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Guide to living well with<br />

I “ took<br />

control of<br />

<strong>my</strong> <strong>Chronic</strong><br />

<strong>Migraine</strong>!<strong>”</strong><br />

Former CNN journalist<br />

Yasmina Ykelenstam<br />

persevered until she found<br />

her path to relief<br />

Don’t put<br />

up with<br />

migraines—<br />

prevent<br />

them!<br />

37 ways<br />

to take<br />

charge!<br />

£ ID your triggers<br />

£ Tune into<br />

symptoms ASAP<br />

£ Treat promptly<br />

£ Be prepared


Guide to living well with<br />

<strong>Migraine</strong><br />

headaches<br />

Good communication with<br />

her care team was key for<br />

Kate McCombs to conquer<br />

her migraines.<br />

10<br />

18<br />

“It worked! I was so happy!<strong>”</strong><br />

says ex-CNN journalist<br />

Yasmina Ykelenstam of a<br />

treatment that helps prevent<br />

her <strong>Chronic</strong> <strong>Migraine</strong>.<br />

New hope<br />

3 Live your best life—<br />

even with migraine!<br />

Why your chances of getting rid of<br />

migraine pain are better than ever<br />

The basics<br />

4 What’s causing your head pain?<br />

Learn the different types of headache<br />

5 The four stages of migraine<br />

6 Steer clear of your triggers<br />

You & your care team<br />

7 Your weekly journal<br />

Track your symptoms to learn your triggers<br />

8 Your healthcare team<br />

9 How medications can help<br />

Real inspiration<br />

10 “I’m conquering <strong>Chronic</strong> <strong>Migraine</strong>!<strong>”</strong><br />

Former CNN journalist Yasmina Ykelenstam<br />

refused to stop looking for a solution to<br />

near constant distress<br />

16 <strong>”</strong>What I’ve learned about migraine<strong>”</strong><br />

Celebs share how they stop the pain<br />

18 “How I took control...<strong>”</strong><br />

How migraine sufferers make every day easier<br />

Feel your best<br />

21 Q&A<br />

Your questions answered by a migraine expert<br />

22 <strong>Migraine</strong>-proof your home<br />

Make your home a safe zone!<br />

24 Questions for your next exam<br />

24 Resources you need now<br />

>> Find these articles and more at<br />

HealthMonitor.com/<strong>Migraine</strong><br />

Reviewed by<br />

Health Monitor’s<br />

migraine experts:<br />

Roger K. Cady, MD—<br />

founder and medical director<br />

of the Headache Care Center in<br />

Springfield, MO. He is the<br />

Associate Executive Chairman of the<br />

National Headache Foundation.<br />

Stephen D. Silberstein, MD—<br />

professor of neurology and director<br />

of the Jefferson Headache Center<br />

at Thomas Jefferson University in<br />

Philadelphia. He is a Fellow of the<br />

American Headache Society and the<br />

American Acade<strong>my</strong> of Neurology.<br />

Editor-in-Chief, Maria Lissandrello<br />

Project Editor, Lindsay Bosslett<br />

Creative Director, John Angelini<br />

Art Director, Jennifer Webber<br />

Production and Project<br />

Management Director,<br />

Kimberly H. Vivas<br />

Account Executive,<br />

Christina Nelson<br />

Alliances and Partnerships<br />

Director, Marc Jensen<br />

Vice President, Human Resources<br />

and Customer Service,<br />

Renee Mormando<br />

Chief Financial Officer,<br />

Ding Yu<br />

Senior Vice President,<br />

Dave Dolton<br />

Senior Vice President,<br />

New Products, Technology<br />

and Strategy, Alex Dong<br />

President, Kenneth Freirich<br />

Chief Executive Officer,<br />

Eric Jensen<br />

Health Monitor Network is the nation’s leading<br />

multimedia patient-education company, with<br />

publications, websites and mobile apps. For more<br />

information, contact: Health Monitor Network,<br />

135 Chestnut Ridge Road, 2nd Floor, Montvale,<br />

NJ 07645; 201-391-1911; customerservice@<br />

healthmonitor.com; www.healthmonitor.com<br />

©2015 Data Centrum Communications, Inc.<br />

This publication is not intended to provide<br />

advice on personal medical matters or to<br />

substitute for consultation with a physician.<br />

The NHF aims to raise awareness<br />

of headache; support research; and<br />

educate the public about it.<br />

The AHMA<br />

exists to E.A.S.E.<br />

the burden of<br />

<strong>Migraine</strong> and other<br />

Headache Disorders through Education,<br />

Awareness, Support and Engagement.<br />

The editorial content of this publication has been<br />

reviewed for accuracy by the National Headache<br />

Foundation (NHF) and the American Headache &<br />

<strong>Migraine</strong> Association (AHMA). This review does<br />

not constitute an endorsement or expression of<br />

opinion by NHF, AHMA or the reviewing healthcare<br />

provider(s) regarding any advertised product or<br />

service or point of view mentioned or advertised.<br />

t<br />

hese days, Patrice R.<br />

Valentine spends time<br />

having fun with friends<br />

and pursues her passions,<br />

including launching a new business.<br />

But it wasn’t always like that. “At<br />

<strong>my</strong> worst, I would have a migraine<br />

that would last for days. Often,<br />

I’d get them two or three times a<br />

month. It was keeping me from<br />

doing <strong>my</strong> job and living <strong>my</strong><br />

life.<strong>”</strong> How did she find relief? “I<br />

refused to give up!<strong>”</strong> she says. “My<br />

doctor and I tried everything, and<br />

finally a treatment came out that<br />

made all the difference.<strong>”</strong> Patrice<br />

even experienced a silver lining:<br />

“By tracking <strong>my</strong> symptoms I also<br />

learned that stress was a trigger for<br />

me—so I quit <strong>my</strong> job to pursue <strong>my</strong><br />

own business. <strong>Migraine</strong>s actually<br />

changed <strong>my</strong> life for the better!<strong>”</strong><br />

Focus on prevention<br />

With today’s treatments, days spent<br />

lying down in dark rooms may be a<br />

thing of the past. Whether you suffer<br />

from episodic migraines (the kind<br />

that occur on fewer than 15 days per<br />

month) or <strong>Chronic</strong> <strong>Migraine</strong> (which<br />

strikes on 15 or more days per month<br />

for at least three months), partnering<br />

with your healthcare team like Patrice<br />

did is key. It’s the best way to take<br />

advantage of the latest learning.<br />

For example, the newest emphasis<br />

is on preventing migraines. In fact the<br />

American Acade<strong>my</strong> of Neurology<br />

has identified nearly a dozen effective<br />

medications that can help do just that.<br />

What’s more, nearly 40% of<br />

patients could benefit from such<br />

preventive therapies, says Stephen D.<br />

Silberstein, MD, professor of<br />

neurology and director of the<br />

Jefferson Headache Center at Thomas<br />

Jefferson University in Philadelphia.<br />

Experts also have a deeper understanding<br />

of what triggers migraines<br />

and how to find faster relief. A pivotal<br />

finding: Treating a migraine quickly<br />

helps the medication work better.<br />

What you can do<br />

If you’re one of the nearly 30<br />

million Americans who suffer from<br />

migraine, it’s time to take a stand.<br />

Start by learning about your<br />

headaches—what type you have<br />

and what triggers them—and<br />

new hope<br />

Live your best life—<br />

even with migraines!<br />

exploring all your treatment<br />

options. That’s where this guide<br />

comes in handy. Get comfortable in<br />

your favorite armchair and read on.<br />

You’ll get tips and real-life<br />

inspiration, which will help you<br />

turn the tables on migraine, just<br />

like Patrice. “I definitely encourage<br />

people to work closely with their<br />

doctors,<strong>”</strong> she says. “You never<br />

know what options might be out<br />

there—or what might be causing<br />

your migraines without your realizing<br />

it. You don’t have to just accept<br />

the pain and discomfort as a part<br />

of your life—get out there and do<br />

something about it!<strong>”</strong><br />

HealthMonitor 3


the basiCS<br />

What’s causing<br />

your headache?<br />

The<br />

the basiCS<br />

4 stages of migraine<br />

If you have migraines you’re familiar with the pain, the nausea and the vomiting. But that<br />

describes only the headache stage of migraine. There are three others, and tuning into them<br />

can help you get more effective treatment. Consider: Treating at the very first sign can help<br />

stave off a full-blown migraine or limit your symptoms. To learn more, read on.<br />

ot really sure? You’re<br />

not alone. Many people<br />

mistake migraines for<br />

sinus infections; it’s easy to confuse<br />

tension and cluster headaches;<br />

and you may not realize there’s a<br />

difference between episodic and<br />

<strong>Chronic</strong> <strong>Migraine</strong>. Yet it’s important<br />

to get to the bottom of your head<br />

pain. That’s because identifying the<br />

type of headache you have can help<br />

your healthcare provider pinpoint<br />

the best treatment for you. To find<br />

out exactly what’s ailing you, read on.<br />

Tension-type: The most<br />

common headache, tension-type<br />

headaches usually cause only mild<br />

to moderate pain. The discomfort<br />

typically begins in the forehead,<br />

temples or the back of your head<br />

or neck. It creates a band-like<br />

sensation around your head, or<br />

a feeling of pressure in head and<br />

neck muscles. The headaches<br />

often occur after feeling stressed,<br />

anxious, fatigued or angry.<br />

Sinus: A study found that 86%<br />

of people who thought they were<br />

having a sinus headache were<br />

actually suffering a migraine—so it’s<br />

important to know the difference.<br />

Sinus headaches typically cause<br />

throbbing pain and a feeling of<br />

pressure around your eyes, cheeks<br />

and forehead. The pain will usually<br />

worsen if you bend or lie down.<br />

They develop when your sinuses<br />

become swollen, usually due to<br />

4 HealthMonitor<br />

<strong>Migraine</strong> or chronic migraine?<br />

<strong>Migraine</strong>: <strong>Migraine</strong> often<br />

begins as a dull ache that develops<br />

into a throbbing and pulsating pain,<br />

often near the temples, as well as the<br />

front or back of one or both sides of<br />

the head. The pain is often accompanied<br />

by nausea, vomiting, and/or<br />

sensitivity to light and noise. Some<br />

may see “aura<strong>”</strong> (see page 5 to learn<br />

more) before the headache strikes.<br />

<strong>Migraine</strong> checklist<br />

Many of the symptoms of a<br />

migraine are unique to that type of<br />

headache. If you’re experiencing<br />

at least two of the symptoms at<br />

right—either before or during your<br />

headache—let your healthcare<br />

provider know.<br />

allergies or a sinus infection. Your<br />

sinuses will often be blocked, so<br />

you may not be able to breathe well<br />

through your nose, and your sense of<br />

taste or smell may be diminished. If<br />

the cause is an infection, you’ll likely<br />

have a low fever, and may have green<br />

or yellow nasal discharge, a sore<br />

throat, soreness in your jaw or teeth,<br />

a cough, and/or fatigue.<br />

Rebound: This type of<br />

headache occurs if you take acute<br />

pain relievers too often (twice a week<br />

or more for several weeks) or use<br />

more than the recommended dosage.<br />

Typically, as soon as the medication<br />

<strong>Chronic</strong> <strong>Migraine</strong>:<br />

With <strong>Chronic</strong> <strong>Migraine</strong>, you can feel<br />

as though you’re never free from your<br />

headaches at all, and while pain medications<br />

may lessen your symptoms,<br />

they never go away completely. Your<br />

care team may diagnose you with<br />

<strong>Chronic</strong> <strong>Migraine</strong> if you have 15 or<br />

more migraine days a month, each<br />

episode lasting four hours or more.<br />

◦ Blurred vision<br />

◦ Dizziness<br />

◦ Fatigue/<br />

sleepiness<br />

◦ Nausea<br />

◦ Sensitivity to<br />

light<br />

◦ Sensitivity to<br />

sound<br />

◦ Vomiting<br />

◦ Lightheadedness/<br />

feeling faint<br />

◦ Sweating or<br />

cold hands<br />

◦ Diarrhea<br />

◦ Other:<br />

____________<br />

wears off, the headache comes back.<br />

You may also experience neck pain,<br />

irritability, difficulty concentrating and<br />

depression.<br />

Cluster: Cluster headaches come<br />

in groups and typically strike without<br />

warning. The head pain, which is<br />

severe, often occurs on only one side of<br />

the head, and may cause the eye to tear<br />

and turn bloodshot, and your nose to<br />

run on the same side. They often begin<br />

in the middle of the night and may last<br />

for weeks or months. Their cause is<br />

not completely known, but researchers<br />

believe they may be the result of a<br />

chemical reaction in the brain.<br />

1 Prodromal (early warning)<br />

• When it happens: Several hours to up to two days<br />

in advance.<br />

• Frequency: About 60% of those with migraines will<br />

experience this phase.<br />

• Possible symptoms: Anxiety, unexplained energy or<br />

feelings of euphoria, irritability, difficulty concentrating,<br />

food cravings, sensitivity to smells or noise, fatigue<br />

with frequent yawning<br />

• What to do: Take the pain reliever your doctor<br />

recommended or prescribed. Doing so right now can<br />

help you avoid a full-on migraine. This is also a good<br />

time to think about possible triggers—for example,<br />

ask yourself what you’ve eaten or had to drink, how<br />

stressed you are and how much sleep you’ve had.<br />

2<br />

Aura phase<br />

(pre-migraine)<br />

• When it happens: About an hour before to right<br />

when the headache strikes.<br />

• Frequency: About 20% of those with migraines<br />

experience this phase, but not necessarily every time.<br />

• Possible symptoms: Changes in vision, such as<br />

flickering, shimmering or flashing lights, tunnel vision,<br />

difficulty focusing, spots of vision loss or zigzag lines<br />

that cross your line of sight; skin sensations, such as<br />

numbness in your extremities or feelings of tingling or<br />

“pins and needles<strong>”</strong> in the face or hands; trouble speaking,<br />

writing or understanding words; muscle weakness<br />

• What to do: Immediately take a pain reliever or the<br />

medication you’ve been prescribed for your migraine.<br />

Make sure you have your migraine tool kit (see page<br />

23) handy and avoid any triggers.<br />

4<br />

3<br />

1<br />

2<br />

Phases of a migraine<br />

1. Prodromal: 24-48 hours<br />

2. Aura phase: 1 hour<br />

3. Headache phase: 4-72 hours<br />

4. Postdromal: 24-48 hours<br />

3<br />

4<br />

Headache phase (during migraine)<br />

• When it happens: This is when the actual headache<br />

strikes; it can last for hours up to several days.<br />

• Frequency: 100% if the migraine is untreated.<br />

• Possible symptoms: Throbbing or pulsing<br />

pain ranging from mild to severe, often on one side<br />

but sometimes both sides of the head; sensitivity<br />

to light, sounds and sometimes smells; nausea<br />

and vomiting; blurred vision; light-headedness<br />

and/or fainting<br />

• What to do: Immediately take a pain reliever or<br />

medication you’ve been prescribed for your migraine.<br />

Relax in a cool, dark, quiet setting.<br />

Postdromal<br />

(after headache)<br />

• When it happens: After the attack phase has subsided,<br />

and lasting for a few hours up to two days.<br />

• Frequency: Most people who experience the attack<br />

phase will experience some form of postdromal phase.<br />

• Possible symptoms: Extreme fatigue,<br />

sluggishness, confusion, irritability, head pain if<br />

you move too quickly or bend over<br />

• What to do: If you’ve been taking acute pain relievers,<br />

start to cut back so you avoid a rebound headache. Continue<br />

to rest and avoid stress or other common triggers.<br />

HealthMonitor 5


the basiCS<br />

you & your care team<br />

Steer clear of<br />

your triggers!<br />

one of the best ways to rein in<br />

your migraines? Avoid<br />

having them in the first<br />

place! One strategy: Zeroing in<br />

on—and avoiding—your triggers,<br />

the culprits that spark the chemical<br />

reactions resulting in migraine. The<br />

thing is, triggers are different for<br />

everyone, and sometimes a combination<br />

is to blame. To learn what sets<br />

off your migraines, see the list below,<br />

and use the journal on the next page<br />

to track your migraines.<br />

Food/food additives.<br />

While food triggers tend to be<br />

unique for each individual, there are<br />

some that are more common. Here<br />

are some of the more likely ones,<br />

according to the National Headache<br />

Foundation and American<br />

Headache Society:<br />

• Aged cheeses (such as blue cheese<br />

and Cheddar)<br />

• Processed meats with nitrates or<br />

nitrites (such as bacon and hot dogs)<br />

• Monosodium glutamate (MSG)<br />

(often found in soy sauce, meat<br />

tenderizers and seasoned salts)<br />

• Artificial sweeteners<br />

• Alcohol (particularly red wine)<br />

• Coffee, tea and other sources<br />

of caffeine<br />

Eyestrain. Particularly from<br />

staring too long at a computer screen,<br />

or attempting to read too-small text or<br />

reading in low light.<br />

Dehydration. Thirst can spark a<br />

migraine; stay hydrated by drinking<br />

plenty of water throughout the day.<br />

Odors. Perfume and/or certain<br />

scented cleaning products can<br />

trigger a headache.<br />

Food temperature. Very hot<br />

(such as hot soup or coffee) and very<br />

cold (such as ice cream) foods can<br />

trigger a migraine in some.<br />

Skipping a meal. <strong>Migraine</strong><br />

sufferers’ bodies crave predictability.<br />

Glare. Nearly 90% of migraine<br />

sufferers are sensitive to light. In<br />

a study in Nature Neuroscience,<br />

researchers found a pathway in the<br />

brain that links the visual system to<br />

that which produces head pain.<br />

Changes in your routine.<br />

<strong>Migraine</strong> sufferers are sensitive to<br />

schedule changes, such as sleeping<br />

too much or too little.<br />

Hormone changes. Sixty<br />

percent of women who suffer<br />

from migraines do so when<br />

estrogen levels drop (such as<br />

before menstruation).<br />

Stress. Everyday hassles like<br />

running late for an appointment<br />

or working long hours to meet a<br />

deadline can cause nerve irritation<br />

and inflammation. Experiencing<br />

“letdown<strong>”</strong> after stress can have the<br />

same effect. “[The migraine] doesn’t<br />

happen when you finish your<br />

deadline, but it can happen the next<br />

day,<strong>”</strong> says Stephen D. Silberstein,<br />

MD, professor of neurology and<br />

director of the Jefferson Headache<br />

Center at Thomas Jefferson<br />

University in Philadelphia.<br />

Intense exercise. It sparks<br />

the release of nitric oxide—a<br />

chemical that can cause nerve<br />

irritation—into the bloodstream.<br />

Cigarette smoke. It can<br />

cause nerve irritation.<br />

A change in<br />

temperature.<br />

Going from either<br />

warm air to cold (such<br />

as being out on a warm<br />

summer day and going<br />

into an air conditioned<br />

room) or vice versa, can<br />

spark a migraine.<br />

A change in<br />

pressure. Changes in barometric<br />

pressure can alter your body’s<br />

chemical balance.<br />

Use this diary to pinpoint your<br />

triggers—and find out how well<br />

your treatments are working.<br />

Your weekly migraine journal<br />

SUNDAY MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY SATURDAY<br />

DATES<br />

What I ate before<br />

<strong>my</strong> headache<br />

How much I slept the<br />

night before<br />

What activities I did that day<br />

What the weather was like<br />

(include temperature, humidity<br />

and barometric pressure)<br />

Rate the severity of your pain<br />

(0 = no pain, 10 = severe pain)<br />

Describe the type of pain<br />

(throbbing, band-like) and its<br />

location (in the temples, etc.)<br />

Note any other symptoms<br />

(nausea, aura, etc.)<br />

Treatments (and doses)<br />

Note how long it took<br />

for you to get relief<br />

6 Guide to Living Well with <strong>Migraine</strong> Headaches<br />

HealthMonitor 7


you & your care team<br />

Your healthcare team<br />

As challenging as it may be to battle migraine, remember that you’re not alone. There’s a<br />

whole team of healthcare providers in your corner. Here is a look at the experts who can<br />

help you develop the best strategy for overcoming your pain:<br />

• A neurologist specializes in<br />

disorders of the brain and nervous<br />

system. Look for one who is boardcertified<br />

in pain or headache medicine.<br />

• A board-certified internist<br />

or family physician with a<br />

background in pain management<br />

and/or headache medicine can<br />

diagnose and treat migraine.<br />

• A physical therapist can teach<br />

exercises to reduce neck tension, which<br />

is common among migraine patients.<br />

He or she may also teach or recommend<br />

other physical activities, such as yoga,<br />

that have been proven to ease symptoms.<br />

We can change<br />

the course of<br />

We can change<br />

this the disorder course of<br />

this disorder<br />

so little can do so much<br />

so little can do so much<br />

• A nurse practitioner (NP)<br />

or physician assistant (PA)<br />

can diagnose and treat migraine.<br />

• A psychologist or<br />

neuropsychologist can help<br />

you learn to better manage stress,<br />

which often triggers migraine,<br />

and can teach you biofeedback<br />

methods. A psychologist can also<br />

help you cope with depression<br />

and/or anxiety.<br />

• A sleep disorder specialist<br />

can diagnose sleeping conditions,<br />

such as sleep apnea, that may be<br />

contributing to your migraines.<br />

After 7,000 years of enduring and searching for relief from migraine, there’s still<br />

no cure. Still worse, for the 3rd most common disorder on the planet and the 4th<br />

most disabling among women worldwide, we’ve had only one class of medication<br />

developed and approved for the treatment of migraine over the last half-century!<br />

While we know more today than ever before about the brain chemistry and circuits<br />

involved, we are still far from safer and more effective treatments.<br />

Yet we have the brain trust – so many talented doctors and scientists across the United<br />

After States 7,000 and years around of enduring the world and searching – who know for relief the path from migraine, forward and there’s know still how to get this<br />

no done. cure. Still What’s worse, missing for the 3rd is enough most common money disorder to do the on the job. planet and the 4th<br />

most disabling among women worldwide, we’ve had only one class of medication<br />

developed and approved for the treatment of migraine over the last half-century!<br />

As a nation, we allocate a pittance to migraine research – less than 1/20th of 1% of<br />

While we know more today than ever before about the brain chemistry and circuits<br />

involved, the budget we are still of the far from National safer and Institutes more effective of Health treatments. – or about $16 million a year. Given<br />

the prevalence and magnitude of migraine, $260 million would be right. Industry and<br />

Yet the we have voluntary the brain sector trust – simply so many cannot talented make doctors up and the scientists difference. across the The United task before us now<br />

States needs and a around kick-start! the world – who know the path forward and know how to get this<br />

done. What’s missing is enough money to do the job.<br />

As a That’s nation, why we the allocate American a pittance <strong>Migraine</strong> to migraine Foundation research and – less Mrs. than Cindy 1/20th McCain of 1% of are partnering<br />

the in budget 2013 of to the launch National the Institutes 36 of MILLION Health – or MIGRAINE about $16 million CAMPAIGN, a year. Given a national public<br />

the mobilization prevalence and and magnitude education of migraine, campaign $260 to million increase would our be right. nation’s Industry research and investment in<br />

the migraine voluntary sector and raise simply public cannot visibility make up for the this difference. enormously The task disabling before us disorder now that affects<br />

needs<br />

more<br />

a kick-start!<br />

than 36 million Americans.<br />

That’s why the American <strong>Migraine</strong> Foundation and Mrs. Cindy McCain are partnering<br />

in 2013 to launch the 36 MILLION MIGRAINE CAMPAIGN, a national public<br />

mobilization and education campaign to increase our nation’s research investment in<br />

migraine and raise public visibility for this enormously disabling disorder that affects<br />

more than 36 million Americans.<br />

Join us and make the difference<br />

us and make the difference<br />

Join us and make the difference<br />

To learn more, visit us at www.American<strong>Migraine</strong>Foundation.org<br />

How medications<br />

can help<br />

Great news: Your chances of getting life-changing<br />

relief from migraines are better than ever, thanks to<br />

a growing number of treatment options, including<br />

proven ways to prevent migraines, according to the latest<br />

guidelines from the American Acade<strong>my</strong> of Neurology.<br />

preventive<br />

acute<br />

Preventive therapies calm your hypersensitive nervous<br />

system so you experience fewer flare-ups. When<br />

a migraine does occur, it is usually less intense. Of<br />

course, during an episode, you can still turn to acute<br />

medications to help ease the pain quickly. Ask your<br />

healthcare provider about the medications in the chart<br />

below to find the right approach for you.<br />

Medication How it is given How it works<br />

Antiepileptic (divalproex sodium,<br />

sodium valproate, topiramate)<br />

Antidepressant<br />

(amitriptyline, venlafaxine)<br />

Beta-blocker<br />

(metoprolol, propranolol, timolol)<br />

Nonsteroidal anti-inflammatory<br />

drug (NSAID) (fenoprofen,<br />

ibuprofen, ketoprofen, naproxen)<br />

Onabotulinum toxin A<br />

(a purified organic product;<br />

for <strong>Chronic</strong> <strong>Migraine</strong> only)<br />

Triptan<br />

(frovatriptan for short-term<br />

prevention of menstrual migraines)<br />

Antinausea (metoclopramide,<br />

prochlorperazine)<br />

Dihydroergotamine<br />

(DHE)<br />

Nonsteroidal anti-inflammatory<br />

drug (NSAID) (acetaminophen,<br />

diclofenac, ibuprofen, naproxen)<br />

Triptan/NSAID combination<br />

(sumatriptan and naproxen sodium)<br />

Triptan (almotriptan, frovatriptan,<br />

naratriptan, sumatriptan)<br />

Pill or syrup<br />

Pill<br />

Pill or injection<br />

Pill, oral solution,<br />

injection<br />

Injection<br />

(in a few locations)<br />

Injection, nasal spray,<br />

pill<br />

Pill, liquid,<br />

suppository<br />

Injection or nasal spray<br />

Pill, oral solution,<br />

injection<br />

Pill<br />

Injection, nasal spray, pill<br />

Stabilizes nerve cells in the brain, making<br />

them less easily activated<br />

Boosts levels of the brain chemical serotonin,<br />

which helps calm the nervous system<br />

Blocks the release of stress hormones like adrenaline<br />

and epinephrine, which can trigger migraines<br />

Relieves inflammation and pain. These<br />

medications are often prescribed on a short-term<br />

basis to women with menstrual migraines and<br />

patients who are suffering from other types of<br />

pain, such as back and/or neck<br />

Quiets hyperactive nerve cells; blocks muscle<br />

contractions in the head, neck and face; and blocks<br />

the release of inflammatory chemicals associated<br />

with migraine pain<br />

Prevents nerves on the surface of the brain<br />

from transmitting pain signals, reduces<br />

inflammation and shrinks swollen blood vessels<br />

Relieves nausea and migraine pain<br />

Blocks pain, reduces inflammation and<br />

shrinks swollen blood vessels<br />

Relieves inflammation and pain<br />

you & your care team<br />

Relieves inflammation, blocks pain and shrinks<br />

swollen blood vessels<br />

Prevents nerves on the surface of the brain<br />

from transmitting pain signals, reduces<br />

inflammation and shrinks swollen blood vessels<br />

HealthMonitor 9


eal inspiration<br />

“I’m conquering<br />

<strong>Chronic</strong> <strong>Migraine</strong>!<strong>”</strong><br />

When faced with a seemingly insurmountable problem—say,<br />

managing <strong>Chronic</strong> <strong>Migraine</strong> in the middle of a war zone—<br />

former CNN journalist Yasmina Ykelenstam knows she has<br />

what it takes to prevail. by Lindsay Bosslett<br />

there is no ‘can’t’ in <strong>my</strong><br />

vocabulary,<strong>”</strong> says Yasmina<br />

Ykelenstam, currently<br />

Yasmina covering a<br />

on one of her nowfrequent<br />

lengthy trips abroad. “Be it<br />

story in downtown<br />

Beirut in 2008.<br />

chartering private helicopters to airlift<br />

equipment, bribing ship captains to<br />

stow us away or finagling team visas to Libya on two<br />

hours’ notice during the Gaddafi years—I’ve done it all.<strong>”</strong><br />

However, her can-do attitude doesn’t mean finding<br />

her path to migraine relief was easy.<br />

“When they were at their worst I found <strong>my</strong>self<br />

banging <strong>my</strong> head against a wall to try and alleviate<br />

the incredible pain,<strong>”</strong> she remembers.<br />

“I explored all <strong>my</strong> options<strong>”</strong><br />

Yasmina was first diagnosed with migraines by “Dr.<br />

Mom,<strong>”</strong> and a headache specialist confirmed it. Then<br />

began the journey to find relief.<br />

“I have tried every migraine medication on the<br />

market: prescription NSAIDs, acetaminophen,<br />

triptans, biofeedback therapy, homeopathic remedies,<br />

meditation, stress reduction, physiotherapy—you<br />

name it.<strong>”</strong> Some would work only for a short time,<br />

some had terrible side effects and none could seem to<br />

really slow down the migraine onslaught.<br />

“The migraines progressed over time. They were<br />

daily at times, or lasted for weeks, in some cases<br />

months,<strong>”</strong> she says. “Eventually <strong>my</strong> doctor told me I didn’t<br />

just have migraines—I had <strong>Chronic</strong> <strong>Migraine</strong> [defined<br />

by 15 or more migraine days a month, each lasting four<br />

hours or more]. You truly haven’t experienced hell until<br />

you’ve had a migraine last for six months. It felt like I<br />

was never not in pain.<strong>”</strong><br />

The migraines became so bad, eventually Yasmina<br />

was afraid to leave her house—let alone travel the<br />

globe to cover news stories. “I was scared in case I<br />

began a migraine and wasn’t able to make it home to<br />

somewhere dark,<strong>”</strong> she says. “And there’s little worse in<br />

life than bouncing around in a Humvee or a military<br />

helicopter while flying though hostile territory in war<br />

zones in that kind of condition.<strong>”</strong><br />

“My answer was out there!<strong>”</strong><br />

Yasmina eventually left her job at CNN to concentrate<br />

on her health. After finding a headache specialist she<br />

could really connect with, she told him how many<br />

treatments she had tried and failed to find relief with. He<br />

convinced her to try an injectable medication that would<br />

prevent her head pain. “It worked! I was so happy,<strong>”</strong> she<br />

says. But as a journalist, Yasmina still felt she needed to<br />

investigate the cause of her migraines.<br />

Yasmina decided to try to see if anything she ate<br />

sparked a migraine. She wrote down any offender foods<br />

and shared the list with her doctor, who finally gave her<br />

an answer: Yasmina had a histamine intolerance.<br />

Histamine is produced by the immune system in<br />

response to foreign invaders entering the body. But in<br />

Yasmina, her histamine response was being triggered<br />

by different foods and cosmetics, causing constant<br />

body-wide inflammation and <strong>Chronic</strong> <strong>Migraine</strong>.<br />

“Now I had a treatment and I knew <strong>my</strong> trigger,<strong>”</strong> she<br />

says. “Thanks to that, for the first time in <strong>my</strong> life I was<br />

finally free of migraines—I couldn’t believe it!<strong>”</strong><br />

Now Yasmina devotes her time to educating others<br />

with migraines to pursue treatment and learn their<br />

triggers. She’s even started her own food blog—<br />

thelowhistaminechef.com—where she features low<br />

,<br />

10 Guide to Living Well with <strong>Migraine</strong> Headaches<br />

HealthMonitor 11


eal inspiration<br />

histamine–reactive recipes and other products.<br />

“I have more than 60,000 readers monthly, so I know<br />

I’m really reaching people,<strong>”</strong> Yasmina says. “I’m just glad<br />

I can help others like I was to finally find relief!<strong>”</strong><br />

Here are some other ways Yasmina learned to control<br />

her <strong>Chronic</strong> <strong>Migraine</strong>—maybe they can work for you!<br />

Give new treatments a fair shake. “Follow what your<br />

doctor says and don’t give up [on a new treatment] if<br />

it doesn’t work right away,<strong>”</strong> Yasmina says, adding that<br />

with treatments like the injections and even dietary<br />

changes, it can take weeks to see relief.<br />

Keep a food journal! “Start a food diary right away!<strong>”</strong><br />

Yasmina emphasizes. “Write down a list of all potential<br />

triggers, then cross them off once you encounter them<br />

and don’t get a migraine.<strong>”</strong> Yasmina used her food diary<br />

to learn she had to eliminate fermented foods, smoked<br />

meats and fish, most alcohols, most vinegars and any<br />

packaged foods with dye and preservatives.<br />

Stay upbeat! “My positive outlook remained because<br />

I knew one day, if I kept trying, I’d take control,<strong>”</strong><br />

Yasmina says. “You have to have faith in yourself, and<br />

don’t feel guilty or like you failed if you need to take<br />

medication.<strong>”</strong><br />

Find others who understand. “Sharing what I have<br />

learned on <strong>my</strong> blog has inspired readers to share<br />

their own stories of recovery with me,<strong>”</strong> Yasmina says.<br />

“Above all, I’m thankful for that and finding this<br />

community of people. We all can help each other, and<br />

there’s no better motivator than helping others.<strong>”</strong><br />

Are you a candidate for<br />

preventive therapies?<br />

It’s possible to short-circuit migraines<br />

before they start with preventive therapies.<br />

These medications are designed to reduce<br />

the frequency and severity of attacks. You<br />

might benefit if you fall into any of the<br />

following categories:<br />

• You aren’t getting relief from acute<br />

medications or you can’t tolerate them.<br />

• Your migraines strike more than once a week<br />

or you need to take headache-relieving<br />

meds more than a few times per week.<br />

• You’re getting complicated forms of<br />

migraine (with aura).<br />

• Your migraines are interfering with your<br />

daily routine.<br />

IMPORTANT SAFETY INFORMATION (Continued)<br />

Do not take BOTOX ® (onabotulinumtoxinA) if you:<br />

are allergic to any of the ingredients in BOTOX ® (see<br />

Medication Guide for ingredients); had an allergic reaction<br />

to any other botulinum toxin product such as Myobloc ®<br />

(rimabotulinumtoxinB), Dysport ® (abobotulinumtoxinA), or<br />

Xeomin ® (incobotulinumtoxinA); have a skin infection at the<br />

planned injection site.<br />

The dose of BOTOX ® is not the same as, or comparable to,<br />

another botulinum toxin product.<br />

Serious and/or immediate allergic reactions have been<br />

reported. These reactions include itching, rash, red itchy<br />

welts, wheezing, asthma symptoms, or dizziness or feeling<br />

faint. Tell your doctor or get medical help right away if you<br />

experience any such symptoms; further injection of BOTOX ®<br />

should be discontinued.<br />

Tell your doctor about all your muscle or nerve conditions<br />

such as a<strong>my</strong>otrophic lateral sclerosis (ALS or Lou Gehrig’s<br />

disease), <strong>my</strong>asthenia gravis, or Lambert-Eaton syndrome,<br />

as you may be at increased risk of serious side effects<br />

including severe dysphagia (difficulty swallowing) and<br />

respiratory compromise (difficulty breathing) from typical<br />

doses of BOTOX ® .<br />

Tell your doctor about all your medical conditions,<br />

including if you: have or have had bleeding problems; have<br />

plans to have surgery; had surgery on your face; weakness<br />

of forehead muscles, such as trouble raising your eyebrows;<br />

drooping eyelids; any other abnormal facial change; are<br />

pregnant or plan to become pregnant (it is not known if<br />

BOTOX ® can harm your unborn baby); are breastfeeding or<br />

plan to breastfeed (it is not known if BOTOX ® passes into<br />

breast milk).<br />

Tell your doctor about all the medicines you take, including<br />

prescription and non-prescription medicines, vitamins, and<br />

herbal products. Using BOTOX ® with certain other<br />

medicines may cause serious side effects. Do not start any<br />

new medicines until you have told your doctor that you<br />

have received BOTOX ® in the past.<br />

Especially tell your doctor if you: have received any other<br />

botulinum toxin product in the last 4 months; have received<br />

injections of botulinum toxin such as Myobloc ® , Dysport ® ,<br />

or Xeomin ® in the past (be sure your doctor knows exactly<br />

which product you received); have recently received an<br />

antibiotic by injection; take muscle relaxants; take an allergy<br />

or cold medicine; take a sleep medicine; take anti-platelets<br />

(aspirin-like products) or anti-coagulants (blood thinners).<br />

Other side effects of BOTOX ® include: dry mouth, discomfort<br />

or pain at the injection site, tiredness, headache, neck pain,<br />

and eye problems: double vision, blurred vision, decreased<br />

eyesight, drooping eyelids, swelling of your eyelids, and<br />

dry eyes.<br />

For more information refer to the Medication Guide or talk<br />

with your doctor.<br />

You are encouraged to report negative side effects of<br />

prescription drugs to the FDA. Visit www.fda.gov/medwatch or<br />

call 1-800-FDA-1088.<br />

Please refer to full Medication Guide including Boxed<br />

Warning on the following pages.<br />

For adults with <strong>Chronic</strong> <strong>Migraine</strong>,<br />

15 or more headache days a month,<br />

each lasting 4 hours or more,<br />

BOTOX ® is the first and only preventive treatment<br />

proven to reduce headache days every month.<br />

BOTOX ® is the only FDA-approved, preventive treatment that is<br />

injected by a doctor every 3 months for people with <strong>Chronic</strong> <strong>Migraine</strong>.<br />

BOTOX ® prevents up to 9 headache days a month, versus up to 7 days<br />

for placebo. BOTOX ® is not approved for adults with migraine who<br />

have 14 or fewer headache days a month.<br />

IMPORTANT SAFETY INFORMATION<br />

BOTOX ® may cause serious side effects that can be life<br />

threatening. Call your doctor or get medical help right away if<br />

you have any of these problems any time (hours to weeks) after<br />

injection of BOTOX ® :<br />

• Problems swallowing, speaking, or breathing, due to weakening<br />

of associated muscles, can be severe and result in loss of life. You<br />

are at the highest risk if these problems are pre-existing before<br />

injection. Swallowing problems may last for several months.<br />

FOR ADULTS WITH<br />

CHRONIC MIGRAINE<br />

injection<br />

Find a headache specialist near you at<br />

Botox<strong>Chronic</strong><strong>Migraine</strong>.com<br />

BOTOX ® is a prescription medicine that is injected to prevent headaches in adults with <strong>Chronic</strong> <strong>Migraine</strong> who have 15 or more days<br />

each month with headache lasting 4 or more hours each day in people 18 years or older. It is not known whether BOTOX ® is safe<br />

or effective to prevent headaches in patients with migraine who have 14 or fewer headache days each month (episodic migraine).<br />

• Spread of toxin effects. The effect of botulinum toxin may affect<br />

areas away from the injection site and cause serious symptoms<br />

including: loss of strength and all-over muscle weakness, double<br />

vision, blurred vision and drooping eyelids, hoarseness or change<br />

or loss of voice (dysphonia), trouble saying words clearly<br />

(dysarthria), loss of bladder control, trouble breathing, trouble<br />

swallowing. If this happens, do not drive a car, operate<br />

machinery, or do other dangerous activities.<br />

There has not been a confirmed serious case of spread of toxin<br />

effect away from the injection site when BOTOX ® has been used at<br />

the recommended dose to treat <strong>Chronic</strong> <strong>Migraine</strong>.<br />

Please see additional Important Safety Information on adjacent page.<br />

12 Guide to Living Well with <strong>Migraine</strong> Headaches<br />

injection<br />

© 2014 Allergan, Inc., Irvine, CA 92612. ® marks owned by Allergan, Inc. Dysport is a registered trademark of Ipsen Biopharm Limited Company.<br />

Myobloc is a registered trademark of Solstice Neurosciences, Inc. Xeomin is a registered trademark of Merz Pharma GmbH & Co KGaA. APC43DI14


MEDICATION GUIDE<br />

BOTOX ®<br />

BOTOX ® Cosmetic<br />

(Boe-tox)<br />

(onabotulinumtoxinA)<br />

for Injection<br />

Read the Medication Guide that comes<br />

with BOTOX or BOTOX Cosmetic before<br />

you start using it and each time it is given<br />

to you. There may be new information.<br />

This information does not take the place of<br />

talking with your doctor about your medical<br />

condition or your treatment. You should<br />

share this information with your family<br />

members and caregivers.<br />

What is the most important information<br />

I should know about BOTOX and<br />

BOTOX Cosmetic?<br />

BOTOX and BOTOX Cosmetic may cause<br />

serious side effects that can be life<br />

threatening, including:<br />

• Problems breathing or swallowing<br />

• Spread of toxin effects<br />

These problems can happen hours, days,<br />

to weeks after an injection of BOTOX or<br />

BOTOX Cosmetic. Call your doctor or get<br />

medical help right away if you have any of<br />

these problems after treatment with BOTOX<br />

or BOTOX Cosmetic:<br />

1. Problems swallowing, speaking, or<br />

breathing. These problems can happen<br />

hours, days, to weeks after an injection of<br />

BOTOX or BOTOX Cosmetic usually because<br />

the muscles that you use to breathe and<br />

swallow can become weak after the injection.<br />

Death can happen as a complication if you<br />

have severe problems with swallowing or<br />

breathing after treatment with BOTOX or<br />

BOTOX Cosmetic.<br />

• People with certain breathing problems may<br />

need to use muscles in their neck to help<br />

them breathe. These people may be at greater<br />

risk for serious breathing problems with<br />

BOTOX or BOTOX Cosmetic.<br />

• Swallowing problems may last for several<br />

months. People who cannot swallow well<br />

may need a feeding tube to receive food and<br />

water. If swallowing problems are severe,<br />

food or liquids may go into your lungs.<br />

People who already have swallowing or<br />

breathing problems before receiving BOTOX<br />

or BOTOX Cosmetic have the highest risk of<br />

getting these problems.<br />

2. Spread of toxin effects. In some cases,<br />

the effect of botulinum toxin may affect areas<br />

of the body away from the injection site and<br />

cause symptoms of a serious condition called<br />

botulism. The symptoms of botulism include:<br />

• loss of strength and muscle weakness<br />

all over the body<br />

• double vision<br />

• blurred vision and drooping eyelids<br />

• hoarseness or change or loss of voice<br />

(dysphonia)<br />

• trouble saying words clearly (dysarthria)<br />

• loss of bladder control<br />

• trouble breathing<br />

• trouble swallowing<br />

These symptoms can happen hours, days, to<br />

weeks after you receive an injection of BOTOX<br />

or BOTOX Cosmetic.<br />

These problems could make it unsafe for you<br />

to drive a car or do other dangerous activities.<br />

See “What should I avoid while receiving<br />

BOTOX or BOTOX Cosmetic?<strong>”</strong><br />

There has not been a confirmed serious case<br />

of spread of toxin effect away from<br />

the injection site when BOTOX has been<br />

used at the recommended dose to treat<br />

chronic migraine, severe underarm sweating,<br />

blepharospasm, or strabismus, or when<br />

BOTOX Cosmetic has been used at the<br />

recommended dose to treat frown lines and/<br />

or crow’s feet lines.<br />

What are BOTOX and BOTOX Cosmetic?<br />

BOTOX is a prescription medicine that is<br />

injected into muscles and used:<br />

• to treat overactive bladder symptoms such<br />

as a strong need to urinate with leaking or<br />

wetting accidents (urge urinary incontinence),<br />

a strong need to urinate right away<br />

(urgency), and urinating often (frequency)<br />

in adults when another type of medicine<br />

(anticholinergic) does not work well enough<br />

or cannot be taken.<br />

• to treat leakage of urine (incontinence)<br />

in adults with overactive bladder due to<br />

neurologic disease when another type of<br />

medicine (anticholinergic) does not work well<br />

enough or cannot be taken.<br />

• to prevent headaches in adults with chronic<br />

migraine who have 15 or more days each<br />

month with headache lasting 4 or more hours<br />

each day.<br />

• to treat increased muscle stiffness in elbow,<br />

wrist, and finger muscles in adults with upper<br />

limb spasticity.<br />

• to treat the abnormal head position and<br />

neck pain that happens with cervical dystonia<br />

(CD) in adults.<br />

• to treat certain types of eye muscle<br />

problems (strabismus) or abnormal<br />

spasm of the eyelids (blepharospasm)<br />

in people 12 years and older.<br />

BOTOX is also injected into the skin to treat<br />

the symptoms of severe underarm sweating<br />

(severe primary axillary hyperhidrosis) when<br />

medicines used on the skin (topical) do not<br />

work well enough.<br />

BOTOX Cosmetic is a prescription medicine<br />

that is injected into muscles and used to<br />

improve the look of moderate to severe<br />

frown lines between the eyebrows (glabellar<br />

lines) in adults for a short period of time<br />

(temporary).<br />

BOTOX Cosmetic is a prescription medicine<br />

that is injected into the area around the side<br />

of the eyes to improve the look of crow’s<br />

feet lines in adults for a short period of time<br />

(temporary).<br />

You may receive treatment for frown lines and<br />

crow’s feet lines at the same time.<br />

It is not known whether BOTOX is safe or<br />

effective in people younger than:<br />

• 18 years of age for treatment of urinary<br />

incontinence<br />

• 18 years of age for treatment of chronic<br />

migraine<br />

• 18 years of age for treatment of spasticity<br />

• 16 years of age for treatment of cervical<br />

dystonia<br />

• 18 years of age for treatment of<br />

hyperhidrosis<br />

• 12 years of age for treatment of strabismus<br />

or blepharospasm<br />

BOTOX Cosmetic is not recommended for<br />

use in children younger than 18 years of age.<br />

It is not known whether BOTOX and<br />

BOTOX Cosmetic are safe or effective to<br />

prevent headaches in people with migraine<br />

who have 14 or fewer headache days each<br />

month (episodic migraine).<br />

It is not known whether BOTOX and<br />

BOTOX Cosmetic are safe or effective for<br />

other types of muscle spasms or for severe<br />

sweating anywhere other than your armpits.<br />

Who should not take BOTOX or<br />

BOTOX Cosmetic?<br />

Do not take BOTOX or BOTOX Cosmetic<br />

if you:<br />

• are allergic to any of the ingredients in<br />

BOTOX or BOTOX Cosmetic. See the end of<br />

this Medication Guide for a list of ingredients<br />

in BOTOX and BOTOX Cosmetic.<br />

• had an allergic reaction to any other<br />

botulinum toxin product such as Myobloc ® ,<br />

Dysport ® , or Xeomin ®<br />

• have a skin infection at the planned injection<br />

site<br />

• are being treated for urinary incontinence<br />

and have a urinary tract infection (UTI)<br />

• are being treated for urinary incontinence<br />

and find that you cannot empty your bladder<br />

on your own (only applies to people who are<br />

not routinely catheterizing)<br />

What should I tell <strong>my</strong> doctor before taking<br />

BOTOX or BOTOX Cosmetic?<br />

Tell your doctor about all your medical<br />

conditions, including if you:<br />

• have a disease that affects your muscles and<br />

nerves (such as a<strong>my</strong>otrophic lateral sclerosis<br />

[ALS or Lou Gehrig’s disease], <strong>my</strong>asthenia<br />

gravis or Lambert-Eaton syndrome). See<br />

“What is the most important information I<br />

should know about BOTOX and<br />

BOTOX Cosmetic?<strong>”</strong><br />

• have allergies to any botulinum toxin<br />

product<br />

• had any side effect from any botulinum<br />

toxin product in the past<br />

• have or have had a breathing problem,<br />

such as asthma or emphysema<br />

• have or have had swallowing problems<br />

• have or have had bleeding problems<br />

• have plans to have surgery<br />

• had surgery on your face<br />

• have weakness of your forehead<br />

muscles, such as trouble raising your<br />

eyebrows<br />

• have drooping eyelids<br />

• have any other change in the way your<br />

face normally looks<br />

• have symptoms of a urinary tract<br />

infection (UTI) and are being treated for<br />

urinary incontinence. Symptoms of a<br />

urinary tract infection may include pain or<br />

burning with urination, frequent urination,<br />

or fever.<br />

• have problems emptying your bladder<br />

on your own and are being treated for<br />

urinary incontinence<br />

• are pregnant or plan to become<br />

pregnant. It is not known if BOTOX or<br />

BOTOX Cosmetic can harm your unborn<br />

baby.<br />

• are breast-feeding or plan to breastfeed.<br />

It is not known if BOTOX or BOTOX<br />

Cosmetic passes into breast milk.<br />

Tell your doctor about all the medicines<br />

you take, including prescription and<br />

nonprescription medicines, vitamins<br />

and herbal products. Using BOTOX or<br />

BOTOX Cosmetic with certain other<br />

medicines may cause serious side effects.<br />

Do not start any new medicines until<br />

you have told your doctor that you have<br />

received BOTOX or BOTOX Cosmetic in<br />

the past.<br />

Especially tell your doctor if you:<br />

• have received any other botulinum toxin<br />

product in the last four months<br />

• have received injections of<br />

botulinum toxin, such as Myobloc ®<br />

(rimabotulinumtoxinB), Dysport ®<br />

(abobotulinumtoxinA), or Xeomin ®<br />

(incobotulinumtoxinA) in the past. Be sure<br />

your doctor knows exactly which product<br />

you received.<br />

• have recently received an antibiotic by<br />

injection<br />

• take muscle relaxants<br />

• take an allergy or cold medicine<br />

• take a sleep medicine<br />

• take anti-platelets (aspirin-like products)<br />

and/or anti-coagulants (blood thinners)<br />

Ask your doctor if you are not sure if your<br />

medicine is one that is listed above.<br />

Know the medicines you take. Keep a list<br />

of your medicines with you to show your<br />

doctor and pharmacist each time you get<br />

a new medicine.<br />

How should I take BOTOX or<br />

BOTOX Cosmetic?<br />

• BOTOX or BOTOX Cosmetic is an<br />

injection that your doctor will give you.<br />

• BOTOX is injected into your affected<br />

muscles, skin, or bladder.<br />

• BOTOX Cosmetic is injected into your<br />

affected muscles.<br />

• Your doctor may change your dose of<br />

BOTOX or BOTOX Cosmetic, until you and<br />

your doctor find the best dose for you.<br />

• Your doctor will tell you how often<br />

you will receive your dose of BOTOX<br />

or BOTOX Cosmetic injections.<br />

What should I avoid while taking BOTOX<br />

or BOTOX Cosmetic?<br />

BOTOX and BOTOX Cosmetic may<br />

cause loss of strength or general muscle<br />

weakness, or vision problems within<br />

hours to weeks of taking BOTOX or<br />

BOTOX Cosmetic. If this happens, do not<br />

drive a car, operate machinery, or<br />

do other dangerous activities. See<br />

“What is the most important information<br />

I should know about BOTOX and<br />

BOTOX Cosmetic?<strong>”</strong><br />

What are the possible side effects of<br />

BOTOX and BOTOX Cosmetic?<br />

BOTOX and BOTOX Cosmetic can cause<br />

serious side effects. See “What is the<br />

most important information I should know<br />

about BOTOX and BOTOX Cosmetic?<strong>”</strong><br />

Other side effects of BOTOX and BOTOX<br />

Cosmetic include:<br />

• dry mouth<br />

• discomfort or pain at the injection site<br />

• tiredness<br />

• headache<br />

• neck pain<br />

• eye problems: double vision, blurred<br />

vision, decreased eyesight, drooping<br />

eyelids, swelling of your eyelids, and dry<br />

eyes.<br />

• urinary tract infection in people being<br />

treated for urinary incontinence<br />

• painful urination in people being treated<br />

for urinary incontinence<br />

• inability to empty your bladder on your<br />

own and are being treated for urinary<br />

incontinence. If you have difficulty fully<br />

emptying your bladder after getting<br />

BOTOX, you may need to use disposable<br />

self-catheters to empty your bladder up to<br />

a few times each day until your bladder is<br />

able to start emptying again.<br />

• allergic reactions. Symptoms of an<br />

allergic reaction to BOTOX or BOTOX<br />

Cosmetic may include: itching, rash, red<br />

itchy welts, wheezing, asthma symptoms,<br />

or dizziness or feeling faint. Tell your<br />

doctor or get medical help right away<br />

if you are wheezing or have asthma<br />

symptoms, or if you become dizzy or faint.<br />

Tell your doctor if you have any side effect<br />

that bothers you or that does not go away.<br />

These are not all the possible side effects<br />

of BOTOX and BOTOX Cosmetic. For<br />

more information, ask your doctor or<br />

pharmacist.<br />

Call your doctor for medical advice about<br />

side effects. You may report side effects to<br />

FDA at 1-800-FDA-1088.<br />

General information about BOTOX and<br />

BOTOX Cosmetic:<br />

Medicines are sometimes prescribed<br />

for purposes other than those listed in a<br />

Medication Guide.<br />

This Medication Guide summarizes the<br />

most important information about BOTOX<br />

and BOTOX Cosmetic. If you would like<br />

more information, talk with your doctor.<br />

You can ask your doctor or pharmacist<br />

for information about BOTOX and BOTOX<br />

Cosmetic that is written for healthcare<br />

professionals.<br />

What are the ingredients in BOTOX and<br />

BOTOX Cosmetic?<br />

Active ingredient: botulinum toxin type A<br />

Inactive ingredients: human albumin and<br />

sodium chloride<br />

Revised: 08/2015<br />

This Medication Guide has been approved<br />

by the U.S. Food and Drug Administration.<br />

Manufactured by: Allergan<br />

Pharmaceuticals Ireland a subsidiary of:<br />

Allergan, Inc.<br />

2525 Dupont Dr.<br />

Irvine, CA 92612<br />

© 2015 Allergan, Inc. All rights reserved.<br />

®<br />

marks owned by Allergan, Inc.<br />

Patented. See: www.allergan.com/<br />

products/patent_notices<br />

Myobloc ® is a registered trademark of<br />

Solstice Neurosciences, Inc.<br />

Dysport ® is a registered trademark of Ipsen<br />

Biopharm Limited Company.<br />

Xeomin ® is a registered trademark of Merz<br />

Pharma GmbH & Co KGaA.<br />

®<br />

Based on 72511US14<br />

APC25LG15


eal inspiration<br />

“What I’ve learned<br />

about migraine<strong>”</strong><br />

Fight back!<br />

“<strong>Migraine</strong>s are the worst! … [I tell<br />

<strong>my</strong> migraine] ‘We are about to go<br />

to blows! #IWin’<strong>”</strong><br />

—Tweeted by reality star Khloé<br />

Kardashian, who eventually<br />

learned her migraines were<br />

triggered by stress.<br />

Treat quickly!<br />

“[When a migraine is about<br />

to strike] I’m nauseated…I get<br />

this light disruption thing.<strong>”</strong><br />

—Comedian and actor Russell<br />

Brand, who was interrupted<br />

in the middle of a standup<br />

routine by signs of a migraine,<br />

but was able to continue<br />

after taking medication.<br />

Enlist friends!<br />

“[<strong>Migraine</strong>s] once made me pass<br />

out on stage. Fortunately, the<br />

boys in <strong>my</strong> band have learned to<br />

tell when it’s coming. They just<br />

take me by the elbow and help<br />

me sit until it passes.<strong>”</strong><br />

—Loretta Lynn, as written in her<br />

memoir Coal Miner’s Daughter.<br />

Get back in<br />

the game!<br />

“Once I decided to seek<br />

professional help for <strong>my</strong><br />

migraine attacks, I learned<br />

that there are effective<br />

treatments that enable me<br />

to ‘get back in the game,’<br />

and I now want to help other<br />

sufferers do the same.<strong>”</strong><br />

—Terrell Davis, player for the<br />

NFL’s Denver Broncos


eal inspiration<br />

“ How I took control<br />

of <strong>my</strong> migraines...<strong>”</strong><br />

These five patients feared they’d never find relief from their<br />

debilitating headaches. Today, they’re working closely with<br />

their healthcare providers and thriving. Here are their tips for<br />

taking back control from migraine. by Lindsay Bosslett<br />

“Managing migraines isn’t about finding one big<br />

answer—it’s a bunch of tiny pieces,<strong>”</strong> says Kate.<br />

“But as long as you keep communicating with<br />

your care team, you won’t have to feel lost.<strong>”</strong><br />

Be patient.<br />

“It is going to take time to find<br />

what works for you,<strong>”</strong> says Kate<br />

McCombs, 30, from New York<br />

City. “Managing migraines isn’t<br />

about finding one big answer—it’s a<br />

bunch of tiny pieces. You may have<br />

many triggers and may have to find<br />

many different ways to avoid them.<br />

You may need more than one<br />

medication or to switch meds at<br />

one point like I did. You may need<br />

to visit more than one doctor. But<br />

as long as you keep trying and keep<br />

finding a way to communicate, you<br />

won’t have to feel lost.<strong>”</strong><br />

Become nutritional<br />

label savvy.<br />

“Once I learned I was allergic to MSG<br />

[monosodium glutamate] and that<br />

it was likely triggering migraines for<br />

me, I was able to cut it out of <strong>my</strong> diet,<strong>”</strong><br />

says Lisa Rosen, 47, Little Falls, NJ,<br />

who has had migraines since her early<br />

teens. “But sometimes it was in food<br />

and I didn’t even know.<strong>”</strong> Food labels<br />

can have some sneaky names for<br />

MSG on labels. If it’s a trigger for you,<br />

avoid anything with the following<br />

listed in its ingredients: the words<br />

Are you doing<br />

all you can to …<br />

PREVENT MIGRAINES?<br />

Today’s treatments can help<br />

fend off migraines—in fact, up<br />

to 40% of migraine sufferers<br />

can benefit from preventive<br />

treatment, studies show. Ask if<br />

you are a candidate.<br />

nip THEM IN THE BUD?<br />

Preventive treatment not right<br />

for you? Then try to identify<br />

your body’s earliest warning<br />

signs of migraine—the sooner<br />

you take an acute medication,<br />

the better it can work to halt<br />

or lessen symptoms.<br />

“Once I discovered MSG was causing <strong>my</strong> migraines I was finally able to cut it<br />

out of <strong>my</strong> diet,<strong>”</strong> Lisa says. “I realized sometimes it hides under different names,<br />

too. But I learned what to avoid, and now I rarely get migraines at all!<strong>”</strong><br />

glutamic or glutamate; textured or<br />

hydrolyzed proteins; yeast extract;<br />

anything labeled as protein-fortified,<br />

ultra-pasteurized, fermented or<br />

enzyme-modified; ajinomoto.<br />

Make sleep<br />

a priority.<br />

“I noticed that I tended to get<br />

migraines on Tuesdays and<br />

Saturdays,<strong>”</strong> says Andrea Stephenson,<br />

46, from Solon, OH, who started<br />

getting migraines six years ago. “I<br />

realized that Tuesdays were after two<br />

nights of going to bed late and getting<br />

up early, and on Saturdays I tended<br />

to sleep in to make up for what I lost<br />

during the week. When I started<br />

getting seven to eight hours sleep<br />

regularly, that helped a lot.<strong>”</strong><br />

Learn your triggers.<br />

“We all have different triggers for<br />

migraines, so just avoiding the<br />

things commonly listed may not<br />

work for you,<strong>”</strong> says Sarah Farver,<br />

48, from Fort Worth, TX, whose<br />

migraines became chronic while<br />

she was in college. “I make sure<br />

to write down when something<br />

uncommon—like lifting a 50-lb.<br />

bag of dog food—triggers one for<br />

me. If I know them, I can avoid<br />

them. Or at least be prepared to<br />

treat very early if I know I’ll be<br />

forced to encounter one.<strong>”</strong><br />

Plan ahead.<br />

“Planning ahead can help avoid<br />

unpleasant surprises and scheduling<br />

messes that trigger migraines,<strong>”</strong><br />

says life-long migraine sufferer<br />

Teri Robert, 60, from Washington,<br />

WV, author of Living Well with<br />

<strong>Migraine</strong> Disease and Headaches<br />

and chairperson at the American<br />

Headache <strong>Migraine</strong> Association.<br />

“Make lists—the last thing you need<br />

is for a migraine to be coming on<br />

as you’re getting ready to travel and<br />

end up forgetting half of what you<br />

need.<strong>”</strong> Teri also recommends making<br />

a migraine kit and keeping it handy<br />

in the car or plane—see page 23 for<br />

what to include.<br />

18 Guide to Living Well with <strong>Migraine</strong> Headaches


eal inspiration<br />

“I know now I have to make sleep a priority,<strong>”</strong><br />

says Andrea. “Sticking to a regular schedule<br />

is essential.<strong>”</strong><br />

Develop your<br />

voice. Kate credits her ability to<br />

communicate clearly with helping her<br />

find relief for her migraines. “The fact<br />

that I can talk openly and honestly<br />

with <strong>my</strong> husband has been a key in<br />

our marriage while managing this<br />

condition,<strong>”</strong> she says. “It’s important<br />

for me to be able to ask <strong>my</strong> friends<br />

to accommodate <strong>my</strong> needs without<br />

alienating them, and to tell <strong>my</strong><br />

doctors what I’m going through<br />

and have them take me seriously.<br />

<strong>Migraine</strong>s are so individual—you<br />

have to be able to say what’s going on<br />

with you specifically. My voice has<br />

been <strong>my</strong> most important ally.<strong>”</strong><br />

Learn your<br />

symptoms. “My migraines<br />

often start with a dull ache in <strong>my</strong><br />

forehead that moves backward,<strong>”</strong><br />

Andrea says. “I often become irritable<br />

and sometimes smells and sounds will<br />

bother me. A sure sign is when I start<br />

20 Guide to Living Well with <strong>Migraine</strong> Headaches<br />

to feel nauseated. The key is taking<br />

<strong>my</strong> medication as soon as I notice<br />

these early symptoms—the earlier the<br />

better, and sometimes I can fend off a<br />

migraine all together.<strong>”</strong><br />

Choose happiness.<br />

“I think everyone has aspects of their<br />

lives that they have to deal with and<br />

work around,<strong>”</strong> Sarah says. “For me,<br />

migraines are just one of those things.<br />

But because of them, I chose to<br />

pursue a fabulous job where I can<br />

work from home now and spend<br />

more time with <strong>my</strong> kids. Happiness<br />

is a choice and choosing to be<br />

thankful for every breath we’re given<br />

is not something to take lightly.<strong>”</strong><br />

Give acupuncture<br />

a try. “My migraines have been<br />

much more rare ever since trying<br />

acupuncture a few years ago,<strong>”</strong> Lisa<br />

says. Acupuncture involves placing<br />

thin, painless needles in different<br />

parts of the body that are associated<br />

with acupoints. And a recent study<br />

published in the Archives of Internal<br />

Medicine did find acupuncture to be<br />

helpful in chronic pain conditions—<br />

just be sure to visit a certified<br />

practitioner; find one at nccaom.org.<br />

Be open to change.<br />

“My migraines started around when I<br />

hit puberty,<strong>”</strong> Kate says. “Because they<br />

were related to <strong>my</strong> menstrual cycle,<br />

they were pretty regular and easier<br />

to plan for. I was able to be treated<br />

by <strong>my</strong> regular doctor for years.<strong>”</strong> All<br />

that changed about a year ago, when<br />

without explanation the migraines<br />

began coming more frequently and<br />

lasting longer. “I knew I needed to try<br />

something different—even though<br />

<strong>my</strong> old treatments had worked for<br />

a long time. That’s when I went to<br />

see a neurologist. He prescribed<br />

an injectable medication, as well as<br />

something I can take daily. It’s<br />

made it so I can work again.<strong>”</strong><br />

Dump the guilt!<br />

“Always take care of yourself,<strong>”</strong> Teri<br />

emphasizes. “We all tend to try to<br />

adapt our schedules to fit with those<br />

of others. If it’s going to trigger a<br />

migraine, just don’t do it—and don’t<br />

feel guilty!<strong>”</strong><br />

“I choose happiness,<strong>”</strong><br />

Sarah says. “Everyone<br />

deals with something;<br />

at least migraines I<br />

can manage!<strong>”</strong><br />

QA &<br />

AM I HAVING CHRONIC MIGRAINE?<br />

I seem to have headaches all the time—I feel<br />

Q like I’m taking pain meds every day, and the pain<br />

never stops. Could I be having <strong>Chronic</strong> <strong>Migraine</strong>?<br />

A<br />

Possibly. You could have <strong>Chronic</strong> <strong>Migraine</strong> if<br />

you suffer 15 or more headaches a month, each<br />

lasting four hours or more. However, taking too many acute<br />

painkillers—medications used to treat the sudden onset of<br />

pain—can also have a rebound effect. Once the medication<br />

wears off, the headache will return. This can happen if you<br />

take more than the recommended dosage, or if you take<br />

the drug too often. Luckily, you don’t have to go off painkillers<br />

cold turkey. If frequent migraines see you turning<br />

to acute painkillers too often, ask your doctor if preventive<br />

medications might be an option for you.<br />

a world without headachE<br />

Our expert:<br />

Stephen D. Silberstein,<br />

MD—professor of neurology<br />

and director of the Jefferson<br />

Headache Center at Thomas Jefferson<br />

University in Philadelphia<br />

AURA—EXPLAINED!<br />

Q<br />

Why do I get aura before a migraine?<br />

Do they mean I get worse migraines than<br />

other people?<br />

A<br />

Auras—which are known to occur in only about<br />

20% of migraines—can include flashes of light,<br />

blind spots, wavy lines or tingling in your hands or face.<br />

Experts suspect the cause is an electrical or chemical<br />

wave that crosses the part of your brain that controls<br />

your sense of vision. In any case, experiencing an aura<br />

has no effect at all on the severity of your migraine. If<br />

anything, consider it a warning that gives you a chance<br />

to take action: Take your meds and find your way to a<br />

cool, dark, quiet place to help fend off or at least lessen<br />

the impact of the headache.<br />

(CAQ)<br />

The National Headache Foundation’s<br />

Certificate of Added Qualification<br />

1 2 3 4 5<br />

Establish Stimulate Serve enhance<br />

a credentialing body physicians’ interest in as an alternative or the ability of patients<br />

for physicians treating headache and its addition to board to identify those<br />

headache and thus management<br />

certification in<br />

physicians with<br />

facilitate patient care.<br />

headache medicine expertise and interest<br />

from the United in headache.<br />

Council of Subspecialties<br />

(UCNS) certification<br />

which requires a<br />

1-year fellowship in<br />

headache medicine<br />

at a qualified center.<br />

Recognize<br />

physicians with an<br />

advanced level of<br />

experience in headache<br />

management.<br />

For more information<br />

[ ]<br />

visit headaches.org/CAQ<br />

[ ]<br />

call (888) NHF-5552


feel your best<br />

<strong>Migraine</strong>-proof your home<br />

Just a few simple changes can turn your<br />

home into a fortress against migraines—and<br />

a refuge to rest in, in case one does strike!<br />

IN THE BEDROOM<br />

Go for thick curtains. Your bedroom can be the<br />

ideal migraine retreat. Thick or “black-out<strong>”</strong> curtains on the<br />

windows will help keep the room dark and cool, and can even<br />

help dampen outside sounds.<br />

Get an air purifier. Dust and dander can be a<br />

trigger for many. You can find free-standing air purifiers for as<br />

low as $40 in home-improvement and electronics stores. Be sure<br />

to change the filter in your furnace, as well, and have your vents<br />

and ducts professionally cleaned once every 3-5 years.<br />

Consider a humidifier or dehumidifier.<br />

Aim for a healthy 35% to 50% humidity inside at all times—that<br />

can mean using a humidifier in winter and a dehumidifier in<br />

summer. Bonus: Maintaining a normal humidity level has been<br />

shown to reduce your likelihood of getting sick!<br />

IN THE KITCHEN<br />

Stop drawers from slamming. When you’re in the midst of a migraine, any noise can<br />

cause a bolt of pain. Pick up little rubber drawer stoppers (or you can make your own by cutting up pencil<br />

erasers!) at a hardware store—they attach to the inside of drawers or cabinet doors and muffle the noise made<br />

when closing them.<br />

Take care with cleaning products. Scented products are a huge migraine trigger for<br />

some. Look for products labeled “perfume-free<strong>”</strong> or “fragrance-free,<strong>”</strong> and be wary of ones that say “all-natural,<strong>”</strong><br />

as these still might have scents that can cause problems. It’s also best to avoid scented detergents, body<br />

products, candles and air fresheners.<br />

Deactivate your fridge light. In the midst of a migraine, you’ll still need to eat and drink<br />

(it’s especially important to stay hydrated!). But the fridge light can exacerbate your migraine. Solution? Simply<br />

remove the bulb and keep a small flashlight nearby—the smaller light beam will help you find the food you<br />

need, and won’t be as problematic for your migraine.<br />

22 Guide to Living Well with <strong>Migraine</strong> Headaches<br />

Your migraine tool kit<br />

If you suffer from<br />

migraines, create<br />

a personalized<br />

migraine kit, which<br />

can come to your<br />

aid if a severe<br />

headache strikes<br />

unexpectedly.<br />

Here’s a list of<br />

what it could<br />

include:<br />

A cold<br />

compress or<br />

pack, which<br />

can help your<br />

throbbing head.<br />

THROUGHOUT<br />

Seal up windows and doors.<br />

A sudden shift in temperature—like you’d experience near<br />

a drafty window—can spark a migraine. Closing up drafts<br />

(either with caulk, insulation or draft guards) will not only<br />

keep the temperature in your house more steady, it will<br />

also help lower your heating and cooling bill.<br />

Change to these light bulbs... Lowwattage<br />

incandescent bulbs, which produce a warm, steady<br />

stream of light. Bright and/or flickering lights—such as<br />

from halogen or fluorescent bulbs—are more likely to<br />

trigger a migraine.<br />

Decorate with care. Paints and carpets that<br />

contain “volatile organic compounds<strong>”</strong> (VOCs) can trigger<br />

or worsen migraines. The compounds get released into the<br />

air over time, and can cause irritation and inflammation<br />

throughout your body. Look for paints that are VOC-free,<br />

such as Benjamin Moore Natura or Low & Zero, and<br />

carpet manufacturers rated as “Green Label<strong>”</strong> by The<br />

Carpet and Rug Institute at carpet-rug.org.<br />

An eye mask<br />

to shield your<br />

eyes from light.<br />

A bottle<br />

of water<br />

Dehydration<br />

can lead to<br />

headaches.<br />

You’ll also<br />

need water<br />

to take your<br />

migraine<br />

medication.<br />

A small<br />

pillow, which<br />

could come in<br />

handy for<br />

resting.<br />

Medication<br />

can treat a<br />

headache ASAP.


you & your care team<br />

9 questions<br />

Good communication is the key to<br />

effective treatment for your migraine.<br />

Get started by asking these questions.<br />

for your next exam<br />

1. Could <strong>my</strong> headache be a migraine?________________________________________________________________________<br />

2. Could I have <strong>Chronic</strong> <strong>Migraine</strong>?____________________________________________________________________________<br />

3. What’s the best way to identify <strong>my</strong> triggers?_________________________________________________________________<br />

4. What are <strong>my</strong> treatment options?___________________________________________________________________________<br />

5. Could I benefit from preventive therapies?__________________________________________________________________<br />

6. How long should I wait to assess if the preventive therapy is working to stop <strong>my</strong> headaches?______________________<br />

7. Should I expect any side effects from <strong>my</strong> treatment(s)? _______________________________________________________<br />

8. How can I tell when a migraine is coming on, and at what point should I start taking acute medication?____________<br />

________________________________________________________________________________________________________<br />

9. When should I come back to see you?_______________________________________________________________________<br />

Resources you need... Looking for more info on migraines? Hoping to connect<br />

with others who understand you? These organizations offer the answers you want and the support you need,<br />

and you can visit them all with a click by logging on to HealthMonitor.com/<strong>Migraine</strong>Resources<br />

This anonymous online health<br />

community is a safe, comforting<br />

place to join and meet others with migraine headaches like<br />

you.. You can share, learn and help others, while keeping your<br />

identity completely confidential. Join the conversation at<br />

HealthKeep.com and download the app in the iTunes Store.<br />

If you have <strong>Chronic</strong> <strong>Migraine</strong>,<br />

don’t live a maybe life. Visit<br />

My<strong>Chronic</strong><strong>Migraine</strong>.com to learn<br />

about treatment options, get inspired by real-life stories,<br />

track your headaches/migraines and find a Headache<br />

Specialist near you.<br />

The AHMA exists to E.A.S.E. the<br />

burden of <strong>Migraine</strong> and other Headache<br />

Disorders through Education, Awareness,<br />

Support, and Engagement.<br />

The National Headache Foundation<br />

enhances the health of those with<br />

migraine by providing educational and<br />

informational resources, supporting headache research<br />

and advocating for the understanding of headache as a<br />

legitimate neurobiological disease.<br />

The American <strong>Migraine</strong><br />

Foundation (AMF) supports<br />

innovative research and education that will lead to<br />

improvement in the lives of those who suffer from migraine<br />

and other related disorders.<br />

The American <strong>Chronic</strong> Pain<br />

Association (ACPA) facilitates<br />

peer support and education for people with chronic<br />

pain and their families so that they may live a fuller life.<br />

ACPA also raises awareness of issues associated with<br />

chronic pain.<br />

NATIONAL FIBROMYALGIA & CHRONIC<br />

PAIN ASSOCIATION. <strong>Migraine</strong>s and<br />

chronic pain are a challenge to manage.<br />

Join the National Fibro<strong>my</strong>algia & <strong>Chronic</strong> Pain Association<br />

(NFMCPA) at FMCPaware.org for education, research<br />

information and important advocacy programs to improve<br />

your healthcare and protect your access to care.<br />

24 Guide to Living Well with <strong>Migraine</strong> Headaches

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