User Guide - PregSafe

SmokerChoose Yes if the patient is a smoker. Although other markers do not appear to beaffected by smoking, HCG levels are on average 24% lower and Inhibin A levels 58%higher in smokers than in non-smokers. These levels tend to counter-balance each otherin Quad screening but experts recommend that screening is more accurate if thesedifferences are corrected using correction factors.RhChoose Yes if the patient has an Rh negative blood type. Rh negative mothers tend tohave somewhat reduced levels of uE3. (Median about 0.85 MoMs)DS HistoryThe DS History field will appear only if the Use Family History checkbox is checked inthe Down Syndrome page of the Conditions section of the Screening menu. Thepossible entries for this field are Yes, No, Unknown and Do not use. You can select yourresponse from the drop-down list by• using the mouse to open the list and make your selection• typing to open the list, using the ↑ and ↓ keys to move to your selectionand pressing to record the selection• typing the first letter of your selection.Choose Yes only if there is a first degree family history, ie either the patient or the fatherof the fetus has Down syndrome, or this patient has had a previous pregnancy where thefetus was affected with Down syndrome.If you choose No, Unknown or Do not use, the calculated risk will be the same but if youchoose Unknown, the phrase “Based on partial information supplied” will appear on thepatient report.If Yes is the choice in the DS history field, and the patient is 35.5 years of age or more,then the patient’s age-based risk is multiplied by a factor of 2. This factor can beamended using site customization AFPX_C650. See Section 3.1.5 of this chapter forinstructions on implementing customizations and Chapter 3, Section 2, Customizations,for a list of customizations.The allowed range of values is 1 to 5.If the patient is less than 35.5 years of age, her age-based risk will be set at 1in 200,regardless of her exact age.The statement on the report that normally gives the age-related risk will state the risk“based on age and family history” if family history is in use.OSB HistoryThe OSB History field will appear only if the Use Family History checkbox is checked inthe OSB page of the Conditions section of the Screening menu. The possible entries forthis field are No, 1,2,3, Unknown and Do not use. You can select your response from thedrop-down list by• using the mouse to open the list and make your selection• typing to open the list, using the ↑ and ↓ keys to move to your selectionand pressing to record the selection• typing the first letter of your selection.The meanings of the available choices are as follows:10