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Figure 2<br />
Tam<br />
E2<br />
GPCR<br />
GP<br />
E2<br />
PLC-PKC<br />
-PKA<br />
N<br />
Tam<br />
<strong>ER</strong><br />
CoA<br />
<strong>ER</strong><br />
Cav<br />
GP<br />
P<br />
P<br />
c-Src<br />
MNAR<br />
HB-EGF<br />
MMPs<br />
Transcription<br />
P<br />
<strong>ER</strong><br />
MAPK / AKT<br />
P<br />
CoA Transcription<br />
TF<br />
EGFR/H<strong>ER</strong>2<br />
Phosphorylation signals<br />
to the nucleus potentiate the<br />
activity of genomic <strong>ER</strong> and other<br />
TFs on gene regulation<br />
GF<br />
Cav<br />
<strong>ER</strong><br />
Shc<br />
<strong>ER</strong><br />
Cav<br />
<strong>ER</strong><br />
IGFR<br />
<strong>ER</strong><br />
MTA1s<br />
E2<br />
M<br />
Tam<br />
TUMOR PROLIF<strong>ER</strong>ATION<br />
ENDOCRINE RESISTANCE
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