mitos droplets

mitosstandard microfluidicproductsdropletsmodular systemsfor droplet microfluidics.Innovators in microfluidic solutions

Dolomite leads the way in droplet researchDolomite, a world leader in the design and manufacture of microfluidic devices, hasintroduced the Micro Droplet Systems which enable rapid advances in droplet microfluidicsallowing users to produce more than 10,000 monodispersed droplets per second.The Micro Droplet Systems are built around Dolomite’s industry leading microfluidic products and benefita broad range of applications including the production of monodispersed emulsions or beads. Thanks totheir modularity, the Micro Droplet Systems provide users with a very cost-effective and flexible solutionoffering:• multiple functionalities: all components can be used independently;• diversification: the droplet systems are easily expandable;• user-friendly design: the droplet systems are quick to connect and easy to operate.The range of Micro Droplet Systems includes:Droplet Starter Systems (Pressure-based and Syringe-based)ideal for initial demonstration of droplet microfluidics and users new to droplet researchDroplet Advanced Systemdesigned for users with some experience in microfluidics and droplet researchDroplet Emulsion Systemideal for the generation, collection and analysis of monodispersed emulsionsExamples of droplet formation using the Micro Droplet Systemswater-in-oil droplets two droplet streams small droplets Ø 70µm Janus particlesDroplet Junction ChipsAll systems include a range of Droplet Junction Chips with different junction geometries, channel sizesand surface properties. The chips have excellent optical transparency for clear imaging of droplets.Advanced hydrophobic coating treatments enable water-in-oil droplets to be generated as well asoil-in-water droplets formed in the untreated chips. Dolomite also offers a wide range of customisedchips tailored to your specific requirements.Innovators in microfluidic solutions

System componentsThe modular systems are built around Dolomite’s industry leading microfluidicproducts. Each system provides a complete solution containing all necessary pumps,connectors and chips to start making droplets immediately.Mitos Droplet Junction Chip in the MitosChip Holder H connected to the MitosEdge Connector 4-wayMitos P-PumpMitos Duo-XS PumpMitos P-Pump 3-wayChamber LidFlow ResistorFlow Starter KitKey system componentsPressure-basedDroplet Starter SystemSyringe-basedDroplet Starter SystemDropletAdvanced SystemDropletEmulsion SystemMitos P-Pump ü x ü üMitos P-Pump 3-way Chamber Lid ü x o oMitos Duo-XS Pump x ü x xMitos Chip Holder H ü ü ü xMitos Edge Connector 4-way ü ü ü üDroplet Chip, 100µm hydrophobic ü ü ü üDroplet Chip, 100µm hydrophilic ü ü ü üDroplet Chip, 190µm hydrophilic o ü ü üDroplet Chip, 190µm hydrophobic o ü ü üCustom Flow Resistor Tubing Kit ü x o oFlow Resistor Kit o x ü üDroplet Collection Module o o o üFlow Starter Kit ü ü ü üü standard componento optional extraThere is a broad range of accessories available including high speed optical systems, reagent kits,priming valves, remote chambers and flow sensors. Please contact us to discuss your requirements orvisit our website www.dolomite-microfluidics.com/droplets for more information.

Droplet Starter SystemsProviding a pulseless and stable liquid flow, thePressure-based system eliminates dead volume andsample waste to effectively reduce reagent costs. Thesystem features an innovative 3-way chamber lidallowing pumping of up to 3 liquids simultaneously.The Syringe-based system provides 2 independentsyringes, with rotary valves, enabling fast automaticrefill from up to 3 different sources, as well asindependent control of each liquid channel.Droplet Advanced SystemThe Droplet Advanced System offers a flexible highperformancesolution for droplet formation. Thepressure driven pumps and flow resistors give the userprecise control over flow rates and droplet size. Quickchanges to flow conditions enable fast optimization ofdroplet parameters.Droplet Emulsion SystemThis system features an innovative quartz collectionmodule for transfer of droplets from chip to bulk fluidwithout flow disturbance. The droplet size can be setprecisely and changed quickly giving the user fullcontrol over emulsion characteristics.Technical informationPressure-basedDroplet StarterSystemSyringe-basedDroplet StarterSystemDropletAdvancedSystemDroplet size range 10 - 150µm 10 - 250µmDroplet production rate> 10,000 droplets per secondMonodispersity Very good Good Very goodPump typePulseless pressuredriven pumpExtra smoothsyringe pumpDropletEmulsionSystemPulseless pressure driven pumpMax. pressure 10bar 6bar 10barIndependent control of fluid channels No YesFlexibility of experimentation Limited Highwww.dolomite-microfluidics.com

Benefits• Highly monodispersed droplets from Ø 10 to 250µm• Water-in-oil and oil-in-water droplets• Precise control over flow rate and droplet size• Stable liquid flow• Wide pressure range 0 - 10bar• Excellent chemical resistance• Cost effective and flexible solution• Easy to set up and useApplicationsThe Micro Droplet Systems benefit a broad range of applicationareas including:• Compartmentalized chemistry• High throughput experimentation• Alginate polymerization• Generation of monodispersed emulsions or beads• Cell encapsulation

The Dolomite Centre Ltd.Unit 1, Anglian Business Park, Royston,Hertfordshire, SG8 5TW, United KingdomT: +44 (0)1763 242491F: +44 (0)1763 246125E: info@dolomite-microfluidics.comW: www.dolomite-microfluidics.comDolomite Microfluidics29 Albion PlaceCharlestown, MA 02129, USAT: 617 848 1 2 1 1F: 617 500 0136E: salesus@dolomite-microfluidics.comW: www.dolomite-microfluidics.com.