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significant effect on DFS, although there was a suggestion of a trend in H<strong>ER</strong>2-positive<br />
tumors. In contrast, among patients whose tumors were <strong>ER</strong>+/PR–, both EGFR and H<strong>ER</strong>2<br />
expression were associated with significantly poorer DFS (for H<strong>ER</strong>-1, HR = 2.4, 95%<br />
CI= 1.0 to 5.4, P=.04; and for H<strong>ER</strong>2, HR = 2.6, 95% CI = 1.1 to 6.0, P=.03.<br />
Adapted with permission of Oxford University Press form Arpino et al. (147).<br />
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