Oil for Life to Balance omega-3 polyunsaturated fatty acids ... - Oil4Life
Oil for Life to Balance omega-3 polyunsaturated fatty acids ... - Oil4Life
Oil for Life to Balance omega-3 polyunsaturated fatty acids ... - Oil4Life
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Supplementation with <strong>omega</strong>-3 were linked <strong>to</strong> an increase of vigour and a decrease of<br />
negative fac<strong>to</strong>rs such as anger, anxiety and depression. These results confirm the influence of<br />
<strong>omega</strong>-3 on the central nervous system. They are also in line with the suggested action of<br />
these compounds on dementia, depression and mood disorders, in which they may act as<br />
mood. The results suggest that some of these effects are due almost exclusively <strong>to</strong> diet, e.g<br />
the reduction of body fat, while others, such as the mood state variations, are mainly due <strong>to</strong><br />
<strong>omega</strong>-3 supplementation and the strong antioxidant defence built in<strong>to</strong> <strong>Oil</strong>4<strong>Life</strong> <strong>Balance</strong>.<br />
About 7% of children between the ages of 5-11 years have been diagnosed with Attention<br />
Deficit Hyperactivity Disorder (ADHD). It is one of most common neurodevelopmental<br />
syndrome of childhood. The symp<strong>to</strong>ms should present itself <strong>for</strong> at least six months be<strong>for</strong>e the<br />
age of 7 years, accompanied by “clinically significant” impairment. The current consensus is<br />
that no biochemical tests can reliably predict ADHD. However, a genetic feature of ADHD<br />
is strongly suggested because the syndrome clusters in families, and two polymorphisms in<br />
the dopamine transporter and recep<strong>to</strong>r genes have been identified that seem <strong>to</strong> influence the<br />
risk of ADHD. General consensus is that many other genes are probably involved in the<br />
transmission of the disorder.<br />
One hypothesis of the etiology of ADHD is concerned with the role of prostaglandins in the<br />
dopaminergic synapses. According <strong>to</strong> this hypothesis, ADHD is caused or worsened by a<br />
deficiency of Prostaglandin E1 (PGE1), which is again caused by the lack of the enzyme<br />
Δ-6-desaturase. Also environmental <strong>to</strong>xicant (lead) might be an etiologic risk fac<strong>to</strong>r <strong>for</strong><br />
ADHD, as is cigarette smoking during pregnancy. Diet may also be an ethiological risk<br />
fac<strong>to</strong>r <strong>for</strong> ADHD. Abnormalities in PUFA metabolism in red blood cell membranes has been<br />
reported in children with ADHD. Children with ADHD have lower levels of long chain<br />
<strong>omega</strong>-3 <strong>fatty</strong> <strong>acids</strong> (EPA+DHA) in their blood, probably due <strong>to</strong> lack of dietary intake in<br />
conjunction with a more rapid metabolism. Our studies have highlighted a deficiency of the<br />
long chain <strong>omega</strong>-3 <strong>fatty</strong> <strong>acids</strong> in the membrane phospholipids of patients affected with<br />
ADHD. Furthermore, the ratio of AA/EPA in phospholipids both in blood and in RBC seems<br />
<strong>to</strong> be elevated. The elevated AA/EPA ratio indicates an increased upstream inflamma<strong>to</strong>ry<br />
potential. In our study of 30 children with ADHD the diet were supplemented with 2.5 mg<br />
/10 kg/day of EPA+DHA 2:1 as in <strong>Oil</strong>4<strong>Life</strong> <strong>Balance</strong>. The supplementation of EPA and<br />
DHA in relatively high doses compared <strong>to</strong> body weight, verified that an improved AA/EPA<br />
balance in the cell membrane increased attention level and decrease both hyperactivity levels<br />
and impulsiveness. There was a correlation between the dose of long chain <strong>omega</strong>-3 <strong>fatty</strong><br />
<strong>acids</strong>, the decrease of AA/EPA ratio and/or the entity of the clinical improvement (score).<br />
Depletion of <strong>omega</strong>-3 <strong>fatty</strong> acid levels in red blood cell membranes of depressed patients has<br />
been reported. A significant positive relationship was observed between the severity of the<br />
illness and the ratio of arachidonic acid <strong>to</strong> eicosapentaenoic acid in serum phospholipids and<br />
in erythrocyte membranes. Preliminary results in our labora<strong>to</strong>ry on depressed elderly patients<br />
demonstrated that counteracting and balancing high levels of AA with EPA+DHA 2:1, as in<br />
<strong>Oil</strong>4<strong>Life</strong> <strong>Balance</strong>, also decreased depression symp<strong>to</strong>ms. Several authors have also reported<br />
lower concentrations of erythrocyte essential <strong>fatty</strong> <strong>acids</strong> among schizophrenic patients as<br />
compared with control. DHA is the major acid of neurological and retinal membranes. It<br />
makes up more than 30% of the structural lipids of the neuron. Low levels of circulating<br />
DHA may be a significant risk in the development of Alzheimer dementia. The inability <strong>to</strong><br />
maintain a high level of DHA may be due <strong>to</strong> a reduced capacity <strong>to</strong> synthesise DHA late in<br />
life, as the result of a reduction in Δ-6-desaturase activity. Alterations in phospholipids,<br />
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