studies

212A AASLD ABSTRACTS HEPATOLOGY, October, 2015
actions condition). Conclusion: The herein presented bioreactor
allows co-culture of LSECs and hepatocytes, maintaining and
enhancing hepatocyte function long-term significantly better
than using monocultures or conventional co-culture methods.
Our approach provides an overwhelming insight in the importance
of the hepatic sinusoid in the development of technology
for liver support in acute liver failure and for drug discovery.
Disclosures:
The following authors have nothing to disclose: Maria Navarro-Zornoza, Xavi
Illa, Carmen Peralta, Rosa Villa, Jordi Gracia-Sancho
9
Prediction of waitlist mortality in patients with portopulmonary
hypertension (POPH): An analysis of the UNOS
database
Hilary M. DuBrock 1,2 , David S. Goldberg 4 , Norman L. Sussman 5 ,
Sonja Bartolome 6 , Zakiyah Kadry 7 , Reena Salgia 8 , Andre M.
De Wolf 9 , David C. Mulligan 10 , Steven M. Kawut 4 , Michael J.
Krowka 3 , Richard Channick 2 ; 1 Medicine, Beth Israel Deaconess
Medical Center, Boston, MA; 2 Medicine, Massachusetts General
Hospital, Boston, MA; 3 Mayo Clinic, Rochester, MN; 4 University
of Pennsylvania, Philadelphia, PA; 5 Baylor College of Medicine,
Houston, TX; 6 UT Southwestern, Dallas, TX; 7 Penn State Hershey
Medical Center, Hershey, PA; 8 Henry Ford Hospital, Detroit, MI;
9 Northwester University, Chicago, IL; 10 Yale New Haven Hospital,
New Haven, CT
Purpose: The current United Network for Organ Sharing
(UNOS) system grants Model for End-Stage Liver Disease
(MELD) exception points to patients with POPH and a mean
pulmonary artery pressure (mPAP) 25 and pulmonary vascular
resistance (PVR)>240] was built using a competing risk subdistribution
hazard model and purposeful selection. Significance
was defined as p16 years of age) were approved for
a POPH MELD exception. In patients with true POPH (n=190),
13(6.8%) died on the waitlist, 4(2.1%) died during transplant,
27(14.2%) were removed for being too sick, 100(52.6%)
patients underwent deceased donor liver transplant, 2(1.1%)
underwent living donor transplant, 9(4.7%) were removed for
other reasons and 35(18.4%) remained active on the waitlist.
Initial MELDNa was a significant univariate predictor of waitlist
mortality (HR 1.121, p