TECHNICAL MANUAL
For Veterinarians - Merial
For Veterinarians - Merial
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ZACTRAN ® (gamithromycin) reaches levels rapidly. 10 *<br />
Gamithromycin Concentrations (µg/mL or µg/g)<br />
100<br />
10<br />
1<br />
0.1<br />
0.01<br />
0.001<br />
| | | | | |<br />
30 minutes<br />
MIC 90<br />
12 hours 24 hours<br />
BAL cells (μg/mL)<br />
PELF (μg/mL)<br />
Lung (μg/g)<br />
0 2 4 6 8 10 12<br />
24<br />
Hours<br />
Results<br />
Within 30 minutes after SC injection, ZACTRAN reaches lung concentrations above<br />
MIC 90<br />
for M. haemolytica, P. multocida and H. somni. 5 *<br />
Gamithromycin is at peak lung tissue concentration within 12 hours, with peak<br />
concentrations in BAL cells and PELF at 24 hours. 5 *<br />
* Clinical relevance has not been determined.<br />
IMPORTANT SAFETY INFORMATION: For use in cattle only. Do not treat cattle within 35 days<br />
of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle<br />
20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine<br />
reproductive performance, pregnancy and lactation have not been determined.<br />
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