INTERPOL HANDBOOK ON DNA DATA EXCHANGE AND PRACTICE

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APPENDIX 7recommendationsfrom the enfsi working groupList of the recommendations from the document as per April 2008:1. Every EU/ENFSI-country should establish a forensic DNA-database and specificlegislation for its implementation and management.2. The type of crime-related stain DNA-profiles which can be included in a DNAdatabaseshould not be restricted.3. To increase the chance of a DNA-profile of a stain to match to a person, the numberof persons which are likely to cause matches in a DNA-database should be as high aslegally (and financially) possible.4. Managers of national DNA-databases should establish (together with otherstakeholders) criteria for the inclusion of partial DNA-profiles to obtain an acceptablebalance between the minimum allowable level of evidential value (match probability) ofa DNA-profile and maximum number of adventitious matches a partial DNA-profileis expected to generate.5. DNA-profiles produced by older commercial kits should be upgraded (if possible)after a match in the national DNA-database to increase the evidential value of thematch and also to fulfil the criteria for international comparison if a country wantsto include DNA-profiles produced by older commercial kits in international searchactions.6. The number of loci in reference samples should be the maximum of the numberof loci present in the kit(s) used for the production of the DNA-profiles of thereference samples to enhance the chance of finding relevant matches with partialDNA-profiles.7. Labs producing DNA-profiles for a DNA-database should, as a minimum, be ISO-17025 (and/or equivalently nationally) accredited and should participate in challengingproficiency tests (for Europe: GEDNAP).8. When low copy number DNA-profiles are included in a DNA-database a dedicated(near) match strategy should be used for them.9. When a new allele is observed in a DNA-profile, its presence should be confirmedby repeated DNA-isolation, PCR, Capillary Electrophoresis and allele calling of theDNA-profile.PAGE 100 APPENDIX 7recommendations from the enfsi working group
10. Alleles from loci with chromosomal anomalies should not be included in a DNAdatabaseas they may be caused by somatic mutations which may only occur in certaintissues/body fluids.11. Wild cards which do not represent a designated allele should not be part of theminimum number of loci/alleles required for a match.12. The guidelines in the document of the ISFG-working group on the analysis of mixedprofiles should be used for the analysis of mixed profiles.13. A numerical match between a reference sample and a mixed profile must always bechecked against the plot of the mixed profile.14. Mixed profiles of more than two persons should not be included in a DNA-databasebecause they cause too many adventitious matches.15. If the removal of a DNA-profile from the DNA-database is dependent on externalinformation, a process should be in place to give the custodian of the DNA-databaseaccess to this information, preferably by means of an automated message to him afteran event which influences the deletion date of a DNA-profile.16. There should be a system which can be consulted by those responsible for samplingpersons to see whether a person is already present in the DNA-database.17. The system which can be consulted by those responsible for sampling persons to seewhether a person is already present in the DNA-database should be combined witha rapid biometric identification system like fingerprints to verify whether a person isalready present in the DNA-database.18. Any DNA-database should have an associated elimination DNA-database (ordatabases) including anybody working on the DNA-samples in the DNA-lab but alsopeople cleaning the labs or performing any other kind of maintenance. Also peopleearlier in the chain of custody like the police and other persons present at the sceneof crime should be included as well as unidentified DNA-profiles found in negativecontrol samples which may come from people involved in manufacturing disposablesand/or chemicals. The latter type of DNA-profiles should be shared with other ENFSIcountries.19. The occurrence of errors in DNA-profiles as a result of human mistakes associatedwith data entry should be avoided as much as possible by automating the allele callingand the DNA-database import process. When DNA-profiles are entered manuallyinto the DNA-database this should be done by a process which detects typing errors,for example by double (blind) entry of data.20. When a DNA-database for historical reasons may contain DNA-profiles with typingand/or allele-calling errors or null alleles, regular searches allowing one or moremismatches may be performed but the pro’s and con’s of this strategy should beevaluated in advance.APPENDIX 7recommendations from the enfsi working groupPAGE 101
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INTERPOLINTERPOL HANDBOOK ONDNA DAT
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INTERPOLINTERPOL HANDBOOK ONDNA DAT
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dna investigative considerations .
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INTRODUCTIONby ronald k. noblethe s
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•back to basics: the use of dna i
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•the dna databaseThe INTERPOL DNA
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PART i: CASE SCENARIOFICTITIOUS SCE
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He cautiously pushes the door open
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The only obvious item of evidential
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• Consider physical evidence that
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DNA SAMPLINGAND EVIDENCE COLLECTION
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•crime scene investigator (csi)Wh
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•potential sources of dnaThere ar
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Open the sampling kit and ensure th
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If at any time during the sampling
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IN THE LABORATORYOnce evidence has
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INTERPRETATION OF THE DNA PROFILEAs
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THE MATCH REPORTTo get to step 5 of
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QUALITY ASSURANCEQuality principles
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to ensure the best possible results
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•in-laboratory trainingAnother as
Page 51 and 52: •key education requirementAnother
Page 53 and 54: PART II: an overviewdna databasesPA
Page 55 and 56: With the increasing use of DNA prof
Page 57 and 58: INTERPOLMember CountryCrimeSceneRef
Page 59 and 60: THE VALUE OF A NATIONAL DNA DATABAS
Page 61 and 62: ESTABLISHING AN EFFECTIVE DNADATABA
Page 63 and 64: •need for a dna databaseOnce the
Page 65 and 66: PublicityOnce a database has been e
Page 67 and 68: It is not only the individual who i
Page 69 and 70: LEGISLATIONSpecific legislation is
Page 71: In conclusion, legislation has to f
Page 74 and 75: THE USE OF POST-CONVICTION DNA TEST
Page 76 and 77: FAMILIAL SEARCHINGThe idea that a D
Page 78 and 79: “Familial searching” has its ad
Page 80 and 81: Recent progress in the forensic use
Page 82 and 83: The most informative target loci fo
Page 84 and 85: Another obvious issue associated wi
Page 86 and 87: APPENDIX 1INTERPOL Standard Set of
Page 88 and 89: 1 16 DNA CODE:VWA THO1 D21S11 FGA D
Page 90 and 91: the process of dna analysisThe biol
Page 92 and 93: AnalysisThe data generated by elect
Page 94 and 95: NameTH01, TPOX,CSF1POmonoplexes(sil
Page 96 and 97: APPENDIX 4questions around anintell
Page 98 and 99: APPENDIX 5DNA FACT SHEETDNA Profili
Page 100 and 101: APPENDIX 6interpol dna search reque
Page 104 and 105: 21. As a national DNA-database regu
Page 106 and 107: Glossary1-24/7AlleleAmelogeninBiolo
Page 108 and 109: Member CountriesMitochondrial DNA(m
Page 110 and 111: ABBREVIATIONSaimsascld/labasipbelte
Page 112 and 113: eferences1 Retrieved from: www.iso.
Page 114 and 115: 40 Sibille, I., Duverneuil, C., Lor
Page 117 and 118: OIPC-INTERPOL200, Quai Chales de Ga
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INTERPOL HANDBOOK ON DNA DATA EXCHANGE AND PRACTICE

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