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230A AASLD ABSTRACTS HEPATOLOGY, October, 2015 could predict the presence of various cancer entities in patients with hepatocellular, colorectal and non-small cell lung carcinoma (HCC, CRC, NSCLC, resp.), as a tool for cancer screening and therapy response monitoring. Methods: MPs were isolated from serum of patients with HCC, CRC, NSCLC and from healthy donors. MP profiling was done after differential ultracentrifugation using FACS analysis for the presence and quantity of AnnexinV + /EpCAM + and AnnexinV + /EpCAM + / CD147 + taMPs. Results: AnnexinV + /EpCAM + and AnnexinV + /EpCAM + /CD147 + taMPs highly significantly separated patients with carcinomas from healthy controls. The calculated cut-off values for AnnexinV + /EpCAM + taMPs were 36.6 /1AnnexinV + MPs in NSCLC, 35.8/1kAnnexinV + MPs in CRC and 31.4/1kAnnexinV + taMPs in HCC. Additionally, AnnexinV + /EpCAM + /CD147 + taMPs indicated the presence of cancer as well as AnnexinV + /EpCAM + taMPs alone. AnnexinV + / EpCAM + taMPs and AnnexinV + /EpCAM + /CD147 + taMPs were increased 2.4-fold (p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 231A respectively. The median (IQR) time intervals were 46.5 (62) and 47.5 (87) days between MRE and biopsy and between ARFI and biopsy, respectively. For diagnosing any fibrosis, MRE had an area under ROC curve (AUROC) of 0.799 (95% CI, 0.723-0.875), which was significantly (p=0.012) higher than ARFI, which had an AUROC of 0.664 (95% CI, 0.568- 0.760). The AUROCs of MRE for diagnosing ≥ stages 2, 3, and 4 fibrosis were 0.885 (95% CI, 0.816-0.953), 0.934 (95% CI, 0.863-1.000), and 0.882 (95% CI, 0.729-1.000), and those for ARFI were 0.848 (95% CI, 0.776-0.921), 0.896 (95% CI, 0.824-0.968), and 0.862 (95% CI, 0.721-1.000). MRE had a higher AUROC than ARFI for discriminating dichotomized fibrosis stages at every dichotomization cutpoint, but the difference in AUROC was smaller as the dichotomization cutpoint increased. Conclusion: In a head-to-head comparison and using contemporaneous liver biopsy as the gold standard, MRE provides significantly higher diagnostic accuracy than ARFI for diagnosing any fibrosis in NAFLD patients. Disclosures: Claude B. Sirlin - Grant/Research Support: GE, Pfizer, Bayer, Guerbet, Siemens Rohit Loomba - Advisory Committees or Review Panels: Galmed Inc, Tobira Inc, Arrowhead Research Inc; Consulting: Gilead Inc, Corgenix Inc, Janssen and Janssen Inc, Zafgen Inc, Celgene Inc, Alnylam Inc, Inanta Inc, Deutrx Inc; Grant/ Research Support: Daiichi Sankyo Inc, AGA, Merck Inc, Promedior Inc, Kinemed Inc, Immuron Inc, Adheron Inc The following authors have nothing to disclose: Jeffrey Y. Cui, Elhamy Heba, Carolyn Hernandez, William Haufe, Jonathan Hooker 46 The predictive value of 13 C-Methacetin breath test (MBT) for liver transplantation (LT) and death: a seven year follow-up study of 206 chronic hepatitis C patients Oliver Goetze 2,1 , Monika Breuer 1 , Andreas Geier 2,1 , Michael Fried 1 , Achim Weber 4 , Yaron Ilan 3 , Beat Mullhaupt 1 ; 1 Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland; 2 Division of Hepatology, University Hospital Würzburg, Würzburg, Germany; 3 Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel; 4 Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland In patients with chronic liver disease, currently used biomarkers demonstrate limited mid- to long-term predictive values to forecast deterioration of liver function leading to liver transplantation (LT) or liver related death. Aim: To determine the predictive value of the 13 C-Methacetin Breath Test (MBT) (BreathID ® ; Exalenz) in forseeing deterioration of liver function leading to LT and/or death in patients with chronic HCV infection. Methods: A total of 265 chronic HCV infected patients were enrolled, out of which 206 patients (71 females) without co-infections and/or liver comorbidities were considered for this analysis. The average BMI was 24.8 kg/m 2 (SD 4.0 kg/ m 2 ), 183 patients underwent liver biopsy and ISHAK scoring and 196 patients underwent MBT. 13 C-Methacetin peak percent dose recovery rate (PDR-Peak) was used as determinant parameter for this analysis. Patients were followed for up to 7 years according to standard of care. During the course of follow-up some patients underwent antiviral treatment as part of routine patient management. Primary analysis was performed on all patients up to one of the following: liver-transplantation, death or response to antiviral treatment, resulting in 161 and 158 patients with biopsy and/or MBT results respectively. Predictive value was assessed using ROC curve and survival analyses. Results: In seven years follow up, PDR-Peak, using cut-off of 20%/h, predicted LT and/or death with HR=12.07 (95%CI 3.48;41.84),p
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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