AIR POLLUTION – MONITORING MODELLING AND HEALTH

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344 Air Pollution <strong>–</strong> Monitoring, Modelling and Health concentrations are high. However, some studies have indicated no association between ambient air pollution and lung function, especially in ambient low-dose exposure (Dockery et al. 1989; Anonymous. 1995). Recently, our population-based epidemiologic study in Taiwanese communities was published to show that traffic-related pollutants CO, NOx, NO 2 , and NO had chronic harmful effects on lung function in children (Lee et al.). Deficits in lung function indices were not significantly related to the ambient levels of O 3 , SO 2 , PM 2.5 , and PM 10 . After adjustment for individual-level confounders, lung function differed only slightly between communities with different levels of air pollution. Our findings indicated that chronic exposure to ambient NOx and CO significantly decreases lung function in children. These findings are in concordance with several previous epidemiologic studies concerning chronic effects of ambient air pollution from Italy (Rosenlund et al. 2009), Finland (Timonen et al. 2002), and California (Peters et al. 1999b). In present data, we found consistent effects of NOx and CO on FVC and FEV1 that represent central airways, whereas the effects on MMEF and PEFR that provide information primarily on damage of the peripheral airways was more limited. Outdoor NO 2 is strongly influenced by local traffic density (Jerrett et al. 2005). Another recent cohort study from California revealed an adverse effect of prenatal exposure to NO 2 and CO on lung function in asthmatic children (Mortimer et al. 2008). Chronic airway inflammation could produce the decreases in lung function indices and the central airways seem to be mainly affected given the stronger signal that we detected for FVC in the present study. Plausible mechanisms of NO 2 pulmonary toxicity have been well described (Persinger et al. 2002) and may contribute to part of our findings. However, in human exposure studies, adverse pulmonary effects of NO 2 have generally been demonstrated at levels of exposure a magnitude higher than reported here (Kraft et al. 2005). The above experimental results contrast recent epidemiologic findings showing associations of asthma outcomes in children with low levels of indoor NO 2 (Belanger et al. 2006), of personal NO 2 (Chauhan et al. 2003), and of ambient NO 2 . The low ambient NO 2 levels we found are more likely to have served as a surrogate for traffic-related air pollutants. Although it is difficult to discuss etiological mechanisms in our cross-sectional design, we believe these pollutants may be causally related to lung function through oxidative stress responses induced by pollutants highly correlated with NO 2 (Seaton et al. 2003; Li et al. 2003). A previous study of Californian children has showed that the acute effect of ambient NO 2 was about -0.4 ml/ppb in contrast to the chronic effect of -1.7 ml/ppb on morning FVC measurements (Linn et al. 1996). Our data also indicated that the chronic effect of NO 2 (-4.81 ml/ppb) was slightly larger than subchronic effect (-4.35 ml/ppb) on FVC. However, subchronic effects of NO 2 were significantly greater than chronic effects on MMEF and PEFR. Comparison of pollutants concentrations between studies is difficult because of differences in the atmospheres and in the measurement techniques. We further conduct meta-analyses for the present and other available studies of ambient NO 2 effects on lung function indices in children. We accepted a priori all studies with individual as the unit of observation. The fixed-effects models were calculated using the Mantel-Haenszel method with inverse variances of individual effect estimates as weights. We also studied heterogeneity of the study-specific effect estimates by plotting the measures of effect and applying Q-statistics. Meta-analyses were undertaken of previously published studies together with the data from the present study of ambient NO 2 exposure. As shown in Figure 1, the pooled estimates for four lung indices provided consistent evidence of significantly adverse
Air Pollution and Health Effects in Children 345 effects. We also elaborated the heterogeneity between the specific estimates by study design and year, but none showed significant Q-statistics. Therefore, only fixed-effect models were systemically used to present pooled effect estimates (Figure 1). A B
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AIR POLLUTION - MONITORING, MODELLI
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Contents Preface IX Chapter 1 Urban
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Preface This book provides a compre
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2 Air Pollution - Monitoring, Model
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10 Air Pollution - Monitoring, Mode
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AIR POLLUTION – MONITORING MODELLING AND HEALTH

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