ER ER ER ER - Endocrine Reviews

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Figure 2 Tam E2 GPCR GP E2 PLC-PKC -PKA N Tam ER CoA ER Cav GP P P c-Src MNAR HB-EGF MMPs Transcription P ER MAPK / AKT P CoA Transcription TF EGFR/HER2 Phosphorylation signals to the nucleus potentiate the activity of genomic ER and other TFs on gene regulation GF Cav ER Shc ER Cav ER IGFR ER MTA1s E2 M Tam TUMOR PROLIFERATION ENDOCRINE RESISTANCE
Figure 3 ER+PR+ ER+PR-
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Endocrine Reviews. First published
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Introduction Breast cancer evolutio
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endocrine therapy, might lead to th
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(also known as estrogen response el
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weaken the inhibitory effects of va
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that it is the E domain at the C-te
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independent or tamoxifen-mediated a
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(Iressa), which can block signaling
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that HER2-positive breast cancer is
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cases that received letrozole had a
Page 21 and 22: preclinical model (102). Furthermor
Page 23 and 24: suppressed/reduced PgR levels may d
Page 25 and 26: PgR-negative tumors have more aggre
Page 27 and 28: consequence of reversing ER-induced
Page 29 and 30: gefitinib combined with estrogen de
Page 31 and 32: performed in one of these trials, c
Page 33 and 34: advanced breast cancer have recentl
Page 35 and 36: act alone to stimulate tumor growth
Page 37 and 38: Table 2. Selected recent ongoing an
Page 39 and 40: estrogen receptor (MNAR), can activ
Page 41 and 42: REFERENCES 1. Group EBCTC 1998 Tamo
Page 43 and 44: 13. De Laurentiis M, Arpino G, Mass
Page 45 and 46: 27. Klinge CM 2001 Estrogen recepto
Page 47 and 48: 42. Schiff R, Massarweh S, Shou J,
Page 49 and 50: antiestrogen-dependent membrane-ini
Page 51 and 52: 70. Pedram A, Razandi M, Aitkenhead
Page 53 and 54: 84. Bunone G, Briand PA, Miksicek R
Page 55 and 56: antihormone response and prevents d
Page 57 and 58: 110. Berry DA, Muss HB, Thor AD, Dr
Page 59 and 60: of hormonal status and HER-2 in bre
Page 61 and 62: 134. Daniel AR, Qiu M, Faivre EJ, O
Page 63 and 64: 146. Baehner FL Quantitative RT-PCR
Page 65 and 66: 158. Massarweh S, Shou J, DiPietro
Page 67 and 68: 169. Polychronis A, Sinnett HD, Had
Page 69 and 70: Antonio Breast Cancer Symposium (ab
Page 71: Figure 1 B Non-Classical Nuclear Ac
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