A Oil 012 - Molecular Biology and Evolution

ND4
Hum
Chi
Gor
Ora
Gib
Jam
Rhm
Crm
Barn
Sqm
Tar
Lem
Molecular Phylogeny and Evolution of Primate mtDNA 63 1
60
SFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANL
I
TVT :: T
TV
R A
S T MY NTL R ! T
S T MY NTL R : T T T
S TT MY NTLR I T T
ST V MY I T F; T
F M I T OFT", F GL N
I !T T V T A AR AT T
MT M I TLARI I T T
120
Hum ALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMK
Chi S F I
Gor T S P T
Ora MAM I :T R TP
Gib F HAS A T IT VI IM RT K
Jam F IA S H IM I H RT MI
Rhm F IA S HIM F I H RA MI
Crm F IT S H IV I H IVRT MI
Barn F IA S H IM I H RA MT
Sqm A V LTI SS F IMF H YAS R i Y&s
Tar I MMAA HLIIV T: LIM R KY Y IM
Lem s I F TMAS II M I L R K Y SH LN
152
Hum PSFTRENTLMFMHLSPILLLSLNPDIITGFSS
Chi L T
Gor I T
Ora L S A AY
Gib L M L FL T N TP
Jam P A I N L T
Rhm P M A I N L T
Crm P M A I N L T
Barn P ML AI N L T
Sam M MT TSKVMPP
Tar P I F LI T KL M TMY
Lem S MLL FT K L PTY
ND 5
60
Hum MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHWKSIVASTFIISLFPTTMFMCLDQE
Chi Y P L I
Gor YA A F: S L
Ora TA F A TA I P TAI AT I I G
Gib A Y AI TA I L MT1 M M T
Jam I PIIMT I TL FA I Y RP D TT MYA PS L IFSN
Rhm I PIMMT I TL FA I Y RP D TT MYA PS L IFSN
Crm I PIMMT I TL FA T Y R D TT MYA T PS L ILSN
Barn I Y PIMMT I TL FA I HL N TAMYA T SS LYFN
Sqm - FSI LM I LA A I STL Y LAIIYAL T TLSMMF ILTG
Tar NLFSSSIL S L T FII TTKKYETHA Y NSI CA MT V ML LYTN
Lem NLLSSF LV II TL IMNVT MY NYP AP SI CA T I ML ISSG
79
Hum VIISNWHWATTQTThLSLS
Chi A
Gor A S I
Ora T VT C T L
Gib T TA LE
Jam TT WS MM LD T
Rhm TT WS LD T
Crm TT WS M LD T
Barn T WS MM LS T
Sqm SM MI IK
Tar M M IH MK C
Lem T MI LK I
FIG. 2.-Amino acid sequences for the carboxy-terminal region of ND4 and amino-terminal region of
NDS, corresponding to nucleotides 2-457 and 660-896 (fig. I), respectively, from the 12 species deduced
from the nucleotide sequences. Amino acids are translated according to the genetic code table of Anderson
et al. (198 1) and represented by single letters. Abbreviations for the species are the same as those in fig. 1.
The whole amino acid sequence for the human is shown on the top. For the other species, only amino acids
different from those in the human sequence are shown. A gap is denoted by a dash (-).
In the ND5 gene of squirrel monkey, three bases corresponding to one amino
acid have been deleted (figs. 1, 2). The deletion occurred at the second codon of the
gene. The 5’-terminal regions of the ND5 gene in starfish (Himeno et al. 1987) and
sea urchin ( Cantatore et al. 1987 ) are -70 bases longer and the same region of Dro-