TECHNICAL MANUAL
For Veterinarians - Merial
For Veterinarians - Merial
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Summary of ZACTRAN ® (gamithromycin)<br />
ZACTRAN is available in 500, 250 and 100 mL sizes.<br />
Trade Name ZACTRAN ®<br />
FDA Approval NADA 141-328<br />
Active Ingredient<br />
Gamithromycin<br />
Antimicrobial Class<br />
Macrolide<br />
Subclass<br />
Azalide<br />
Formulation<br />
150 mg/mL<br />
Dosage<br />
6 mg/kg<br />
Injection Volume<br />
2 mL/110 lbs.<br />
(1 mL/25 kg)<br />
Low Plasma Binding 3 * 26%<br />
High Available Free Drug 3 * 74%<br />
Bioavailability 4 *<br />
Complete<br />
High Volume of Distribution 3 * 25 L/kg<br />
Rapid Treatment Response 1 24 hours<br />
BRD Treatment Duration 3 10 days<br />
BRD Control Duration 2,3 10 days<br />
About ZACTRAN:<br />
• Novel subclass of macrolide with a structural difference 5<br />
• Treated cattle showed a significant improvement<br />
in BRD clinical signs within 24 hours 1<br />
• Provides 10-day BRD treatment duration 1,3<br />
• Provides 10-day BRD control duration 2,3<br />
• Convenient and ready-to-use<br />
• A real alternative for BRD treatment and control 3<br />
* Clinical relevance has not been determined.<br />
IMPORTANT SAFETY INFORMATION: For use in cattle only. Do not treat cattle within 35 days<br />
of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle<br />
20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine<br />
reproductive performance, pregnancy and lactation have not been determined.<br />
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