Issue 2 - Bcon-instruments.nl

CONTENTSBASKETS 4BASKET SHAFTS 8SPIN SHAFT ACCESSORIES 9PADDLES 10CAPSULE SINKERS 12VESSELS 16VESSEL COVERS 20FILTERS 22SAMPLING CANNULAE 26TRANSDERMAL TESTING 32BIOBIODISSOLUTION ACCESSORIES 34FELODIPINE TEST BASKET 35CALIBRATION TOOLS 36GLASS ACCESSORIES 38IINTRINSIC DISSOLUTION 39DISINTEGRATION 40ZMISCCALIPER LIFESCIENCES (ZYMARK) 41MISC ACCESSORIES 42OEMINDEXINDEX – OEM REFERENCE 43INDEX – PART NUMBER 453

APPARATUS 1CalevaCompatible BasketsPart No. Description OEM RefBSK010-CA 10 Mesh Stainless Steel Basket 0810123BSK020-CA 20 Mesh Stainless Steel Basket 0810021BSK040-CA 40 Mesh Stainless Steel Basket 0810019BSKSUP-CA Suppository Basket, Plastic –BSK010-CA BSK020-CA BSK040-CA BSKSUP-CADistekCompatible BasketsPart No. Description OEM RefBSK010-DK 10 Mesh Stainless Steel Basket 2821-0160BSK010-DKC10 Mesh Stainless Steel Basket,Evolution Series2800-0041BSK020-DK 20 Mesh Stainless Steel Basket 2821-0159BSK020-DKC20 Mesh Stainless Steel Basket,Evolution Series2800-0042BSK040-DK 40 Mesh Stainless Steel Basket 2821-0072BSK040-DKC40 Mesh Stainless Steel Basket,Evolution SeriesBSKPTD-40 40 Mesh PTFE Coated Basket –2800-0032BSKSUP-DK Suppository Basket, Plastic 3250-0445BSK010-DK BSK010-DKC BSK020-DK BSK020-DKCBSK040-DK BSK040-DKC BSKSUP-DKErwekaCompatible BasketsPart No. Description OEM RefBSK020-EW 20 Mesh Stainless Steel Basket 90-000-0015BSK040-EW 40 Mesh Stainless Steel Basket 90-000-0040BSKSUP-EW Suppository Basket, Plastic –BSK020-EW BSK040-EW BSKSUP-EWTel: +44 (0)1452 310210Continued overleaf...5

BASKETSHansonCompatible BasketsPart No. Description OEM RefBSK010-HR 10 Mesh Stainless Steel Basket 65-220-010BSK020-HR 20 Mesh Stainless Steel Basket 65-220-020BSK040-HR 40 Mesh Stainless Steel Basket 65-220-000BSKPTH-40 40 Mesh PTFE Coated Basket –BSKSUP-HR Suppository Basket, Plastic 65-700-048BSK010-HR BSK020-HR BSK040-HRBSKPTH-40BSKSUP-HRPharmatestCompatible BasketsPart No. Description OEM RefBSK010-PT 10 Mesh Stainless Steel Basket –BSK020-PT 20 Mesh Stainless Steel Basket –BSK040-PT 40 Mesh Stainless Steel Basket –BSKSUP-PT Suppository Basket, Plastic –BSK010-PT BSK020-PT BSK040-PT BSKSUP-PTSotaxCompatible BasketsPart No. Description OEM RefBSK010-SX 10 Mesh Stainless Steel Basket –BSK020-SX 20 Mesh Stainless Steel Basket –BSK040-SX 40 Mesh Stainless Steel Basket 2830BSKSUP-SX Suppository Basket, Plastic –BSK010-SX BSK020-SX BSK040-SX BSKSUP-SX6Email: sales@labhut.com

APPARATUS 1VanKelCompatible BasketsPart No. Description OEM RefBSK010-01 10 Mesh Stainless Steel Basket 12-2125BSK020-01 20 Mesh Stainless Steel Basket 12-2120BSK040-01 40 Mesh Stainless Steel Basket 12-2100BSK040-01PL40 Mesh Precision Length StainlessSteel BasketBSKPTV-40 40 Mesh PTFE Coated Basket 12-2110–BSK010-01BSK020-01BSK040-01BSK100-01 100 Mesh Stainless Steel Basket 12-2154BSK150-01 50x150 Mesh Stainless Steel Basket 12-2152BSKSUP-01 Suppository Basket, Plastic 12-2130STABSK-10Stationary Basket Assembly withBasket Shaft and 10 Mesh Basket12-2061STABSK-20Stationary Basket Assembly withBasket Shaft and 20 Mesh Basket12-2060STABSK-40Stationary Basket Assembly withBasket Shaft and 40 Mesh Basket12-2063BSKPTV-40BSKSUP-01STABSK-10 STABSK-20 STABSK-40!USP 26 Felodipine Test Basket – See page 35Dissolution Basket StorageProlong the life of baskets and save moneyTo ensure they meet USP requirements, it is essential that for alltests, baskets are not bent or deformed.The chances of accidentally damaging baskets can be significantlyreduced with the use of a good quality basket holder, such asthis.Key Benefits:• Compatible with all popular basket types (Caleva, Distek,Erweka, Hanson, Pharmatest, Sotax, VanKel, Zymark)• O-rings ensure baskets are held firmly to the holder• Stores up to 12 baskets• Fully stackable, letting you transport many baskets at a time• Low cost – it pays for itself by preventing damage to justone basket!Part No. Description OEM RefBSKHLD-12Stackable Dissolution Basket Holder,12 Position–Tel: +44 (0)1452 3102107

BASKET SHAFTSAPPARATUS 1The Basket Shaft APPARATUS 1iThe basket shaft is the metallic drive shaft in Apparatus 1which is connected to the cylindrical basket. See page 4 formore information on Apparatus 1.All shafts are constructed from type 316 electropolishedstainless steel.Spring-Clip StyleKey ConsiderationsClip or Clipless?Spring Clips – The standard dissolution basket is designedto attach to the basket shaft using spring clips. Over timethese clips can become bent or corroded which can lead toexcessive wobble of the basket on the shaft.O-Ring – The clipless basket fixes to the shaft using anO-ring instead of clips. While it can be argued that thisdesign reduces wobble and is easier to use, the USP stillspecifies the use of clips and proof of equivalence may berequired if a clipless alternative is to be used.O-ring StyleCare & MaintenanceShaft Storage – Bent or scratched shafts fail to complywith USP regulations so it is essential not to store shafts ona desk or loose in a drawer where damage or corrosion canoccur.Proper storage in a basket shaft/paddle holder can preventdamage occurring. See page 11 for basket shaft holders.Wobble – A Wobble Meter (WOBMET-MI) is available tomonitor basket shaft wobble. See page 37.DistekAll basket shafts are lasermarked with a unique serialnumber for easy identificationCompatible Basket ShaftsPart No. Description OEM RefBSDRNG-16 16.5” (420mm) O-Ring Style Basket Shaft 2821-0074BSHT16-02 16.5” (420mm) Spring Clip Style Basket Shaft –BSDRNG-19 19” (480mm) O-Ring Style Basket Shaft 2821-0097SHFT16.5-DK 16.5” (420mm) Detachable Shaft 2800-0165BSKHUB-DK Basket Adaptor, O-Ring Style 2851-1052BSKHUB-DKC Basket Adaptor, Evolution Series Only 3200-0038BSKCLP-DK Basket Clip, Evolution Series Only 3100-0017HansonCompatible Basket ShaftsSHFT16.5-DKBSKHUB-DKBSKHUB-DKCPart No. Description OEM RefBSKSHT-16 16” (405mm) Spring Clip Style Basket Shaft 65-237-000VanKelCompatible Basket ShaftsPart No. Description OEM RefBSKSHT-13 13” (330mm) Spring Clip Style Basket Shaft 12-2073BSKSHT-15 15” (380mm) Spring Clip Style Basket Shaft 12-2070BSKCLP-DKBSKSHT-15CBSKSHT-15COBSKSHT-15CBSKSHT-15CO15” (380mm) Spring Clip Style ConicalBasket Shaft15” (380mm) O-Ring Style ConicalBasket Shaft12-207512-2050BSKSHT-19 19” (480mm) Spring Clip Style Basket Shaft 12-20808Email: sales@labhut.com

SPIN SHAFT ACCESSORIESSpin Shafts APPARATUS 1 / 2 / 6iVanKelSpin Shaft AccessoriesSpin On/Off Shafts for Apparatus 1, 2 and 6 offer a quick,convenient change between paddle and basket methodswithout the need to reset the shaft height.These two-piece basket/paddle/cylinder shafts join abovethe media to prevent potential contamination.Part No. Description OEM RefSPNSHT-13SPNSHT-15SPNSHT-19Spin ON/OFF 14.5” (370mm) ShaftFor V-Series (when fully assembled)Spin ON/OFF 15” (380mm) Shaft(when fully assembled)Spin ON/OFF 19” (480mm) Shaft(when fully assembled)–12-140012-1401Key ConsiderationsSPNBSK-01SPNRNG-01Spin ON/OFF Spring Clip StyleBasket Shaft, 316 S.S.Spin ON/OFF O-Ring Style BasketShaft, 316 S.S.12-143012-1431Spin Shaft Features:SPNBSK-ZM2Spin ON/OFF Double O-Ring StyleConical Basket Shaft, 316 S.S.–• Spin On/Off Shafts may be used in any VanKeldissolution apparatus, including the V-Series• It is unnecessary to remove the shaft when changingapparatus• There is no need to readjust shaft height or the lockingmechanism• The attachment connection for Spin On/Off Shaftsis located outside the media, eliminating any chance ofcontamination• Precision manufacturing has assured USP complianceand detachable components meet USP specifications• Wobble data is well within USP tolerance• Spin On/Off Shafts are engineered to minimise the riskof cross-threading and ensure a secure connection• Spin On/Off Shafts are less expensive than maintainingtwo different sets of shaftsSPNEPD-01SPNSHT-19SPNSHT-15Spin ON/OFF Electropolished316 S.S. PaddleSPNSHT-1312-1421SPNNPD-01 Spin ON/OFF PTFE Coated Paddle 12-1420SPNTPD-01 Spin ON/OFF Solid PTFE Paddle –SPNAP6-01Spin ON/OFF USP APP 6 RotatingCylinder for Transdermal Patches,Electropolished 316 S.S.–Care & MaintenanceSPNBSK-01Spin On/Off Shaft Storage – Bent or scratched shaftsfail to comply with USP regulations so it is essential not tostore shafts on a desk or loose in a drawer where damage orcorrosion can occur.Proper storage in a basket shaft/paddle holder can preventdamage occurring. See page 11 for basket shaft holders.SPNRNG-01SPNBSK-ZM2All spin shafts are laser markedwith a unique serial numberfor easy identificationSPNEPD-01SPNNPD-01SPNTPD-01Tel: +44 (0)1452 3102109

PADDLESThe Paddle APPARATUS 2iApparatus 2, commonly known as the paddle method, hassimilar physical specifications to those of Apparatus 1 with apaddle substituted for the rotating basket.Some of the dimensions and tolerances for the paddle are criticalif consistent results are to be obtained from vessel to vessel.The USP specifies that the paddle must rotate smoothlywithout significant wobble. The arc of the paddle bladecreates considerable flow and any wobble will have anexaggerated effect on the flow profile.The contours of the paddle blade must not includeany sharp edges – at the tips for instance – that couldproduce turbulent instead of laminar flow patterns. The USPconstrains wobble and vertical alignment with the axis of thevessel to within ±2.0mm.All paddles are U.S. Pharmacopeia compliant whereapplicable and meet machine manufacturer specificationsASamplingPointVesselPaddleCapsuleSinkerKey ConsiderationsTypes of paddle:Electropolished Type 316 Stainless Steel – Thestrong 316 stainless steel (316 S.S.) shaft has a high resistanceto bending. It is electropolished for smooth rotation.PTFE Coated – The USP suggests that paddles may becoated with an inert coating. Most paddles are accordinglycoated with PTFE or another inert coating. Such coatingserves two purposes:• It prevents corrosion and the introduction of unwantedions into the media• It seals the joint where the blade is attached to theshaft, thus preventing the accumulation ofcontaminant tracesSolid PTFE – The single piece moulded design features afluoropolymer blade and single-piece stem moulded over anelectropolished, 316 stainless steel shaft.The innovative design features no paddle-to-shaft joint,thus eliminating potential cross-contamination and removinga probable corrosion path. Wobble is also considerablyreduced in the solid PTFE paddle due to its being a singlepiece cast.DistekCompatible PaddlesPart No. Description OEM RefEPD016-02 16.5” (420mm) Electropolished 316 S.S. Paddle 2800-0010NPD016-02 16.5” (420mm) PTFE Coated Paddle 2800-0002TPD016-02 16.5” (420mm) Solid PTFE Paddle 2800-0178TUMSCR-DKHansonThumb Screw for Distek CompatiblePaddle ShaftsCompatible PaddlesPart No. Description OEM RefEPD016-01 16” (405mm) Electropolished 316 S.S. Paddle 65-700-036NPD016-01 16” (405mm) PTFE Coated Paddle 65-700-030TPD016-01 16” (405mm) Solid PTFE Paddle 72-800-456TPD018-01 18” (460mm) Solid PTFE Paddle 72-800-461VanKelCompatible Paddles–Part No. Description OEM RefCare & MaintenancePaddle Storage – Bent or scratched paddles fail tocomply with USP regulations so it is essential not to storepaddles on a desk or loose in a drawer where damage orcorrosion can occur.Proper storage in a basket shaft/paddle holder can preventdamage occurring. See paddle holders on page 11.Wobble – A Wobble Meter (WOBMET-MI) is available tomonitor paddle wobble. See page 37.EPD013-0114.5” (370mm) Electropolished 316 S.S.Paddle for V-Series12-1035EPD015-01 15” (380mm) Electropolished 316 S.S. Paddle 12-1030EPD019-01 19” (485mm) Electropolished 316 S.S. Paddle 12-1040NPD013-0114.5” (370mm) PTFE Coated Paddlefor V-Series12-1005NPD015-01 15” (380mm) PTFE Coated Paddle 12-1000NPD019-01 19” (485mm) PTFE Coated Paddle 12-1010TPD013-0114.5” (370mm) Solid PTFE Paddlefor V-SeriesTPD015-01 15” (380mm) Solid PTFE Paddle –TPD019-01 19” (485mm) Solid PTFE Paddle ––10Email: sales@labhut.com

APPARATUS 2PTFE Coated Paddle(NPD series)Solid PTFE Paddle(TPD series)Polished Stainless Steel Paddle(EPD series)All paddles are laser markedwith a unique serial numberfor easy identification.TUMSCR-DKBasket Shaft/Paddle HoldersIdeal for both basket shaft and paddle storageKey Benefits:• Prevents shafts/paddles from becoming bent or scratched• Allows quick and easy transport of many shafts/paddles• Handy end plate to stop shafts/paddles sliding out when carrying• Holds all lengths and types of basket shafts and paddles• Non-corrosive, quality plastic construction• Space-saving, attractive design• Available in both 12 and 16 shaft capacitiesPart No. Description OEM RefPADHLD-12A Basket Shaft/Paddle Rack, 12 Position –PADHLD-16A Basket Shaft/Paddle Rack, 16 Position – PADHLD-12ADual Purpose:This basket shaft/paddle holder is designed for optimal handling and storage of both basket shafts and paddles.Why not use one to keep a set of both paddles and basket shafts next to each bath?Tel: +44 (0)1452 31021011

CAPSULE SINKERSThe Sinker APPARATUS 2i Key ConsiderationsFloating tablets rarely dissolve at a reproducible rate. Usinga sinker in Apparatus 2 fixes the tablet to a certain point andaids reproducibility. Sinkers can also be useful where tabletsmay stick to the sides of the vessel.USP 711 states:“A small, loose piece of non-reactive material such as notmore than a few turns of wire helix may be attached todosage units that would otherwise float. Other validatedsinker devices may be used.”Once a sinker design is selected for a particular application,the dimensions and drawings should be recorded to ensureuniformity in the procedure.Basket SinkersPart No. Description OEM RefCUSBSK-JPJapanese Pharmacopeia Basket Sinker (Thishas same dimensions as sinker shown in USP)BSK008-01 8 Mesh Basket Sinker –BSK008-JP8 Mesh Basket Sinker,Japanese Pharmacopeia Size12-3070SNK008-VK 8 Mesh Basket Sinker with Lid 12-3062SNK010-VK 10 Mesh Basket Sinker with Lid 12-3060SNK040-VK 40 Mesh Basket Sinker with Lid 12-3064–VVVVInevitably, home-made sinkers tend not to be reproducibleand so commercially available sinkers are quite popular. Thechoice of sinker will depend on the tablet or capsule.General Guidelines:● Sinker Size – The sinker should have minimalsurface contact with the tablet as this can affect thedissolution rate. Sinkers are available in different sizesto accommodate most capsule/tablet dimensions.See the sinker and capsule guides on pages 14 and 15.● Sinker Weight should preferably be kept to aminimum – just enough to have the desired effect.● PTFE Coated Sinkers can be used where theremay be a reaction between steel and the tablet.They also work well with magnetic retrievers.● Uncoated type 316 stainless steel sinkers are moredurable than coated sinkers.● Basket Sinkers can be used but care should betaken that the outer coating of the tablet does notclog the mesh.● Wire Spirals should be as wide as practically possibleto avoid clogging which would affect the dissolution rate.Pronged SinkersPart No. Description OEM RefCAPWHT-VK 3 Pronged Capsule Sinker 12-3050MAGWHT-VK 3 Pronged Capsule Sinker with Magnetic Legs 12-3056CAPWHT-SV 3 Pronged Capsule Sinker, 316 S.S. –VVCUSBSK-JPBSK008-01BSK008-JPCAPWHT-VK / MAGWHT-VKCAPWHT-SVO-Ring SinkersO-ring sinkers feature an expandable rubber ring. This lets thecapsule swell whilst still maintaining adequate sinking.Part No. Description OEM RefCAPWHT-S99 O-Ring Sinker, 316 S.S. 8399 SSNK008-VKSNK010-VKSNK040-VKS = SotaxV = VanKelAll Capsule Sinkers are shown at Actual SizeCAPWHT-S9912Email: sales@labhut.com

APPARATUS 2Spiral SinkersPart No. Description OEM RefCAPWHT-TR Time Release Capsule Sinker –CAPWHT-PC Breath Film Sinker –CAPWST-15 4 Spiral Sotax Style 316 S.S. Capsule Sinker 8280SCAPWHT-04 4 Spiral PTFE Coated Capsule Sinker –CAPWHT-4S 4 Spiral 316 S.S. Capsule Sinker –CAPWHT-LG 4 Spiral PTFE Coated Capsule Sinker –CAPWHT-TRCAPWHT-PCCAPWHT-XL 4 Spiral PTFE Coated Capsule Sinker –CAPWST-18 5 Spiral Sotax Style 316 S.S. Capsule Sinker 7346SCAPWST-19 6 Spiral Sotax Style 316 S.S. Capsule Sinker 8283SCAPWHT-2S 6 Spiral 316 S.S. Capsule Sinker –CAPWHT-02 6 Spiral PTFE Coated Capsule Sinker –CAPWHT-XS 6 Spiral 316 S.S. Capsule Sinker –CAPWST-15CAPWHT-04CAPWST-23 7 Spiral Sotax Style 316 S.S. Capsule Sinker 6881CAPWST-31 10 Spiral Sotax Style 316 S.S. Capsule Sinker 7349SSCAPWHT-4S CAPWHT-LG CAPWHT-XL CAPWST-18 CAPWST-19CAPWHT-2S CAPWHT-02CAPWHT-XS CAPWST-23 CAPWST-31All Capsule Sinkers are shown at Actual SizeType 316 Stainless Steel WireThis wire is ideal for winding your own tablet sinkers,especially if you have non-standard sized tablets. It is thesame high-quality wire used to construct the LabHut basketsinkers and spiral sinkers and is very easy to work with.Part No. Description OEM RefWIRESK-VK316 Stainless Steel Wire, 0.024”(0.6mm) Diameter, 50’ (15m) Roll12-3000 VCustom SinkersLabHut can supply custom sinkers to any specification.Please contact us with your requirements.Part No. Description OEM RefCAPWHT-CUS Custom weights & sinkers –!Extensive details on all sinkers and capsules – SEE OVERLEAFTel: +44 (0)1452 310210Continued overleaf...13

CAPSULE SINKERSSinker Type Part Number Style Material Coating(inches)Inside Diameter(mm)CUSBSK-JP Basket, JP 316 S.S. – 0.470 11.9BSK008-01 Basket, 8 Mesh 316 S.S. – 0.620 15.7BASKETBSK008-JP Basket, 8 Mesh 316 S.S. – 0.410 10.4SNK008-VK Basket, 8 Mesh 316 S.S. – 0.788 20.0SNK010-VK Basket, 10 Mesh 316 S.S. – 0.788 20.0SNK040-VK Basket, 40 Mesh 316 S.S. – 0.788 20.0CAPWHT-VK 3 Prong Nylon / P.P. – 0.200 5.1PRONGEDMAGWHT-VK 3 Prong Nylon / P.P. – 0.200 5.1CAPWHT-SV 3 Prong 316 S.S. – 0.275 0.210 7.0 5.3O-RING CAPWHT-S99 O-Ring 316 S.S. – 0.466 11.8CAPWHT-TR Butterfly 316 S.S. – 0.224 5.7CAPWHT-PC Strip Film 316 S.S. – 0.436 11.0CAPWST-15 Helix 316 S.S. – 0.197 5.0CAPWHT-04 Helix Music Wire PTFE 0.385 9.8CAPWHT-4S Helix 316 S.S. – 0.385 9.8CAPWHT-LG Helix Music Wire PTFE 0.410 10.4SPIRALCAPWHT-XL Helix Music Wire PTFE 0.465 11.8CAPWST-18 Helix 316 S.S. – 0.236 6.0CAPWST-19 Helix 316 S.S. – 0.276 7.0CAPWHT-2S Helix 316 S.S. – 0.370 9.4CAPWHT-02 Helix Music Wire PTFE 0.370 9.4CAPWHT-XS Helix 316 S.S. – 0.580 14.7CAPWST-23 Helix 316 S.S. – 0.315 8.0CAPWST-31 Helix 316 S.S. – 0.433 11.0WIRE WIRESK-VK Sinker Wire 50’ 316 S.S. – – –CAPSULESCapsule Size(inches)Length(mm)(inches)Diameter(mm)000 1.029 26.1 0.390 9.9100E 1.012 25.7 0.336 8.5300 0.917 23.3 0.336 8.530E 0.909 23.1 0.301 7.650 0.854 21.7 0.301 7.651 0.765 19.4 0.272 6.912 0.709 18.0 0.250 6.353 0.626 15.9 0.229 5.834 0.563 14.3 0.209 5.325 0.437 11.1 0.193 4.9114Email: sales@labhut.com

APPARATUS 2Inside Length(inches)(mm)Wire Diameter(inches)(mm)MaxCapsuleSizeNo. of CoilsWeight (g)0.935 23.7 0.039 0.99 00 8 4.001.060 26.9 0.028 0.71 000 9 5.400.790 20.1 0.028 0.71 1 8 3.850.461 11.7 0.028 0.71 000 – 17.600.461 11.7 0.025 0.64 000 – 19.000.461 11.7 0.010 0.25 000 – 20.001.000 25.4 – – 2 – 0.901.000 25.4 – – 2 – 1.20NEED ANY FURTHERADVICE ON SINKERS?Emailsales@labhut.com1.040 26.4 – – 1 (min=3) – 1.251.015 25.8 – – 1 – 1.140.386 9.8 0.026 0.66 – – 0.550.436 11.1 0.035 0.89 – – 1.200.610 15.5 0.016 0.41 5 6 0.600.840 21.3 0.043 1.09 0 5 1.700.840 21.3 0.047 1.19 0 5 1.951.100 27.9 0.043 1.09 000 6.5 2.001.150 29.2 0.043 1.09 000 5.5 2.150.709 18.0 0.016 0.41 3 8.7 0.750.760 19.3 0.016 0.41 2 8 1.000.840 21.3 0.043 1.09 0 8.5 2.850.840 21.3 0.050 1.27 0 8.5 2.050.885 22.5 0.047 1.19 Special* 8.5 3.600.905 23.0 0.016 0.41 0 9 0.951.220 31.0 0.031 0.79 000 11.9 3.25– – 0.032 0.81 – – –* The Maximum Capsule Sizeof CAPWHT-XS is described as“Special” because this sinkeris often used in veterinaryapplications where the capsulediameter can be very large– this sinker has an insidediameter of 0.580” (14.7mm)to accommodate such capsules.Capsules shown at actual size000 00E 00 0E 0 1 2 3 4 5Tel: +44 (0)1452 31021015

VESSELSThe VesseliCare & MaintenanceGood dissolution vessels are critical in obtaining correct andreproducible results and are sometimes overlooked as a keyelement in the dissolution test.All vessels should meet the physical dimensions of the USPand have a hemispherical bottom which means that theyshould be perfectly rounded with no obvious join with thesides and no ‘bumps’ of glass on the inside. Wall thicknessesshould be even and reproducible.Although the USP states the dimensions for vessels, thetolerances are actually quite wide, meaning vessels associatedwith various dissolution baths are not dimensionally thesame. Replacing a vessel with one not specifically designedfor the instrument could impair vessel centering and paddleheight. Also larger or smaller inside diameters can affectvessel hydrodynamics.All LabHut vessels come complete with a certificate of compliance.All vessels are U.S. Pharmacopeia compliant whereapplicable and meet machine manufacturer specificationsVessel Cleaning – It is important that vessels are cleanprior to use – this is relevant when using capsules that havesticky coatings. This is necessary for two reasons – theremay be contamination of the media which could lead to ahigh result or the tablet under test may stick to the vesselwalls leading to a low result – this tends to show when usingprednisone.Any good laboratory detergent should work well to cleanvessels. It can be used with hot water and a soft-bristledbrush. Rinse with tap water (the hardness does a great jobof removing soap residue) followed by a final rinse of purifiedwater. It may also be necessary sometimes to use a towelwetted with methanol to remove really stubborn residues.Vessel Storage – Vessels that are clipped or scratchedshould not be used. Small tablet particles can get stuck inthe grooves. Severely scratched vessels can also affect thedynamics of the solution.Proper storage in a vessel stand can prevent damageoccurring. See vessel stands on page 18.Key ConsiderationsMost baskets are graduated andall glass and plastic vessels areserialised for easy identificationGlass Vessels benefit from goodthermal conductivity (it is often necessaryto have the temperature of the waterbath as much as 2°C higher than theanalysis temperature when using plasticvessels).Another advantage of using glass vesselsis their high resistance to scratching,which means they have to be replacedless frequently.Glass VesselAmber VesselAmber Vessels can be used if lightsensitive compounds are being tested.They are available in glass and plastic.Plastic Vessels can be used in place of glass where appropriate. The plastic must not interfere with theanalysis by sorbing, leaching or reacting with the analyte. Typically styrene acrylonitrile is used.Plastic vessels have the advantage over glass in that they are very reproducible – the vessel is made from a mouldrather than hand-formed. This reduces possible errors in setting the paddle height and centering and can givevery reproducible results.Another advantage of plastic vessels is that they have feet so they can stand upright independently.The biggest disadvantage is that plastic is very prone to scratching and cracking, requiring frequent replacement.Plastic VesselPeak Vessels are designed to prevent cone formation at thebase of the vessel.An undesirable poorly stirred cone shaped region can developunder the paddle during USP Apparatus 2 dissolution tests. Peakvessels have a cone shape moulded into the bottom of the vesselthat improves the hydrodynamics around the dosage form andleads to more reproducible dissolution rates.Peak VesselThe peak effectively displaces the unstirred cone, forcing thematerial tested into the region of appropriate hydrodynamics,where all surfaces of the dosage are constantly and uniformlyexposed to the moving medium.Peak vessels do not comply with USP specifications and cannot besubstituted in existing applications.Conventional VesselPeak Vessel16Email: sales@labhut.com

CalevaCompatible VesselsPart No. Description OEM RefGLA900-CA 1000ml Clear Glass Vessel 0810004GLA900-AC 1000ml Amber Glass Vessel 0810009GLA900-CAGLA900-ACDistekCompatible VesselsPart No. Description OEM RefGLA200-DK 200ml Clear Glass Vessel 3010-0095GLA500-DK 500ml Clear Glass Vessel –GLA900-DK 1000ml Clear Glass Vessel 3010-0069GLA900-AD 1000ml Amber Glass Vessel –GLA9CR-DKGLA9CR-AD1000ml Clear Glass Vessel withCentering Ring1000ml Amber Glass Vessel withCentering Ring3010-00933010-0023GLA9PK-DK 1000ml Clear Glass Peak Vessel 3010-0550PLA900-DK 1000ml Clear Plastic Vessel 3350-0095PLA900-AD 1000ml Amber Plastic Vessel –FLU9CL-DKFLU900-DK1000ml Clear FluoropolymerVessel1000ml Opaque FluoropolymerVesselGLA02K-DK 2000ml Clear Glass Vessel 3010-0285RING01-DK Plastic Centering Ring 3350-0096VSCLIP-DK Vessel Hold Down Clamp 2821-0257––GLA200-DKGLA9CR-DKGLA500-DKGLA900-DKGLA900-ADRING01-DK VSCLIP-DKGLA9CR-ADGLA9PK-DKPLA900-DKPLA900-ADFLU9CL-DKFLU900-DKGLA02K-DKErwekaCompatible VesselsPart No. Description OEM RefGLA900-EW 1000ml Clear Glass Vessel 80-000-1002GLA900-AW 1000ml Amber Glass Vessel 80-000-1004PLA900-EW 1000ml Clear Plastic Vessel –GLA02K-EW 2000ml Clear Glass Vessel 80-000-2002GLA900-EW GLA900-AW PLA900-EW GLA02K-EWTel: +44 (0)1452 310210Continued overleaf...17

VESSELSHansonCompatible VesselsPart No. Description OEM RefGLA500-HR 500ml Clear Glass Vessel –GLA900-HR 1000ml Clear Glass Vessel 72-600-510GLA900-AH 1000ml Amber Glass Vessel 72-600-556GLA9PK-HR1000ml Clear Glass Peak Vesselwith Centering Ring–PLA900-HR 1000ml Clear Plastic Vessel 91-030-003PLA900-AH 1000ml Amber Plastic Vessel –FLU9CL-HR1000ml Clear FluoropolymerVessel–GLA500-HRGLA900-HRGLA900-AHFLU900-HR1000ml Opaque FluoropolymerVessel–GLA02K-HR 2000ml Clear Glass Vessel 72-600-509GLA9PK-HR PLA900-HRPLA900-AHFLU9CL-HR FLU900-HRGLA02K-HRPharmatestCompatible VesselsPart No. Description OEM RefGLA900-PT 1000ml Clear Glass Vessel 303-5225GLA900-AT 1000ml Amber Glass Vessel 303-5425PLA900-PT 1000ml Clear Plastic Vessel –PLA900-AP 1000ml Amber Plastic Vessel –GLA900-PTGLA900-ATPLA900-PTPLA900-APUniversal Vessel StandsFor the safe transportation and storage of vesselsDue to their shape, dissolution vessels are difficultto hold securely. This can often result in scratched,chipped or even smashed vessels.The steel/acrylic stands are available in 6 or 8 vesselcapacities and can hold vessels from any dissolutionbath manufacturer.They can also be stacked together to save bench spaceand enable you to transport many vessels at a time.VESSTD-06APart No. Description OEM RefVESSTD-06A Vessel Stand, 6 Position –VESSTD-08A Vessel Stand, 8 Position – VESSTD-08A (Stacked)18Email: sales@labhut.com

SotaxCompatible VesselsPart No. Description OEM RefGLA900-ST 1000ml Clear Glass Vessel 2503GLA900-AS 1000ml Amber Glass Vessel 2503-2GLA900-STVanKelCompatible VesselsPart No. Description OEM RefGLA100-VK 100ml Clear Glass Vessel 12-5040GLA200-VK 200ml Clear Glass Vessel 12-5050GLA500-01 500ml Clear Glass Vessel 12-5060GLA900-01 1000ml Clear Glass Vessel 12-5000GLA900-AV 1000ml Amber Glass Vessel 12-5010GLA9PK-01 1000ml Clear Glass Peak Vessel 12-5500GLA9PK-VKGLA900-VKGLA9AM-VK1000ml Clear TruCenter GlassPeak Vessel for V-Series Baths1000ml Clear TruCenter GlassVessel for V-Series Baths1000ml Amber TruCenter GlassVessel for V-Series Baths12-512512-503512-5020PLA900-01 1000ml Clear Plastic Vessel 12-5200PLA900-AV 1000ml Amber Plastic Vessel –FLU9CL-01FLU900-011000ml Clear FluoropolymerVessel1000ml Opaque FluoropolymerVesselGLA02K-01 2000ml Clear Glass Vessel 12-5070––GLA100-VK GLA200-VK GLA500-01GLA900-01GLA900-AV GLA9PK-01 GLA9PK-VKGLA900-VKEZLBKT-01Vessel Centering Bracket, 6Replaceable Pins12-6050EZLKIT-01Vessel Centering Bracket RepairKit (set of 12 pins)–EZLPEG-01 Vessel Centering Bracket Peg 12-6065VK600A-CRPlastic Centering Ring Assemblyfor VK600/6000 Series12-6000GLA9AM-VKPLA900-01PLA900-AVFLU9CL-01Experiencing Vessel CenteringBrackets with Broken “Pins”?Original equipment centering bracketsoften encounter one or more brokencentering pins. This results inunbalanced centering, which can easilyexceed USP (711) specifications.EZLBKT-01The centering pins on EZLBKT-01are more robust to begin with andare easily replaceable if broken withEZLKIT-01.EZLKIT-01FLU900-01GLA02K-VKV600A-CREZLPEG-01Tel: +44 (0)1452 31021019

VESSEL COVERSThe Cover i Key ConsiderationsThe loss of media due to evaporation and condensationcan be considerable. Vessel Covers should reduce theseproblems and provide openings to accommodate cannulaeand stoppers.Cover styles include all common one-piece and hingedcovers, as well as a unique rotary configuration.Industry standard openings are provided to accommodatestandard cannulae and stoppers.Evaporation Losses are reduced by using vessel coverswith a minimal open area during the test. Slots and holes fortemperature verification, sample introduction and samplecollection should be closed when not in use.Cannula Stoppers – Cannulae can be used with stoppersduring manual sampling to ensure that the sample is alwaystaken from the same depth.Vessel covers must have the appropriate hole for thestopper (which is attached to the cannula) to sit in.The stopper and cannula must match the vessel cover typeor manufacturer.See page 26 for sampling cannulae and stoppers.DistekCompatible Vessel CoversVanKelCompatible Vessel CoversPart No. Description OEM RefCOVERD-00COVERD-01COVERD-02COVERD-BKCOVERAD-BKCOVERD-HGCOVDHG-SBLow Evaporation Rotary Cover,0.53” (13.5mm) Cannula Hole DiameterClear Hinged Cover,0.53” (13.5mm) Cannula Hole DiameterAmber Hinged Cover,0.53” (13.5mm) Cannula Hole DiameterClear Hinged Cover with Large CentreHole for Easy Basket Access,0.53” (13.5mm) Cannula Hole DiameterAmber Hinged Cover with LargeCentre Hole for Easy Basket Access,0.53” (13.5mm) Cannula Hole DiameterClear Low Evaporation Hinged Cover,0.53” (13.5mm) Cannula Hole DiameterClear Stationary Basket ApparatusHinged Cover–3250-0089–3250-0070––3250-0081COVPLG-7D 7th Position Cover Plug 3350-0109COVPLG-DK Probe Hole Plug 5720-4037COVCAP-DK Clear Cap for Basket Access Cover 3250-0019COVCAP-AD Amber Cap for Basket Access Cover –HINGE-DK Plastic Hinge 5560-6011HansonCompatible Vessel CoversPart No. Description OEM RefCOVERV-00COVERV-01COVERV-02Low Evaporation Rotary Cover,0.31” (7.9mm) Cannula Hole DiameterClear Cover with Paddle Slot,0.31” (7.9mm) Cannula Hole DiameterAmber Cover with Paddle Slot,0.31” (7.9mm) Cannula Hole Diameter–12-630012-6320COVERV-03 Clear Solid Cover 12-6330COVERV-04COVERV-HGCOVERV-LLCOVERV-LLHGCOVERV-LLSBCOVERV-LLVSCOVHGV-SBCOVERV-6KClear Evaporation Cover for DosageDelivery Module,0.31” (7.9mm) Cannula Hole DiameterClear Low Evaporation Hinged Cover,0.31” (7.9mm) Cannula Hole DiameterLow Loss Evaporation Cover, ConicalShape,0.78” (19.8mm) Cannula Hole DiameterLow Loss Evaporation Hinged Cover,Conical Shape,0.78” (19.8mm) Cannula Hole DiameterStationary Basket Apparatus Low LossEvaporation Hinged Cover, Conical ShapeTruCenter Low Loss EvaporationHinged Cover, Conical Shape,0.78” (19.8mm) Cannula Hole DiameterClear Stationary Basket ApparatusHinged CoverClear Evaporation Cover forVK600/VK6000 Series,0.31” (7.9mm) Cannula Hole Diameter12-6310–12-046912-6328–12-6327–12-6200Part No. Description OEM RefCOVERH-00Low Evaporation Rotary Cover,0.53” (13.5mm) Cannula Hole Diameter65-233-170COVERH-01 Clear Cover with Paddle Slot 72-500-215COVERH-02 Grey Cover with Paddle Slot 72-800-603COVERH-03 Amber Cover with Paddle Slot –COVERH-04 Clear Solid Cover –COVERH-HGCOVERH-LLClear Low Evaporation Hinged Cover,0.53” (13.5mm) Cannula Hole DiameterLow Loss Evaporation Cover,Conical Shape95-590-046–CAN’T DECIDEWHICH VESSELCOVER TO USE?Emailsales@labhut.com20Email: sales@labhut.com

COVERD-00COVERD-01COVERD-02COVERD-BKCOVERAD-BKCOVERD-HGCOVDHG-SB COVPLG-7D COVPLG-DKCOVCAP-DKHINGE-DKCOVERH-00COVERH-01COVERH-02COVERH-03COVERH-04COVERH-HGCOVERH-LLCOVERV-00COVERV-01COVERV-02COVERV-03COVERV-04COVERV-HGCOVERV-LLCOVERV-LLHGCOVERV-LLVSCOVERV-6KTel: +44 (0)1452 31021021

FILTERSThe FilteriAlmost every dissolution test relies on samples being taken to produce a result. Filters are used to preventparticles of tablet from getting into the sample and affecting the spectrophotometer or HPLC results.Filters should be shown not to adsorb any compounds of interest.All filters are U.S. Pharmacopeia compliant whereapplicable and meet machine manufacturer specificationsKey ConsiderationsMost manufacturers use a filter on the end of the samplingcannula. These cannula filters are made of UHMWPolyethylene for larger porosities or Poroplast for lower porosities(1-5µm) and are completely inert to most compounds.With filters, porosities are nominal and represent an averagepore size rather than an absolute pore size. Thus a 35µm and40µm filter will perform in much the same way.If in-line filters are used it is important that a small amountof media is pushed back in the reverse direction to washparticles off the filter back into the vessel. Particles are partof the tablet and as such should be kept inside the vesseldissolving with the rest of the tablet.Failure to do this results in the particles staying on the filter.The effect of this is not only to remove the particles fromthe media but next time a sample is taken, the media ispulled through the particles stuck to the filter which can giveerroneously high readings.When selecting a filter, it is wise to conduct some tests toensure that there is no sample absorption onto the filter.If this is a problem then alternative filters and materials areavailable but external filtration may be required.Cannula Filters(see all manufacturers,pages 23-25)Cannula Filters,VanKel Style(see VanKel, page 25)Types of filter:Cannula FiltersCannula Filters generally have a large surface area andmay affect the hydrodynamics in the vessel. Howeverthey have a good flow rate and may be used when highlevels of particulates are present to prevent particulatesblocking the sample probes. A large porosity range isavailable. Different manufacturers recommend differentfilters for use with their sample probes and not all areinterchangeable because of differences in probe diameter.Filter DiscsSome low volume sample probes require an In-LineFilter Disc (or filter frit) which has a lower surface areathan a cannula filter. These are designed to keep thefiltration process outside the vessel but may suffer fromblocking due to the lower surface area.This problem can be solved with the Hi-Cap cannulawhich uses standard cannula filters outside the vessel.See page 30.Filter TipsFilter Tips are smaller than cannula filters and fit onthe end of larger diameter sample probes.Filter Discs(see Distek,page 23)Filter Tips(see VanKel,page 25)For EXPERT ADVICEon obtaining thecorrect filter for yourcannula emailsales@labhut.com22Email: sales@labhut.com

Caleva Compatible Cannula FiltersCaleva tablet dissolution baths normally use cannula style filters with a large range of porosities.Part No. Description Quantity OEM RefFIL001-CA-100FIL001-CA-10001µm Cannula Filters, Poroplast100 Pack1000 Case08101000810101FIL004-CA-100FIL004-CA-10004µm Cannula Filters, Poroplast100 Pack1000 Case08101030810104FIL010-CA-100FIL010-CA-100010µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case08101060810107FIL035-CA-100FIL035-CA-100035µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case08101420810143FIL040-CA-100FIL040-CA-100040µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case08100970810098FIL070-CA-100FIL070-CA-100070µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––Caleva Cannula FilterDistekCompatible Filter Discs and Cannula FiltersDistek tablet dissolution baths utilise a narrow sample probe that incorporates a small filter disc at thetop. As these small filters can become blocked, an external filter at the end of the sample probe maybe used instead of, or in addition to the filter disc.Part No. Description Quantity OEM RefFIL010-DK 10µm Filter Discs, UHMW Polyethylene 1000 Case 5720-0203FIL045-DK 45µm Filter Discs, UHMW Polyethylene 1000 Case 5720-0275FIL070-DK 70µm Filter Discs, UHMW Polyethylene 1000 Case –FIL090-DK 90µm Filter Discs, UHMW Polyethylene 1000 Case –Distek Filter DiscFIL10S-DK-100FIL10S-DK-100010µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case5720-05005720-0501FIL20S-DK-100FIL20S-DK-100020µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case––FIL35S-DK-100FIL35S-DK-100035µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case5720-0220-1005720-0220-1000FIL45S-DK-100FIL45S-DK-100045µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case5720-0020-1005720-0020-1000FIL70S-DK-100FIL70S-DK-100070µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case5720-05025720-0503Distek Cannula FilterErweka Compatible Cannula FiltersErweka tablet dissolution baths normally use cannula style filters with a large range of porosities.Part No. Description Quantity OEM RefFIL001-EW-100FIL001-EW-10001µm Cannula Filters, Poroplast100 Pack1000 Case90-000-001390-000-0013FIL004-EW-100FIL004-EW-10004µm Cannula Filters, Poroplast100 Pack1000 Case90-000-002390-000-0023FIL010-EW-100FIL010-EW-100010µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case90-000-003390-000-0033FIL020-EW-100FIL020-EW-100020µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL035-EW-100FIL035-EW-100035µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL040-EW-100FIL040-EW-1000FIL070-EW-100FIL070-EW-100040µm Cannula Filters, UHMW Polyethylene70µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case100 Pack1000 Case––––Erweka Cannula FilterTel: +44 (0)1452 310210Continued overleaf...23

FILTERSHansonCompatible Cannula FiltersHanson Research dissolution baths normally use cannula style filters. The Hanson/Waters Dissolution/HPLC Interface uses a narrow bore (1/16” ID) filter instead of the normal cannula diameter. Both typesare supplied, as listed below.Part No. Description Quantity OEM RefFIL001-HR-100FIL001-HR-10001µm Cannula Filters, Poroplast100 Pack1000 Case27-101-08727-101-097FIL004-HR-100FIL004-HR-10004µm Cannula Filters, Poroplast100 Pack1000 Case27-101-08827-101-098FIL010-HR-100FIL010-HR-100010µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case27-101-07427-101-091FIL020-HR-100FIL020-HR-100020µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL035-HR-100FIL035-HR-100035µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case27-101-08527-101-095FIL045-HR-100FIL045-HR-100045µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case27-101-089–FIL070-HR-100FIL070-HR-100070µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case27-101-08227-101-092FIL10S-HR-100FIL10S-HR-100010µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case27-101-08327-101-093FIL35S-HR-100FIL35S-HR-100035µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case27-101-08627-101-096FIL45S-HR-100FIL45S-HR-100045µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case27-101-090–FIL70S-HR-100FIL70S-HR-100070µm Cannula Filters, 1/16” (1.6mm) ID,UHMW Polyethylene100 Pack1000 Case27-101-08427-101-094Cannula FilterColour CodingCannula filters are colour codedfor easy identification of porosity.FIL010-HR-100/1000FIL070-HR-100/1000FIL10S-HR-100/1000Pharmatest Compatible Cannula FiltersPharmatest dissolution baths normally use cannula style filters.Part No. Description Quantity OEM RefFIL001-PT-100FIL001-PT-10001µm Cannula Filters, Poroplast100 Pack1000 Case––FIL004-PT-100FIL004-PT-10004µm Cannula Filters, Poroplast100 Pack1000 Case––FIL005-PT-100FIL005-PT-10005µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case31-63511-50–FIL010-PT-100FIL010-PT-100010µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL035-PT-100FIL035-PT-100035µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case–31-63211-50FIL070-PT-100FIL070-PT-100070µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––Pharmatest Cannula Filter24Email: sales@labhut.com

SotaxCompatible Cannula FiltersSotax dissolution baths use a closed design. For manual and automatic sampling it is necessary to mountthe sampling cannula through the drive head of the bath. This allows the use of cannula filters.Part No. Description Quantity OEM RefFIL010-SX-100FIL010-SX-100010µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL035-SX-100FIL035-SX-100035µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL070-SX-100FIL070-SX-100070µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––Sotax Cannula FilterVanKelCompatible Cannula Filters and Filter TipsVanKel baths normally use either cannula style filters or filter tips. The filter tips fit on the end of largerdiameter sample probes.Part No. Description Quantity OEM RefFIL010-01-100FIL010-01-100010µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case17-400017-4000FIL010-VK-100FIL010-VK-100010µm Direct Fit Cannula Filters (no Tygon tubingneeded), UHMW Polyethylene100 Pack1000 Case––FIL020-01-100FIL020-01-100020µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL035-01-100FIL035-01-100035µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case17-401017-4010FIL035-VK-100FIL035-VK-100035µm Direct Fit Cannula Filters (no Tygon tubingneeded), UHMW Polyethylene100 Pack1000 Case––FIL045-01-100FIL045-01-100045µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case––FIL070-01-100FIL070-01-100070µm Cannula Filters, UHMW Polyethylene100 Pack1000 Case17-402017-4020FIL070-VK-100FIL070-VK-100070µm Direct Fit Cannula Filters (no Tygon tubingneeded), UHMW Polyethylene100 Pack1000 Case––FILTIP-02 2µm Filter Tips 1000 Case 17-4100FILTIP-05 5µm Filter Tips 1000 Case 17-4110FILTIP-10 10µm Filter Tips 1000 Case 17-4120FILTIP-20 20µm Filter Tips 1000 Case 17-4130FILTIP-45 45µm Filter Tips 1000 Case 17-4140VanKel Filter TipTygon Tubing Troubles?Go for a Direct Fit!FIL010-01-100/1000FIL020-01-100/1000FIL035-01-100/1000FIL070-01-100/1000The VanKel series of DirectFit Cannula Filters have beendesigned to fit directly onto theend of the standard VanKel(Varian) style manual andautomated cannula. No Tygontubing needed!Tel: +44 (0)1452 31021025

SAMPLING CANNULAEThe CannulaiAlmost every dissolution test relies on samples being takento produce a result. It is important that the sampling methoddoes not adversely affect the accuracy of the dissolution test.Sampling errors are very common and are often the cause oferroneous results. The sampling position is critical but so too isthe type of sampling cannula (also known as a probe) used.The USP defines the sampling point as:“A zone half way between the top of the media and top ofthe paddle or basket not less than 1cm from the vessel wall.”Key ConsiderationsSampling Position – The sampling position is importantparticularly for tests with baskets as there can be aconcentration profile between the bottom of the vessel andthe stirring element. It is less noticeable with paddles as theextra agitation provides for a more uniform flow profile.The sampling position is different for 500ml and 900ml tests.This can create problems for equipment that uses ‘through theshaft’ sampling.Cannula Length – Cannulae vary in length from 4.75”(120mm) to 15” (380mm). These extended lengths arenormally used for “through the head sampling” whereby thecannula passes through the drive head of the dissolution bath.Cannula Material – The cannulae are made from eitherstainless steel or PEEK so that they do not adsorb or interferewith the active ingredient.Stoppers – Cannulae can be used with stoppers duringmanual sampling to ensure that the sample is always takenfrom the same depth. Stoppers are attached to the cannulaeand sit in a hole in the vessel cover. If these are to be usedthen it is important to get the stopper and cannula to matchthe vessel cover type or manufacturer.The range of self-tightening stoppers can be installed andpositioned without the need for tools such as screwdrivers orspanners. See below for more details.Selecting a Self-Tightening Cannula StopperSelf-tightening cannula stoppers offer aconvenient method of setting the cannulasampling position in accordance with USP 711.Adjustable cannula stoppers are available for Distek,Hanson and VanKel cannulae.Part Numbering System:CANSTP - 065 - 53Cannula ODStopper ODSince there are numerous configurations of cannulae anddissolution instruments in common use, the specific applicationshould be reviewed to ensure correct stopper selection.The two factors which determine the specific stopper choice are:1) Cannula outside diameter2) Stopper outside diameterCANNULA ODSTOPPER ODInches Manufacturer Inches Manufacturer.065 (1/16”) Distek/Hanson .31 VanKel.078 VanKel .44 Hanson/Waters.125 (1/8”) Hanson .53 Distek.142 VanKelThe part numbering system incorporates both cannula andstopper outside diameters.CannulaLockNutFerrulStopperSTOPPER ODCANNULA ODStopper Configurations:Common configurations are listed with the appropriate cannulae. Configurations not listed areavailable by special order. Email sales@labhut.com or call +44 (0)1452 310210.26Email: sales@labhut.com

CalevaCompatible Sampling CannulaePart No. Description OEM RefCAN475-SC120mm (4.75”) Bent Stainless Steel Cannula withLuer Adapter, for 900ml Manual Sampling–CAN775-SC195mm (7.75”) Bent Stainless Steel Cannula withLuer Adapter, for 500ml Manual Sampling–CAN475-PC120mm (4.75”) Bent PEEK Cannula with LuerAdapter, for 900ml Manual Sampling–CAN775-PC195mm (7.75”) Bent PEEK Cannula with LuerAdapter, for 500ml Manual Sampling–CAN475-SCCAN475-PCCANSTP-CA Adjustable Cannula Stopper –CAN775-SCCAN775-PCDistekCompatible Sampling CannulaePart No. Description OEM RefCAN500-DK 500ml Sampling Probe 2910-0500CAN900-DK 900ml Sampling Probe 2910-0900CAN01K-DK 1000ml Sampling Probe 2910-1000CAN5PK-DK16 500ml PEEK Sampling Probe, 1/16” (1.6mm) OD –CAN9PK-DK8 900ml PEEK Sampling Probe, 1/8” (3.2mm) OD –CANRET-DK Return Probe 2910-0001CANSTP-065-53Distek/Hanson 1/16” (1.6mm) Self-TighteningCannula Stopper for Distek Covers–FILASY-DK Inline Filter Housing Assembly for Distek Style Filters –LE87-6 Male Luer to Female Luer, Thread Style Elbow 5720-9074SFTL-6 Female Luer Lug Style with 5/16” Hex to 1/4-28 UNF Thread 5720-9059CAN500-DK CAN900-DK CAN01K-DKSMTLL-6 Male Luer Integral Lock Ring to 1/4-28 UNF Thread 5720-9060CANRET-DK CANSTP-065-53FILASY-DK LE87-6 SFTL-6 SMTLL-6!Filters for all Cannulae – See pages 22-25Tel: +44 (0)1452 310210Continued overleaf...27

SAMPLING CANNULAEErwekaCompatible Sampling CannulaePart No. Description OEM RefCAN475-SH120mm (4.75”) Bent Stainless Steel Cannula withLuer Adapter, for 900ml Manual Sampling–CAN775-SH195mm (7.75”) Bent Stainless Steel Cannula withLuer Adapter, for 500ml Manual Sampling–CAN015-SH380mm (15”) Bent Stainless Steel Cannula with LuerAdapter, Through Head Mount–CAN475-PH120mm (4.75”) Bent PEEK Cannula with LuerAdapter, for 900ml Manual Sampling–CAN475-SHCAN475-PHCAN775-PHCAN015-PH195mm (7.75”) Bent PEEK Cannula with LuerAdapter, for 500ml Manual Sampling380mm (15”) Bent PEEK Cannula with Luer Adapter,Through Head Mount––CANSTP-EW Adjustable Cannula Stopper –CAN775-SHCAN775-PHCAN015-PHCANS15-PHCAN015-SHCAN015-PHCAN775-PHCAN475-PHHansonCompatible Sampling CannulaePart No. Description OEM RefCAN475-HRCAN775-HR4.75” (120mm) Bent Stainless Steel Cannulawith Luer Adapter and Permanent Tip7.75” (195mm) Bent Stainless Steel Cannulawith Luer Adapter and Permanent Tip––CAN015-SHCAN775-SHCAN475-SHCANS15-SHCAN015-HR15” (380mm) Bent Stainless Steel Cannula,1/8” (3.2mm) OD, 0.085” (2.2mm) ID72-300-304CAN475-SH4.75” (120mm) Bent Stainless Steel Cannulawith Luer Adapter, for 900ml Manual Sampling,1/8” (3.2mm) OD95-590-002CAN775-SH7.75” (195mm) Bent Stainless Steel Cannulawith Luer Adapter, for 500ml Manual Sampling,1/8” (3.2mm) OD95-590-001CAN015-SH15” (380mm) Bent Stainless Steel Cannulawith Luer Adapter, Through Head Mount,1/8” (3.2mm) OD95-590-003CANS15-SH15” (380mm) Straight Stainless Steel Cannulawith Luer Adapter, Through Head Mount,1/8” (3.2mm) OD–CAN475-PH4.75” (120mm) Bent PEEK Cannulawith Luer Adapter, for 900ml Manual Sampling,1/8” (3.2mm) OD95-590-005CAN475-HRCAN775-PH7.75” (195mm) Bent PEEK Cannulawith Luer Adapter, for 500ml Manual Sampling,1/8” (3.2mm) OD95-590-004CAN015-PH15” (380mm) Bent PEEK Cannula with LuerAdapter, Through Head Mount, 1/8” (3.2mm) OD 95-590-006CAN775-HRCANS15-PHCANSTP-065-53CANSTP-125-3115” (380mm) Straight PEEK Cannula with LuerAdapter, 1/8” (3.2mm) ODDistek/Hanson 1/16” (1.6mm) Self-TighteningCannula Stopper for Distek CoversHanson 1/8” (3.2mm) OD Self-TighteningCannula Stopper for VanKel Covers–––CAN015-HRCANSTP-065-53CANSTP-125-53Hanson 1/8” (3.2mm) OD Self-TighteningCannula Stopper for Distek Covers–TUMSCR-HRAdjustable Cannula Stopper(for use with all 15” (380mm) cannulae)–TUMSCR-HRCANSTP-125-31CANSTP-125-5328Email: sales@labhut.com

PharmatestCompatible Sampling CannulaePart No. Description OEM RefCAN475-SP120mm (4.75”) Bent Stainless Steel Cannula withLuer Adapter, for 900ml Manual Sampling–CAN775-SP195mm (7.75”) Bent Stainless Steel Cannula withLuer Adapter, for 500ml Manual Sampling–CAN475-PP120mm (4.75”) Bent PEEK Cannula with LuerAdapter, for 900ml Manual Sampling–CAN775-PP195mm (7.75”) Bent PEEK Cannula with LuerAdapter, for 500ml Manual Sampling–CAN475-SPCAN475-PPCANSTP-PT Adjustable Cannula Stopper –CAN775-SPCAN775-PPNEED HELP selectingthe correct cannulafor your application?Emailsales@labhut.comSotaxCompatible Sampling CannulaePart No. Description OEM RefCAN013-STCAN013-ST-5CAN013-ST-9330mm (13”) Bent Stainless Steel Cannulawith Luer Adapter, Through Head Mount330mm (13”) Stainless Steel Cannula,Including Stopper and Sleeve, for 500ml Sampling330mm (13”) Stainless Steel Cannula,Including Stopper and Sleeve, for 900ml Sampling–––PRBFSR-STPRBNSR-STPRBFSR-5SPRBFSR-9SCombined Sample/Return Cannulawith Filter HousingCombined Sample/Return Cannulawithout Filter Housing500ml Sample/Return Probe Fixedwith Filter Housing, Stopper & Up/Down Collars900ml Sample/Return Probe Fixedwith Filter Housing, Stopper & Up/Down Collars––––CANSTP-ST Adjustable Cannula Stopper (for use with CAN013-ST) –CADSTP-STValidation Stopper(two holes for manual and auto cannulae)–CAN013-ST-9CAN013-ST-5CAN013-STCANSTP-STPRBFSR-STPRBNSR-STPRBFSR-5SPRBFSR-9STel: +44 (0)1452 310210Continued overleaf...29

SAMPLING CANNULAEVanKelCompatible Sampling CannulaePart No. Description OEM RefCAN475-014.75” (120mm) bent SS cannula with luer adapter,for 900ml sampling, 0.083” (2.1mm) OD12-3200CAN775-017.75” (195mm) bent SS cannula with luer adapter,for 500ml sampling, 0.083” (2.1mm) OD12-3210CA8475-VK4.75” (120mm) bent SS cannula with luer adapter,for 900ml sampling, 1/8” (3.2mm) OD–CA8775-VK7.75” (195mm) bent SS cannula with luer adapter,for 500ml sampling, 1/8” (3.2mm) OD–CA8015-VKCA8475-PV15” (380mm) bent SS cannula with luer adapter,through head mount, 1/8” (3.2mm) OD4.75” (120mm) bent PEEK cannula with luer adapter,for 900ml sampling, 1/8” (3.2mm) OD––CA8475-PVCA8775-PV7.75” (195mm) bent PEEK cannula with luer adapter,for 500ml sampling, 1/8” (3.2mm) OD–CA8015-PV15” (380mm) bent PEEK cannula with luer adapter,through head mount, 1/8” (3.2mm) OD–CA8775-PVCANRET-25 2.5” (65mm) Autosampling Return Cannula 17-3320CAN900-45 4.5” (115mm) Autosampling Cannula 17-3300CAN500-60 6.5” (165mm) Autosampling Cannula 17-3305PROBEX-VK 500ml Cannula Extension Kit 17-3306CA8015-PVCANSTP-078-31VanKel Standard Self-Tightening Cannula Stopperfor VanKel Covers–CA8475-VKCANSTP-142-31VanKel 1/8” (3.2mm) OD Self-Tightening CannulaStopper for VanKel Covers–CA8775-VKCA8015-VKCANRET-25CAN475-01CAN900-45CAN775-01 CAN500-60PROBEX-VK CANSTP-078-31 CANSTP-142-31!Filters for all Cannulae – See pages 22-2530Email: sales@labhut.com

Disposable Sampling CannulaeNo more cleaning or cross-contaminationKey Features:• Made from high quality stainless steel• Compatible with all open dissolution baths• Use standard cannula filters• Luer connection for easy fixing to syringes• No cleaning required, saving time and expense• Eliminates the chance of sample cross contamination• Very low cost compared to standard steel cannulaeTraditional sampling cannulae require care,effective cleaning and can be expensive.The disposable cannulae are thrownaway after use meaning no cleaningis required and cross-contaminationis eliminated.Cannula AssemblyPart No. Description Quantity OEM RefDISP475-HRDISPCAN-CUSTHansonDisposable SamplingCannula, 900mlDisposable SamplingCannula, Custom Size30 Pack –Any –Compatible Cannula Filters (See page 24)Part No. Description Quantity OEM RefFIL10S-HR-100FIL10S-HR-1000FIL35S-HR-100FIL35S-HR-1000FIL45S-HR-100FIL45S-HR-1000FIL70S-HR-100FIL70S-HR-100010µm Cannula Filters,1/16” (1.6mm) ID35µm Cannula Filters,1/16” (1.6mm) ID45µm Cannula Filters,1/16” (1.6mm) ID70µm Cannula Filters,1/16” (1.6mm) ID100 Pack1000 Case100 Pack1000 Case100 Pack1000 Case100 Pack1000 Case27-101-08327-101-09327-101-08627-101-09627-101-090–27-101-08427-101-094DISP475-HRTwist lock capFilterHi-Cap High Capacity Sampling CannulaeIncreased capacity for most brands of dissolution bathAvailable for 500ml, 900ml and 1000ml tests, this new style samplingprobe has an inert twist-lock housing which safely contains a standardVanKel cannula filter. This means that the same cannula filters can beused for different dissolution baths, offering increased flexibility.The surface area of the VanKel cannula filter is greater than 7 times thatof the small filter disc that is traditionally used in this style of sampleprobe.The Hi-Cap’s thin low-volume stainless steel cannula can remain in thevessel throughout the dissolution test without affecting the dissolutionresult, removing the need for an automated probe lift. The cannula simplysits in the vessel cover and samples from the same position every time.Cannula AssemblyPart No. Description OEM RefCAN500-DVHi-Cap High capacity sampling cannulafor most dissolution baths, 500ml–CAN900-DVHi-Cap High capacity sampling cannulafor most dissolution baths, 900ml–CannulaCAN01K-DVHi-Cap High capacity sampling cannulafor most dissolution baths, 1000ml–CAN01K-DVVanKelCompatible Cannula Filters (See page 25)Part No. Description Quantity OEM RefFIL010-01-100FIL010-01-1000FIL020-01-100FIL020-01-1000FIL035-01-100FIL035-01-1000FIL045-01-100FIL045-01-1000FIL070-01-100FIL070-01-100010µm Cannula Filters,UHMW Polyethylene20µm Cannula Filters,UHMW Polyethylene35µm Cannula Filters,UHMW Polyethylene45µm Cannula Filters,UHMW Polyethylene70µm Cannula Filters,UHMW Polyethylene100 Pack1000 Case100 Pack1000 Case100 Pack1000 Case100 Pack1000 Case100 Pack1000 Case17-400017-4000––17-401017-4010––17-402017-4020Tel: +44 (0)1452 31021031

TRANSDERMAL TESTINGPaddle Over Disc APPARATUS 5iWith paddle over disc, a transdermal patch is placed eitherbetween a glass disc and an inert PTFE mesh (APPFIVE-HR),or directly onto a stainless steel mesh (APPFIVE-V35,APPFIVE-V56 and APPFIVE-V80). This is placed at thebottom of the vessel, with the mesh facing upwards, undera rotating paddle.Transdermal testing is carried out at 32°C to reflect thetemperature of the skin.Other variables such as the height setting and samplingrequirements are the same as for USP Method 2.The LabHut USP 5 apparatus is compatible with all brands ofdissolution bath.ASamplingPointVesselPaddleDiscAssemblyKey ConsiderationsThe APPFIVE-HR watch glass patch holder is a borosilicatewatch glass with a 17 mesh PTFE screen, held togetherby plastic clips. Patches up to 90mm in diameter can betested. It is compatible with all brands of dissolution bathand conforms exactly to the USP specification.The APPFIVE-V35, APPFIVE-V56 and APPFIVE-V80patch holders have stainless steel screens and canaccommodate various patch sizes.Various meshes are available for APPFIVE-V35.APPFIVE-HRAPPFIVE-HRCLIPTransdermal Patch Holders and AccessoriesPart No. Description OEM RefAPPFIVE-HRWatch Glass Transdermal Patch Holderwith 17 Mesh Screen and 4 Plastic Clips65-190-093APPFIVE-HRCLIP Plastic Clip for APPFIVE-HR (each) 65-190-205APPFIVE-HRSCR 17 Mesh PTFE Screen for APPFIVE-HR 65-190-190HHHAPPFIVE-HRSCRAPPFIVE-V35APPFIVE-V56Transdermal Patch Holder, 1.38”(35mm) Opening (40 Mesh Screen)Transdermal Patch Holder, 2.20”(56mm) Opening (120 Mesh Screen)12-420012-4230VVAPPFIVE-V80APPFIVE-V80APP5S16-35Transdermal Patch Holder, 3.15”(80mm) Opening (16 x 16 Mesh Screen)16 Mesh 316 Stainless Steel Screenfor APPFIVE-V35 (pack of 25)––APPFIVE-V56APP5S20-35APP5S30-3520 Mesh 316 Stainless Steel Screenfor APPFIVE-V35 (pack of 25)30 Mesh 316 Stainless Steel Screenfor APPFIVE-V35 (pack of 25)––APPFIVE-V35APP5S40-3540 Mesh 316 Stainless Steel Screenfor APPFIVE-V35 (pack of 25)–APP5S16-35 APP5S20-35 APP5S30-35 APP5S40-3532Email: sales@labhut.com

APPARATUS 5 & 6Rotating Cylinder APPARATUS 6iThe USP 6 rotating cylinder is similar to USP Method 1 (therotating basket). With USP Method 6 however, the basketassembly is replaced by a solid stainless steel cylinder.The transdermal patch is fixed to the outside surface of thecylinder.Transdermal testing is carried out at 32°C to reflect thetemperature of the skin.Other variables such as the height setting and samplingrequirements are the same as for USP Method 1.The LabHut USP 6 apparatus is compatible with most brandsof dissolution bath.ASamplingPointVesselRotatingCylinderTransdermalPatch(Fixed to outsidesurface of cylinder)Key ConsiderationsThe extension (APPSIX-EX) is used when the transdermalpatch requires a larger area (see picture below).Rotating Cylinderassembled withextensionAPPSIX-01H= HansonV = VanKelRotating CylinderAPPSIX-EXRotating Cylinderviewed from belowPart No. Description OEM RefAPPSIX-01APPSIX-EXRotating Cylinder for Transdermal Patches,Electropolished 316 Stainless SteelRotating Cylinder Extension for APPSIX-01,Electropolished 316 Stainless Steel12-136065-590-011–65-590-012VHHSpin On/OffThe rotating cylinder is also available as a Spin ON/OFFshaft. See SPNAP6-01 on page 9.Tel: +44 (0)1452 31021033

BIOBIODISSOLUTION ACCESSORIESAPPARATUS 3Caps & CoversPart No. Description OEM RefEVACOV-05 PVC Evaporation Cover for 300ml Glass Vessels 27-1500EVACOV-07 PTFE Evaporation Cover for 300ml Glass Vessels –LOWCAP-03 Lower Cap for 300ml Glass Vessels 27-1020LOWCAP-05Lower Cap for 300ml Glass Vessels, WiderVanKel Style27-1050UPPCAP-03 Upper Cap for 300ml Glass Vessels 27-1000 VVVVEVACOV-05EVACOV-07LOWCAP-03 LOWCAP-05 UPPCAP-03Vessels & Sampling TubesPart No. Description OEM RefGLA300-01 Outer Vessel, 300ml, Clear Glass, Non-graduated –GLA300-02 Outer Vessel, 300ml, Clear Glass, Graduated 27-5100GLA300-03Outer Vessel, 300ml, Clear Glass, Class A,with 250ml markGLA300-AV Outer Vessel, 300ml, Amber Glass, Non-graduated –GLAIST-01 Inner Sampling Tube, 100ml, Clear Glass 27-5000GLAIST-AV Inner Sampling Tube, 100ml, Amber Glass ––VVGLA300-01GLA300-02GLA300-03GLA300-AVScreensScreens with 1.25” diameters for 300ml glass vessels.Part No. Description OEM RefMSHSCR-20 20 Mesh 316 Stainless Steel Screen 27-2100 VMSHSCR-30 30 Mesh 316 Stainless Steel Screen 27-2103 VMSHSCR-40 40 Mesh 316 Stainless Steel Screen 27-2105 VPOLSCR-20 20 Mesh Polypropylene Screen 27-2000 VPOLSCR-30 30 Mesh Polypropylene Screen –POLSCR-40 40 Mesh Polypropylene Screen 27-2005 VPOLSCR-1K 100 Mesh Polypropylene Screen 27-2015 VGLAIST-01GLAIST-AVMSHSCR-20 MSHSCR-30 MSHSCR-40 POLSCR-20 POLSCR-30POLSCR-40POLSCR-1K34Email: sales@labhut.com

APPARATUS 26FELODIPINE TEST BASKETThe Stationary Basket APPARATUS 26iThe USP Monograph for Felodipine Extended-Release Tabletsspecifies the use of a quadrangular stationary basket. TheLabHut Stationary Basket fully complies with the USPMonograph.The LabHut Felodipine Basket is made from precision weldedstainless steel mesh and the basket is securely fixed to theshaft and will not easily bend or break off.The basket also features a small flap to prevent the tabletescaping during testing. The flap is fabricated such that itwill not fall off or be lost during use.USP 26 requires the use of a basket suspended a precisedistance from the paddle shaft, which in turn requires theuse of a modified vessel cover.VesselSuspendedBasketPaddleKey ConsiderationsThe Stationary Basket method offers a potential solutionto problems associated with floating, sticking and swellingdosage forms.While the use of sinkers may solve similar problems, theirfinal position in the dissolution vessel may vary, thuscontributing to variations in test results – these variationscan be eliminated by using the stationary basket.(Suitability for certain applications must be verified.)Felodipine Stationary BasketPart No. Description OEM RefSTABSK-VK8USP 26 Felodipine Test StationaryBasket12-2069 VCompatible Vessel Covers (See page 20)Part No. Description OEM RefCOVDHG-SBCOVHGV-SBClear Stationary Basket ApparatusHinged Cover for Distek BathsClear Stationary Basket ApparatusHinged Cover for VanKel Baths3250-0081–DD= DistekV = VanKelStationary Basket Spacer (See page 37)Part No. Description OEM RefDEPSET-SB Stationary Basket Spacer, 1cm –DEPSET-SBTel: +44 (0)1452 31021035

CALIBRATION TOOLSControlling Hardware VariablesiTo achieve reliable and consistent results in dissolution testing it is essential to control many small variables. Some of thesevariables have been defined in the USP and some have yet to be addressed in the compendium due to a lack of data ordisagreements about how they can be measured. The variables are described below in Key Considerations.Key ConsiderationsWobbleVibrationShaft CenteringUse: WOBMET-MIThe USP limit for wobble is ±2mm. If there issignificant wobble it can have a significant effecton the dissolution rate. The wobble can be causedby a bent or loose shaft or a misshapen basket.The easiest way to check for wobble is byeye (2mm will be easily seen) but it shouldbe quantified by a suitable tool. To check shaft straightness simplyroll the shaft over a bench top – it should roll smoothly and notstick up at the end. Wobble can be kept to a minimum by handlingthe baskets and shafts with care – they should be kept in properholders rather than just collectively in a drawer. See page 11 forbasket shaft/paddle holders.Wobble is measured just above the paddle blade or on the bottomrim of the basket.Use: VIBMET-UNVibration is one of the most significant causesof failure but is not yet defined within the USP(it states ‘no significant vibration’). Part ofthe problem is defining what limits should beacceptable as vibration varies with frequency.Vibration should be seen as excess energy which istransferred to the vessel and will almost certainlyincrease the dissolution rate. An increase of5-10% is possible.The most common cause of vibration is the water bath pump ora worn drive belt in the motor unit. Other causes of vibration aretypically caused by other pieces of equipment on the same bench.Use: CNTGAG-MIThe USP definition for stirring is that the shaft shouldbe within ±2mm of the centre. This parameter is fairlyeasy to measure in open-design dissolution baths but isdifficult to measure in the ‘clam shutting’ designs.Shaft centering is dependent on two parameters– the position of the spindle (this is factory-set) andthe position of the vessels. If the vessels are not setcorrectly or are loose then there is a possibility that thecentering will be incorrect. An off-centre shaft can addsignificantly to the dissolution rate.Basket & Paddle HeightUse: DEPSET-MIThe USP states that the bottom of the basket/paddle is 25mm ±2mm above the bottom of thevessel. This parameter is normally measuredusing one of several designs of height tester. Theheight is important for having reproducible mediahydrodynamics. Incorrectly set paddle heights cancause both high and low readings.Shaft RPMUse: TACHOM-UNThe USP limit for stirring is ±4% of the set speed of the test.This level of shaft control was set during the early daysof equipment manufacturing where surging motors (whichtemporarily increased or decreased the speed) were difficultto control. All modern equipment can now control the speedto within ±0.5rpm so this problem is rare. However the RPMstill needs to be validated with a suitable tachometer.VesselsSee: Vessels (page 16)Vessel design is something that is often overlooked by the analyst.The USP allows for a significant variation in the specification ofthe vessels with a height of 160-170mm and an ID of 98-106mm.This variation means that if vessels are changed in the baththen the paddle height and centering measurements need to berechecked.Vessels should ideally be serialised. They should be smooth andclean. Small ridges on the inside of a vessel can greatly increasethe dissolution rate whilst scratches and sticky or gummy patchescan reduce the dissolution rate.Bath LevelUse: LEVEL-UNThe level of a dissolution bath is often overlooked.It should not be assumed that the laboratory benchis level. This is one of the parameters that shouldbe checked on installation and some dissolutiontesters have an in-built level checking device.Testers which are not level can give erroneous results and themedia rotation is not linear within the vessel.Level should be tested front to back as well as side to side. Acalibrated level will provide an accurate measurement of this. Ifthe bath is moved for any reason then this parameter will need tobe re-checked.Vertical AlignmentThe vertical alignment of the shafts to the base of the dissolutionbath is critical to the correct operation of the system. From anadjustment point of view, there is little that the user can do aboutit and it should be set by the manufacturer.However, it is a good idea to check the alignment – this shouldalways be checked by the manufacturer on installation becausephysical trauma can occur during shipping. If an error is found thenthe manufacturer should be contacted to correct the problem.The simplest method to check the alignment yourself is with aset square available from any tool store. Remove the vessels andlower the shaft until it is just below the base plate. Take the squareand align it with the base and shaft to check the vertical alignmentof the shaft.TemperatureTemperature control in tablet dissolution testing is criticalas a change in temperature has a linear effect on thedissolution rate. Temperature should be measured with acalibrated thermometer, either analogue or digital, andshould normally be 37°C.The specified temperature should be measured ineach vessel prior to each run commencing. There isa temptation to only measure temperature in a few ofthe vessels and assume that they are all the same. Thismay not necessarily be the case as temperature gradientscan occur within a water bath that affect the speed ofequilibration of all the vessels.Most dissolution baths display the temperature of the bathitself but this should not be taken as an indication of thetemperature inside the vessel. Typically it is necessaryto run the water bath as much as 0.5°C or so above therequired temperature to ensure the correct temperatureinside the vessel. If plastic vessels are used instead of glassthen this may result in a greater difference in temperature.Use: THERMD-LC36 Email: sales@labhut.com

Calibration ToolsPart No. Description OEM RefCNTGAG-MI Multi-Instrument Vessel Centering Gauge –DEPGAG-VK Depth Set Gauge, VanKel Style 12-7300DEPSET-MI Ball Style Depth Set Gauge –DEPSET-SB Stationary Basket Spacer, 1cm –DPSPBK-VK Basket Height Spacer 12-7210DPSPPD-VK Paddle Height Spacer 12-7200LEVEL-UN Universal Precision Spirit Level –TACHOM-UN Optical Tachometer –THERMD-LC Calibrated Digital Thermometer –VALTOL-KTVALTOL-CUSTValidation Toolkit (centering gauge,depth set gauge, level, wobble meter)Custom Validation Toolkit(any combination of calibration tools)VIBMET-UN Vibration Meter with probe and case –WOBMET-MIWobble Meter (including vessel coverand brackets) for all open top baths–––VVVVALTOL-KTCNTGAG-MIWOBMET-MIDEPSET-SBDEPSET-MIDPSPBK-VKDEPGAG-VKLEVEL-UNTACHOM-UNDPSPPD-VKRe-Calibration ServicePart No.DescriptionRECAL-CGVessel Centering Gauge Recalibration ServiceRECAL-LVUniversal Spirit Level Recalibration ServiceRECAL-TAOptical Tachometer Recalibration ServiceRECAL-VM Vibration Meter Recalibration ServiceRECAL-WM Wobble Meter Recalibration Service(Re-calibration recommended on an annual basis)THERMD-LCVIBMET-UNV = VanKelTel: +44 (0)1452 31021037

GLASS ACCESSORIESVolumetric FlasksPart No. Description OEM RefVOLFLK-05VOLFLK-09VOLFLK-1KVOLFLK-X5VOLFLK-X9VOLFLK-X1500ml Volumetric Flask, Class A,Calibrated at 20°C900ml Volumetric Flask, Class A,Calibrated at 20°C1000ml Volumetric Flask, Class A,Calibrated at 20°C500ml Volumetric Flask, Class A,Calibrated at 37°C900ml Volumetric Flask, Class A,Calibrated at 37°C1000ml Volumetric Flask, Class A,Calibrated at 37°C––––––VOLFLK-05 VOLFLK-X9 VOLFLK-X1Tapped DensityPart No. Description OEM RefGLA100-01GLA1CA-01GLA250-01100ml Funnel Top Cylinder, Graduated,Hexagonal Base100ml Funnel Top Cylinder, Graduated,Hexagonal Base, Class A, Calibrated at 20°C250ml Funnel Top Cylinder, Graduated,Hexagonal Base52-5010 V–52-5020 VGLA100-01GLA1CA-01GLA250-01Rotating Bottle ApparatusPart No. Description OEM RefRBAASSY-01RBAASSY-02100ml Clear Glass Bottle and Cap,Viton Liner100ml Clear Glass Bottle and Decant Cap,40 Mesh ScreenRBSCRN-40 40 Mesh Screen for 100ml Decant Cap 32-1220 V––RBAASSY-01 RBAASSY-02 BRBSCRN-40Misc Glass AccessoriesPart No. Description OEM RefFLEAK-150 100ml Glass Fleaker –FLEAK-300 300ml Glass Fleaker –GLATUB-A/25x150mm50ml Amber Outer Media Tube for12 Valve APP 727-5160 VFLEAK-150FLEAK-300GLATUB-A/25x150mm38 Email: sales@labhut.com

INTRINSIC DISSOLUTIONI“Wood Apparatus Design”iThe Intrinsic Dissolution Apparatus below is based onthe conventional “Wood Apparatus Design”. This industrystandard configuration has a long and successful history.This design uses standard dissolution vessels and providesbetter centering and easier dosage placement thancompeting designs.Intrinsic Dissolution ApparatusPart No. Description OEM RefIDASET-01Intrinsic Dissolution Apparatus Set–95-590-201HIDADIE-01IDAPCH-018mm Intrinsic Die with Gasket, 316Stainless Steel8mm Punch and Handle12-412095-590-20412-414095-590-203VHVHIDASET-01(Set includes: IDADIE-01, IDAPCH-01, IDAPLT-01, IDASNH-01)IDAPLT-01Surface Plate with Screws12-413095-590-205VHIDAPRS-01IDASNH-012 Ton Universal Intrinsic PressShaft and Holder, 316 Stainless Steel–95-590-20612-415095-590-202HVHIDADIE-01IDAPCH-01IDAPLT-01IDAPRS-01H= HansonIDASNH-01V = VanKelTel: +44 (0)1452 31021039

DISINTEGRATIONVanKelDisintegration AccessoriesPart No. Description OEM RefDISASY-06DISASY-P6Basket Assembly with 6 Glass Tubes and 10 MeshStainless Steel Screens, for VanKelBasket Assembly with 6 Plastic Tubes and 10 MeshStainless Steel Screens, for VanKel37-2001DISTUB-06 Glass Disintegration Tubes for 6 Tube Assembly 37-5000DISTUB-P6 Plastic Disintegration Tubes for 6 Tube Assembly –FDISK-VK Fluted Plastic Disc for 6 Tube Assembly 37-4000GLA900-DB 900ml Disintegration Beaker, Flared Top 37-5200GLA905-DB 900ml Disintegration Beaker, Flat Top 37-5305–DISASY-06 / DISASY-P6DISTUB-06DISTUB-P6FDISK-VKGLA900-DBGLA905-DB40Email: sales@labhut.com

CALIPER LIFESCIENCES (ZYMARK)ZZymarkCompatible BasketsPart No. Description OEM RefBSK040-ZM 40 Mesh Stainless Steel Basket 63127BSK040-ZM240 Mesh Precision LengthStainless Steel Basket–BSK040-ZMBSK040-ZM2Precision Length BasketThe Precision Length Basket(BSK040-ZM2) is specificallydesigned for use with CaliperMultidose and other roboticdissolution systems. It has along usable life in the demandingrobotic environment.ZymarkCompatible Basket ShaftsPart No. Description OEM RefBSKSHT-ZM215” (380mm) Double O-Ring StyleConical Basket Shaft–Spin On/OffThe double O-ring conical basket shaft is also available as aSpin ON/OFF shaft. See SPNBSK-ZM2 on page 9.BSKSHT-ZM2ZymarkCompatible VesselsPart No. Description OEM RefGLA9CR-ZM1000ml Clear Glass Vessel withCentering Ring58730CNTRNG-ZM Multidose Centering Ring 69606GLA9CR-ZMCNTRNG-ZMZymarkMiscellaneousPart No. Description OEM RefADTPIN-ZM Multidose Adapter Pin 48481LOCPIN-ZM Multidose Locater Pin 48479RETRNG-ZM Multidose Vessel Retainer –RETRNG-ZMTel: +44 (0)1452 31021041

MISCMISC ACCESSORIESTubingPart No. Description OEM RefPPTUBV-01PPTUBV-02Peristaltic Pump Tubing, Santoprene,Coded Purple & White (Set of 8)Peristaltic Pump Tubing, Silicone,Coded Purple & White (Set of 8)17-600017-6010VVPPTUBV-01PPTUBV-02PPTUBD-01Peristaltic Pump Tubing,Santoprene (Set of 6)5640-0337DTAATUB-HP3 Collar Tygon Auto Analyser Tubing,0.08” (2.06mm) ID (Set of 12)5041-2166DTEFTUB-HPFEP PTFE Tubing for HP 1/32” (0.8mm) IDx 1/16” (1.6mm) OD, 500’ (152m) Roll–TEFTUB-8VColour Coded Sample PTFE Tubing, 0.42”(10.67mm) ID x 0.066” (1.68mm) OD,8 Lengths of 50’ (15m)17-6035VTUBINGTygon Tubing, 1/16” (1.6mm) x 1/8”(3.2mm) (Sold by Foot)–PPTUBD-02TEFTUB-8VTEFTUB-HPTAATUB-HPTUBINGD= DistekV = VanKelPaper RollsPart No. Description OEM RefPAP100-01Plain Paper Rolls for Report Center II,2.25” (57mm) Wide (Pack of 25)12-9995TPP100-01 Thermal Paper Rolls (Pack of 25) 12-9994 VVClear Bath AlgaecideClear Bath is a liquid algae inhibitor for use with alltypes of dissolution bath. Using just 10-15 drops pergallon keeps a dissolution bath clean. One bottle willtreat 1500 to 1900 litres of water.Part No. Description OEM Ref105540Clear Bath Algaecide.230ml (8fl oz) Bottle–105540Glass SyringesPart No. Description OEM RefSYR020-01 20cc Glass Syringe 12-3230 VPAP100-01TPP100-01SYR020-0142Email: sales@labhut.com

INDEX – OEM REFERENCEOEMCalevaOEM ReferenceDistekOEM ReferenceHansonOEM ReferenceOEM Ref Part No. Page No.0810004 GLA900-CA 170810009 GLA900-AC 170810019 BSK040-CA 50810021 BSK020-CA 50810097 FIL040-CA-100 230810098 FIL040-CA-1000 230810100 FIL001-CA-100 230810101 FIL001-CA-1000 230810103 FIL004-CA-100 230810104 FIL004-CA-1000 230810106 FIL010-CA-100 230810107 FIL010-CA-1000 230810123 BSK010-CA 50810142 FIL035-CA-100 230810143 FIL035-CA-1000 23ErwekaOEM ReferenceOEM Ref Part No. Page No.80-000-1002 GLA900-EW 1780-000-1004 GLA900-AW 1780-000-2002 GLA02K-EW 1790-000-0013 FIL001-EW-100FIL001-EW-100090-000-0015 BSK020-EW 590-000-0023 FIL004-EW-100FIL004-EW-100090-000-0033 FIL010-EW-100FIL010-EW-100090-000-0040 BSK040-EW 5Pharmatest232323OEM ReferenceOEM Ref Part No. Page No.303-5225 GLA900-PT 18303-5425 GLA900-AT 1831-63211-50 FIL-035-PT-1000 2431-63511-50 FIL-005-PT-100 24OEM Ref Part No. Page No.2800-0002 NPD016-02 102800-0010 EPD016-02 102800-0032 BSK040-DKC 52800-0041 BSK010-DKC 52800-0042 BSK020-DKC 52800-0165 SHFT16.5-DK 82800-0178 TPD016-02 102821-0072 BSK040-DK 52821-0074 BSDRNG-16 82821-0097 BSDRNG-19 82821-0159 BSK020-DK 52821-0160 BSK010-DK 52821-0257 VSCLIP-DK 172851-1052 BSKHUB-DK 82910-0001 CANRET-DK 272910-0500 CAN500-DK 272910-0900 CAN900-DK 272910-1000 CAN01K-DK 273010-0023 GLA9CR-AD 173010-0069 GLA900-DK 173010-0093 GLA9CR-DK 173010-0095 GLA200-DK 173010-0285 GLA02K-DK 173010-0550 GLA9PK-DK 173100-0017 BSKCLP-DK 83200-0038 BSKHUB-DKC 83250-0019 COVCAP-DK 203250-0070 COVERD-BK 203250-0081 COVDHG-SB 20,353250-0089 COVERD-01 203250-0445 BSKSUP-DK 53350-0095 PLA900-DK 173350-0096 RING01-DK 173350-0109 COVPLG-7D 205041-2166 TAATUB-HP 425560-6011 HINGE-DK 205640-0337 PPTUBD-01 425720-0020-100 FIL45S-DK-100 235720-0020-1000 FIL45S-DK-1000 235720-0203 FIL010-DK 235720-0220-100 FIL35S-DK-100 235720-0220-1000 FIL35S-DK-1000 235720-0275 FIL045-DK 235720-0500 FIL10S-DK-100 235720-0501 FIL10S-DK-1000 235720-0502 FIL70S-DK-100 235720-0503 FIL70S-DK-1000 235720-4037 COVPLG-DK 205720-9059 SFTL-6 275720-9060 SMTLL-6 275720-9074 LE87-6 27OEM Ref Part No. Page No.27-101-074 FIL010-HR-100 2427-101-082 FIL070-HR-100 2427-101-083 FIL10S-HR-100 24,3127-101-084 FIL70S-HR-100 24,3127-101-085 FIL035-HR-100 2427-101-086 FIL35S-HR-100 24,3127-101-087 FIL001-HR-100 2427-101-088 FIL004-HR-100 2427-101-089 FIL045-HR-100 2427-101-090 FIL45S-HR-100 24,3127-101-091 FIL010-HR-1000 2427-101-092 FIL070-HR-1000 2427-101-093 FIL10S-HR-1000 24,3127-101-094 FIL70S-HR-1000 24,3127-101-095 FIL035-HR-1000 2427-101-096 FIL35S-HR-1000 24,3127-101-097 FIL001-HR-1000 2427-101-098 FIL004-HR-1000 2465-190-093 APPFIVE-HR 3265-190-190 APPFIVE-HRSCR 3265-190-205 APPFIVE-HRCLIP 3265-220-000 BSK040-HR 665-220-010 BSK010-HR 665-220-020 BSK020-HR 665-233-170 COVERH-00 2065-237-000 BSKSHT-16 865-590-011 APPSIX-01 3365-590-012 APPSIX-EX 3365-700-030 NPD016-01 1065-700-036 EPD016-01 1065-700-048 BSKSUP-HR 672-300-304 CAN015-HR 2872-500-215 COVERH-01 2072-600-509 GLA02K-HR 1872-600-510 GLA900-HR 1872-600-556 GLA900-AH 1872-800-456 TPD016-01 1072-800-461 TPD018-01 1072-800-603 COVERH-02 2091-030-003 PLA900-HR 1895-590-001 CAN775-SH 2895-590-002 CAN475-SH 2895-590-003 CAN015-SH 2895-590-004 CAN775-PH 2895-590-005 CAN475-PH 2895-590-006 CAN015-PH 2895-590-046 COVERH-HG 2095-590-201 IDASET-01 3995-590-202 IDASNH-01 3995-590-203 IDAPCH-01 3995-590-204 IDADIE-01 3995-590-205 IDAPLT-01 3995-590-206 IDAPRS-01 39Tel: +44 (0)1452 310210Continued overleaf...43

OEMINDEX – OEM REFERENCEVanKelOEM ReferenceVanKelOEM ReferenceVanKelOEM ReferenceOEM Ref Part No. Page No.12-0469 COVERV-LL 2012-1000 NPD015-01 1012-1005 NPD013-01 1012-1010 NPD019-01 1012-1030 EPD015-01 1012-1035 EPD013-01 1012-1040 EPD019-01 1012-1360 APPSIX-01 3312-1400 SPNSHT-15 912-1401 SPNSHT-19 912-1420 SPNNPD-01 912-1421 SPNEPD-01 912-1430 SPNBSK-01 912-1431 SPNRNG-01 912-2050 BSKSHT-15CO 812-2060 STABSK-20 712-2061 STABSK-10 712-2063 STABSK-40 712-2069 STABSK-VK8 3512-2070 BSKSHT-15 812-2073 BSKSHT-13 812-2075 BSKSHT-15C 812-2080 BSKSHT-19 812-2100 BSK040-01 712-2110 BSKPTV-40 712-2120 BSK020-01 712-2125 BSK010-01 712-2130 BSKSUP-01 712-2152 BSK150-01 712-2154 BSK100-01 712-3000 WIRESK-VK 1312-3050 CAPWHT-VK 1212-3056 MAGWHT-VK 1212-3060 SNK010-VK 1212-3062 SNK008-VK 1212-3064 SNK040-VK 1212-3070 CUSBSK-JP 1212-3200 CAN475-01 3012-3210 CAN775-01 3012-3230 SYR020-01 4212-4120 IDADIE-01 3912-4130 IDAPLT-01 3912-4140 IDAPCH-01 3912-4150 IDASNH-01 3912-4200 APPFIVE-V35 3212-4230 APPFIVE-V56 3212-5000 GLA900-01 1912-5010 GLA900-AV 1912-5020 GLA9AM-VK 1912-5035 GLA900-VK 1912-5040 GLA100-VK 19OEM Ref Part No. Page No.12-5050 GLA200-VK 1912-5060 GLA500-01 1912-5070 GLA02K-01 1912-5125 GLA9PK-VK 1912-5200 PLA900-01 1912-5500 GLA9PK-01 1912-6000 VK600A-CR 1912-6050 EZLBKT-01 1912-6065 EZLPEG-01 1912-6200 COVERV-6K 2012-6300 COVERV-01 2012-6310 COVERV-04 2012-6320 COVERV-02 2012-6327 COVERV-LLVS 2012-6328 COVERV-LLHG 2012-6330 COVERV-03 2012-7200 DPSPPD-VK 3712-7210 DPSPBK-VK 3712-7300 DEPGAG-VK 3712-9994 TPP100-01 4212-9995 PAP100-01 4217-3300 CAN900-45 3017-3305 CAN500-60 3017-3306 PROBEX-VK 3017-3320 CANRET-25 3017-400017-401017-4020FIL010-01-100/FIL010-01-1000FIL035-01-100/FIL035-01-1000FIL070-01-100/FIL070-01-100025,3125,3125,3117-4100 FILTIP-02 2517-4110 FILTIP-05 2517-4120 FILTIP-10 2517-4130 FILTIP-20 2517-4140 FILTIP-45 2517-6000 PPTUBV-01 4217-6010 PPTUBV-02 4217-6035 TEFTUB-8V 4227-1000 UPPCAP-03 3427-1020 LOWCAP-03 3427-1050 LOWCAP-05 3427-1500 EVACOV-05 3427-2000 POLSCR-20 3427-2005 POLSCR-40 3427-2015 POLSCR-1K 3427-2100 MSHSCR-20 3427-2103 MSHSCR-30 3427-2105 MSHSCR-40 3427-5000 GLAIST-01 3427-5100 GLA300-02 34OEM Ref Part No. Page No.27-5160ZymarkGLATUB-A/25x150mm3832-1220 RBSCRN-40 3837-2001 DISASY-06 4037-4000 FDISK-VK 4037-5000 DISTUB-06 4037-5200 GLA900-DB 4037-5305 GLA905-DB 4052-5010 GLA100-01 3852-5020 GLA250-01 38SotaxOEM ReferenceOEM Ref Part No. Page No.2503 GLA900-ST 192503-2 GLA900-AS 192830 BSK040-SX 66881 CAPWST-23 137346 CAPWST-18 137349 CAPWST-31 138280 CAPWST-15 138283 CAPWST-19 138399 CAPWHT-S99 12OEM ReferenceOEM Ref Part No. Page No.48479 LOCPIN-ZM 4148481 ADTPIN-ZM 4158730 GLA9CR-ZM 4163127 BSK040-ZM 4169606 CNTRNG-ZM 41If you cannot find what you needplease contact us sales@labhut.com+44 (0)1452 310210+44 (0)1452 30007544Email: sales@labhut.com

INDEX – PART NUMBERINDEXPart No.Page No.Part No.Page No.Part No.Page No.Part No.Page No.Part No.Page No.105540 42BSKSHT-15CO 8CANSTP-125-53 28DEPGAG-VK 37FIL020-EW-100 23ADTPIN-ZM 41BSKSHT-16 8CANSTP-142-31 30DEPSET-MI 37FIL020-EW-1000 23APP5S16-35 32BSKSHT-19 8CANSTP-CA 27DEPSET-SB 35,37FIL020-HR-100 24APP5S20-35 32BSKSHT-ZM2 41CANSTP-EW 28DISASY-06 40FIL020-HR-1000 24APP5S30-35 32BSKSUP-01 7CANSTP-PT 29DISASY-P6 40FIL035-01-100 25,31APP5S40-35 32BSKSUP-CA 5CANSTP-ST 29DISP475-HR 31FIL035-01-1000 25,31APPFIVE-HR 32BSKSUP-DK 5CAPWHT-02 13DISPCAN-CUST 31FIL035-CA-100 23APPFIVE-HRCLIP 32BSKSUP-EW 5CAPWHT-04 13DISTUB-06 40FIL035-CA-1000 23APPFIVE-HRSCR 32BSKSUP-HR 6CAPWHT2S 13DISTUB-P6 40FIL035-EW-100 23APPFIVE-V35 32BSKSUP-PT 6CAPWHT-4S 13DPSPBK-VK 37FIL035-EW-1000 23APPFIVE-V56 32BSKSUP-SX 6CAPWHT-CUS 13DPSPPD-VK 37FIL035-HR-100 24APPFIVE-V80 32CA8015-PV 30CAPWHT-LG 13EPD013-01 10FIL035-HR-1000 24APPSIX-01 33CA8015-VK 30CAPWHT-PC 13EPD015-01 10FIL035-PT-100 24APPSIX-EX 33CA8475-PV 30CAPWHT-S99 12EPD016-01 10FIL035-PT-1000 24BSDRNG-16 8CA8475-VK 30CAPWHT-SV 12EPD016-02 10FIL035-SX-100 25BSDRNG-19 8CA8775-PV 30CAPWHT-TR 13EPD019-01 10FIL035-SX-1000 25BSHT16-02 8CA8775-VK 30CAPWHT-VK 12EVACOV-05 34FIL035-VK-100 25BSK008-01 12CADSTP-ST 29CAPWHT-XL 13EVACOV-07 34FIL035-VK-1000 25BSK008-JP 12CAN013-ST 29CAPWHT-XS 13EZLBKT-01 19FIL040-CA-100 23BSK010-01 7CAN013-ST-5 29CAPWST-15 13EZLKIT-01 19FIL040-CA-1000 23BSK010-CA 5CAN013-ST-9 29CAPWST-18 13EZLPEG-01 19FIL040-EW-100 23BSK010-DK 5CAN015-HR 28CAPWST-19 13FDISK-VK 40FIL040-EW-1000 23BSK010-DKC 5CAN015-PH 28CAPWST-23 13FIL001-CA-100 23FIL045-01-100 25,31BSK010-HR 6CAN015-SH 28CAPWST-31 13FIL001-CA-1000 23FIL045-01-1000 25,31BSK010-PT 6CAN01K-DK 27CNTGAG-MI 37FIL001-EW-100 23FIL045-DK 23BSK010-SX 6CAN01K-DV 31CNTRNG-ZM 41FIL001-EW-1000 23FIL045-HR-100 24BSK020-01 7CAN475-01 30COVCAP-AD 20FIL001-HR-100 24FIL045-HR-1000 24BSK020-CA 5CAN475-HR 28COVCAP-DK 20FIL001-HR-1000 24FIL070-01-100 25,31BSK020-DK 5CAN475-PC 27COVDHG-SB 20,35FIL001-PT-100 24FIL070-01-1000 25,31BSK020-DKC 5CAN475-PH 28COVERAD-BK 20FIL001-PT-1000 24FIL070-CA-100 23BSK020-EW 5CAN475-PP 29COVERD-00 20FIL004-CA-100 23FIL070-CA-1000 23BSK020-HR 6CAN475-SC 27COVERD-01 20FIL004-CA-1000 23FIL070-DK 23BSK020-PT 6CAN475-SH 28COVERD-02 20FIL004-EW-100 23FIL070-EW-100 23BSK020-SX 6CAN475-SP 29COVERD-BK 20FIL004-EW-1000 23FIL070-EW-1000 23BSK040-01 7CAN500-60 30COVERD-HG 20FIL004-HR-100 24FIL070-HR-100 24BSK040-01PL 7CAN500-DK 27COVERH-00 20FIL004-HR-1000 24FIL070-HR-1000 24BSK040-CA 5CAN500-DV 31COVERH-01 20FIL004-PT-100 24FIL070-PT-100 24BSK040-DK 5CAN5PK-DK16 27COVERH-02 20FIL004-PT-1000 24FIL070-PT-1000 24BSK040-DKC 5CAN775-01 30COVERH-03 20FIL005-PT-100 24FIL070-SX-100 25BSK040-EW 5CAN775-HR 28COVERH-04 20FIL005-PT-1000 24FIL070-SX-1000 25BSK040-HR 6CAN775-PC 27COVERH-HG 20FIL010-01-100 25,31FIL070-VK-100 25BSK040-PT 6CAN775-PH 28COVERH-LL 20FIL010-01-1000 25,31FIL070-VK-1000 25BSK040-SX 6CAN775-PP 29COVERV-00 20FIL010-CA-100 23FIL090-DK 23BSK040-ZM 41CAN775-SC 27COVERV-01 20FIL010-CA-1000 23FIL10S-DK-100 23BSK040-ZM2 41CAN775-SH 28COVERV-02 20FIL010-DK 23FIL10S-DK-1000 23BSK100-01 7CAN775-SP 29COVERV-03 20FIL010-EW-100 23FIL10S-HR-100 24,31BSK150-01 7CAN900-45 30COVERV-04 20FIL010-EW-1000 23FIL10S-HR-1000 24,31BSKCLP-DK 8CAN900-DK 27COVERV-6K 20FIL010-HR-100 24FIL20S-DK-100 23BSKHLD-12 7CAN900-DV 31COVERV-HG 20FIL010-HR-1000 24FIL20S-DK-1000 23BSKHUB-DK 8CAN9PK-DK8 27COVERV-LL 20FIL010-PT-100 24FIL35S-DK-100 23BSKHUB-DKC 8CANRET-25 30COVERV-LLHG 20FIL010-PT-1000 24FIL35S-DK-1000 23BSKPTD-40 5CANRET-DK 27COVERV-LLSB 20FIL010-SX-100 25FIL35S-HR-100 24,31BSKPTH-40 6CANS15-PH 28COVERV-LLVS 20FIL010-SX-1000 25FIL35S-HR-1000 24,31BSKPTV-40 7CANS15-SH 28COVHGV-SB 20,35FIL010-VK-100 25FIL45S-DK-100 23BSKSHT-13 8CANSTP-065-53 27,28COVPLG-7D 20FIL010-VK-1000 25FIL45S-DK-1000 23BSKSHT-15 8CANSTP-078-31 30COVPLG-DK 20FIL020-01-100 25,31FIL45S-HR-100 24,31BSKSHT-15C 8CANSTP-125-31 28CUSBSK-JP 12FIL020-01-1000 25,31FIL45S-HR-1000 24,31Tel: +44 (0)1452 310210Continued overleaf...45

INDEXINDEX – PART NUMBERPart No.Page No.Part No.Page No.Part No.Page No.Part No.Page No.FIL70S-DK-100 23GLA9PK-DK 17PROBEX-VK 30VOLFLK-X1 38FIL70S-DK-1000 23GLA9PK-HR 18RBAASSY-01 38VOLFLK-X5 38FIL70S-HR-100 24,31GLA9PK-VK 19RBAASSY-02 38VOLFLK-X9 38FIL70S-HR-1000 24,31GLAIST-01 34RBSCRN-40 38VSCLIP-DK 17FILASY-DK 27GLAIST-AV 34RECAL-CG 37WIRESK-VK 13FILTIP-02 25FILTIP-05 25GLATUB-A/25x150mm38RECAL-LV 37RECAL-TA 37WOBMET-MI 37FILTIP-10 25HINGE-DK 20RECAL-VM 37FILTIP-20 25IDADIE-01 39RECAL-WM 37FILTIP-45 25IDADIE-01 39RETRNG-ZM 41FLEAK-150 38IDAPCH-01 39RING01-DK 17FLEAK-300 38IDAPCH-01 39SFTL-6 27FLU900-01 19IDAPLT-01 39SHFT16.5-DK 8FLU900-DK 17IDAPLT-01 39SMTLL-6 27FLU900-HR 18IDAPRS-01 39SNK008-VK 12FLU9CL-01 19IDAPRS-01 39SNK010-VK 12FLU9CL-DK 17IDASET-01 39SNK040-VK 12FLU9CL-HR 18IDASET-01 39SPNAP6-01 9GLA02K-01 19IDASNH-01 39SPNBSK-01 9GLA02K-DK 17IDASNH-01 39SPNBSK-ZM2 9GLA02K-EW 17LE87-6 27SPNEPD-01 9GLA02K-HR 18LEVEL-UN 37SPNNPD-01 9GLA100-01 38LOCPIN-ZM 41SPNRNG-01 9GLA100-VK 19LOWCAP-03 34SPNSHT-13 9GLA1CA-01 38LOWCAP-05 34SPNSHT-15 9GLA200-DK 17MAGWHT-VK 12SPNSHT-19 9GLA200-VK 19MSHSCR-20 34SPNTPD-01 9GLA250-01 38MSHSCR-30 34STABSK-10 7GLA300-01 34GLA300-02 34GLA300-03 34GLA300-AV 34GLA500-01 19GLA500-DK 17GLA500-HR 18GLA900-01 19MSHSCR-40 34NPD013-01 10NPD015-01 10NPD016-01 10NPD016-02 10NPD019-01 10PADHLD-12A 11PADHLD-16A 11STABSK-20 7STABSK-40 7STABSK-VK8 35SYR020-01 42TAATUB-HP 42TACHOM-UN 37TEFTUB-8V 42TEFTUB-HP 42If you cannot find what you needplease contact us sales@labhut.com+44 (0)1452 310210+44 (0)1452 300075GLA900-AC 17PAP100-01 42THERMD-LC 37GLA900-AD 17PLA900-01 19TPD013-01 10GLA900-AW 17PLA900-AD 17TPD015-01 10GLA900-AH 18PLA900-AH 18TPD016-01 10GLA900-AS 19PLA900-AP 18TPD016-02 10GLA900-AT 18PLA900-AV 19TPD018-01 10GLA900-AV 19PLA900-DK 17TPD019-01 10GLA900-CA 17PLA900-EW 17TPP100-01 42GLA900-DB 40PLA900-HR 18TUBING 42GLA900-DK 17PLA900-PT 18TUMSCR-DK 10GLA900-EW 17POLSCR-1K 34TUMSCR-HR 28GLA900-HR 18POLSCR-20 34UPPCAP-03 34GLA900-PT 18POLSCR-30 34VALTOL-CUST 37GLA900-ST 19POLSCR-40 34VALTOL-KT 37GLA900-VK 19PPTUBD-01 42VESSTD-06A 18GLA905-DB 40PPTUBV-01 42VESSTD-08A 18GLA9AM-VK 19PPTUBV-02 42VIBMET-UN 37GLA9CR-AD 17PRBFSR-5S 29VK600A-CR 19GLA9CR-DK 17PRBFSR-9S 29VOLFLK-05 38GLA9CR-ZM 41PRBFSR-ST 29VOLFLK-09 38GLA9PK-01 19PRBNSR-ST 29VOLFLK-1K 3846 Email: sales@labhut.com

LabHut comtablet dissolution accessoriesOrder online at: www.labhut.comLabHut.com is an international supplier of chromatography and dissolution products. From our UKheadquarters, we currently supply directly to customers in over 60 countries, plus many more locallythrough our international distributor network!Quality Products...At LabHut, we stock top quality products that offer bothexcellent performance and value for money.We supply over 4,000 products from a number ofinnovative manufacturers:• Dissolution Accessories & Consumables• Syringe Filters• Autosampler Vials, Caps, Septa and Inserts• GC & LC Autosamplers• HPLC Columns• Detector Lamps• HPLC Instruments• Microtiter Plates• Chromatography Validation Equipment... and Customer Service to match!Not sure if a product is suitable for your application?Need more information? Looking for advice? Then getin contact!There’s more to LabHut than the website! Ourexperienced and fully qualified team are always onhand to offer advice and answer any questions youmay have.You can contact us by email at sales@labhut.com.Or phone us on +44 (0)1452 310210.What’s more, we’ll still be here and happy to help youafter your purchase, ensuring you really get the mostfrom your investment.www.labhut.comTabletDissolution.com is the reference site for SMI-LabHut’s range of tablet dissolution instruments andconsumables. It runs alongside LabHut.com, which sells the dissolution products.www.tabletdissolution.comThe dissolution accessories and consumables at LabHut.com are manufactured by Quality Lab Accessories LLC(QLA) in Bridgewater, New Jersey, USA.QLA’s experienced engineering staff and manufacturing facility produce the highest quality products that are industrystandards.www.qla-llc.comOrdering and Product InformationAll of the LabHut Tablet Dissolution products can be ordered onlineat www.labhut.com or by calling +44 (0)1452 310210. They arealso available through distributors worldwide. To find your localdistributor please visit www.labhut.com/distributors.All trademarks acknowledged.Copyright © 2008SMI-LabHut LtdALL RIGHTS RESERVEDPrinted in the UK, February 2008.

Your Local Distributor:SMI-LabHut LtdSMI-LabHut LtdThe GranaryThe SteadingsMaisemoreGloucestershireGL2 8EYUKTel: +44 (0)1452 310210Fax: +44 (0)1452 300075Email: sales@labhut.comWebsite: www.labhut.com