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169. Polychronis A, Sinnett HD, Hadjiminas D, Singhal H, Mansi JL,<br />

Shivapatham D, Shousha S, Jiang J, Peston D, Barrett N, Vigushin D,<br />

Morrison K, Beresford E, Ali S, Slade MJ, Coombes RC 2005 Preoperative<br />

gefitinib versus gefitinib and anastrozole in postmenopausal patients with<br />

oestrogen-receptor positive and epidermal-growth-factor-receptor-positive<br />

primary breast cancer: a double-blind placebo-controlled phase II randomised<br />

trial. Lancet Oncol 6:383-91<br />

170. Winer E, Cobleigh MA, Dickler M, Miller K, Fehrenbacher L, Jones C,<br />

Justice R 2002 Phase II multicenter study to evaluate the efficacy and safety of<br />

Tarceva (erlotinib, OSI-774) in women with previously treated locally advanced<br />

or metastatic breast cancer. Breast Can. Res. Treat. 76:A445<br />

171. Rusnak DW, Lackey K, Affleck K, Wood <strong>ER</strong>, Alligood KJ, Rhodes N, Keith<br />

BR, Murray DM, Knight WB, Mullin RJ, Gilmer TM 2001 The effects of the<br />

novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase<br />

inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines<br />

in vitro and in vivo. Mol Cancer Ther 1:85-94<br />

172. Spector NL, Xia W, Burris H, 3rd, Hurwitz H, Dees EC, Dowlati A, O'Neil B,<br />

Overmoyer B, Marcom PK, Blackwell KL, Smith DA, Koch KM, Stead A,<br />

Mangum S, Ellis MJ, Liu L, Man AK, Bremer TM, Harris J, Bacus S 2005<br />

Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and<br />

ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with<br />

advanced malignancies. J Clin Oncol 23:2502-12<br />

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