more than 60 conditions including cardiovascular<br />

disease, diabetes and cancers. ARI has assisted in<br />

commercialization and deployment of DNA+ as part of<br />

<strong>Apollo</strong> Personalized health checks (APHCs).<br />

MyPLATELET<br />

Sapien and AHERF launched its first and novel personalized medicine diagnostic test<br />

“myPLATELET” at <strong>Apollo</strong> Hyderabad and Bhubaneswar. The test helps to determine<br />

patient’s response to their blood-thinning medication and supports decision-making<br />

by the cardiologists to personalize therapy for better outcomes. This is the only test<br />

in India that combines both genetic and platelet function response to enable tailored<br />

anti-platelet therapy for each patient. 300 diagnostic tests have been undertaken so<br />

far.<br />

6


Cover Story<br />

<strong>Apollo</strong> Research Bulletin<br />

Liquid Biopsy for Brain Tumors<br />

AHERF researchers along with clinicians from <strong>Apollo</strong> Hospitals have established and<br />

developed a liquid biopsy diagnostic for brain tumours. AHERF has collaborated with<br />

Datar Genetics Ltd; a leading genetics service provider, to validate a non invasive<br />

blood based diagnostic of Glioblastomas (the most fatal and aggressive type of brain<br />

tumour). Both organizations have co-validated the assay and the path breaking test is<br />

likely to be introduced first at <strong>Apollo</strong> in February 2016. The liquid biopsy is one of the<br />

top 15 breakthrough technologies of 2015(MIT Tech Review). It places <strong>Apollo</strong> at the<br />

global forefront in research.<br />

Upcoming Projects in Genetics<br />

Urine based test for cervical cancer<br />

A leading U.S. based genetics company has developed<br />

a urine based HPV HR test for the screening of cervical<br />

cancer using DNA sequencing. ARI is working closely<br />

with Sapien in finalizing the collaboration. We believe<br />

that leveraging this technology cervical cancer<br />

screening will increase manifold. This shall enable us<br />

to diagnose & treat cervical cancer in time and there<br />

by impacting incidence nationally.<br />

Reccurence Monitoring for Breast cancer<br />

OncoStem Diagnostics is a US-India clinical diagnostic start-up. Sapien is collaborating<br />

with Oncostem to validate & launch a novel recurrence prediction test for breast cancer.<br />

The project is expected to be launched in India by May 2016.<br />

7


Global Reach<br />

<strong>Apollo</strong> Research Bulletin<br />

Cross-country Reach out: Israel Medical device companies<br />

<strong>Apollo</strong> Research and Innovations (ARI) proactively<br />

contacted the Israel Trade Commission for getting<br />

medical devices studies at <strong>Apollo</strong>.<br />

17 companies from Israel evinced interest for<br />

validation of medical devices and 4 of these<br />

projects are in progress/completed in one or more<br />

of our hospitals. Early Sense & Sight Diagnostics<br />

are likely to be deployed in hospital shortly.<br />

Global Alliance : <strong>Apollo</strong> Hospitals and HealthXL<br />

<strong>Apollo</strong> Hospitals enabled by ARI has recently joined<br />

HealthXL, a global forum for Healthcare innovation<br />

that converges healthcare professionals, medical<br />

device and diagnostics providers to ideate, design<br />

and propose solutions to various healthcare<br />

challenges.<br />

HealthXL is unique community comprising of<br />

marquee partners such as Cleveland clinic, UCLA,<br />

Merck, Ernst & Young, IBM, Google etc. dedicated<br />

to healthcare innovation.<br />

This association will enable <strong>Apollo</strong> clinicians,<br />

paramedics and administrators to be aligned with<br />

cutting edge developments in healthcare and will<br />

also present us with opportunities to participate in<br />

international projects on healthcare with diverse<br />

teams across organisations & geographies.<br />

AAHRPP accreditation : Global gold standard for clinical<br />

research<br />

ARI has applied for AAHRPP accreditation which is the global gold standard for<br />

clinical research. Hence, preparing <strong>Apollo</strong> with rigorous standards for ethics, quality,<br />

and protections of human research. AAHRPP<br />

accreditation will earn us a place among the<br />

world’s most respected, trustworthy research<br />

organizations. For the time in AAHRPP’s history, 5<br />

hospitals from the same hospital group are being<br />

considered for accreditation. This will make us one<br />

of few front runners in India.<br />

8


In the Spotlight<br />

<strong>Apollo</strong> Research Bulletin<br />

Healthcare Innovation Accelerator<br />

<strong>Apollo</strong> hospitals is in process of exploring a<br />

healthcare Innovation fund for start-ups. Such a<br />

framework will allow <strong>Apollo</strong> to proactively identify<br />

disruptive innovations constantly whilst connecting<br />

with a global network. Such innovation shall be<br />

oriented towards solving problems faced by the<br />

lower and middle income countries (LMIC).<br />

Early Sense: A unique monitoring device for oncology wards<br />

<strong>Apollo</strong> Hospitals is shortly set to<br />

introduce a cutting edge Israeli<br />

technology called Early Sense. The<br />

system is intended to monitor and track<br />

patients’ heart rate, respiratory rate,<br />

and patient’s mobility to early sense<br />

developing complications and early<br />

intervene to prevent any fatal events.<br />

ARI has completed a pilot study for<br />

clinical validation of the product.<br />

The technology will add significant value when introduced in oncology ward enabling<br />

<strong>Apollo</strong> to take extra care of it patients<br />

Eris: Single Largest Study including 100 Principal Investigator<br />

This is one of its kind of Study has been conducted<br />

with an objective to assess the comparison of<br />

Ambulatory Blood Pressure Monitoring (ABPM)<br />

versus Office Blood Pressure Monitoring (OBPM)<br />

in patients with newly diagnosed, controlled and<br />

uncontrolled hypertension. This study has been<br />

by 100 investigators across 8 sites pan-India.<br />

Conducted. The vision is to change the paradigm<br />

of hypertension management, based on patterns<br />

emerging from hypertension data.<br />

9


Other key Projects & Activities<br />

<strong>Apollo</strong> Research Bulletin<br />

Sapien Biosciences<br />

Sapien Biosciences is a joint venture between <strong>Apollo</strong> Hospitals & Saarum Innovations,<br />

creating a world-class bio-bank and providing personalized medicine solutions.<br />

Sapien’s focus is to develop novel clinical and R&D applications. Through its sister<br />

concern Saarum Sciences, Sapien also intends to partner with healthcare enterprises<br />

and drug discovery companies globally to study disease epidemiology, develop<br />

new cell lines, create cell based platforms, assist in drug screening, discover new<br />

biomarkers etc.<br />

Sapien has already rolled out genetic tests myPLATELET and myCarDiOTM so as to<br />

create momentum in this new space. Further, Sapien has forged a key collaboration<br />

with Oncostem diagnostics, a Bangalore based organization focused on oncology<br />

biomarkers. Currently both companies are working together to a breast cancer<br />

recurrence prognostic biomarker. This test is likely to be available at a fraction of the<br />

cost. For existing breast cancer survivors/patients it will enable personalized monitoring<br />

and intervention.<br />

Collaboration with Medtronic<br />

ARI hand held the Medtronic project from concept<br />

to an advanced stage of commercial negotiations.<br />

Facilitating an interface with our clinicians and<br />

administrators, ARI assited Medtronic to converge<br />

clinical and operational challenges to create an<br />

aspirational dialysis product. The current prototype<br />

consumes only 6 liters of purified water vs. 120<br />

liters used by a conventional device. The vision is<br />

to enable dialysis for patients, using minimal water.<br />

The project has now been transitioned to AHLL for<br />

realization.<br />

Clinical validation of Innovative Knee<br />

Brace at <strong>Apollo</strong><br />

Unloader One is a knee brace for Osteoarthritis<br />

patients. The braces helps in prolonging the time<br />

to surgery for OA I and II patients. The brace<br />

is uniquely designed to help in increasing the<br />

space between the joints and have an additional<br />

silicon coating internally to reduce rashes. ARI<br />

has successfully completed a pilot study for the<br />

validation of Unloader One OA.<br />

10


Other key Projects & Activities<br />

<strong>Apollo</strong> Research Bulletin<br />

USV – Investigator Initiated Study for<br />

Type II Diabetes Drug<br />

<strong>Apollo</strong> has recently signed an agreement with USV<br />

for a phase IV Investigator Initiated Study in Type 2<br />

diabetes in Indian population. The study duration<br />

is 1 year and is being conducted by 5 investigator<br />

across 4 <strong>Apollo</strong> centers. It is one of the larger studies<br />

initiated by investigators.<br />

Genpraxis – Remote Genetic Counseling Platform<br />

Genpraxis is a provider of next generation<br />

sequencing clinical diagnostics for inherited disease<br />

and precision medicine. It is entering into remote<br />

genetic counseling sector where single platform will<br />

provide one stop shop for physician and patients.<br />

ARI has assisted HNG in closing a term sheet to<br />

realize this venture. The Genepraxis is a spin off<br />

from Yale University & shall enable opening a larger<br />

collaboration.<br />

Lipotest Meal - Diagnostic meal for performing Fat Tolerance<br />

Test<br />

The test is developed by D-Genomeres, Greece. The Lipotest-meal is a diagnostic<br />

meal used for diagnosing the abnormal postprandial lipaemia (Fat Tolerance Test). It<br />

is the meal that someone consumes in order to perform the Fat Tolerance Test. The<br />

lipo-test meal used in OFTT is a diagnostic tool which is given as a mousse in fasting<br />

condition to patients.<br />

ARI has completed the study and the outcome are<br />

in line with the current knowledge.<br />

In the absence of a standardized fat tolerance test<br />

in India, Lipotest meal provides an opportunity<br />

to test the postprandial lipemia as a risk factor<br />

for cardiovascular disease.<br />

11


Upcoming<br />

<strong>Apollo</strong> Research Bulletin<br />

Digital India: Enabling accessible Healthcare via Drones<br />

<strong>Apollo</strong>’s vision to enhance healthcare reach to the<br />

last mile has gathered further momentum with a<br />

concept being created to use unmanned aerial<br />

vehicles (UAVs). More popularly known as drones,<br />

these UAVs have potential to travel at over 60 miles/<br />

hour and enable sample collection and medicine<br />

delivery quickly. Such a precise point to point<br />

aerial medium for transportation becomes critical<br />

in difficult terrains or inaccessible areas. Further<br />

scope includes emergency services (defibrillation)<br />

and augments Telemedicine. A concept proposal<br />

has been created with a U.S. Based start-up and submitted to the Director General<br />

Civil Aviation (DCGA). If realised <strong>Apollo</strong> would pioneer a disruptive way to enhance<br />

healthcare reach.<br />

Biopmedical: Israeli technology for cervical cancer screening<br />

An Israeli medical device start up, Biopmedical<br />

has developed a digital portable optical probe for<br />

screening and diagnosis of cervical cancer using<br />

optical signatures. Biop was accepted for IBM’s<br />

first ever accelerator program. Ginni Rometty, CEO<br />

of IBM, mentioned Biopmedical as a “promising”<br />

company in her speech. The device provides a<br />

360 degree, high resolution view of the cervix by<br />

recording four optical characteristics of the scanned<br />

tissue. ARI has completed the technical evaluation<br />

for the device. ARI is in process to commence a<br />

clinical validation study for the device.<br />

Sight Diagnostics: 2 minutes Point of care Malaria diagnosis<br />

<strong>Apollo</strong> is collaborating with SightDx for introducing<br />

an image-processing device; Parasight Platform<br />

for blood analysis. Parasight combines cutting<br />

edge computer vision algorithms, custom low cost<br />

hardware and novel blood preparation techniques to<br />

detect malaria in a rapid, reliable and completely<br />

automated fashion. ARI has successfully completed<br />

a pilot study for clinical validation of the product and<br />

has facilitated discussion at <strong>Apollo</strong>. This technology<br />

shall allow <strong>Apollo</strong> to introduce a much more efficient,<br />

potable and accurate malaria diagnostic system to India.<br />

12


Events<br />

<strong>Apollo</strong> Research Bulletin<br />

1st ever Healthcare Devthon organized at <strong>Apollo</strong> Hospitals<br />

BioAsia hosted a Healthcare Devthon in association with <strong>Apollo</strong> Hospitals. It was<br />

a co-creation exercise that brought healthcare experts, engineers, technologists<br />

and developers together onto a platform to discover, design and rapidly prototype<br />

technologies and solutions in the life sciences and healthcare fields. The event took<br />

place in 4 phases namely; Domain immersion, Design thinking & ideation, Prototyping<br />

and Showcasing at BioAsia 2015. 150 innovators participated in the event held at<br />

<strong>Apollo</strong> Medical College, Hyderabad. The Healthcare Devthon also facilitated meaningful<br />

interactions between the participants and doctors from <strong>Apollo</strong> hospitals which helped<br />

them gather insights into the functioning and understand on-ground challenges.<br />

13


Events<br />

<strong>Apollo</strong> Research Bulletin<br />

ARI hosted International Clinical trial day with ISCR<br />

ARI team hosted the ‘International Clinical<br />

trial day’ celebration at <strong>Apollo</strong> Health City,<br />

Hyderabad in collaboration with Navchetna<br />

(an awareness & Advocacy Initiative for<br />

Clinical Research by Indian Society for<br />

Clinical Research), KIMS and NIMS. Over<br />

85 investigators, study coordinators,<br />

Ethics committees, students, patients<br />

and regulatory representative participated<br />

in the event. The event commenced with<br />

a welcome note by Dr. Ravindra Babu,<br />

Medical. Superintendent, <strong>Apollo</strong> Hospitals,<br />

Hyderabad. The clinical research<br />

team at ARI introduced the concept of<br />

International Clinical Trials Day and the<br />

Clinical research film by ISCR. There were<br />

several investigators and patients who<br />

shared their stories and experiences of<br />

participating in the clinical trials.<br />

ISCR-<strong>Apollo</strong> Pharmacovigilance Symposium held at <strong>Apollo</strong><br />

Chennai<br />

ARI organized a seminar on ‘Best Practices<br />

in Pharmacovigilance for Healthcare<br />

Professionals in Contemporary Indian<br />

Scenario’ in association with Indian<br />

Society for Clinical Research(ISCR) at<br />

<strong>Apollo</strong> Main Hospital, Chennai on 29th<br />

July 2015.<br />

The event was attended by doctors,<br />

clinical pharmacists, senior nurses,<br />

pharmacologists, Clinical Research Team<br />

members and also ISCR Members and<br />

representatives of ISCR’s Accredited<br />

Member Organizations (AMOs).<br />

There were thoughts shared by healthcare<br />

professionals on Spreading awareness<br />

of Pharmacovigilance and stressing the<br />

importance of Pharmacovigilance in<br />

Patient Safety.<br />

14


Thought Leadership<br />

<strong>Apollo</strong> Research Bulletin<br />

Publications : Express Healthcare<br />

<strong>Apollo</strong> Research and Innovation has<br />

achieved an unprecedented share of<br />

voice in as many as 50+ media clips<br />

across papers, journals and social media.<br />

An example of contributing in thought<br />

leaders is illustrated through a quote in<br />

the “Genetic Diagnostics Special” column<br />

of Express Healthcare. The article is a<br />

general analysis on the genetic diagnosis<br />

sector’s growth in India.<br />

Read more: http://www.financialexpress.com/article/healthcare/digital-issue/<br />

express-healthcare-vol-9-no-6-june-2015/80082/<br />

15


Thought Leadership<br />

<strong>Apollo</strong> Research Bulletin<br />

Events and Conferences<br />

ARI represented <strong>Apollo</strong> Hospitals in various events and conferences that were held in<br />

2014 -15in India.<br />

Some of the major conferences in which ARI was represented as a speaker/panelist<br />

were :<br />

<br />

<br />

<br />

<br />

<br />

<br />

FICCI Conference ‘Innovation Enabling Access’ 2014, New Delhi.<br />

VCCircle Healthcare Investment Summit 2014, Mumbai.<br />

DIA 2014 9th Annual India Conference 2014, Mumbai.<br />

Wish Foundation: SCALE Healthcare Innovations Summit 2014, New Delhi.<br />

CII Conference “India-Netherlands cooperation on Healthcare” 2014, New Delhi.<br />

Indo US Technology Summit 2014, Noida.<br />

ISB Leadership Summit 2014, Hyderabad.<br />

<br />

CAMTech India Boot camp 2015, Bangalore.<br />

ISCR Annual conference 2015, New Delhi.<br />

<br />

<br />

<br />

MEDinISRAEL-3rd Medical Devices & Hit International Conference, Tel Aviv.<br />

Nuviun Digital Health Live conference, Dubai.<br />

IBC’s Healthcare Management Conference 2015, Singapore.<br />

16


Social Initiative<br />

<strong>Apollo</strong> Research Bulletin<br />

<strong>Apollo</strong> Pharmacy & <strong>Apollo</strong> Hospitals Educational<br />

and Research Foundation (AHERF) will supply free<br />

medicines to the elderly<br />

<br />

<br />

<br />

<br />

15 old age homes from Chennai would get assistance of free medicine delivery for<br />

an year.<br />

<strong>Apollo</strong> Group has undertaken this project to ensure that even the elderly have easy<br />

access to medication.<br />

<strong>Apollo</strong>’s CSR team along with <strong>Apollo</strong> pharmacy will work together for distribution of<br />

medicines and accountability and will visit these homes twice a month for any scope<br />

of improving the activities.<br />

This initiative would subsequently be expanded to other cities and towns; Starting<br />

with Delhi, 16 old age homes with over 990 inmates will benefit through the project.<br />

17


Testimonials<br />

<strong>Apollo</strong> Research Bulletin<br />

We truly believe that the significance of our efforts & impact<br />

is measured by testimonials from our stakeholders<br />

Dr. Amitava Ray<br />

Sr. Neurologist,<br />

<strong>Apollo</strong> Hospitals<br />

“As practicing clinicians we constantly come across problem that<br />

do not have ready made solutions. I had a similar conundrum<br />

about 2 years ago when I wanted to find a better way of diagnosing<br />

brain tumours other than drilling holes in the head. I discussed<br />

the problem with team ARI and 2 years later the product is about<br />

to be launched and the first of its kind in the world. I would thank<br />

team ARI without which it would not have been possible.”<br />

“I finally had a chance to review the study results in detail and<br />

they are almost better than even the BRIGGS study which we<br />

use globally at the moment to talk about the findings over a 6<br />

mo period with Unloader One. Kudos to your clinical team for a<br />

fantastic and quality publication. I hope the AHERF team is as<br />

satisfied with the results as we are !.”<br />

Mr. Ajay Sasikumar Nair<br />

Director of Marketing<br />

Asia, Ossur<br />

Dr. C. Venkata S. Ram<br />

MD, Director , <strong>Apollo</strong><br />

Institute for Blood<br />

Pressure Management<br />

“I am writing to express my appreciation for AHERF for the<br />

wonderful work they do in conducting high quality research,<br />

innovation and medical education. Upon joining <strong>Apollo</strong>, my very<br />

first research endeavor required the services of AHERF. Thanks, to<br />

them, we have completed the largest clinical study in India using<br />

24 hours Ambulatory blood pressure monitoring. The study was<br />

completed in record time without any hurdles and I am extremely<br />

happy to have been the PI of this study-first of its kind in India. At<br />

<strong>Apollo</strong>, we are fortunate to have AHERF as a partner to conduct<br />

world caliber research and innovations in the medical field.”<br />

“In order to help nurses to respond timely to warning signs of<br />

critical events, EarlySense monitoring system was installed in<br />

our Oncology unit. it is a user friendly and convenient gadget<br />

which helps nurses monitor heart rate, SPO2, respiratory rate<br />

and patient movements. It has helped in reducing the number of<br />

critical events on time thus preventing code blue situations. Many<br />

doctors prefer to get their patients hooked on to the system.<br />

Early warning signs has significantly improved the outcomes.<br />

In my opinion this system enables nurses to recognize patient<br />

deteriorations faster and helps clinicians for more effective<br />

intervention.”<br />

Ms. Usha Banerjeee<br />

Group Nursing Director<br />

<strong>Apollo</strong> Hospitals<br />

18


Media Corner<br />

<strong>Apollo</strong> Research Bulletin<br />

19


Media Corner<br />

<strong>Apollo</strong> Research Bulletin<br />

20


About Us<br />

<strong>Apollo</strong> Research Bulletin<br />

<strong>Apollo</strong> Research and Innovations(ARI)<br />

<strong>Apollo</strong> Research and Innovations (ARI) is<br />

a division of <strong>Apollo</strong> Hospitals Enterprise<br />

Limited (AHEL) spearheading research,<br />

innovations and research related<br />

educational programs. The vision of ARI<br />

is to foster innovation in Technology,<br />

Therapy, Processes and Business<br />

models to achieve greater access,<br />

affordable costs and global quality<br />

standards. At <strong>Apollo</strong>, we believe in driving<br />

clinical excellence and patient benefit<br />

by incubating innovative enterprises<br />

and encouraging Research & Innovation<br />

Some of the key areas of innovations<br />

include Convergence of Healthcare with<br />

Life Sciences & Technology, Innovation in<br />

Software, Innovation in Medical devices<br />

and Innovation in Public Health.<br />

Stemcyte India Pvt. Limited<br />

Stemcyte India Private Limited is<br />

a Company incorporated in 2007,<br />

located in <strong>Apollo</strong> Hospital campus in<br />

Ahmedabad. The Company is focussed<br />

on establishing a hybrid public umbilical<br />

stem cell bank to provide umbilical cord<br />

blood units to transplant physicians<br />

around the world and a private umbilical<br />

stem cell bank to allow families in India<br />

to store them for their family’s use. The<br />

Company will also perform scientific<br />

and clinical research to increase the<br />

effectiveness, efficiency and use of<br />

umbilical cord blood (UCB) stem cells.<br />

The Company has developed and<br />

maintained highest level of infrastructure<br />

required for efficient storage of umbilical<br />

cord blood banks as per the rigorous<br />

standards of the law.<br />

Sapien Biosciences<br />

Sapien Biosciences is a joint venture<br />

between <strong>Apollo</strong> Hospitals & Saarum<br />

Innovations focusing on for novel<br />

clinical and R&D applications. Sapien’s<br />

primary objective is to build a highquality<br />

bio-repository that integrates<br />

ethically consented human samples<br />

with associated medical, pathological<br />

& diagnostic data and leverage this<br />

resource to develop & deliver high-end<br />

diagnostic applications.<br />

<strong>Apollo</strong> Hospitals Educational and<br />

Research Foundation (AHERF)<br />

<strong>Apollo</strong> Hospitals Educational and<br />

Research Foundation (AHERF) is an<br />

autonomous organization recognized<br />

by the Department of Scientific and<br />

Industrial Research (DSIR) as a “Scientific<br />

and Industrial Research Organization<br />

(SIRO)”, to carry out research,<br />

educational and training programs to<br />

further basic and translational research.<br />

We aspire to lead programs that have a<br />

bearing on the health, social, economic<br />

and indus trial needs of India<br />

ARI interfaces with the above enterprises & several collaborators<br />

whereby the project requires evaluating, validating & introducing<br />

novel Healthcare solutions to <strong>Apollo</strong><br />

21


Drivers of Innovation<br />

<strong>Apollo</strong> Research Bulletin<br />

Mr. Seemant Jauhari<br />

CEO – Research and<br />

Innovations, <strong>Apollo</strong><br />

Hospitals<br />

Mr. Seemant Jauhari is a visionary in healthcare research and innovations. He<br />

has over 14 years of experience in General Management, Strategy, Business<br />

Consulting & Innovations.<br />

His forte has been commencing new initiatives and establishing enterprises<br />

through innovative business models. He has been instrumental in architecting<br />

new collaborations in Life Sciences, Genetics, Medical Devices and Software<br />

converging multiple healthcare related interfaces. He has evaluated and<br />

proposed various innovative and actionable solutions to reduce the cost<br />

of health care and lead to improved health outcomes. Seemant represents<br />

<strong>Apollo</strong> Hospitals at various international and Indian fora.<br />

Seemant is a post graduate from the India School of Business (ISB),<br />

Hyderabad and an engineer from the Birla Institute of Technology, Mesra. He<br />

has had diverse experiences across business consulting at Ernst & Young,<br />

Strategy & transformation at Nokia Solutions Networks and IT consulting at<br />

Tata Consultancy Services.<br />

A laboratory specialist and a Researcher with experience in clinical diagnostic<br />

laboratories for 20 years, healthcare management for 5 years and clinical<br />

research for 16 years.<br />

Dr. Jayanthi Swaminathan has Masters degree in Biochemistry and Sociology<br />

with an MBA in Pharmaceutical Management and PhD in Alternate System<br />

of Medicine Research. She has to her credit, 5 years of experience as Senior<br />

Clinical Biochemist at Christian Medical College Hospital Vellore, 4 years<br />

of management experience with IIM Bangalore as Research Associate on<br />

healthcare management research projects, 2 year experience as Quality<br />

Assurance Manager for a domestic pharmaceutical firm manufacturing<br />

diagnostics and biological and 15 years of experience as Scientific Officer in<br />

laboratory services – Biochemistry Department of <strong>Apollo</strong> Hospitals Chennai.<br />

She has about 16 years of clinical research experience with the <strong>Apollo</strong> Group<br />

where she is in establishing, coordinating, conducting and managing 17<br />

clinical trial sites across the <strong>Apollo</strong> Hospitals Group with over 850 clinical<br />

trials to the credit.<br />

Dr. Jayanthi Swaminathan<br />

Sr. General Manager<br />

ARI & AHERF<br />

22<br />

14 years of site man<br />

17 operat


Scientific Advisory Team<br />

<strong>Apollo</strong> Research Bulletin<br />

Prof. Nirmal Ganguly<br />

Chairman Research Task<br />

<strong>Apollo</strong> Hospitals<br />

Prof. Nirmal Ganguly is a distinguished Biotechnology Research Professor,<br />

Department of Biotechnology. He is former Director General, ICMR and<br />

Governing Body Member of 27 Indian institutes and Public Health Foundation<br />

of India<br />

Prof. Ganguly is MBBS, MD, DSc (hc), and Fellow of all the Indian Science<br />

Academies; the Imperial College Faculty of Medicine, London and several other<br />

prestigious institutions. Prof. Ganguly has published more than 775 research<br />

papers and has supervised 130 Ph.D theses. His interest encompasses the<br />

disciplines of Immunology, Biotechnology and Public Health. Dr. Ganguly is<br />

recipient of 7 International and 112 National Awards. He has been honored<br />

with the prestigious Padma Bhushan Award on 26th January, 2008 in the field<br />

of “Medicine”.<br />

Dr. Sita Naik, is an eminent Clinical Immunologist and a medical educationist,<br />

with an undergraduate training at Maulana Azad Medical College, New Delhi<br />

and post-graduate training in Pathology at Postgraduate Institute of Medical<br />

Education and Research (PGIMER), Chandigarh. She had post-doctoral<br />

training in Transplantation Immunology at the National Institutes of Health,<br />

USA.<br />

She has served on many committees of the Indian Medical Research Council,<br />

Department of Biotechnology and Department of Science and Technology.<br />

Her area of research has been immunology of infectious diseases and<br />

autoimmunity. She has published 145 peer reviewed research papers and<br />

contributed 36 book chapters. In recognition of her contribution she has<br />

been elected Fellow of National Academy of Medical Sciences.<br />

Dr Sita Naik<br />

Scientific Advisor<br />

AHERF<br />

agement experience<br />

ional sites<br />

23


Innovation Doodles<br />

<strong>Apollo</strong> Research Bulletin<br />

We aspire to create an idea repository which could be leveraged to trigger clinical<br />

innovations at <strong>Apollo</strong>. So if you have an idea please do contact us stating your name,<br />

contact details, idea concept, problem and solution. Based on the information provided,<br />

we will leverage on our in-house expertise and industry links to translate your idea to<br />

reality through collaborations and creative business models.<br />

You never know, your idea could make a fundamental<br />

difference for the benefit of humanity!<br />

24<br />

<strong>Apollo</strong><br />

Research and<br />

Innovations ( ARI)<br />

Contact Us:<br />

TEAM ARI<br />

T: +91 44 28295465 | Email: jayanthi.s@aherf.net<br />

Visit us at: www.aherf.org / www.apolloari.com

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