a-collection-of-research-articles-on-the-medical-potential-of-cow-urine
a-collection-of-research-articles-on-the-medical-potential-of-cow-urine
a-collection-of-research-articles-on-the-medical-potential-of-cow-urine
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ISSN NO 2320-5407 Internati<strong>on</strong>al Journal <str<strong>on</strong>g>of</str<strong>on</strong>g> Advanced Research (2013), Volume 1, Issue 5, 71-78<br />
Journal homepage: http://www.journalijar.com<br />
INTERNATIONAL JOURNAL<br />
OF ADVANCED RESEARCH<br />
RESEARCH ARTICLE<br />
Evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> Anticancer properties <str<strong>on</strong>g>of</str<strong>on</strong>g> Taxusbaccata and Badri <strong>cow</strong> <strong>urine</strong> in mice: Clinicohematological<br />
study<br />
Ankita Joshi, and R.S. Chauha<br />
1. Post Doctoral Fellow, Cell Culture Laboratory, Institute <str<strong>on</strong>g>of</str<strong>on</strong>g> Biotechnology, G.B. Pant University <str<strong>on</strong>g>of</str<strong>on</strong>g> Agriculture<br />
and Technology, Patwadangar-263128, Nainital, Uttarakhand, INDIA.<br />
2. Campus Director, Institute <str<strong>on</strong>g>of</str<strong>on</strong>g> Biotechnology, G.B. Pant University <str<strong>on</strong>g>of</str<strong>on</strong>g> Agriculture and Technology, Patwadangar-<br />
263128, Nainital, Uttarakhand, INDIA.<br />
Manuscript Info<br />
Manuscript History:<br />
Received: 12 June 2013<br />
Final Accepted: 23 June 2013<br />
Published Online: July 2013<br />
Key words:<br />
Badri<strong>cow</strong> <strong>urine</strong>,<br />
Taxusbaccata, Mice,<br />
Body weight, hematology.<br />
Abstract<br />
In <strong>the</strong> present investigati<strong>on</strong>, <strong>the</strong> anticancerous effect <str<strong>on</strong>g>of</str<strong>on</strong>g> Taxusbacaata and<br />
distilled Badri <strong>cow</strong> <strong>urine</strong> was studied in mice for clinicohematology and<br />
body weight for a period <str<strong>on</strong>g>of</str<strong>on</strong>g> six m<strong>on</strong>th at an interval <str<strong>on</strong>g>of</str<strong>on</strong>g> 15 days. The study<br />
revealed that <strong>the</strong> values <str<strong>on</strong>g>of</str<strong>on</strong>g> total leucocyte count (TLC), absolute lymphocyte<br />
count (ALC) and absolute neutrophil count (ANC) were significantly<br />
increased in <strong>the</strong> treated groups <str<strong>on</strong>g>of</str<strong>on</strong>g> mice ei<strong>the</strong>r by CUD al<strong>on</strong>e and in<br />
combinati<strong>on</strong> withTaxusbaccata extracts. At180th day, it was found that <strong>the</strong>re<br />
was an increase in body weight, Hemoglobin c<strong>on</strong>tent (Hb), total erythrocyte<br />
count (TEC), total leucocyte count (TLC), absolute lymphocyte count (ALC)<br />
and absolute neutrophil count (ANC) levels in CUD +A treated group as<br />
23%, 23.99%, 41%, 40%, 40.31%, and 40.13%, respectively. This clearly<br />
indicate <strong>the</strong>, increase in vitality and defence mechanism <str<strong>on</strong>g>of</str<strong>on</strong>g> body which in<br />
turn helps in fur<strong>the</strong>r healing <str<strong>on</strong>g>of</str<strong>on</strong>g> cancer.<br />
Copy Right, IJAR, 2013,. All rights reserved.<br />
Introducti<strong>on</strong><br />
Cancer is a disease involving dynamic changes in<br />
genome and is characterized by <strong>the</strong> unc<strong>on</strong>trolled,<br />
uncoordinated and purposeless proliferati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g><br />
malignant cells and <strong>the</strong>ir ability to spread, ei<strong>the</strong>r by<br />
growth in <strong>the</strong> adjacent tissue through invasi<strong>on</strong> or by<br />
implantati<strong>on</strong> at distant sites through metastasis.<br />
World cancer report issued by Internati<strong>on</strong>al Agency<br />
for Research <strong>on</strong> Cancer (IARC) reported in 2003 that<br />
cancer rate is set to increase at an alarming rate<br />
globally. The 5-year relative survival rate for all<br />
cancers diagnosed between 1999-2005 is 68%, up<br />
from 50% in 1975-1977. (Kinzler and Vogelstein,<br />
2002)(Jemal et al., 2011).<br />
In India about 70% <str<strong>on</strong>g>of</str<strong>on</strong>g> populati<strong>on</strong> obtains <strong>medical</strong><br />
help from private practiti<strong>on</strong>ers and half <str<strong>on</strong>g>of</str<strong>on</strong>g> those who<br />
seek medicinal help obtain it from alternative and<br />
traditi<strong>on</strong>al medicine (Kumar et al., 2004). Poverty<br />
and socioec<strong>on</strong>omic status are o<strong>the</strong>r hurdles in<br />
treatment (Pal and Mittal, 2004). American cancer<br />
society defines complementary and alternative<br />
medicines (CAM) simply as anything which is not<br />
c<strong>on</strong>venti<strong>on</strong>al (Zollman and Vickers, 1999; Park et al.,<br />
2003). There are various CAM used for cancer<br />
patient worldwide viz. Herbal medicine, acupuncture,<br />
Ayurveda, biological agents, traditi<strong>on</strong>al Chinese<br />
medicines, meditati<strong>on</strong> and yoga etc. However, use <str<strong>on</strong>g>of</str<strong>on</strong>g><br />
herbs for cancer treatment is very popular throughout<br />
<strong>the</strong> world.<br />
Distilled <strong>cow</strong> <strong>urine</strong> protects DNA and<br />
repairs it rapidly as observed after damage due to<br />
pesticides. It protects chromosomal aberrati<strong>on</strong>s by<br />
mitocycin in human leukocyte. Cow <strong>urine</strong> helps <strong>the</strong><br />
lymphocytes to survive and not to commit suicide<br />
(apoptosis). Pathogenic effect <str<strong>on</strong>g>of</str<strong>on</strong>g> free radicals are<br />
prevented through <strong>cow</strong> <strong>urine</strong> <strong>the</strong>rapy. Use <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>cow</strong><br />
<strong>urine</strong> <strong>on</strong>e can get <strong>the</strong> charm <str<strong>on</strong>g>of</str<strong>on</strong>g> a youth as it prevents<br />
<strong>the</strong> free radicals formati<strong>on</strong>. Taxus baccata,<br />
comm<strong>on</strong>ly known as THUNER, which is mainly<br />
found in high altitude area like, Patwadangar,<br />
Nainital India also had anticancer and antiviral<br />
properties. It is a small to medium-sized evergreen<br />
tree, growing 10-20 m tall, excepti<strong>on</strong>ally up to 28 m.<br />
It is relatively slow growing, but can be very l<strong>on</strong>glived,<br />
with <strong>the</strong> maximum recorded trunk diameter <str<strong>on</strong>g>of</str<strong>on</strong>g><br />
71