a-collection-of-research-articles-on-the-medical-potential-of-cow-urine
a-collection-of-research-articles-on-the-medical-potential-of-cow-urine
a-collection-of-research-articles-on-the-medical-potential-of-cow-urine
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Original Research Paper<br />
Lipid-lowering activity <str<strong>on</strong>g>of</str<strong>on</strong>g> Cow <strong>urine</strong> ark in guinea pigs fed with a high<br />
cholesterol diet<br />
Chawda Hiren Manubhai 1 , Mandavia Divyesh Rasiklal 1 , Baxi Seema Natvarlal 2 , Vadgama<br />
Vishalkumar Kishorbhai 1 , Tripathi Chandrabhanu Rajkishor 1* <br />
1 Department <str<strong>on</strong>g>of</str<strong>on</strong>g> Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India<br />
2 Department <str<strong>on</strong>g>of</str<strong>on</strong>g> Pathology, Government Medical College, Bhavnagar-364001, Gujarat, India<br />
Article history:<br />
Received: Sep 28, 2013<br />
Received in revised form:<br />
Apr 5, 2014<br />
Accepted: May 14, 2014<br />
Vol. 4, No. 5, Sep-Oct 2014,<br />
354-363.<br />
* Corresp<strong>on</strong>ding Author:<br />
Tel: +919825951678<br />
Fax: +9102782422011<br />
cbrtripathi@yahoo.co.in<br />
Keywords:<br />
Antioxidant activity<br />
Cow <strong>urine</strong> ark<br />
Dyslipidemia<br />
Hypolipidemia<br />
Guinea pig<br />
Statin<br />
Abstract<br />
Objectives: Cow <strong>urine</strong> ark (CUA), known as “Amrita” as<br />
menti<strong>on</strong>ed in Ayurveda, c<strong>on</strong>tains anti-hyperglycemic and<br />
antioxidant effects. Therefore, we designed <strong>the</strong> present study to<br />
evaluate <strong>the</strong> lipid lowering activity <str<strong>on</strong>g>of</str<strong>on</strong>g> CUA and its possible<br />
implicati<strong>on</strong> in metabolic syndrome.<br />
Materials and Methods: Thirty guinea pigs <str<strong>on</strong>g>of</str<strong>on</strong>g> ei<strong>the</strong>r sex were<br />
divided into five groups: Group 1 and 2 serving as a vehicle and<br />
sham c<strong>on</strong>trol, received normal and high fat diet for 60 days<br />
respectively; Group 3, 4 and 5 received high fat diet for 60 days<br />
with CUA 0.8 ml/kg, 1.6 ml/kg and rosuvastatin (1.5 mg/kg) <strong>on</strong><br />
<strong>the</strong>last 30 days <str<strong>on</strong>g>of</str<strong>on</strong>g> study period, respectively. Serum lipid pr<str<strong>on</strong>g>of</str<strong>on</strong>g>ile<br />
(total cholesterol, triglycerides, LDL-C, VLDL-C, HDL-C, total<br />
Cholesterol/HDL-C) and serum enzymes (ALT, AST, ALP, LDH<br />
and CK-MB) were performed in each group at <strong>the</strong> beginning and<br />
end <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>the</strong> study. Histological study <str<strong>on</strong>g>of</str<strong>on</strong>g> liver and kidney was d<strong>on</strong>e<br />
in each group.<br />
Results: CUA (0.8 ml/kg) significantly decreased <strong>the</strong> serum<br />
triglycerides and VLDL-C, but CUA (1.6 ml/kg) decreased <strong>the</strong><br />
total serum Cholesterol, triglycerides and VLDL-C (p < 0.05).<br />
Higher dose (1.6 ml/kg) <str<strong>on</strong>g>of</str<strong>on</strong>g> CUA also increased HDL-C level,<br />
significantly (p < 0.05). CUA reduced serum AST, ALP and LDH<br />
level, which was statistically significant as well, while it also<br />
decreased <strong>the</strong> accumulati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> lipid in hepatocytes as compared to<br />
sham c<strong>on</strong>trol.<br />
C<strong>on</strong>clusi<strong>on</strong>s: CUA reduced triglycerides, increased HDL-C and<br />
found to be hepatoprotective in animals that are <strong>on</strong> a high fat diet.<br />
Please cite this paper as:<br />
Chawda Hiren M, Mandavia DR, Baxi SN, Vadgama VK, Tripathi CR.Lipid-lowering activity <str<strong>on</strong>g>of</str<strong>on</strong>g> Cow <strong>urine</strong> ark<br />
in guinea pigs fed with a high cholesterol Diet. Avicenna J Phytomed, 2014; 4 (5): 354-363.<br />
Introducti<strong>on</strong><br />
Cardiovascular diseases (CVD) are<br />
emerging problem in developing countries<br />
(Freedman, 2003; Badim<strong>on</strong> et al., 2010).<br />
CVD may become <strong>the</strong> reas<strong>on</strong> for <strong>the</strong> loss<br />
<str<strong>on</strong>g>of</str<strong>on</strong>g> 17.9 milli<strong>on</strong> Potentially Productive<br />
Years <str<strong>on</strong>g>of</str<strong>on</strong>g> Life Lost (PPYLL) in India, by<br />
2030 (Anchala et al., 2012). Dyslipidaemia<br />
is well recognized risk factor for <strong>the</strong><br />
development <str<strong>on</strong>g>of</str<strong>on</strong>g> cardiovascular diseases<br />
AJP, Vol. 4, No. 5, Sep-Oct 2014 354