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TECHNICAL MANUAL

For Veterinarians - Merial

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ZACTRAN ® (gamithromycin) reaches levels rapidly. 10 *<br />

Gamithromycin Concentrations (µg/mL or µg/g)<br />

100<br />

10<br />

1<br />

0.1<br />

0.01<br />

0.001<br />

| | | | | |<br />

30 minutes<br />

MIC 90<br />

12 hours 24 hours<br />

BAL cells (μg/mL)<br />

PELF (μg/mL)<br />

Lung (μg/g)<br />

0 2 4 6 8 10 12<br />

24<br />

Hours<br />

Results<br />

Within 30 minutes after SC injection, ZACTRAN reaches lung concentrations above<br />

MIC 90<br />

for M. haemolytica, P. multocida and H. somni. 5 *<br />

Gamithromycin is at peak lung tissue concentration within 12 hours, with peak<br />

concentrations in BAL cells and PELF at 24 hours. 5 *<br />

* Clinical relevance has not been determined.<br />

IMPORTANT SAFETY INFORMATION: For use in cattle only. Do not treat cattle within 35 days<br />

of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle<br />

20 months of age or older, or in calves to be processed for veal. The effects of ZACTRAN on bovine<br />

reproductive performance, pregnancy and lactation have not been determined.<br />

11

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